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Compile Data Set for Download or QSAR

Found 64 hits Enz. Inhib. hit(s) with all data for entry = 50011946   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112379
PNG
(1-(3-Chloro-phenyl)-4-{2-[3-(2-methoxy-4'-trifluor...)
Show SMILES COc1cc(Cn2cncc2CCN2CCN(C(=O)C2)c2cccc(Cl)c2)ccc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C30H28ClF3N4O2/c1-40-28-15-21(5-10-27(28)22-6-8-23(9-7-22)30(32,33)34)18-37-20-35-17-26(37)11-12-36-13-14-38(29(39)19-36)25-4-2-3-24(31)16-25/h2-10,15-17,20H,11-14,18-19H2,1H3
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n/an/a 0.170n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112387
PNG
(3-oxo-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22...)
Show SMILES O=C1CN2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5CC2)ccc4C#N)cc13
Show InChI InChI=1S/C27H23N5O2/c28-14-21-5-4-19-12-26(21)34-23-7-6-20-2-1-3-25(24(20)13-23)32-11-10-30(17-27(32)33)9-8-22-15-29-18-31(22)16-19/h1-7,12-13,15,18H,8-11,16-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112387
PNG
(3-oxo-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22...)
Show SMILES O=C1CN2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5CC2)ccc4C#N)cc13
Show InChI InChI=1S/C27H23N5O2/c28-14-21-5-4-19-12-26(21)34-23-7-6-20-2-1-3-25(24(20)13-23)32-11-10-30(17-27(32)33)9-8-22-15-29-18-31(22)16-19/h1-7,12-13,15,18H,8-11,16-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112383
PNG
(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Show SMILES FC(F)(F)CCCCc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C31H31F3N4O2/c32-31(33,34)12-2-1-4-24-8-7-22-16-29(24)40-26-10-9-23-5-3-6-28(27(23)17-26)38-15-14-36(20-30(38)39)13-11-25-18-35-21-37(25)19-22/h3,5-10,16-18,21H,1-2,4,11-15,19-20H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112372
PNG
(17-(5,5,5-trifluoro-1-pentynyl)-19-oxa-2,5,10,12-t...)
Show SMILES FC(F)(F)CCC#Cc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C31H27F3N4O2/c32-31(33,34)12-2-1-4-24-8-7-22-16-29(24)40-26-10-9-23-5-3-6-28(27(23)17-26)38-15-14-36(20-30(38)39)13-11-25-18-35-21-37(25)19-22/h3,5-10,16-18,21H,2,11-15,19-20H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112381
PNG
(17-(4-trifluoromethylphenyl)-19-oxa-2,5,10,12-tetr...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C33H27F3N4O2/c34-33(35,36)25-8-5-24(6-9-25)28-11-4-22-16-31(28)42-27-10-7-23-2-1-3-30(29(23)17-27)40-15-14-38(20-32(40)41)13-12-26-18-37-21-39(26)19-22/h1-11,16-18,21H,12-15,19-20H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112379
PNG
(1-(3-Chloro-phenyl)-4-{2-[3-(2-methoxy-4'-trifluor...)
Show SMILES COc1cc(Cn2cncc2CCN2CCN(C(=O)C2)c2cccc(Cl)c2)ccc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C30H28ClF3N4O2/c1-40-28-15-21(5-10-27(28)22-6-8-23(9-7-22)30(32,33)34)18-37-20-35-17-26(37)11-12-36-13-14-38(29(39)19-36)25-4-2-3-24(31)16-25/h2-10,15-17,20H,11-14,18-19H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112390
PNG
(17-bromo-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2...)
Show SMILES Brc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C26H23BrN4O2/c27-23-7-4-18-12-25(23)33-21-6-5-19-2-1-3-24(22(19)13-21)31-11-10-29(16-26(31)32)9-8-20-14-28-17-30(20)15-18/h1-7,12-14,17H,8-11,15-16H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112375
PNG
(1-(3-Chloro-phenyl)-4-[3-(2-methoxy-4'-trifluorome...)
Show SMILES COc1cc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)ccc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H26ClF3N4O2/c1-39-27-13-20(5-10-26(27)21-6-8-22(9-7-21)29(31,32)33)16-36-19-34-15-25(36)17-35-11-12-37(28(38)18-35)24-4-2-3-23(30)14-24/h2-10,13-15,19H,11-12,16-18H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112390
PNG
(17-bromo-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2...)
Show SMILES Brc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C26H23BrN4O2/c27-23-7-4-18-12-25(23)33-21-6-5-19-2-1-3-24(22(19)13-21)31-11-10-29(16-26(31)32)9-8-20-14-28-17-30(20)15-18/h1-7,12-14,17H,8-11,15-16H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50097071
PNG
(4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]MET...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O
Show InChI InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112381
PNG
(17-(4-trifluoromethylphenyl)-19-oxa-2,5,10,12-tetr...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C33H27F3N4O2/c34-33(35,36)25-8-5-24(6-9-25)28-11-4-22-16-31(28)42-27-10-7-23-2-1-3-30(29(23)17-27)40-15-14-38(20-32(40)41)13-12-26-18-37-21-39(26)19-22/h1-11,16-18,21H,12-15,19-20H2
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n/an/a 2.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112383
PNG
(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Show SMILES FC(F)(F)CCCCc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C31H31F3N4O2/c32-31(33,34)12-2-1-4-24-8-7-22-16-29(24)40-26-10-9-23-5-3-6-28(27(23)17-26)38-15-14-36(20-30(38)39)13-11-25-18-35-21-37(25)19-22/h3,5-10,16-18,21H,1-2,4,11-15,19-20H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112372
PNG
(17-(5,5,5-trifluoro-1-pentynyl)-19-oxa-2,5,10,12-t...)
Show SMILES FC(F)(F)CCC#Cc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C31H27F3N4O2/c32-31(33,34)12-2-1-4-24-8-7-22-16-29(24)40-26-10-9-23-5-3-6-28(27(23)17-26)38-15-14-36(20-30(38)39)13-11-25-18-35-21-37(25)19-22/h3,5-10,16-18,21H,2,11-15,19-20H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112377
PNG
(1-(3-Chloro-phenyl)-4-[3-(4'-trifluoromethyl-biphe...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H24ClF3N4O/c29-24-2-1-3-25(14-24)36-13-12-34(18-27(36)37)17-26-15-33-19-35(26)16-20-4-6-21(7-5-20)22-8-10-23(11-9-22)28(30,31)32/h1-11,14-15,19H,12-13,16-18H2
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n/an/a 5.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112372
PNG
(17-(5,5,5-trifluoro-1-pentynyl)-19-oxa-2,5,10,12-t...)
Show SMILES FC(F)(F)CCC#Cc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C31H27F3N4O2/c32-31(33,34)12-2-1-4-24-8-7-22-16-29(24)40-26-10-9-23-5-3-6-28(27(23)17-26)38-15-14-36(20-30(38)39)13-11-25-18-35-21-37(25)19-22/h3,5-10,16-18,21H,2,11-15,19-20H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112388
PNG
(19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22,5.114...)
Show SMILES O=C1CN2CCN1c1cccc3ccc(Oc4cccc(Cn5cncc5CC2)c4)cc13
Show InChI InChI=1S/C26H24N4O2/c31-26-17-28-10-9-21-15-27-18-29(21)16-19-3-1-5-22(13-19)32-23-8-7-20-4-2-6-25(24(20)14-23)30(26)12-11-28/h1-8,13-15,18H,9-12,16-17H2
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n/an/a 8n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112373
PNG
(4-[3-(4'-Chloro-biphenyl-4-ylmethyl)-3H-imidazol-4...)
Show SMILES Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H24Cl2N4O/c28-23-10-8-22(9-11-23)21-6-4-20(5-7-21)16-32-19-30-15-26(32)17-31-12-13-33(27(34)18-31)25-3-1-2-24(29)14-25/h1-11,14-15,19H,12-13,16-18H2
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Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112378
PNG
(17-butyl-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2...)
Show SMILES CCCCc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C30H32N4O2/c1-2-3-5-24-9-8-22-16-29(24)36-26-11-10-23-6-4-7-28(27(23)17-26)34-15-14-32(20-30(34)35)13-12-25-18-31-21-33(25)19-22/h4,6-11,16-18,21H,2-3,5,12-15,19-20H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112375
PNG
(1-(3-Chloro-phenyl)-4-[3-(2-methoxy-4'-trifluorome...)
Show SMILES COc1cc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)ccc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H26ClF3N4O2/c1-39-27-13-20(5-10-26(27)21-6-8-22(9-7-21)29(31,32)33)16-36-19-34-15-25(36)17-35-11-12-37(28(38)18-35)24-4-2-3-23(30)14-24/h2-10,13-15,19H,11-12,16-18H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of geranylgeranylation of Rap1a in PSN-1 cells


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112374
PNG
(4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2ccccc2)CC1=O
Show InChI InChI=1S/C27H25ClN4O/c28-24-7-4-8-25(15-24)32-14-13-30(19-27(32)33)18-26-16-29-20-31(26)17-21-9-11-23(12-10-21)22-5-2-1-3-6-22/h1-12,15-16,20H,13-14,17-19H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112376
PNG
(1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethyl-phe...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C27H23ClF3N5O/c28-22-2-1-3-23(12-22)36-11-10-34(17-26(36)37)16-24-14-32-18-35(24)15-19-4-9-25(33-13-19)20-5-7-21(8-6-20)27(29,30)31/h1-9,12-14,18H,10-11,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112382
PNG
(1-(3-Chloro-phenyl)-4-[3-(4'-fluoro-biphenyl-4-ylm...)
Show SMILES Fc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H24ClFN4O/c28-23-2-1-3-25(14-23)33-13-12-31(18-27(33)34)17-26-15-30-19-32(26)16-20-4-6-21(7-5-20)22-8-10-24(29)11-9-22/h1-11,14-15,19H,12-13,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112381
PNG
(17-(4-trifluoromethylphenyl)-19-oxa-2,5,10,12-tetr...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C33H27F3N4O2/c34-33(35,36)25-8-5-24(6-9-25)28-11-4-22-16-31(28)42-27-10-7-23-2-1-3-30(29(23)17-27)40-15-14-38(20-32(40)41)13-12-26-18-37-21-39(26)19-22/h1-11,16-18,21H,12-15,19-20H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112387
PNG
(3-oxo-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22...)
Show SMILES O=C1CN2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5CC2)ccc4C#N)cc13
Show InChI InChI=1S/C27H23N5O2/c28-14-21-5-4-19-12-26(21)34-23-7-6-20-2-1-3-25(24(20)13-23)32-11-10-30(17-27(32)33)9-8-22-15-29-18-31(22)16-19/h1-7,12-13,15,18H,8-11,16-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of geranylgeranylation of Rap1a in PSN-1 cells


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112392
PNG
(4-[3-(3'-Chloro-biphenyl-4-ylmethyl)-3H-imidazol-4...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2cccc(Cl)c2)CC1=O
Show InChI InChI=1S/C27H24Cl2N4O/c28-23-4-1-3-22(13-23)21-9-7-20(8-10-21)16-32-19-30-15-26(32)17-31-11-12-33(27(34)18-31)25-6-2-5-24(29)14-25/h1-10,13-15,19H,11-12,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112389
PNG
(1-(3-Chloro-phenyl)-4-{3-[6-(4-chloro-phenyl)-pyri...)
Show SMILES Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C26H23Cl2N5O/c27-21-7-5-20(6-8-21)25-9-4-19(13-30-25)15-32-18-29-14-24(32)16-31-10-11-33(26(34)17-31)23-3-1-2-22(28)12-23/h1-9,12-14,18H,10-11,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112377
PNG
(1-(3-Chloro-phenyl)-4-[3-(4'-trifluoromethyl-biphe...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H24ClF3N4O/c29-24-2-1-3-25(14-24)36-13-12-34(18-27(36)37)17-26-15-33-19-35(26)16-20-4-6-21(7-5-20)22-8-10-23(11-9-22)28(30,31)32/h1-11,14-15,19H,12-13,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112385
PNG
(1-(3-Chloro-phenyl)-4-[3-(3',5'-dichloro-biphenyl-...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2cc(Cl)cc(Cl)c2)CC1=O
Show InChI InChI=1S/C27H23Cl3N4O/c28-22-2-1-3-25(13-22)34-9-8-32(17-27(34)35)16-26-14-31-18-33(26)15-19-4-6-20(7-5-19)21-10-23(29)12-24(30)11-21/h1-7,10-14,18H,8-9,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112391
PNG
(1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethoxy-ph...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C27H23ClF3N5O2/c28-21-2-1-3-22(12-21)36-11-10-34(17-26(36)37)16-23-14-32-18-35(23)15-19-4-9-25(33-13-19)20-5-7-24(8-6-20)38-27(29,30)31/h1-9,12-14,18H,10-11,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112383
PNG
(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Show SMILES FC(F)(F)CCCCc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C31H31F3N4O2/c32-31(33,34)12-2-1-4-24-8-7-22-16-29(24)40-26-10-9-23-5-3-6-28(27(23)17-26)38-15-14-36(20-30(38)39)13-11-25-18-35-21-37(25)19-22/h3,5-10,16-18,21H,1-2,4,11-15,19-20H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112375
PNG
(1-(3-Chloro-phenyl)-4-[3-(2-methoxy-4'-trifluorome...)
Show SMILES COc1cc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)ccc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H26ClF3N4O2/c1-39-27-13-20(5-10-26(27)21-6-8-22(9-7-21)29(31,32)33)16-36-19-34-15-25(36)17-35-11-12-37(28(38)18-35)24-4-2-3-23(30)14-24/h2-10,13-15,19H,11-12,16-18H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50097071
PNG
(4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]MET...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O
Show InChI InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112377
PNG
(1-(3-Chloro-phenyl)-4-[3-(4'-trifluoromethyl-biphe...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H24ClF3N4O/c29-24-2-1-3-25(14-24)36-13-12-34(18-27(36)37)17-26-15-33-19-35(26)16-20-4-6-21(7-5-20)22-8-10-23(11-9-22)28(30,31)32/h1-11,14-15,19H,12-13,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112379
PNG
(1-(3-Chloro-phenyl)-4-{2-[3-(2-methoxy-4'-trifluor...)
Show SMILES COc1cc(Cn2cncc2CCN2CCN(C(=O)C2)c2cccc(Cl)c2)ccc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C30H28ClF3N4O2/c1-40-28-15-21(5-10-27(28)22-6-8-23(9-7-22)30(32,33)34)18-37-20-35-17-26(37)11-12-36-13-14-38(29(39)19-36)25-4-2-3-24(31)16-25/h2-10,15-17,20H,11-14,18-19H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112376
PNG
(1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethyl-phe...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C27H23ClF3N5O/c28-22-2-1-3-23(12-22)36-11-10-34(17-26(36)37)16-24-14-32-18-35(24)15-19-4-9-25(33-13-19)20-5-7-21(8-6-20)27(29,30)31/h1-9,12-14,18H,10-11,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112390
PNG
(17-bromo-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2...)
Show SMILES Brc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34
Show InChI InChI=1S/C26H23BrN4O2/c27-23-7-4-18-12-25(23)33-21-6-5-19-2-1-3-24(22(19)13-21)31-11-10-29(16-26(31)32)9-8-20-14-28-17-30(20)15-18/h1-7,12-14,17H,8-11,15-16H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112373
PNG
(4-[3-(4'-Chloro-biphenyl-4-ylmethyl)-3H-imidazol-4...)
Show SMILES Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H24Cl2N4O/c28-23-10-8-22(9-11-23)21-6-4-20(5-7-21)16-32-19-30-15-26(32)17-31-12-13-33(27(34)18-31)25-3-1-2-24(29)14-25/h1-11,14-15,19H,12-13,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112373
PNG
(4-[3-(4'-Chloro-biphenyl-4-ylmethyl)-3H-imidazol-4...)
Show SMILES Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H24Cl2N4O/c28-23-10-8-22(9-11-23)21-6-4-20(5-7-21)16-32-19-30-15-26(32)17-31-12-13-33(27(34)18-31)25-3-1-2-24(29)14-25/h1-11,14-15,19H,12-13,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112389
PNG
(1-(3-Chloro-phenyl)-4-{3-[6-(4-chloro-phenyl)-pyri...)
Show SMILES Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C26H23Cl2N5O/c27-21-7-5-20(6-8-21)25-9-4-19(13-30-25)15-32-18-29-14-24(32)16-31-10-11-33(26(34)17-31)23-3-1-2-22(28)12-23/h1-9,12-14,18H,10-11,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112384
PNG
(1-(3-Chloro-phenyl)-4-[3-(2'-methoxy-4'-trifluorom...)
Show SMILES COc1cc(ccc1-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1)C(F)(F)F
Show InChI InChI=1S/C29H26ClF3N4O2/c1-39-27-13-22(29(31,32)33)9-10-26(27)21-7-5-20(6-8-21)16-36-19-34-15-25(36)17-35-11-12-37(28(38)18-35)24-4-2-3-23(30)14-24/h2-10,13-15,19H,11-12,16-18H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112386
PNG
(1-(3-Chloro-phenyl)-4-[3-(3'-trifluoromethyl-biphe...)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H24ClF3N4O/c29-24-5-2-6-25(14-24)36-12-11-34(18-27(36)37)17-26-15-33-19-35(26)16-20-7-9-21(10-8-20)22-3-1-4-23(13-22)28(30,31)32/h1-10,13-15,19H,11-12,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112385
PNG
(1-(3-Chloro-phenyl)-4-[3-(3',5'-dichloro-biphenyl-...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2cc(Cl)cc(Cl)c2)CC1=O
Show InChI InChI=1S/C27H23Cl3N4O/c28-22-2-1-3-25(13-22)34-9-8-32(17-27(34)35)16-26-14-31-18-33(26)15-19-4-6-20(7-5-19)21-10-23(29)12-24(30)11-21/h1-7,10-14,18H,8-9,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for Farnesyl Transferase Inhibition to displace 50% of radiolabeled Farnesyltransferase inhibitors from Farnesyltransferase in v-Ha-ras-transf...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112376
PNG
(1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethyl-phe...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C27H23ClF3N5O/c28-22-2-1-3-23(12-22)36-11-10-34(17-26(36)37)16-24-14-32-18-35(24)15-19-4-9-25(33-13-19)20-5-7-21(8-6-20)27(29,30)31/h1-9,12-14,18H,10-11,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112388
PNG
(19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22,5.114...)
Show SMILES O=C1CN2CCN1c1cccc3ccc(Oc4cccc(Cn5cncc5CC2)c4)cc13
Show InChI InChI=1S/C26H24N4O2/c31-26-17-28-10-9-21-15-27-18-29(21)16-19-3-1-5-22(13-19)32-23-8-7-20-4-2-6-25(24(20)14-23)30(26)12-11-28/h1-8,13-15,18H,9-12,16-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112391
PNG
(1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethoxy-ph...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C27H23ClF3N5O2/c28-21-2-1-3-22(12-21)36-11-10-34(17-26(36)37)16-23-14-32-18-35(23)15-19-4-9-25(33-13-19)20-5-7-24(8-6-20)38-27(29,30)31/h1-9,12-14,18H,10-11,15-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112392
PNG
(4-[3-(3'-Chloro-biphenyl-4-ylmethyl)-3H-imidazol-4...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2cccc(Cl)c2)CC1=O
Show InChI InChI=1S/C27H24Cl2N4O/c28-23-4-1-3-22(13-23)21-9-7-20(8-10-21)16-32-19-30-15-26(32)17-31-11-12-33(27(34)18-31)25-6-2-5-24(29)14-25/h1-10,13-15,19H,11-12,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112382
PNG
(1-(3-Chloro-phenyl)-4-[3-(4'-fluoro-biphenyl-4-ylm...)
Show SMILES Fc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H24ClFN4O/c28-23-2-1-3-25(14-23)33-13-12-31(18-27(33)34)17-26-15-30-19-32(26)16-20-4-6-21(7-5-20)22-8-10-24(29)11-9-22/h1-11,14-15,19H,12-13,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50112386
PNG
(1-(3-Chloro-phenyl)-4-[3-(3'-trifluoromethyl-biphe...)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H24ClF3N4O/c29-24-5-2-6-25(14-24)36-12-11-34(18-27(36)37)17-26-15-33-19-35(26)16-20-7-9-21(10-8-20)22-3-1-4-23(13-22)28(30,31)32/h1-10,13-15,19H,11-12,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50112382
PNG
(1-(3-Chloro-phenyl)-4-[3-(4'-fluoro-biphenyl-4-ylm...)
Show SMILES Fc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H24ClFN4O/c28-23-2-1-3-25(14-23)33-13-12-31(18-27(33)34)17-26-15-30-19-32(26)16-20-4-6-21(7-5-20)22-8-10-24(29)11-9-22/h1-11,14-15,19H,12-13,16-18H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...


Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair
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