Found 232 hits Enz. Inhib. hit(s) with all data for entry = 50017130 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002445
(CHEMBL2113171)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(OC(CF)CF)=C(Cl)C3=O)c2cc1OC |t:13,23| Show InChI InChI=1S/C21H20ClF2N3O6/c1-30-3-4-32-17-7-13-12(5-16(17)31-2)21(26-10-25-13)27-14-6-15(28)20(18(22)19(14)29)33-11(8-23)9-24/h5-7,10-11H,3-4,8-9H2,1-2H3,(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002593
(CHEMBL2113187)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4cccc(F)c4)=CC3=O)c2cc1OC |c:26,t:13| Show InChI InChI=1S/C24H20FN3O6/c1-31-6-7-33-23-11-17-16(9-22(23)32-2)24(27-13-26-17)28-18-10-20(30)21(12-19(18)29)34-15-5-3-4-14(25)8-15/h3-5,8-13H,6-7H2,1-2H3,(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177852
(3-Chloro-2-ethoxy-5-{[6-methoxy-7-(2-methoxyethoxy...)Show SMILES CCOC1=C(Cl)C(=O)C(Nc2ncnc3cc(OCCOC)c(OC)cc23)=CC1=O |c:3,28| Show InChI InChI=1S/C20H20ClN3O6/c1-4-29-19-14(25)8-13(18(26)17(19)21)24-20-11-7-15(28-3)16(30-6-5-27-2)9-12(11)22-10-23-20/h7-10H,4-6H2,1-3H3,(H,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002446
(CHEMBL2113172)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(OC)=C(Cl)C3=O)c2cc1OC |t:13,19| Show InChI InChI=1S/C19H18ClN3O6/c1-26-4-5-29-15-8-11-10(6-14(15)27-2)19(22-9-21-11)23-12-7-13(24)18(28-3)16(20)17(12)25/h6-9H,4-5H2,1-3H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002446
(CHEMBL2113172)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(OC)=C(Cl)C3=O)c2cc1OC |t:13,19| Show InChI InChI=1S/C19H18ClN3O6/c1-26-4-5-29-15-8-11-10(6-14(15)27-2)19(22-9-21-11)23-12-7-13(24)18(28-3)16(20)17(12)25/h6-9H,4-5H2,1-3H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177827
(3-Chloro-2-[(3-fluorobenzyl)oxy]-5-{[6-methoxy-7-(...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCc4cccc(F)c4)=C(Cl)C3=O)c2cc1OC |w:12.11,t:27| Show InChI InChI=1S/C25H21ClFN3O6/c1-33-6-7-35-21-11-17-16(9-20(21)34-2)25(29-13-28-17)30-18-10-19(31)24(22(26)23(18)32)36-12-14-4-3-5-15(27)8-14/h3-5,8-9,11,13H,6-7,10,12H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177845
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#Cc4ccccc4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:22| Show InChI InChI=1S/C31H30N4O5/c1-38-29-17-23-24(19-30(29)40-16-8-14-35-12-5-6-13-35)32-21-33-31(23)34-25-18-27(37)28(20-26(25)36)39-15-7-11-22-9-3-2-4-10-22/h2-4,9-10,17,19-21H,5-6,8,12-16,18H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177829
(2-Chloro-3-methoxy-5-{[6-methoxy-7-(2-methoxyethox...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(Cl)=C(OC)C3=O)c2cc1OC |w:12.11,t:18| Show InChI InChI=1S/C19H18ClN3O6/c1-26-4-5-29-15-8-11-10(6-14(15)27-2)19(22-9-21-11)23-12-7-13(24)16(20)18(28-3)17(12)25/h6,8-9H,4-5,7H2,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177845
