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Compile Data Set for Download or QSAR

Found 147 hits of ic50 data for polymerid = 1380,1566,50000040,50007003   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126030
PNG
(4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-pheny...)
Show SMILES Cn1cncc1C(O)(C#Cc1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C30H21N3O/c1-33-21-32-20-29(33)30(34,17-16-22-8-3-2-4-9-22)25-15-14-24(19-31)28(18-25)27-13-7-11-23-10-5-6-12-26(23)27/h2-15,18,20-21,34H,1H3
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n/an/a 3.10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126045
PNG
(4-[3-(4-Chloro-phenyl)-1-hydroxy-1-(3-methyl-3H-im...)
Show SMILES Cn1cncc1C(O)(C#Cc1ccc(Cl)cc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C30H20ClN3O/c1-34-20-33-19-29(34)30(35,16-15-21-9-13-25(31)14-10-21)24-12-11-23(18-32)28(17-24)27-8-4-6-22-5-2-3-7-26(22)27/h2-14,17,19-20,35H,1H3
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n/an/a 9.5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127299
PNG
(5-[(5-Cyano-3',5'-difluoro-biphenyl-2-ylmethoxy)-(...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cc(F)cc(F)c1)C#N)c1ccc(nc1)C#N
Show InChI InChI=1S/C25H17F2N5O/c1-32-15-30-13-24(32)25(17-4-5-22(11-29)31-12-17)33-14-18-3-2-16(10-28)6-23(18)19-7-20(26)9-21(27)8-19/h2-9,12-13,15,25H,14H2,1H3
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n/an/a>10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126035
PNG
(4-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imi...)
Show SMILES Cn1cncc1C(O)(C#Cc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C31H20N4O/c1-35-21-34-20-30(35)31(36,16-15-22-9-11-23(18-32)12-10-22)26-14-13-25(19-33)29(17-26)28-8-4-6-24-5-2-3-7-27(24)28/h2-14,17,20-21,36H,1H3
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n/an/a 10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127319
PNG
(5-[(2-Benzo[1,3]dioxol-5-yl-4-cyano-benzyloxy)-(3-...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc2OCOc2c1)C#N)c1ccc(nc1)C#N
Show InChI InChI=1S/C26H19N5O3/c1-31-15-29-13-23(31)26(19-4-6-21(11-28)30-12-19)32-14-20-3-2-17(10-27)8-22(20)18-5-7-24-25(9-18)34-16-33-24/h2-9,12-13,15,26H,14,16H2,1H3
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n/an/a>10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127314
PNG
(5-[(5-Cyano-3'-methoxy-biphenyl-2-ylmethoxy)-(3-me...)
Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(nc1)C#N)C#N
Show InChI InChI=1S/C26H21N5O2/c1-31-17-29-15-25(31)26(20-8-9-22(13-28)30-14-20)33-16-21-7-6-18(12-27)10-24(21)19-4-3-5-23(11-19)32-2/h3-11,14-15,17,26H,16H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127325
PNG
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Show SMILES Cn1cncc1C(OCc1ccc(nc1N1CCOCC1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22N6O2/c1-28-16-26-14-21(28)22(18-4-2-17(12-24)3-5-18)31-15-19-6-7-20(13-25)27-23(19)29-8-10-30-11-9-29/h2-7,14,16,22H,8-11,15H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127308
PNG
(5-[(4-Cyano-2-naphthalen-1-yl-benzyloxy)-(3-methyl...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc2ccccc12)C#N)c1ccc(nc1)C#N
Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-28(34)29(22-11-12-24(15-31)33-16-22)35-18-23-10-9-20(14-30)13-27(23)26-8-4-6-21-5-2-3-7-25(21)26/h2-13,16-17,19,29H,18H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127305
PNG
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccccc1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H19N5O/c1-30-17-28-15-23(30)25(20-9-7-18(13-26)8-10-20)31-16-21-11-12-22(14-27)29-24(21)19-5-3-2-4-6-19/h2-12,15,17,25H,16H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127328
PNG
(5-(3-Chloro-phenyl)-4-[(4-cyano-phenyl)-(3-methyl-...)
Show SMILES Cn1cncc1C(OCc1cc(ncc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H18ClN5O/c1-31-16-29-14-24(31)25(18-7-5-17(11-27)6-8-18)32-15-20-10-22(12-28)30-13-23(20)19-3-2-4-21(26)9-19/h2-10,13-14,16,25H,15H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126027
PNG
(4-[3-(4-Ethynyl-phenyl)-1-hydroxy-1-(3-methyl-3H-i...)
Show SMILES Cn1cncc1C(O)(C#Cc1ccc(cc1)C#C)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C32H21N3O/c1-3-23-11-13-24(14-12-23)17-18-32(36,31-21-34-22-35(31)2)27-16-15-26(20-33)30(19-27)29-10-6-8-25-7-4-5-9-28(25)29/h1,4-16,19,21-22,36H,2H3
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126031
PNG
(4-[3-(4-Ethyl-phenyl)-1-hydroxy-1-(3-methyl-3H-imi...)
Show SMILES CCc1ccc(cc1)C#CC(O)(c1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C32H25N3O/c1-3-23-11-13-24(14-12-23)17-18-32(36,31-21-34-22-35(31)2)27-16-15-26(20-33)30(19-27)29-10-6-8-25-7-4-5-9-28(25)29/h4-16,19,21-22,36H,3H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13389
PNG
(4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(35-19-22-11-9-21(16-31)10-12-22)24-13-14-25(17-32)28(15-24)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3
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Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127315
PNG
(6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H...)
Show SMILES Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-28(34)29(35-18-24-12-9-20(14-30)16-33-24)22-10-11-23(15-31)27(13-22)26-8-4-6-21-5-2-3-7-25(21)26/h2-13,16-17,19,29H,18H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126037
PNG
(4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(6-me...)
Show SMILES Cc1ccc(cn1)C#CC(O)(c1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C30H22N4O/c1-21-10-11-22(18-33-21)14-15-30(35,29-19-32-20-34(29)2)25-13-12-24(17-31)28(16-25)27-9-5-7-23-6-3-4-8-26(23)27/h3-13,16,18-20,35H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127309
PNG
(4-{6-Cyano-3-[(4-cyano-phenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1cncc1C(OCc1ccc(nc1N1CCN(CC1)C(=O)OC(C)(C)C)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H31N7O3/c1-28(2,3)38-27(36)35-13-11-34(12-14-35)26-22(9-10-23(16-30)32-26)18-37-25(24-17-31-19-33(24)4)21-7-5-20(15-29)6-8-21/h5-10,17,19,25H,11-14,18H2,1-4H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13413
PNG
(A313326 Analogue 60b)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H23N5O3S/c1-19-3-11-24(12-4-19)36(33,34)31-25-13-21(15-29)7-10-23(25)17-35-27(26-16-30-18-32(26)2)22-8-5-20(14-28)6-9-22/h3-13,16,18,27,31H,17H2,1-2H3
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Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126043
PNG
(4-[3-(3-Amino-phenyl)-1-hydroxy-1-(3-methyl-3H-imi...)
Show SMILES Cn1cncc1C(O)(C#Cc1cccc(N)c1)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C30H22N4O/c1-34-20-33-19-29(34)30(35,15-14-21-6-4-9-25(32)16-21)24-13-12-23(18-31)28(17-24)27-11-5-8-22-7-2-3-10-26(22)27/h2-13,16-17,19-20,35H,32H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126024
PNG
(4-[3-(5,3'-Dichloro-biphenyl-2-yl)-1-hydroxy-1-(3-...)
Show SMILES Cn1cncc1C(O)(C#Cc1ccc(Cl)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H17Cl2N3O/c1-31-17-30-16-25(31)26(32,21-8-5-18(15-29)6-9-21)12-11-19-7-10-23(28)14-24(19)20-3-2-4-22(27)13-20/h2-10,13-14,16-17,32H,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13414
PNG
(A313326 Analogue 60c | N-(5-cyano-2-{[(4-cyanophen...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1NS(=O)(=O)c1cccc2ccccc12)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C30H23N5O3S/c1-35-20-33-18-28(35)30(24-12-9-21(16-31)10-13-24)38-19-25-14-11-22(17-32)15-27(25)34-39(36,37)29-8-4-6-23-5-2-3-7-26(23)29/h2-15,18,20,30,34H,19H2,1H3
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Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127329
PNG
(4-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2cccnc12
Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-27(34)29(35-18-21-9-7-20(15-30)8-10-21)23-11-12-24(16-31)26(14-23)25-6-2-4-22-5-3-13-33-28(22)25/h2-14,17,19,29H,18H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13404
PNG
(4-{[(3-chloro-4-cyanophenyl)(1-methyl-1H-imidazol-...)
Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(C#N)c(Cl)c1)C#N
Show InChI InChI=1S/C27H21ClN4O2/c1-32-17-31-15-26(32)27(20-8-9-21(14-30)25(28)12-20)34-16-22-7-6-18(13-29)10-24(22)19-4-3-5-23(11-19)33-2/h3-12,15,17,27H,16H2,1-2H3
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Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126032
PNG
(5-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imi...)
Show SMILES Cc1ccccc1-c1cc(ccc1C#N)C(O)(C#Cc1ccc(cc1)C#N)c1cncn1C
Show InChI InChI=1S/C28H20N4O/c1-20-5-3-4-6-25(20)26-15-24(12-11-23(26)17-30)28(33,27-18-31-19-32(27)2)14-13-21-7-9-22(16-29)10-8-21/h3-12,15,18-19,33H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13412
PNG
(A313326 Analogue 60a | N-(5-cyano-2-{[(4-cyanophen...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1NS(=O)(=O)c1cccs1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C24H19N5O3S2/c1-29-16-27-14-22(29)24(19-7-4-17(12-25)5-8-19)32-15-20-9-6-18(13-26)11-21(20)28-34(30,31)23-3-2-10-33-23/h2-11,14,16,24,28H,15H2,1H3
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Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126029
PNG
(5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-pheny...)
Show SMILES Cc1ccccc1-c1cc(ccc1C#N)C(O)(C#Cc1ccccc1)c1cncn1C
Show InChI InChI=1S/C27H21N3O/c1-20-8-6-7-11-24(20)25-16-23(13-12-22(25)17-28)27(31,26-18-29-19-30(26)2)15-14-21-9-4-3-5-10-21/h3-13,16,18-19,31H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126039
PNG
(4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(4-pe...)
Show SMILES CCCCCc1ccc(cc1)C#CC(O)(c1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12
Show InChI InChI=1S/C35H31N3O/c1-3-4-5-9-26-14-16-27(17-15-26)20-21-35(39,34-24-37-25-38(34)2)30-19-18-29(23-36)33(22-30)32-13-8-11-28-10-6-7-12-31(28)32/h6-8,10-19,22,24-25,39H,3-5,9H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126033
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES Cn1cncc1C(O)(C#Cc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H17F3N4O2/c1-35-18-34-17-26(35)27(36,23-9-6-19(15-32)7-10-23)12-11-21-8-5-20(16-33)13-25(21)22-3-2-4-24(14-22)37-28(29,30)31/h2-10,13-14,17-18,36H,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127313
PNG
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-23(34)25(18-7-5-17(12-30)6-8-18)35-15-20-9-10-21(13-31)33-24(20)19-3-2-4-22(11-19)36-26(27,28)29/h2-11,14,16,25H,15H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13405
PNG
(3-(3-chlorophenyl)-4-{[(4-cyano-3-fluorophenyl)(1-...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H18ClFN4O/c1-32-16-31-14-25(32)26(19-7-8-20(13-30)24(28)11-19)33-15-21-6-5-17(12-29)9-23(21)18-3-2-4-22(27)10-18/h2-11,14,16,26H,15H2,1H3
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Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127307
PNG
(4-{5-(3-Chloro-phenyl)-3-cyano-6-[(4-cyano-phenyl)...)
Show SMILES Cn1cncc1C(OCc1nc(N2CCN(CC2)C(=O)OC(C)(C)C)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C34H34ClN7O3/c1-34(2,3)45-33(43)42-14-12-41(13-15-42)32-26(19-37)17-28(25-6-5-7-27(35)16-25)29(39-32)21-44-31(30-20-38-22-40(30)4)24-10-8-23(18-36)9-11-24/h5-11,16-17,20,22,31H,12-15,21H2,1-4H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126042
PNG
(4-[3-(5-Chloro-3'-methoxy-biphenyl-2-yl)-1-hydroxy...)
Show SMILES COc1cccc(c1)-c1cc(Cl)ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H20ClN3O2/c1-31-18-30-17-26(31)27(32,22-9-6-19(16-29)7-10-22)13-12-20-8-11-23(28)15-25(20)21-4-3-5-24(14-21)33-2/h3-11,14-15,17-18,32H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13392
PNG
(4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...)
Show SMILES CCOc1ccc(cc1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H24N4O2/c1-3-33-25-12-10-22(11-13-25)26-14-21(16-30)6-9-24(26)18-34-28(27-17-31-19-32(27)2)23-7-4-20(15-29)5-8-23/h4-14,17,19,28H,3,18H2,1-2H3
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Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127320
PNG
(5'-(3-Chloro-phenyl)-6'-[(4-cyano-phenyl)-(3-methy...)
Show SMILES Cn1cncc1C(OCc1nc(N2CCC(O)CC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C30H27ClN6O2/c1-36-19-34-17-28(36)29(21-7-5-20(15-32)6-8-21)39-18-27-26(22-3-2-4-24(31)13-22)14-23(16-33)30(35-27)37-11-9-25(38)10-12-37/h2-8,13-14,17,19,25,29,38H,9-12,18H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126040
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES COc1cccc(c1)-c1cc(ccc1CCC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H24N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,12-13H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50103331
PNG
(4-(5-{[1-(Naphthalene-1-carbonyl)-pyrrolidin-3-yla...)
Show SMILES O=C(N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N)c1cccc2ccccc12
Show InChI InChI=1S/C27H25N5O/c28-14-20-8-10-21(11-9-20)17-32-19-29-15-24(32)16-30-23-12-13-31(18-23)27(33)26-7-3-5-22-4-1-2-6-25(22)26/h1-11,15,19,23,30H,12-13,16-18H2/t23-/m0/s1
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n/an/a 880n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration of geranylgeranyl-protein transferase type I

J Med Chem 44: 2933-49 (2001)


BindingDB Entry DOI: 10.7270/Q2FF3RNW
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13396
PNG
(4-({[2-(3-methoxyphenyl)-4-nitrophenyl]methoxy}(1-...)
Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)[N+]([O-])=O
Show InChI InChI=1S/C26H22N4O4/c1-29-17-28-15-25(29)26(19-8-6-18(14-27)7-9-19)34-16-21-10-11-22(30(31)32)13-24(21)20-4-3-5-23(12-20)33-2/h3-13,15,17,26H,16H2,1-2H3
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Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127300
PNG
(5-[(3',5'-Dichloro-5-cyano-biphenyl-2-ylmethoxy)-(...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(nc1)C#N
Show InChI InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-24(32)25(17-4-5-22(11-29)31-12-17)33-14-18-3-2-16(10-28)6-23(18)19-7-20(26)9-21(27)8-19/h2-9,12-13,15,25H,14H2,1H3
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n/an/a 960n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127306
PNG
(5-[(5-Cyano-3'-trifluoromethoxy-biphenyl-2-ylmetho...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(nc1)C#N
Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-24(34)25(19-7-8-21(12-31)33-13-19)35-15-20-6-5-17(11-30)9-23(20)18-3-2-4-22(10-18)36-26(27,28)29/h2-10,13-14,16,25H,15H2,1H3
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n/an/a 990n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13376
PNG
(4-({[4-chloro-2-(4-chlorophenyl)phenyl]methoxy}(1-...)
Show SMILES Cn1cncc1C(OCc1ccc(Cl)cc1-c1ccc(Cl)cc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H19Cl2N3O/c1-30-16-29-14-24(30)25(19-4-2-17(13-28)3-5-19)31-15-20-8-11-22(27)12-23(20)18-6-9-21(26)10-7-18/h2-12,14,16,25H,15H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127321
PNG
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccc2OC(F)(F)Oc2c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H17F2N5O3/c1-33-15-31-13-21(33)25(17-4-2-16(11-29)3-5-17)34-14-19-6-8-20(12-30)32-24(19)18-7-9-22-23(10-18)36-26(27,28)35-22/h2-10,13,15,25H,14H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13393
PNG
(4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc(OC(F)(F)F)cc1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H19F3N4O2/c1-34-17-33-15-25(34)26(21-5-2-18(13-31)3-6-21)35-16-22-7-4-19(14-32)12-24(22)20-8-10-23(11-9-20)36-27(28,29)30/h2-12,15,17,26H,16H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126028
PNG
(3',5'-Dichloro-6-[3-(4-cyano-phenyl)-3-hydroxy-3-(...)
Show SMILES Cn1cncc1C(O)(C#Cc1ccc(cc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H16Cl2N4O/c1-33-17-32-16-26(33)27(34,22-6-3-18(14-30)4-7-22)9-8-20-5-2-19(15-31)10-25(20)21-11-23(28)13-24(29)12-21/h2-7,10-13,16-17,34H,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127333
PNG
(2-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)-c1cccc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H18ClN5O/c1-31-16-29-14-23(31)25(18-7-5-17(12-27)6-8-18)32-15-22-10-9-20(13-28)24(30-22)19-3-2-4-21(26)11-19/h2-11,14,16,25H,15H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127311
PNG
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccc(OC(F)(F)F)cc1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-23(34)25(19-4-2-17(12-30)3-5-19)35-15-20-6-9-21(13-31)33-24(20)18-7-10-22(11-8-18)36-26(27,28)29/h2-11,14,16,25H,15H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50126044
PNG
(5-[(4-Cyano-phenyl)-hydroxy-(3-methyl-3H-imidazol-...)
Show SMILES Cc1ccccc1-c1cc(ccc1C#N)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H20N4O/c1-18-5-3-4-6-23(18)24-13-22(12-9-20(24)15-28)26(31,25-16-29-17-30(25)2)21-10-7-19(14-27)8-11-21/h3-13,16-17,31H,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras

Bioorg Med Chem Lett 13: 1293-6 (2003)


BindingDB Entry DOI: 10.7270/Q2DV1J8J
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13408
PNG
(3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1,2-dimethy...)
Show SMILES Cc1ncc(C(OCc2ccc(cc2-c2cccc(Cl)c2)C#N)c2ccc(cc2)C#N)n1C
Show InChI InChI=1S/C27H21ClN4O/c1-18-31-16-26(32(18)2)27(21-9-6-19(14-29)7-10-21)33-17-23-11-8-20(15-30)12-25(23)22-4-3-5-24(28)13-22/h3-13,16,27H,17H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13382
PNG
(3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H19ClN4O/c1-31-17-30-15-25(31)26(20-8-5-18(13-28)6-9-20)32-16-22-10-7-19(14-29)11-24(22)21-3-2-4-23(27)12-21/h2-12,15,17,26H,16H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13375
PNG
(4-({[4-chloro-2-(3-chlorophenyl)phenyl]methoxy}(1-...)
Show SMILES Cn1cncc1C(OCc1ccc(Cl)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H19Cl2N3O/c1-30-16-29-14-24(30)25(18-7-5-17(13-28)6-8-18)31-15-20-9-10-22(27)12-23(20)19-3-2-4-21(26)11-19/h2-12,14,16,25H,15H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Homo sapiens (Human))		BDBM50127324
PNG
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-23(32)25(17-4-2-16(11-28)3-5-17)33-14-18-6-7-22(12-29)31-24(18)19-8-20(26)10-21(27)9-19/h2-10,13,15,25H,14H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I

Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta


(Bos taurus (bovine))		BDBM13415
PNG
(4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1NCc1cc(F)cc(F)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H21F2N5O/c1-34-17-32-15-26(34)27(21-5-2-18(12-30)3-6-21)35-16-22-7-4-19(13-31)10-25(22)33-14-20-8-23(28)11-24(29)9-20/h2-11,15,17,27,33H,14,16H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Globe Pharmaceutical R and Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...

J Med Chem 47: 612-26 (2004)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2Z60M8D
More data for this
Ligand-Target Pair
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