Compile Data Set for Download or QSAR

Found 102 hits Enz. Inhib. hit(s) with all data for entry = 50016758   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50173245 (1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dih...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(F)ccc12 Show InChI InChI=1S/C22H31FN2O/c1-24-20-10-9-18(23)15-19(20)22(21(24)26)11-13-25(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173251 (1'-cyclooctylmethyl-1-methylspiro[2,3-dihydro-1H-i...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C22H32N2O/c1-23-20-12-8-7-11-19(20)22(21(23)25)13-15-24(16-14-22)17-18-9-5-3-2-4-6-10-18/h7-8,11-12,18H,2-6,9-10,13-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173256 (1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2c1cccc2C Show InChI InChI=1S/C23H34N2O/c1-18-9-8-12-20-21(18)23(22(26)24(20)2)13-15-25(16-14-23)17-19-10-6-4-3-5-7-11-19/h8-9,12,19H,3-7,10-11,13-17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173275 (1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-...) Show SMILES O=C1N(CC2CO2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C24H34N2O2/c27-23-24(21-10-6-7-11-22(21)26(23)17-20-18-28-20)12-14-25(15-13-24)16-19-8-4-2-1-3-5-9-19/h6-7,10-11,19-20H,1-5,8-9,12-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173246 (1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-...) Show SMILES CC(C)c1ccc2N(C)C(=O)C3(CCN(CC4CCCCCCC4)CC3)c2c1 Show InChI InChI=1S/C25H38N2O/c1-19(2)21-11-12-23-22(17-21)25(24(28)26(23)3)13-15-27(16-14-25)18-20-9-7-5-4-6-8-10-20/h11-12,17,19-20H,4-10,13-16,18H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173254 (CHEMBL434944 | methyl 2-[1'-cyclooctylmethyl-2-oxo...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C24H34N2O3/c1-29-22(27)18-26-21-12-8-7-11-20(21)24(23(26)28)13-15-25(16-14-24)17-19-9-5-3-2-4-6-10-19/h7-8,11-12,19H,2-6,9-10,13-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173244 (1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazina...) Show SMILES OC(CNCCN1CCOCC1)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C30H48N4O3/c35-26(22-31-14-17-32-18-20-37-21-19-32)24-34-28-11-7-6-10-27(28)30(29(34)36)12-15-33(16-13-30)23-25-8-4-2-1-3-5-9-25/h6-7,10-11,25-26,31,35H,1-5,8-9,12-24H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173264 (CHEMBL197942 | methyl 2-[1'-[4-(tert-butyl)cyclohe...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCC(CC3)C(C)(C)C)CC2)c2ccccc12 |(5.06,2.61,;3.55,2.29,;2.53,3.43,;2.99,4.89,;1.03,3.1,;.54,1.65,;1.45,.39,;2.99,.39,;.54,-.87,;2.06,-1.17,;2.53,-2.64,;1.5,-3.79,;1.97,-5.26,;.92,-6.4,;-.58,-6.07,;-1.6,-7.19,;-1.14,-8.66,;.36,-9.01,;1.41,-7.86,;-2.19,-9.81,;-1.07,-10.88,;-3.28,-8.73,;-3.28,-10.9,;-.02,-3.46,;-.48,-2.01,;-.93,-.38,;-2.26,-1.15,;-3.59,-.38,;-3.59,1.16,;-2.26,1.93,;-.93,1.16,)| Show InChI InChI=1S/C26H38N2O3/c1-25(2,3)20-11-9-19(10-12-20)17-27-15-13-26(14-16-27)21-7-5-6-8-22(21)28(24(26)30)18-23(29)31-4/h5-8,19-20H,9-18H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173244 (1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazina...) Show SMILES OC(CNCCN1CCOCC1)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C30H48N4O3/c35-26(22-31-14-17-32-18-20-37-21-19-32)24-34-28-11-7-6-10-27(28)30(29(34)36)12-15-33(16-13-30)23-25-8-4-2-1-3-5-9-25/h6-7,10-11,25-26,31,35H,1-5,8-9,12-24H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173243 (1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-i...) Show SMILES O=C1N(Cc2ccccc2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C28H36N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h4,7-10,13-16,23H,1-3,5-6,11-12,17-22H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173252 (1'-cyclooctylmethyl-6-hydroxy-1-methylspiro[2,3-di...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(O)cc12 Show InChI InChI=1S/C22H32N2O2/c1-23-20-15-18(25)9-10-19(20)22(21(23)26)11-13-24(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17,25H,2-8,11-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173266 (CHEMBL264066 | methyl 2-[2-oxo-1'-(3-trifluorometh...) Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3cccc(c3)C(F)(F)F)CC2)c2ccccc12 Show InChI InChI=1S/C23H23F3N2O3/c1-31-20(29)15-28-19-8-3-2-7-18(19)22(21(28)30)9-11-27(12-10-22)14-16-5-4-6-17(13-16)23(24,25)26/h2-8,13H,9-12,14-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173268 (1'-cyclooctylmethyl-1,6-dimethylspiro[2,3-dihydro-...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(C)cc12 Show InChI InChI=1S/C23H34N2O/c1-18-10-11-20-21(16-18)24(2)22(26)23(20)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173253 (2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...) Show SMILES CC(=O)OCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C25H36N2O3/c1-20(28)30-18-17-27-23-12-8-7-11-22(23)25(24(27)29)13-15-26(16-14-25)19-21-9-5-3-2-4-6-10-21/h7-8,11-12,21H,2-6,9-10,13-19H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173269 (1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amin...) Show SMILES CCN(CC(O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12)Cc1ccc(C)cc1 Show InChI InChI=1S/C34H49N3O2/c1-3-35(23-29-17-15-27(2)16-18-29)25-30(38)26-37-32-14-10-9-13-31(32)34(33(37)39)19-21-36(22-20-34)24-28-11-7-5-4-6-8-12-28/h9-10,13-18,28,30,38H,3-8,11-12,19-26H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173271 (CHEMBL444620 | methyl 2-[1'-(2-naphthylmethyl)-2-o...) Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccc4ccccc4c3)CC2)c2ccccc12 Show InChI InChI=1S/C26H26N2O3/c1-31-24(29)18-28-23-9-5-4-8-22(23)26(25(28)30)12-14-27(15-13-26)17-19-10-11-20-6-2-3-7-21(20)16-19/h2-11,16H,12-15,17-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173245 (1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dih...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(F)ccc12 Show InChI InChI=1S/C22H31FN2O/c1-24-20-10-9-18(23)15-19(20)22(21(24)26)11-13-25(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173267 (1'-cyclooctylmethyl-1-(2-hydroxyethyl)spiro[2,3-di...) Show SMILES OCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C23H34N2O2/c26-17-16-25-21-11-7-6-10-20(21)23(22(25)27)12-14-24(15-13-23)18-19-8-4-2-1-3-5-9-19/h6-7,10-11,19,26H,1-5,8-9,12-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50173252 (1'-cyclooctylmethyl-6-hydroxy-1-methylspiro[2,3-di...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(O)cc12 Show InChI InChI=1S/C22H32N2O2/c1-23-20-15-18(25)9-10-19(20)22(21(23)26)11-13-24(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17,25H,2-8,11-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173269 (1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amin...) Show SMILES CCN(CC(O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12)Cc1ccc(C)cc1 Show InChI InChI=1S/C34H49N3O2/c1-3-35(23-29-17-15-27(2)16-18-29)25-30(38)26-37-32-14-10-9-13-31(32)34(33(37)39)19-21-36(22-20-34)24-28-11-7-5-4-6-8-12-28/h9-10,13-18,28,30,38H,3-8,11-12,19-26H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173281 (CHEMBL198046 | methyl 2-[1'-(1,2-dihydro-5-acenaph...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC2)c2ccc3CCc4cccc2c34)c2ccccc12 Show InChI InChI=1S/C27H26N2O3/c1-32-24(30)17-29-23-8-3-2-7-21(23)27(26(29)31)13-15-28(16-14-27)22-12-11-19-10-9-18-5-4-6-20(22)25(18)19/h2-8,11-12H,9-10,13-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173247 (1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4...) Show SMILES O=C1Nc2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C21H30N2O/c24-20-21(18-10-6-7-11-19(18)22-20)12-14-23(15-13-21)16-17-8-4-2-1-3-5-9-17/h6-7,10-11,17H,1-5,8-9,12-16H2,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173247 (1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4...) Show SMILES O=C1Nc2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C21H30N2O/c24-20-21(18-10-6-7-11-19(18)22-20)12-14-23(15-13-21)16-17-8-4-2-1-3-5-9-17/h6-7,10-11,17H,1-5,8-9,12-16H2,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173250 (1'-cyclooctylmethyl-1,5-dimethylspiro[2,3-dihydro-...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(C)ccc12 Show InChI InChI=1S/C23H34N2O/c1-18-10-11-21-20(16-18)23(22(26)24(21)2)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173280 (CHEMBL198678 | methyl 2-[1'-(1-naphthylmethyl)-2-o...) Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3cccc4ccccc34)CC2)c2ccccc12 Show InChI InChI=1S/C26H26N2O3/c1-31-24(29)18-28-23-12-5-4-11-22(23)26(25(28)30)13-15-27(16-14-26)17-20-9-6-8-19-7-2-3-10-21(19)20/h2-12H,13-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50173256 (1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2c1cccc2C Show InChI InChI=1S/C23H34N2O/c1-18-9-8-12-20-21(18)23(22(26)24(20)2)13-15-25(16-14-23)17-19-10-6-4-3-5-7-11-19/h8-9,12,19H,3-7,10-11,13-17H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173275 (1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-...) Show SMILES O=C1N(CC2CO2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C24H34N2O2/c27-23-24(21-10-6-7-11-22(21)26(23)17-20-18-28-20)12-14-25(15-13-24)16-19-8-4-2-1-3-5-9-19/h6-7,10-11,19-20H,1-5,8-9,12-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50173244 (1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazina...) Show SMILES OC(CNCCN1CCOCC1)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C30H48N4O3/c35-26(22-31-14-17-32-18-20-37-21-19-32)24-34-28-11-7-6-10-27(28)30(29(34)36)12-15-33(16-13-30)23-25-8-4-2-1-3-5-9-25/h6-7,10-11,25-26,31,35H,1-5,8-9,12-24H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173284 (CHEMBL427010 | methyl 2-[1'-cycloheptylmethyl-2-ox...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C23H32N2O3/c1-28-21(26)17-25-20-11-7-6-10-19(20)23(22(25)27)12-14-24(15-13-23)16-18-8-4-2-3-5-9-18/h6-7,10-11,18H,2-5,8-9,12-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173250 (1'-cyclooctylmethyl-1,5-dimethylspiro[2,3-dihydro-...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(C)ccc12 Show InChI InChI=1S/C23H34N2O/c1-18-10-11-21-20(16-18)23(22(26)24(21)2)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173256 (1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2c1cccc2C Show InChI InChI=1S/C23H34N2O/c1-18-9-8-12-20-21(18)23(22(26)24(20)2)13-15-25(16-14-23)17-19-10-6-4-3-5-7-11-19/h8-9,12,19H,3-7,10-11,13-17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173274 (1'-cyclooctylmethyl-1-methyl-5-trifluoromethylspir...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C23H31F3N2O/c1-27-20-10-9-18(23(24,25)26)15-19(20)22(21(27)29)11-13-28(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50173269 (1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amin...) Show SMILES CCN(CC(O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12)Cc1ccc(C)cc1 Show InChI InChI=1S/C34H49N3O2/c1-3-35(23-29-17-15-27(2)16-18-29)25-30(38)26-37-32-14-10-9-13-31(32)34(33(37)39)19-21-36(22-20-34)24-28-11-7-5-4-6-8-12-28/h9-10,13-18,28,30,38H,3-8,11-12,19-26H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173254 (CHEMBL434944 | methyl 2-[1'-cyclooctylmethyl-2-oxo...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C24H34N2O3/c1-29-22(27)18-26-21-12-8-7-11-20(21)24(23(26)28)13-15-25(16-14-24)17-19-9-5-3-2-4-6-10-19/h7-8,11-12,19H,2-6,9-10,13-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173283 (1-cyclohexylmethyl-1'-cyclooctylmethylspiro[2,3-di...) Show SMILES O=C1N(CC2CCCCC2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C28H42N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h9-10,15-16,23-24H,1-8,11-14,17-22H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173248 (CHEMBL373222 | methyl 2-[1'-(4-chlorobenzyl)-2-oxo...) Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc12 Show InChI InChI=1S/C22H23ClN2O3/c1-28-20(26)15-25-19-5-3-2-4-18(19)22(21(25)27)10-12-24(13-11-22)14-16-6-8-17(23)9-7-16/h2-9H,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173261 (CHEMBL198099 | methyl 2-[1'-cyclohexylmethyl-2-oxo...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C22H30N2O3/c1-27-20(25)16-24-19-10-6-5-9-18(19)22(21(24)26)11-13-23(14-12-22)15-17-7-3-2-4-8-17/h5-6,9-10,17H,2-4,7-8,11-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173263 (CHEMBL198167 | methyl 2-[1'-hexyl-2-oxospiro[2,3-d...) Show SMILES CCCCCCN1CCC2(CC1)C(=O)N(CC(=O)OC)c1ccccc21 Show InChI InChI=1S/C21H30N2O3/c1-3-4-5-8-13-22-14-11-21(12-15-22)17-9-6-7-10-18(17)23(20(21)25)16-19(24)26-2/h6-7,9-10H,3-5,8,11-16H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50173275 (1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-...) Show SMILES O=C1N(CC2CO2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C24H34N2O2/c27-23-24(21-10-6-7-11-22(21)26(23)17-20-18-28-20)12-14-25(15-13-24)16-19-8-4-2-1-3-5-9-19/h6-7,10-11,19-20H,1-5,8-9,12-18H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173249 (CHEMBL197880 | methyl 2-[2-oxo-1'-(4-trifluorometh...) Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccc(cc3)C(F)(F)F)CC2)c2ccccc12 Show InChI InChI=1S/C23H23F3N2O3/c1-31-20(29)15-28-19-5-3-2-4-18(19)22(21(28)30)10-12-27(13-11-22)14-16-6-8-17(9-7-16)23(24,25)26/h2-9H,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173276 (CHEMBL380580 | methyl 2-[2-oxo-1'-perhydro-2-napht...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC2)C2CCC3CCCCC3C2)c2ccccc12 Show InChI InChI=1S/C25H34N2O3/c1-30-23(28)17-27-22-9-5-4-8-21(22)25(24(27)29)12-14-26(15-13-25)20-11-10-18-6-2-3-7-19(18)16-20/h4-5,8-9,18-20H,2-3,6-7,10-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173251 (1'-cyclooctylmethyl-1-methylspiro[2,3-dihydro-1H-i...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C22H32N2O/c1-23-20-12-8-7-11-19(20)22(21(23)25)13-15-24(16-14-22)17-18-9-5-3-2-4-6-10-18/h7-8,11-12,18H,2-6,9-10,13-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50173243 (1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-i...) Show SMILES O=C1N(Cc2ccccc2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C28H36N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h4,7-10,13-16,23H,1-3,5-6,11-12,17-22H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50173246 (1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-...) Show SMILES CC(C)c1ccc2N(C)C(=O)C3(CCN(CC4CCCCCCC4)CC3)c2c1 Show InChI InChI=1S/C25H38N2O/c1-19(2)21-11-12-23-22(17-21)25(24(28)26(23)3)13-15-27(16-14-25)18-20-9-7-5-4-6-8-10-20/h11-12,17,19-20H,4-10,13-16,18H2,1-3H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50173245 (1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dih...) Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(F)ccc12 Show InChI InChI=1S/C22H31FN2O/c1-24-20-10-9-18(23)15-19(20)22(21(24)26)11-13-25(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173272 (CHEMBL370226 | methyl 2-[2-oxo-1'-(1,2,3,4-tetrahy...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC2)C2CCc3ccccc3C2)c2ccccc12 Show InChI InChI=1S/C25H28N2O3/c1-30-23(28)17-27-22-9-5-4-8-21(22)25(24(27)29)12-14-26(15-13-25)20-11-10-18-6-2-3-7-19(18)16-20/h2-9,20H,10-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173243 (1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-i...) Show SMILES O=C1N(Cc2ccccc2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C28H36N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h4,7-10,13-16,23H,1-3,5-6,11-12,17-22H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50173247 (1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4...) Show SMILES O=C1Nc2ccccc2C11CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C21H30N2O/c24-20-21(18-10-6-7-11-19(18)22-20)12-14-23(15-13-21)16-17-8-4-2-1-3-5-9-17/h6-7,10-11,17H,1-5,8-9,12-16H2,(H,22,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.11E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50173270 (CHEMBL370782 | methyl 2-[1'-cyclododecylmethyl-2-o...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCCCCCCC3)CC2)c2ccccc12 Show InChI InChI=1S/C28H42N2O3/c1-33-26(31)22-30-25-16-12-11-15-24(25)28(27(30)32)17-19-29(20-18-28)21-23-13-9-7-5-3-2-4-6-8-10-14-23/h11-12,15-16,23H,2-10,13-14,17-22H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50173255 (1'-cyclooctylmethyl-6-methoxy-1-methylspiro[2,3-di...) Show SMILES COc1ccc2c(c1)N(C)C(=O)C21CCN(CC2CCCCCCC2)CC1 Show InChI InChI=1S/C23H34N2O2/c1-24-21-16-19(27-2)10-11-20(21)23(22(24)26)12-14-25(15-13-23)17-18-8-6-4-3-5-7-9-18/h10-11,16,18H,3-9,12-15,17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair

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