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#Cc4ccccc4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:22| Show InChI InChI=1S/C31H30N4O5/c1-38-29-17-23-24(19-30(29)40-16-8-14-35-12-5-6-13-35)32-21-33-31(23)34-25-18-27(37)28(20-26(25)36)39-15-7-11-22-9-3-2-4-10-22/h2-4,9-10,17,19-21H,5-6,8,12-16,18H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177836
(2-{[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]a...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCCOc4ccccc4)=CC3=O)c2cc1OC |w:12.11,c:28| Show InChI InChI=1S/C26H25N3O7/c1-32-8-9-36-25-14-19-18(12-24(25)33-2)26(28-16-27-19)29-20-13-22(31)23(15-21(20)30)35-11-10-34-17-6-4-3-5-7-17/h3-7,12,14-16H,8-11,13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177845
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#Cc4ccccc4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:22| Show InChI InChI=1S/C31H30N4O5/c1-38-29-17-23-24(19-30(29)40-16-8-14-35-12-5-6-13-35)32-21-33-31(23)34-25-18-27(37)28(20-26(25)36)39-15-7-11-22-9-3-2-4-10-22/h2-4,9-10,17,19-21H,5-6,8,12-16,18H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177848
(2-Chloro-3-isopropoxy-5-{[6-methoxy-7-(2-methoxyet...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(Cl)=C(OC(C)C)C3=O)c2cc1OC |w:12.11,t:18| Show InChI InChI=1S/C21H22ClN3O6/c1-11(2)31-20-18(22)15(26)8-14(19(20)27)25-21-12-7-16(29-4)17(30-6-5-28-3)9-13(12)23-10-24-21/h7,9-11H,5-6,8H2,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177845
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#Cc4ccccc4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:22| Show InChI InChI=1S/C31H30N4O5/c1-38-29-17-23-24(19-30(29)40-16-8-14-35-12-5-6-13-35)32-21-33-31(23)34-25-18-27(37)28(20-26(25)36)39-15-7-11-22-9-3-2-4-10-22/h2-4,9-10,17,19-21H,5-6,8,12-16,18H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002578
(CHEMBL2113199)Show SMILES COc1cc2c(NC3=CC(=O)C(OCc4ccccn4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |c:20,t:7| Show InChI InChI=1S/C28H29N5O5/c1-36-26-13-20-21(15-27(26)37-12-6-11-33-9-4-5-10-33)30-18-31-28(20)32-22-14-24(35)25(16-23(22)34)38-17-19-7-2-3-8-29-19/h2-3,7-8,13-16,18H,4-6,9-12,17H2,1H3,(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002585
(CHEMBL2113191)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Cl)=C(OCC4CC4)C3=O)c2cc1OC |t:13,18| Show InChI InChI=1S/C22H22ClN3O6/c1-29-5-6-31-18-9-14-13(7-17(18)30-2)22(25-11-24-14)26-15-8-16(27)19(23)21(20(15)28)32-10-12-3-4-12/h7-9,11-12H,3-6,10H2,1-2H3,(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002579
(CHEMBL2113164)Show SMILES COc1cc2c(NC3=CC(=O)C(OCC(F)F)=CC3=O)ncnc2cc1OCCCN1CCCC1 |c:16,t:7| Show InChI InChI=1S/C24H26F2N4O5/c1-33-21-9-15-16(11-22(21)34-8-4-7-30-5-2-3-6-30)27-14-28-24(15)29-17-10-19(32)20(12-18(17)31)35-13-23(25)26/h9-12,14,23H,2-8,13H2,1H3,(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177850
(2-[3-(Ethylamino)phenoxy]-5-{[6-methoxy-7-(2-metho...)Show SMILES CCNc1cccc(OC2=CC(=O)C(Nc3ncnc4cc(OCCOC)c(OC)cc34)=CC2=O)c1 |c:33,t:9| Show InChI InChI=1S/C26H26N4O6/c1-4-27-16-6-5-7-17(10-16)36-23-14-21(31)20(12-22(23)32)30-26-18-11-24(34-3)25(35-9-8-33-2)13-19(18)28-15-29-26/h5-7,10-15,27H,4,8-9H2,1-3H3,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002439
(CHEMBL2113174)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccccc4)=CC3=O)c2cc1OC |c:25,t:13| Show InChI InChI=1S/C24H21N3O6/c1-30-8-9-32-23-12-17-16(10-22(23)31-2)24(26-14-25-17)27-18-11-20(29)21(13-19(18)28)33-15-6-4-3-5-7-15/h3-7,10-14H,8-9H2,1-2H3,(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177834
(2-Methoxy-5-{[6-methoxy-7-(3-pyrrolidin-1-ylpropox...)Show SMILES COC1=CC(=O)C(Nc2ncnc3cc(OCCCN4CCCC4)c(OC)cc23)=CC1=O |c:31,t:2| Show InChI InChI=1S/C23H26N4O5/c1-30-20-13-18(28)17(11-19(20)29)26-23-15-10-21(31-2)22(12-16(15)24-14-25-23)32-9-5-8-27-6-3-4-7-27/h10-14H,3-9H2,1-2H3,(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002445
(CHEMBL2113171)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(OC(CF)CF)=C(Cl)C3=O)c2cc1OC |t:13,23| Show InChI InChI=1S/C21H20ClF2N3O6/c1-30-3-4-32-17-7-13-12(5-16(17)31-2)21(26-10-25-13)27-14-6-15(28)20(18(22)19(14)29)33-11(8-23)9-24/h5-7,10-11H,3-4,8-9H2,1-2H3,(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177834
(2-Methoxy-5-{[6-methoxy-7-(3-pyrrolidin-1-ylpropox...)Show SMILES COC1=CC(=O)C(Nc2ncnc3cc(OCCCN4CCCC4)c(OC)cc23)=CC1=O |c:31,t:2| Show InChI InChI=1S/C23H26N4O5/c1-30-20-13-18(28)17(11-19(20)29)26-23-15-10-21(31-2)22(12-16(15)24-14-25-23)32-9-5-8-27-6-3-4-7-27/h10-14H,3-9H2,1-2H3,(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002579
(CHEMBL2113164)Show SMILES COc1cc2c(NC3=CC(=O)C(OCC(F)F)=CC3=O)ncnc2cc1OCCCN1CCCC1 |c:16,t:7| Show InChI InChI=1S/C24H26F2N4O5/c1-33-21-9-15-16(11-22(21)34-8-4-7-30-5-2-3-6-30)27-14-28-24(15)29-17-10-19(32)20(12-18(17)31)35-13-23(25)26/h9-12,14,23H,2-8,13H2,1H3,(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177810
(2-{[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]a...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCC#Cc4ccccc4)=CC3=O)c2cc1OC |w:12.11,c:28| Show InChI InChI=1S/C27H23N3O6/c1-33-11-12-36-26-15-20-19(13-25(26)34-2)27(29-17-28-20)30-21-14-23(32)24(16-22(21)31)35-10-6-9-18-7-4-3-5-8-18/h3-5,7-8,13,15-17H,10-12,14H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177830
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OC(C#C)c4ccccc4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:22| Show InChI InChI=1S/C31H30N4O5/c1-3-27(21-10-5-4-6-11-21)40-28-19-25(36)24(17-26(28)37)34-31-22-16-29(38-2)30(18-23(22)32-20-33-31)39-15-9-14-35-12-7-8-13-35/h1,4-6,10-11,16,18-20,27H,7-9,12-15,17H2,2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177803
(2-[2-Fluoro-1-(fluoromethyl)ethoxy]-5-({6-methoxy-...)Show SMILES COc1cc2c(N=C3CC(=O)C(OC(CF)CF)=CC3=O)ncnc2cc1OCC1CCN(C)CC1 |w:6.5,c:17| Show InChI InChI=1S/C25H28F2N4O5/c1-31-5-3-15(4-6-31)13-35-24-9-18-17(7-23(24)34-2)25(29-14-28-18)30-19-8-21(33)22(10-20(19)32)36-16(11-26)12-27/h7,9-10,14-16H,3-6,8,11-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002588
(CHEMBL2113183)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C=C(OC)C3=O)c2cc1OC |t:13,17| Show InChI InChI=1S/C19H19N3O6/c1-25-4-5-28-16-9-13-12(8-15(16)26-2)19(21-10-20-13)22-14-6-11(23)7-17(27-3)18(14)24/h6-10H,4-5H2,1-3H3,(H,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002587
(CHEMBL2113184)Show SMILES COc1cc2c(NC3=CC(=O)C(OCCN(C)c4ccccc4)=CC3=O)ncnc2cc1OCC1CCN(C)CC1 |c:23,t:7| Show InChI InChI=1S/C31H35N5O5/c1-35-11-9-21(10-12-35)19-41-30-17-24-23(15-29(30)39-3)31(33-20-32-24)34-25-16-27(38)28(18-26(25)37)40-14-13-36(2)22-7-5-4-6-8-22/h4-8,15-18,20-21H,9-14,19H2,1-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002577
(CHEMBL2113163)Show SMILES COc1cc2c(NC3=CC(=O)C(OCc4ccco4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |c:19,t:7| Show InChI InChI=1S/C27H28N4O6/c1-34-25-12-19-20(14-26(25)36-11-5-9-31-7-2-3-8-31)28-17-29-27(19)30-21-13-23(33)24(15-22(21)32)37-16-18-6-4-10-35-18/h4,6,10,12-15,17H,2-3,5,7-9,11,16H2,1H3,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002449
(CHEMBL2113166)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Cl)=CC3=O)c2cc1OC |c:18,t:13| Show InChI InChI=1S/C18H16ClN3O5/c1-25-3-4-27-17-8-12-10(5-16(17)26-2)18(21-9-20-12)22-13-7-14(23)11(19)6-15(13)24/h5-9H,3-4H2,1-2H3,(H,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177833
(2-(2,2-Difluoroethoxy)-5-{[6-methoxy-7-(2-methoxye...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCC(F)F)=CC3=O)c2cc1OC |w:12.11,c:22| Show InChI InChI=1S/C20H19F2N3O6/c1-28-3-4-30-18-7-12-11(5-17(18)29-2)20(24-10-23-12)25-13-6-15(27)16(8-14(13)26)31-9-19(21)22/h5,7-8,10,19H,3-4,6,9H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177817
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:25| Show InChI InChI=1S/C29H25F5N4O5/c1-41-22-9-15-17(11-23(22)42-8-4-7-38-5-2-3-6-38)35-14-36-29(15)37-18-10-20(40)21(12-19(18)39)43-13-16-24(30)26(32)28(34)27(33)25(16)31/h9,11-12,14H,2-8,10,13H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002592
(CHEMBL2113188)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(OC(c4ccccc4)C(F)(F)F)=CC3=O)c2cc1OC |c:30,t:13| Show InChI InChI=1S/C26H22F3N3O6/c1-35-8-9-37-23-12-17-16(10-22(23)36-2)25(31-14-30-17)32-18-11-20(34)21(13-19(18)33)38-24(26(27,28)29)15-6-4-3-5-7-15/h3-7,10-14,24H,8-9H2,1-2H3,(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177836
(2-{[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]a...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCCOc4ccccc4)=CC3=O)c2cc1OC |w:12.11,c:28| Show InChI InChI=1S/C26H25N3O7/c1-32-8-9-36-25-14-19-18(12-24(25)33-2)26(28-16-27-19)29-20-13-22(31)23(15-21(20)30)35-11-10-34-17-6-4-3-5-7-17/h3-7,12,14-16H,8-11,13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177835
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#C)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:15| Show InChI InChI=1S/C25H26N4O5/c1-3-10-33-22-15-20(30)19(13-21(22)31)28-25-17-12-23(32-2)24(14-18(17)26-16-27-25)34-11-6-9-29-7-4-5-8-29/h1,12,14-16H,4-11,13H2,2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177847
(2-Methoxy-5-({6-methoxy-7-[(1-methylpiperidin-4-yl...)Show SMILES COC1=CC(=O)C(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)=CC1=O |c:31,t:2| Show InChI InChI=1S/C23H26N4O5/c1-27-6-4-14(5-7-27)12-32-22-10-16-15(8-21(22)31-3)23(25-13-24-16)26-17-9-19(29)20(30-2)11-18(17)28/h8-11,13-14H,4-7,12H2,1-3H3,(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002446
(CHEMBL2113172)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(OC)=C(Cl)C3=O)c2cc1OC |t:13,19| Show InChI InChI=1S/C19H18ClN3O6/c1-26-4-5-29-15-8-11-10(6-14(15)27-2)19(22-9-21-11)23-12-7-13(24)18(28-3)16(20)17(12)25/h6-9H,4-5H2,1-3H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177835
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#C)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:15| Show InChI InChI=1S/C25H26N4O5/c1-3-10-33-22-15-20(30)19(13-21(22)31)28-25-17-12-23(32-2)24(14-18(17)26-16-27-25)34-11-6-9-29-7-4-5-8-29/h1,12,14-16H,4-11,13H2,2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002577
(CHEMBL2113163)Show SMILES COc1cc2c(NC3=CC(=O)C(OCc4ccco4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |c:19,t:7| Show InChI InChI=1S/C27H28N4O6/c1-34-25-12-19-20(14-26(25)36-11-5-9-31-7-2-3-8-31)28-17-29-27(19)30-21-13-23(33)24(15-22(21)32)37-16-18-6-4-10-35-18/h4,6,10,12-15,17H,2-3,5,7-9,11,16H2,1H3,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177803
(2-[2-Fluoro-1-(fluoromethyl)ethoxy]-5-({6-methoxy-...)Show SMILES COc1cc2c(N=C3CC(=O)C(OC(CF)CF)=CC3=O)ncnc2cc1OCC1CCN(C)CC1 |w:6.5,c:17| Show InChI InChI=1S/C25H28F2N4O5/c1-31-5-3-15(4-6-31)13-35-24-9-18-17(7-23(24)34-2)25(29-14-28-18)30-19-8-21(33)22(10-20(19)32)36-16(11-26)12-27/h7,9-10,14-16H,3-6,8,11-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177830
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OC(C#C)c4ccccc4)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:22| Show InChI InChI=1S/C31H30N4O5/c1-3-27(21-10-5-4-6-11-21)40-28-19-25(36)24(17-26(28)37)34-31-22-16-29(38-2)30(18-23(22)32-20-33-31)39-15-9-14-35-12-7-8-13-35/h1,4-6,10-11,16,18-20,27H,7-9,12-15,17H2,2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002584
(CHEMBL2113192)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(OC(CF)CF)=C(OC)C3=O)c2cc1OC |t:13,23| Show InChI InChI=1S/C22H23F2N3O7/c1-30-4-5-33-18-8-14-13(6-17(18)31-2)22(26-11-25-14)27-15-7-16(28)20(21(32-3)19(15)29)34-12(9-23)10-24/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177797
(2-{[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]a...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)c2cc1OC |w:12.11,c:31| Show InChI InChI=1S/C25H18F5N3O6/c1-36-3-4-38-19-7-13-11(5-18(19)37-2)25(32-10-31-13)33-14-6-16(35)17(8-15(14)34)39-9-12-20(26)22(28)24(30)23(29)21(12)27/h5,7-8,10H,3-4,6,9H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002594
(CHEMBL2113186)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccc(cc4)-n4ccnc4)=CC3=O)c2cc1OC |c:31,t:13| Show InChI InChI=1S/C27H23N5O6/c1-35-9-10-37-26-13-20-19(11-25(26)36-2)27(30-15-29-20)31-21-12-23(34)24(14-22(21)33)38-18-5-3-17(4-6-18)32-8-7-28-16-32/h3-8,11-16H,9-10H2,1-2H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002587
(CHEMBL2113184)Show SMILES COc1cc2c(NC3=CC(=O)C(OCCN(C)c4ccccc4)=CC3=O)ncnc2cc1OCC1CCN(C)CC1 |c:23,t:7| Show InChI InChI=1S/C31H35N5O5/c1-35-11-9-21(10-12-35)19-41-30-17-24-23(15-29(30)39-3)31(33-20-32-24)34-25-16-27(38)28(18-26(25)37)40-14-13-36(2)22-7-5-4-6-8-22/h4-8,15-18,20-21H,9-14,19H2,1-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002442
(CHEMBL2113178)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C=CC3=O)c2cc1OC |c:17,t:13| Show InChI InChI=1S/C18H17N3O5/c1-24-5-6-26-17-9-13-12(8-16(17)25-2)18(20-10-19-13)21-14-7-11(22)3-4-15(14)23/h3-4,7-10H,5-6H2,1-2H3,(H,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177817
(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)Show SMILES COc1cc2c(N=C3CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:25| Show InChI InChI=1S/C29H25F5N4O5/c1-41-22-9-15-17(11-23(22)42-8-4-7-38-5-2-3-6-38)35-14-36-29(15)37-18-10-20(40)21(12-19(18)39)43-13-16-24(30)26(32)28(34)27(33)25(16)31/h9,11-12,14H,2-8,10,13H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002583
(CHEMBL2113193)Show SMILES COc1cc2c(NC3=CC(=O)C(OC(CF)CF)=CC3=O)ncnc2cc1OCCCN1CCCC1 |c:17,t:7| Show InChI InChI=1S/C25H28F2N4O5/c1-34-23-9-17-18(11-24(23)35-8-4-7-31-5-2-3-6-31)28-15-29-25(17)30-19-10-21(33)22(12-20(19)32)36-16(13-26)14-27/h9-12,15-16H,2-8,13-14H2,1H3,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177827
(3-Chloro-2-[(3-fluorobenzyl)oxy]-5-{[6-methoxy-7-(...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCc4cccc(F)c4)=C(Cl)C3=O)c2cc1OC |w:12.11,t:27| Show InChI InChI=1S/C25H21ClFN3O6/c1-33-6-7-35-21-11-17-16(9-20(21)34-2)25(29-13-28-17)30-18-10-19(31)24(22(26)23(18)32)36-12-14-4-3-5-15(27)8-14/h3-5,8-9,11,13H,6-7,10,12H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177803
(2-[2-Fluoro-1-(fluoromethyl)ethoxy]-5-({6-methoxy-...)Show SMILES COc1cc2c(N=C3CC(=O)C(OC(CF)CF)=CC3=O)ncnc2cc1OCC1CCN(C)CC1 |w:6.5,c:17| Show InChI InChI=1S/C25H28F2N4O5/c1-31-5-3-15(4-6-31)13-35-24-9-18-17(7-23(24)34-2)25(29-14-28-18)30-19-8-21(33)22(10-20(19)32)36-16(11-26)12-27/h7,9-10,14-16H,3-6,8,11-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50177811
(2-{[-6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]...)Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(=CC3=O)N3CC(C)OC3=O)c2cc1OC |w:12.11,c:17| Show InChI InChI=1S/C22H22N4O7/c1-12-10-26(22(29)33-12)16-9-17(27)15(7-18(16)28)25-21-13-6-19(31-3)20(32-5-4-30-2)8-14(13)23-11-24-21/h6,8-9,11-12H,4-5,7,10H2,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |