Compile Data Set for Download or QSAR

Found 432 hits of ic50 for UniProtKB: P07861   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Rattus norvegicus (Rat))	BDBM50008612 (CHEMBL154588 | Sodium; 3-(2-mercaptomethyl-3-pheny...) Show SMILES [O-]S(=O)(=O)c1cccc(NC(=O)C(CS)Cc2ccccc2)c1 Show InChI InChI=1S/C16H17NO4S2/c18-16(13(11-22)9-12-5-2-1-3-6-12)17-14-7-4-8-15(10-14)23(19,20)21/h1-8,10,13,22H,9,11H2,(H,17,18)(H,19,20,21)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against enkephalinase enzyme from rat.				J Med Chem 35: 602-8 (1992) BindingDB Entry DOI: 10.7270/Q2QZ28ZD
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024094 ((R,S) 2-(2-Mercaptomethyl-3-phenyl-propionylamino)...) Show SMILES C[C@@H](NC(=O)[C@H](CS)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C13H17NO3S/c1-9(13(16)17)14-12(15)11(8-18)7-10-5-3-2-4-6-10/h2-6,9,11,18H,7-8H2,1H3,(H,14,15)(H,16,17)/t9-,11+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.410	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase				J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024101 ((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...) Show SMILES C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C13H17NO3S/c1-9(13(16)17)14-12(15)11(8-18)7-10-5-3-2-4-6-10/h2-6,9,11,18H,7-8H2,1H3,(H,14,15)(H,16,17)/t9-,11+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase				J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024100 ((R,S) N-(1-Mercaptomethyl-2-phenyl-ethyl)-2-methyl...) Show SMILES C[C@@H](C(O)=O)C(=O)N[C@H](CS)Cc1ccccc1 Show InChI InChI=1S/C13H17NO3S/c1-9(13(16)17)12(15)14-11(8-18)7-10-5-3-2-4-6-10/h2-6,9,11,18H,7-8H2,1H3,(H,14,15)(H,16,17)/t9-,11+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase				J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50251742 ((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...) Show SMILES CC(C)C[C@H](NP(O)(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r| Show InChI InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatum				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neprilysin (Rattus norvegicus (Rat))	BDBM50197517 ((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...) Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C21H30ClNO4/c1-27-14-10-17(19(24)25)15-21(11-2-3-12-21)20(26)23-13-4-5-16-6-8-18(22)9-7-16/h6-9,17H,2-5,10-15H2,1H3,(H,23,26)(H,24,25)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat NEP				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024097 ((R,R) N-(1-Mercaptomethyl-2-phenyl-ethyl)-2-methyl...) Show SMILES C[C@H](C(O)=O)C(=O)N[C@H](CS)Cc1ccccc1 Show InChI InChI=1S/C13H17NO3S/c1-9(13(16)17)12(15)14-11(8-18)7-10-5-3-2-4-6-10/h2-6,9,11,18H,7-8H2,1H3,(H,14,15)(H,16,17)/t9-,11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase				J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034841 ((S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoyl)-p...) Show SMILES OC(=O)CCNC(=O)[C@@H](CCC(O)=O)Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H23NO5/c23-19(24)11-10-18(21(27)22-13-12-20(25)26)14-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-9,18H,10-14H2,(H,22,27)(H,23,24)(H,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034846 ((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...) Show SMILES C[C@H](C[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O)C(O)=O Show InChI InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024098 ((R,R) 2-(1-Mercaptomethyl-2-phenyl-ethylcarbamoyl)...) Show SMILES CC(C)C[C@H](C(O)=O)C(=O)N[C@H](CS)Cc1ccccc1 Show InChI InChI=1S/C16H23NO3S/c1-11(2)8-14(16(19)20)15(18)17-13(10-21)9-12-6-4-3-5-7-12/h3-7,11,13-14,21H,8-10H2,1-2H3,(H,17,18)(H,19,20)/t13-,14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase				J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50042828 (4-Hydroxy-1-(9-mercaptomethyl-10-oxo-azecane-2-car...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)C1CCCCCCC(CS)C(=O)N1)C(O)=O Show InChI InChI=1S/C16H26N2O5S/c19-11-7-13(16(22)23)18(8-11)15(21)12-6-4-2-1-3-5-10(9-24)14(20)17-12/h10-13,19,24H,1-9H2,(H,17,20)(H,22,23)/t10?,11-,12?,13+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of NEP 24.11 from rat kidney				J Med Chem 36: 3821-8 (1994) BindingDB Entry DOI: 10.7270/Q2ZS2X5D
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50008616 (CHEMBL157625 | Sodium; 2-(2-mercaptomethyl-3-pheny...) Show SMILES [O-]S(=O)(=O)CCNC(=O)[C@@H](CS)Cc1ccccc1 Show InChI InChI=1S/C12H17NO4S2/c14-12(13-6-7-19(15,16)17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,13,14)(H,15,16,17)/p-1/t11-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against enkephalinase enzyme from rat.				J Med Chem 35: 602-8 (1992) BindingDB Entry DOI: 10.7270/Q2QZ28ZD
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50008595 (CHEMBL351330 | Sodium; 4-(2-mercaptomethyl-4-methy...) Show SMILES CC(C)CC(CS)C(=O)Nc1ccc(cc1)S([O-])(=O)=O Show InChI InChI=1S/C13H19NO4S2/c1-9(2)7-10(8-19)13(15)14-11-3-5-12(6-4-11)20(16,17)18/h3-6,9-10,19H,7-8H2,1-2H3,(H,14,15)(H,16,17,18)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against enkephalinase enzyme from rat.				J Med Chem 35: 602-8 (1992) BindingDB Entry DOI: 10.7270/Q2QZ28ZD
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) Show SMILES OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)c1nnn[nH]1 Show InChI InChI=1S/C16H18N5O3P/c22-25(23,24)11-17-15(16-18-20-21-19-16)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15,17H,10-11H2,(H2,22,23,24)(H,18,19,20,21)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	0.930	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP)				Bioorg Med Chem Lett 5: 145-150 (1995) Article DOI: 10.1016/0960-894X(94)00474-T BindingDB Entry DOI: 10.7270/Q2G160SW
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) Show SMILES OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)c1nnn[nH]1 Show InChI InChI=1S/C16H18N5O3P/c22-25(23,24)11-17-15(16-18-20-21-19-16)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15,17H,10-11H2,(H2,22,23,24)(H,18,19,20,21)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Biomedical Research Curated by ChEMBL					Assay Description In vitro inhibition of rat neutral endopeptidase				J Med Chem 43: 488-504 (2000) BindingDB Entry DOI: 10.7270/Q21G0MZR
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50025917 ((2-Hydroxyaminomethyl-3-phenyl-propionylamino)-ace...) Show SMILES ONCC(Cc1ccccc1)C(=O)NCC(O)=O Show InChI InChI=1S/C12H16N2O4/c15-11(16)8-13-12(17)10(7-14-18)6-9-4-2-1-3-5-9/h1-5,10,14,18H,6-8H2,(H,13,17)(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of enkephalinase purified from rat kidney.				J Med Chem 28: 1158-69 (1985) BindingDB Entry DOI: 10.7270/Q20C4WB5
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50025920 ((2-Hydroxycarbamoyl-3-phenyl-propionylamino)-aceti...) Show SMILES COC(=O)CNC(=O)C(Cc1ccccc1)C(=O)NO Show InChI InChI=1S/C13H16N2O5/c1-20-11(16)8-14-12(17)10(13(18)15-19)7-9-5-3-2-4-6-9/h2-6,10,19H,7-8H2,1H3,(H,14,17)(H,15,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of enkephalinase purified from rat kidney.				J Med Chem 28: 1158-69 (1985) BindingDB Entry DOI: 10.7270/Q20C4WB5
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50008602 (CHEMBL435444 | Sodium; 4-(2-mercaptomethyl-3-p-tol...) Show SMILES Cc1ccc(CC(CS)C(=O)Nc2ccc(cc2)S([O-])(=O)=O)cc1 Show InChI InChI=1S/C17H19NO4S2/c1-12-2-4-13(5-3-12)10-14(11-23)17(19)18-15-6-8-16(9-7-15)24(20,21)22/h2-9,14,23H,10-11H2,1H3,(H,18,19)(H,20,21,22)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against enkephalinase enzyme from rat.				J Med Chem 35: 602-8 (1992) BindingDB Entry DOI: 10.7270/Q2QZ28ZD
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048318 ((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](CCc1ccccc1)C(O)=O Show InChI InChI=1S/C21H30N2O4S/c1-14(2)17(28)18(24)23-21(12-6-7-13-21)20(27)22-16(19(25)26)11-10-15-8-4-3-5-9-15/h3-5,8-9,14,16-17,28H,6-7,10-13H2,1-2H3,(H,22,27)(H,23,24)(H,25,26)/t16-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50025914 (2-Benzyl-N-(benzylcarbamoyl-methyl)-3-(formyl-hydr...) Show SMILES ON(CC(Cc1ccccc1)C(=O)NCC(=O)NCc1ccccc1)C=O Show InChI InChI=1S/C20H23N3O4/c24-15-23(27)14-18(11-16-7-3-1-4-8-16)20(26)22-13-19(25)21-12-17-9-5-2-6-10-17/h1-10,15,18,27H,11-14H2,(H,21,25)(H,22,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of enkephalinase purified from rat kidney.				J Med Chem 28: 1158-69 (1985) BindingDB Entry DOI: 10.7270/Q20C4WB5
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50085454 (CHEMBL90388 | N-formyl hydroxylamine containing di...) Show SMILES ON(C[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O)C=O Show InChI InChI=1S/C23H25N3O6/c27-15-25(32)13-18(12-16-6-2-1-3-7-16)22(30)24-19-11-10-17-8-4-5-9-20(17)26(23(19)31)14-21(28)29/h1-9,15,18-19,32H,10-14H2,(H,24,30)(H,28,29)/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Neutral endopeptidase				Bioorg Med Chem Lett 10: 257-60 (2000) BindingDB Entry DOI: 10.7270/Q2BK1BJ8
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50002022 ((2-Benzyl-3-hydroxycarbamoyl-propionylamino)-aceti...) Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NCC(O)=O Show InChI InChI=1S/C13H16N2O5/c16-11(15-20)7-10(13(19)14-8-12(17)18)6-9-4-2-1-3-5-9/h1-5,10,20H,6-8H2,(H,14,19)(H,15,16)(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of enkephalinase purified from rat kidney.				J Med Chem 28: 1158-69 (1985) BindingDB Entry DOI: 10.7270/Q20C4WB5
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50285328 (CHEMBL285747 | {[(S)-2-Biphenyl-4-yl-1-(1H-tetrazo...) Show SMILES OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)Nc1nnn[nH]1 Show InChI InChI=1S/C17H19N6O4P/c24-16(19-17-20-22-23-21-17)15(18-11-28(25,26)27)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15,18H,10-11H2,(H2,25,26,27)(H2,19,20,21,22,23,24)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP)				Bioorg Med Chem Lett 5: 145-150 (1995) Article DOI: 10.1016/0960-894X(94)00474-T BindingDB Entry DOI: 10.7270/Q2G160SW
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048320 ((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1cccs1)C(O)=O Show InChI InChI=1S/C18H26N2O4S2/c1-11(2)14(25)15(21)20-18(7-3-4-8-18)17(24)19-13(16(22)23)10-12-6-5-9-26-12/h5-6,9,11,13-14,25H,3-4,7-8,10H2,1-2H3,(H,19,24)(H,20,21)(H,22,23)/t13-,14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048312 ((S)-3-(4-Hydroxy-phenyl)-2-{[1-((S)-2-mercapto-3-m...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C20H28N2O5S/c1-12(2)16(28)17(24)22-20(9-3-4-10-20)19(27)21-15(18(25)26)11-13-5-7-14(23)8-6-13/h5-8,12,15-16,23,28H,3-4,9-11H2,1-2H3,(H,21,27)(H,22,24)(H,25,26)/t15-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024099 ((R,S) 2-(1-Mercaptomethyl-2-phenyl-ethylcarbamoyl)...) Show SMILES CC(C)C[C@@H](C(O)=O)C(=O)N[C@H](CS)Cc1ccccc1 Show InChI InChI=1S/C16H23NO3S/c1-11(2)8-14(16(19)20)15(18)17-13(10-21)9-12-6-4-3-5-7-12/h3-7,11,13-14,21H,8-10H2,1-2H3,(H,17,18)(H,19,20)/t13-,14+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase				J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM21641 (2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...) Show SMILES OC(=O)CNC(=O)C(CS)Cc1ccccc1 Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neprilysin (Rattus norvegicus (Rat))	BDBM50025913 (CHEMBL16457 | [2-(Formyl-hydroxy-amino)-3-phenyl-p...) Show SMILES ON(C=O)C(Cc1ccccc1)C(=O)NCC(O)=O Show InChI InChI=1S/C12H14N2O5/c15-8-14(19)10(12(18)13-7-11(16)17)6-9-4-2-1-3-5-9/h1-5,8,10,19H,6-7H2,(H,13,18)(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of enkephalinase purified from rat kidney.				J Med Chem 28: 1158-69 (1985) BindingDB Entry DOI: 10.7270/Q20C4WB5
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50285340 (CHEMBL290285 | {[(S)-2-(2-Methoxy-biphenyl-4-yl)-1...) Show SMILES COc1cc(C[C@H](NCP(O)(O)=O)c2nnn[nH]2)ccc1-c1ccccc1 Show InChI InChI=1S/C17H20N5O4P/c1-26-16-10-12(7-8-14(16)13-5-3-2-4-6-13)9-15(17-19-21-22-20-17)18-11-27(23,24)25/h2-8,10,15,18H,9,11H2,1H3,(H2,23,24,25)(H,19,20,21,22)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP)				Bioorg Med Chem Lett 5: 145-150 (1995) Article DOI: 10.1016/0960-894X(94)00474-T BindingDB Entry DOI: 10.7270/Q2G160SW
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50008605 (CHEMBL157663 | Sodium; 2-(2-mercaptomethyl-3-pheny...) Show SMILES [O-]S(=O)(=O)CCNC(=O)C(CS)Cc1ccccc1 Show InChI InChI=1S/C12H17NO4S2/c14-12(13-6-7-19(15,16)17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,13,14)(H,15,16,17)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against enkephalinase enzyme from rat.				J Med Chem 35: 602-8 (1992) BindingDB Entry DOI: 10.7270/Q2QZ28ZD
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024096 (((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) Show SMILES OC(=O)CNC(=O)[C@H](CS)Cc1ccccc1 Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition of rat kidney neutral endopeptidase				Bioorg Med Chem Lett 6: 2097-2102 (1996) Article DOI: 10.1016/0960-894X(96)00375-7 BindingDB Entry DOI: 10.7270/Q2X92B8K
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP 24.11) from rat kidney cortex membranes				Bioorg Med Chem Lett 4: 539-542 (1994) Article DOI: 10.1016/S0960-894X(01)80150-5 BindingDB Entry DOI: 10.7270/Q2736QV0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50282859 ((2S,4S)-1-[(S)-2-((S)-2-Mercaptomethyl-3-phenyl-pr...) Show SMILES C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(O)=O)Sc1ccccc1 Show InChI InChI=1S/C24H28N2O4S2/c1-16(25-22(27)18(15-31)12-17-8-4-2-5-9-17)23(28)26-14-20(13-21(26)24(29)30)32-19-10-6-3-7-11-19/h2-11,16,18,20-21,31H,12-15H2,1H3,(H,25,27)(H,29,30)/t16-,18+,20-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of rat kidney neutral endopeptidase (NEP) by fluorometric assay using Dansyl-Gly-Phe-Arg as substrate				Bioorg Med Chem Lett 4: 1783-1788 (1994) Article DOI: 10.1016/S0960-894X(01)80371-1 BindingDB Entry DOI: 10.7270/Q2Z3204W
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024096 (((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) Show SMILES OC(=O)CNC(=O)[C@H](CS)Cc1ccccc1 Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase				J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50008590 (CHEMBL154774 | Sodium; 4-(2-mercaptomethyl-3-pheny...) Show SMILES [O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccccc2)cc1 Show InChI InChI=1S/C16H17NO4S2/c18-16(13(11-22)10-12-4-2-1-3-5-12)17-14-6-8-15(9-7-14)23(19,20)21/h1-9,13,22H,10-11H2,(H,17,18)(H,19,20,21)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against enkephalinase enzyme from rat.				J Med Chem 35: 602-8 (1992) BindingDB Entry DOI: 10.7270/Q2QZ28ZD
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50085460 ((4S,7S,12bR)-7-[(R)-2-Benzyl-3-(formyl-hydroxy-ami...) Show SMILES ON(C[C@@H](Cc1ccccc1)C(=O)N[C@H]1Cc2ccccc2[C@H]2CCC[C@H](N2C1=O)C(O)=O)C=O Show InChI InChI=1S/C26H29N3O6/c30-16-28(35)15-19(13-17-7-2-1-3-8-17)24(31)27-21-14-18-9-4-5-10-20(18)22-11-6-12-23(26(33)34)29(22)25(21)32/h1-5,7-10,16,19,21-23,35H,6,11-15H2,(H,27,31)(H,33,34)/t19-,21+,22-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Neutral endopeptidase				Bioorg Med Chem Lett 10: 257-60 (2000) BindingDB Entry DOI: 10.7270/Q2BK1BJ8
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048304 ((S)-3-(4-Fluoro-phenyl)-2-{[1-((S)-2-mercapto-3-me...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(O)=O Show InChI InChI=1S/C20H27FN2O4S/c1-12(2)16(28)17(24)23-20(9-3-4-10-20)19(27)22-15(18(25)26)11-13-5-7-14(21)8-6-13/h5-8,12,15-16,28H,3-4,9-11H2,1-2H3,(H,22,27)(H,23,24)(H,25,26)/t15-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description In vitro inhibition of Neutral endopeptidase (NEP) enzyme				J Med Chem 37: 498-511 (1994) BindingDB Entry DOI: 10.7270/Q2H70GF9
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50024102 (((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) Show SMILES OC(=O)CNC(=O)[C@@H](CS)Cc1ccccc1 Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)/t10-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase				J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neprilysin (Rattus norvegicus (Rat))	BDBM50024102 (((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) Show SMILES OC(=O)CNC(=O)[C@@H](CS)Cc1ccccc1 Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)/t10-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition of rat kidney neutral endopeptidase				Bioorg Med Chem Lett 6: 2097-2102 (1996) Article DOI: 10.1016/0960-894X(96)00375-7 BindingDB Entry DOI: 10.7270/Q2X92B8K
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50020158 ((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...) Show SMILES CC(NC(=O)C(CC(=O)NO)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of enkephalinase purified from rat kidney.				J Med Chem 28: 1158-69 (1985) BindingDB Entry DOI: 10.7270/Q20C4WB5
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50042835 (1-(9-Mercaptomethyl-10-oxo-azecane-2-carbonyl)-pyr...) Show SMILES OC(=O)[C@@H]1CCCN1C(=O)C1CCCCCCC(CS)C(=O)N1 Show InChI InChI=1S/C16H26N2O4S/c19-14-11(10-23)6-3-1-2-4-7-12(17-14)15(20)18-9-5-8-13(18)16(21)22/h11-13,23H,1-10H2,(H,17,19)(H,21,22)/t11?,12?,13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of NEP 24.11 from rat kidney				J Med Chem 36: 3821-8 (1994) BindingDB Entry DOI: 10.7270/Q2ZS2X5D
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50040401 ((S)-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-pro...) Show SMILES OC(=O)[C@@H](NC(=O)C(Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O)c1ccccc1 Show InChI InChI=1S/C24H25N2O6P/c27-23(26-22(24(28)29)20-9-5-2-6-10-20)21(25-16-33(30,31)32)15-17-11-13-19(14-12-17)18-7-3-1-4-8-18/h1-14,21-22,25H,15-16H2,(H,26,27)(H,28,29)(H2,30,31,32)/t21?,22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description In vitro inhibition of Neutral endopeptidase (NEP) enzyme				J Med Chem 37: 498-511 (1994) BindingDB Entry DOI: 10.7270/Q2H70GF9
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50282855 ((S)-1-[(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propio...) Show SMILES CCC[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O Show InChI InChI=1S/C20H28N2O4S/c1-2-7-16(19(24)22-11-6-10-17(22)20(25)26)21-18(23)15(13-27)12-14-8-4-3-5-9-14/h3-5,8-9,15-17,27H,2,6-7,10-13H2,1H3,(H,21,23)(H,25,26)/t15-,16+,17+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of rat kidney neutral endopeptidase (NEP) by fluorometric assay using Dansyl-Gly-Phe-Arg as substrate				Bioorg Med Chem Lett 4: 1783-1788 (1994) Article DOI: 10.1016/S0960-894X(01)80371-1 BindingDB Entry DOI: 10.7270/Q2Z3204W
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM85433 (NEP inhibitor, 6m) Show SMILES OC(=O)c1cc(NC(=O)C(CS)Cc2ccccc2)c[nH]1 Show InChI InChI=1S/C15H16N2O3S/c18-14(17-12-7-13(15(19)20)16-8-12)11(9-21)6-10-4-2-1-3-5-10/h1-5,7-8,11,16,21H,6,9H2,(H,17,18)(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
R&D, Zambon Group Spa					Assay Description Enzyme inhibition assay using neutrol endopeptiase EC 3.4.24.11 (NEP).				J Enzym Inhib 12: 155-60 (1997) Article DOI: 10.3109/14756369709035816 BindingDB Entry DOI: 10.7270/Q2FQ9V4F
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048303 ((S)-3-(5-Hydroxy-1H-indol-3-yl)-2-{[1-((S)-2-merca...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(O)=O Show InChI InChI=1S/C22H29N3O5S/c1-12(2)18(31)19(27)25-22(7-3-4-8-22)21(30)24-17(20(28)29)9-13-11-23-16-6-5-14(26)10-15(13)16/h5-6,10-12,17-18,23,26,31H,3-4,7-9H2,1-2H3,(H,24,30)(H,25,27)(H,28,29)/t17-,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM85434 (NEP inhibitor, 6n) Show SMILES OC(=O)c1cc(NC(=O)C(CS)Cc2ccc(Cl)cc2)c[nH]1 Show InChI InChI=1S/C15H15ClN2O3S/c16-11-3-1-9(2-4-11)5-10(8-22)14(19)18-12-6-13(15(20)21)17-7-12/h1-4,6-7,10,17,22H,5,8H2,(H,18,19)(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
R&D, Zambon Group Spa					Assay Description Enzyme inhibition assay using neutrol endopeptiase EC 3.4.24.11 (NEP).				J Enzym Inhib 12: 155-60 (1997) Article DOI: 10.3109/14756369709035816 BindingDB Entry DOI: 10.7270/Q2FQ9V4F
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 432 total )  |  Next  |  Last  >>

Jump to: