Compile Data Set for Download or QSAR

Found 75 hits Enz. Inhib. hit(s) with all data for entry = 698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5140 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CC(O)CNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C26H29ClFN7O3/c1-4-35(5-2)12-16(36)11-29-26(38)21-8-14(3)20(33-21)10-17-22-23(30-13-31-24(22)34-25(17)37)32-15-6-7-19(28)18(27)9-15/h6-10,13,16,33,36H,4-5,11-12H2,1-3H3,(H,29,38)(H2,30,31,32,34,37)/b17-10-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5146 (5-{[(5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-6-oxo-5...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c12)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C34H34N8O3/c1-22-17-28(34(44)35-10-12-41-13-15-45-16-14-41)39-27(22)19-26-30-31(36-21-37-32(30)40-33(26)43)38-25-7-8-29-24(18-25)9-11-42(29)20-23-5-3-2-4-6-23/h2-9,11,17-19,21,39H,10,12-16,20H2,1H3,(H,35,44)(H2,36,37,38,40,43)/b26-19-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5138 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H27ClFN7O2/c1-4-34(5-2)9-8-28-25(36)20-10-14(3)19(32-20)12-16-21-22(29-13-30-23(21)33-24(16)35)31-15-6-7-18(27)17(26)11-15/h6-7,10-13,32H,4-5,8-9H2,1-3H3,(H,28,36)(H2,29,30,31,33,35)/b16-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5145 ((5Z)-4-[(1-benzyl-1H-indazol-5-yl)amino]-5-{[3-met...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C31H28N8O3/c1-19-13-25(31(41)38-9-11-42-12-10-38)36-24(19)15-23-27-28(32-18-33-29(27)37-30(23)40)35-22-7-8-26-21(14-22)16-34-39(26)17-20-5-3-2-4-6-20/h2-8,13-16,18,36H,9-12,17H2,1H3,(H2,32,33,35,37,40)/b23-15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5134 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-meth...) Show SMILES CN1CCN(CC1)C(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C24H23ClFN7O2/c1-13-9-19(24(35)33-7-5-32(2)6-8-33)30-18(13)11-15-20-21(27-12-28-22(20)31-23(15)34)29-14-3-4-17(26)16(25)10-14/h3-4,9-12,30H,5-8H2,1-2H3,(H2,27,28,29,31,34)/b15-11-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5144 ((5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-5-{[3-methy...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C32H29N7O3/c1-20-15-26(32(41)38-11-13-42-14-12-38)36-25(20)17-24-28-29(33-19-34-30(28)37-31(24)40)35-23-7-8-27-22(16-23)9-10-39(27)18-21-5-3-2-4-6-21/h2-10,15-17,19,36H,11-14,18H2,1H3,(H2,33,34,35,37,40)/b24-17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5127 (3-(5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-o...) Show SMILES Cc1cc(CCC(O)=O)[nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C21H17ClFN5O3/c1-10-6-11(3-5-17(29)30)26-16(10)8-13-18-19(24-9-25-20(18)28-21(13)31)27-12-2-4-15(23)14(22)7-12/h2,4,6-9,26H,3,5H2,1H3,(H,29,30)(H2,24,25,27,28,31)/b13-8-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5139 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({5-[(3,...) Show SMILES CC1CN(CC(C)N1)C(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H25ClFN7O2/c1-12-6-20(25(36)34-9-13(2)30-14(3)10-34)32-19(12)8-16-21-22(28-11-29-23(21)33-24(16)35)31-15-4-5-18(27)17(26)7-15/h4-8,11,13-14,30,32H,9-10H2,1-3H3,(H2,28,29,31,33,35)/b16-8-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5130 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c12)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C25H25ClFN7O3/c1-14-10-20(25(36)28-4-5-34-6-8-37-9-7-34)32-19(14)12-16-21-22(29-13-30-23(21)33-24(16)35)31-15-2-3-18(27)17(26)11-15/h2-3,10-13,32H,4-9H2,1H3,(H,28,36)(H2,29,30,31,33,35)/b16-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5137 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({5-[(4-...) Show SMILES CCN1CCN(CC1)C(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H25ClFN7O2/c1-3-33-6-8-34(9-7-33)25(36)20-10-14(2)19(31-20)12-16-21-22(28-13-29-23(21)32-24(16)35)30-15-4-5-18(27)17(26)11-15/h4-5,10-13,31H,3,6-9H2,1-2H3,(H2,28,29,30,32,35)/b16-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5141 (5-{[(5Z)-4-[(3-ethynylphenyl)amino]-6-oxo-5H,6H,7H...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3cccc(c3)C#C)c12)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C27H27N7O3/c1-3-18-5-4-6-19(14-18)31-24-23-20(26(35)33-25(23)30-16-29-24)15-21-17(2)13-22(32-21)27(36)28-7-8-34-9-11-37-12-10-34/h1,4-6,13-16,32H,7-12H2,2H3,(H,28,36)(H2,29,30,31,33,35)/b20-15-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5129 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES Fc1ccc(Nc2ncnc3NC(=O)\C(=C/c4ccc([nH]4)C(=O)NCCN4CCOCC4)c23)cc1Cl Show InChI InChI=1S/C24H23ClFN7O3/c25-17-12-15(1-3-18(17)26)31-21-20-16(23(34)32-22(20)29-13-28-21)11-14-2-4-19(30-14)24(35)27-5-6-33-7-9-36-10-8-33/h1-4,11-13,30H,5-10H2,(H,27,35)(H2,28,29,31,32,34)/b16-11-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5128 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c12)C(O)=O Show InChI InChI=1S/C19H13ClFN5O3/c1-8-4-14(19(28)29)25-13(8)6-10-15-16(22-7-23-17(15)26-18(10)27)24-9-2-3-12(21)11(20)5-9/h2-7,25H,1H3,(H,28,29)(H2,22,23,24,26,27)/b10-6-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5142 (5-{[(5Z)-4-[(4-chloro-2-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(Cl)cc4F)c23)[nH]1 Show InChI InChI=1S/C25H27ClFN7O2/c1-4-34(5-2)9-8-28-25(36)20-10-14(3)19(31-20)12-16-21-22(29-13-30-23(21)33-24(16)35)32-18-7-6-15(26)11-17(18)27/h6-7,10-13,31H,4-5,8-9H2,1-3H3,(H,28,36)(H2,29,30,32,33,35)/b16-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5126 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-[(3,5-di...) Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C19H15ClFN5O/c1-9-5-10(2)24-15(9)7-12-16-17(22-8-23-18(16)26-19(12)27)25-11-3-4-14(21)13(20)6-11/h3-8,24H,1-2H3,(H2,22,23,25,26,27)/b12-7-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5133 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-{[3-meth...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C23H20ClFN6O3/c1-12-8-18(23(33)31-4-6-34-7-5-31)29-17(12)10-14-19-20(26-11-27-21(19)30-22(14)32)28-13-2-3-16(25)15(24)9-13/h2-3,8-11,29H,4-7H2,1H3,(H2,26,27,28,30,32)/b14-10-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5124 (3-(5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-o...) Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c(C)c1CCC(O)=O Show InChI InChI=1S/C22H19ClFN5O3/c1-10-13(4-6-18(30)31)11(2)27-17(10)8-14-19-20(25-9-26-21(19)29-22(14)32)28-12-3-5-16(24)15(23)7-12/h3,5,7-9,27H,4,6H2,1-2H3,(H,30,31)(H2,25,26,28,29,32)/b14-8-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5125 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c1C Show InChI InChI=1S/C26H29ClFN7O2/c1-5-35(6-2)10-9-29-26(37)21-14(3)20(32-15(21)4)12-17-22-23(30-13-31-24(22)34-25(17)36)33-16-7-8-19(28)18(27)11-16/h7-8,11-13,32H,5-6,9-10H2,1-4H3,(H,29,37)(H2,30,31,33,34,36)/b17-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5135 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({4-meth...) Show SMILES CN1CCN(CC1)C(=O)c1[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)cc1C Show InChI InChI=1S/C24H23ClFN7O2/c1-13-9-15(29-20(13)24(35)33-7-5-32(2)6-8-33)10-16-19-21(27-12-28-22(19)31-23(16)34)30-14-3-4-18(26)17(25)11-14/h3-4,9-12,29H,5-8H2,1-2H3,(H2,27,28,30,31,34)/b16-10-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5138 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H27ClFN7O2/c1-4-34(5-2)9-8-28-25(36)20-10-14(3)19(32-20)12-16-21-22(29-13-30-23(21)33-24(16)35)31-15-6-7-18(27)17(26)11-15/h6-7,10-13,32H,4-5,8-9H2,1-3H3,(H,28,36)(H2,29,30,31,33,35)/b16-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5140 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CC(O)CNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C26H29ClFN7O3/c1-4-35(5-2)12-16(36)11-29-26(38)21-8-14(3)20(33-21)10-17-22-23(30-13-31-24(22)34-25(17)37)32-15-6-7-19(28)18(27)9-15/h6-10,13,16,33,36H,4-5,11-12H2,1-3H3,(H,29,38)(H2,30,31,32,34,37)/b17-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5136 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-meth...) Show SMILES CN1CCN(CC1)C(=O)c1c[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c1C Show InChI InChI=1S/C24H23ClFN7O2/c1-13-16(24(35)33-7-5-32(2)6-8-33)11-27-19(13)10-15-20-21(28-12-29-22(20)31-23(15)34)30-14-3-4-18(26)17(25)9-14/h3-4,9-12,27H,5-8H2,1-2H3,(H2,28,29,30,31,34)/b15-10-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5142 (5-{[(5Z)-4-[(4-chloro-2-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(Cl)cc4F)c23)[nH]1 Show InChI InChI=1S/C25H27ClFN7O2/c1-4-34(5-2)9-8-28-25(36)20-10-14(3)19(31-20)12-16-21-22(29-13-30-23(21)33-24(16)35)32-18-7-6-15(26)11-17(18)27/h6-7,10-13,31H,4-5,8-9H2,1-3H3,(H,28,36)(H2,29,30,32,33,35)/b16-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5143 ((5Z)-4-(2,3-dihydro-1H-inden-5-ylamino)-5-{[3-meth...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4CCCc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H26N6O3/c1-15-11-21(26(34)32-7-9-35-10-8-32)30-20(15)13-19-22-23(27-14-28-24(22)31-25(19)33)29-18-6-5-16-3-2-4-17(16)12-18/h5-6,11-14,30H,2-4,7-10H2,1H3,(H2,27,28,29,31,33)/b19-13-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5139 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({5-[(3,...) Show SMILES CC1CN(CC(C)N1)C(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H25ClFN7O2/c1-12-6-20(25(36)34-9-13(2)30-14(3)10-34)32-19(12)8-16-21-22(28-11-29-23(21)33-24(16)35)31-15-4-5-18(27)17(26)7-15/h4-8,11,13-14,30,32H,9-10H2,1-3H3,(H2,28,29,31,33,35)/b16-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5144 ((5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-5-{[3-methy...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C32H29N7O3/c1-20-15-26(32(41)38-11-13-42-14-12-38)36-25(20)17-24-28-29(33-19-34-30(28)37-31(24)40)35-23-7-8-27-22(16-23)9-10-39(27)18-21-5-3-2-4-6-21/h2-10,15-17,19,36H,11-14,18H2,1H3,(H2,33,34,35,37,40)/b24-17-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5145 ((5Z)-4-[(1-benzyl-1H-indazol-5-yl)amino]-5-{[3-met...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C31H28N8O3/c1-19-13-25(31(41)38-9-11-42-12-10-38)36-24(19)15-23-27-28(32-18-33-29(27)37-30(23)40)35-22-7-8-26-21(14-22)16-34-39(26)17-20-5-3-2-4-6-20/h2-8,13-16,18,36H,9-12,17H2,1H3,(H2,32,33,35,37,40)/b23-15-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5143 ((5Z)-4-(2,3-dihydro-1H-inden-5-ylamino)-5-{[3-meth...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4CCCc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H26N6O3/c1-15-11-21(26(34)32-7-9-35-10-8-32)30-20(15)13-19-22-23(27-14-28-24(22)31-25(19)33)29-18-6-5-16-3-2-4-17(16)12-18/h5-6,11-14,30H,2-4,7-10H2,1H3,(H2,27,28,29,31,33)/b19-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5125 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c1C Show InChI InChI=1S/C26H29ClFN7O2/c1-5-35(6-2)10-9-29-26(37)21-14(3)20(32-15(21)4)12-17-22-23(30-13-31-24(22)34-25(17)36)33-16-7-8-19(28)18(27)11-16/h7-8,11-13,32H,5-6,9-10H2,1-4H3,(H,29,37)(H2,30,31,33,34,36)/b17-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.47E+3	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5146 (5-{[(5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-6-oxo-5...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c12)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C34H34N8O3/c1-22-17-28(34(44)35-10-12-41-13-15-45-16-14-41)39-27(22)19-26-30-31(36-21-37-32(30)40-33(26)43)38-25-7-8-29-24(18-25)9-11-42(29)20-23-5-3-2-4-6-23/h2-9,11,17-19,21,39H,10,12-16,20H2,1H3,(H,35,44)(H2,36,37,38,40,43)/b26-19-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5132 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-7-meth...) Show SMILES CN1C(=O)\C(=C/c2[nH]c(cc2C)C(=O)NCCN2CCOCC2)c2c1ncnc2Nc1ccc(F)c(Cl)c1 Show InChI InChI=1S/C26H27ClFN7O3/c1-15-11-21(25(36)29-5-6-35-7-9-38-10-8-35)33-20(15)13-17-22-23(30-14-31-24(22)34(2)26(17)37)32-16-3-4-19(28)18(27)12-16/h3-4,11-14,33H,5-10H2,1-2H3,(H,29,36)(H,30,31,32)/b17-13-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5142 (5-{[(5Z)-4-[(4-chloro-2-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(Cl)cc4F)c23)[nH]1 Show InChI InChI=1S/C25H27ClFN7O2/c1-4-34(5-2)9-8-28-25(36)20-10-14(3)19(31-20)12-16-21-22(29-13-30-23(21)33-24(16)35)32-18-7-6-15(26)11-17(18)27/h6-7,10-13,31H,4-5,8-9H2,1-3H3,(H,28,36)(H2,29,30,32,33,35)/b16-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5131 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-[(3,5-di...) Show SMILES CN1C(=O)\C(=C/c2[nH]c(C)cc2C)c2c1ncnc2Nc1ccc(F)c(Cl)c1 Show InChI InChI=1S/C20H17ClFN5O/c1-10-6-11(2)25-16(10)8-13-17-18(23-9-24-19(17)27(3)20(13)28)26-12-4-5-15(22)14(21)7-12/h4-9,25H,1-3H3,(H,23,24,26)/b13-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.82E+3	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5128 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c12)C(O)=O Show InChI InChI=1S/C19H13ClFN5O3/c1-8-4-14(19(28)29)25-13(8)6-10-15-16(22-7-23-17(15)26-18(10)27)24-9-2-3-12(21)11(20)5-9/h2-7,25H,1H3,(H,28,29)(H2,22,23,24,26,27)/b10-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.92E+3	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5145 ((5Z)-4-[(1-benzyl-1H-indazol-5-yl)amino]-5-{[3-met...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C31H28N8O3/c1-19-13-25(31(41)38-9-11-42-12-10-38)36-24(19)15-23-27-28(32-18-33-29(27)37-30(23)40)35-22-7-8-26-21(14-22)16-34-39(26)17-20-5-3-2-4-6-20/h2-8,13-16,18,36H,9-12,17H2,1H3,(H2,32,33,35,37,40)/b23-15-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5132 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-7-meth...) Show SMILES CN1C(=O)\C(=C/c2[nH]c(cc2C)C(=O)NCCN2CCOCC2)c2c1ncnc2Nc1ccc(F)c(Cl)c1 Show InChI InChI=1S/C26H27ClFN7O3/c1-15-11-21(25(36)29-5-6-35-7-9-38-10-8-35)33-20(15)13-17-22-23(30-14-31-24(22)34(2)26(17)37)32-16-3-4-19(28)18(27)12-16/h3-4,11-14,33H,5-10H2,1-2H3,(H,29,36)(H,30,31,32)/b17-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5126 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-[(3,5-di...) Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C19H15ClFN5O/c1-9-5-10(2)24-15(9)7-12-16-17(22-8-23-18(16)26-19(12)27)25-11-3-4-14(21)13(20)6-11/h3-8,24H,1-2H3,(H2,22,23,25,26,27)/b12-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.65E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5123 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-(1H-pyrr...) Show SMILES Fc1ccc(Nc2ncnc3NC(=O)\C(=C/c4ccc[nH]4)c23)cc1Cl Show InChI InChI=1S/C17H11ClFN5O/c18-12-7-10(3-4-13(12)19)23-15-14-11(6-9-2-1-5-20-9)17(25)24-16(14)22-8-21-15/h1-8,20H,(H2,21,22,23,24,25)/b11-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5124 (3-(5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-o...) Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c(C)c1CCC(O)=O Show InChI InChI=1S/C22H19ClFN5O3/c1-10-13(4-6-18(30)31)11(2)27-17(10)8-14-19-20(25-9-26-21(19)29-22(14)32)28-12-3-5-16(24)15(23)7-12/h3,5,7-9,27H,4,6H2,1-2H3,(H,30,31)(H2,25,26,28,29,32)/b14-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5127 (3-(5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-o...) Show SMILES Cc1cc(CCC(O)=O)[nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C21H17ClFN5O3/c1-10-6-11(3-5-17(29)30)26-16(10)8-13-18-19(24-9-25-20(18)28-21(13)31)27-12-2-4-15(23)14(22)7-12/h2,4,6-9,26H,3,5H2,1H3,(H,29,30)(H2,24,25,27,28,31)/b13-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5129 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES Fc1ccc(Nc2ncnc3NC(=O)\C(=C/c4ccc([nH]4)C(=O)NCCN4CCOCC4)c23)cc1Cl Show InChI InChI=1S/C24H23ClFN7O3/c25-17-12-15(1-3-18(17)26)31-21-20-16(23(34)32-22(20)29-13-28-21)11-14-2-4-19(30-14)24(35)27-5-6-33-7-9-36-10-8-33/h1-4,11-13,30H,5-10H2,(H,27,35)(H2,28,29,31,32,34)/b16-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5130 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c12)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C25H25ClFN7O3/c1-14-10-20(25(36)28-4-5-34-6-8-37-9-7-34)32-19(14)12-16-21-22(29-13-30-23(21)33-24(16)35)31-15-2-3-18(27)17(26)11-15/h2-3,10-13,32H,4-9H2,1H3,(H,28,36)(H2,29,30,31,33,35)/b16-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5133 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-{[3-meth...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C23H20ClFN6O3/c1-12-8-18(23(33)31-4-6-34-7-5-31)29-17(12)10-14-19-20(26-11-27-21(19)30-22(14)32)28-13-2-3-16(25)15(24)9-13/h2-3,8-11,29H,4-7H2,1H3,(H2,26,27,28,30,32)/b14-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5134 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-meth...) Show SMILES CN1CCN(CC1)C(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C24H23ClFN7O2/c1-13-9-19(24(35)33-7-5-32(2)6-8-33)30-18(13)11-15-20-21(27-12-28-22(20)31-23(15)34)29-14-3-4-17(26)16(25)10-14/h3-4,9-12,30H,5-8H2,1-2H3,(H2,27,28,29,31,34)/b15-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5135 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({4-meth...) Show SMILES CN1CCN(CC1)C(=O)c1[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)cc1C Show InChI InChI=1S/C24H23ClFN7O2/c1-13-9-15(29-20(13)24(35)33-7-5-32(2)6-8-33)10-16-19-21(27-12-28-22(19)31-23(16)34)30-14-3-4-18(26)17(25)11-14/h3-4,9-12,29H,5-8H2,1-2H3,(H2,27,28,30,31,34)/b16-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5136 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-meth...) Show SMILES CN1CCN(CC1)C(=O)c1c[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c1C Show InChI InChI=1S/C24H23ClFN7O2/c1-13-16(24(35)33-7-5-32(2)6-8-33)11-27-19(13)10-15-20-21(28-12-29-22(20)31-23(15)34)30-14-3-4-18(26)17(25)9-14/h3-4,9-12,27H,5-8H2,1-2H3,(H2,28,29,30,31,34)/b15-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5137 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({5-[(4-...) Show SMILES CCN1CCN(CC1)C(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H25ClFN7O2/c1-3-33-6-8-34(9-7-33)25(36)20-10-14(2)19(31-20)12-16-21-22(28-13-29-23(21)32-24(16)35)30-15-4-5-18(27)17(26)11-15/h4-5,10-13,31H,3,6-9H2,1-2H3,(H2,28,29,30,32,35)/b16-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5141 (5-{[(5Z)-4-[(3-ethynylphenyl)amino]-6-oxo-5H,6H,7H...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3cccc(c3)C#C)c12)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C27H27N7O3/c1-3-18-5-4-6-19(14-18)31-24-23-20(26(35)33-25(23)30-16-29-24)15-21-17(2)13-22(32-21)27(36)28-7-8-34-9-11-37-12-10-34/h1,4-6,13-16,32H,7-12H2,2H3,(H,28,36)(H2,29,30,31,33,35)/b20-15-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5147 ((5Z)-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-py...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(N3CCCCC3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3/c1-14-11-17(22(30)28-7-9-31-10-8-28)25-16(14)12-15-18-19(26-21(15)29)23-13-24-20(18)27-5-3-2-4-6-27/h11-13,25H,2-10H2,1H3,(H,23,24,26,29)/b15-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5123 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-(1H-pyrr...) Show SMILES Fc1ccc(Nc2ncnc3NC(=O)\C(=C/c4ccc[nH]4)c23)cc1Cl Show InChI InChI=1S/C17H11ClFN5O/c18-12-7-10(3-4-13(12)19)23-15-14-11(6-9-2-1-5-20-9)17(25)24-16(14)22-8-21-15/h1-8,20H,(H2,21,22,23,24,25)/b11-6-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair

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