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PubMed code 9784112

Compile data set for download or QSAR
Found 87 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3096
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)|
Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)
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n/an/a 9n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3097
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 64 | 6-(2,...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-1.48,-2.74,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)|
Show InChI InChI=1S/C27H29Cl2N5O2/c1-4-33(5-2)14-15-36-20-12-10-19(11-13-20)31-27-30-17-18-16-21(24-22(28)8-7-9-23(24)29)26(35)34(6-3)25(18)32-27/h7-13,16-17H,4-6,14-15H2,1-3H3,(H,30,31,32)
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n/an/a 17n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3097
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 64 | 6-(2,...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-1.48,-2.74,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)|
Show InChI InChI=1S/C27H29Cl2N5O2/c1-4-33(5-2)14-15-36-20-12-10-19(11-13-20)31-27-30-17-18-16-21(24-22(28)8-7-9-23(24)29)26(35)34(6-3)25(18)32-27/h7-13,16-17H,4-6,14-15H2,1-3H3,(H,30,31,32)
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n/an/a 30n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4077
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1
Show InChI InChI=1S/C27H31N5O2/c1-4-31(5-2)16-17-34-23-14-12-22(13-15-23)29-27-28-19-21-18-24(20-10-8-7-9-11-20)26(33)32(6-3)25(21)30-27/h7-15,18-19H,4-6,16-17H2,1-3H3,(H,28,29,30)
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n/an/a 31n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4077
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1
Show InChI InChI=1S/C27H31N5O2/c1-4-31(5-2)16-17-34-23-14-12-22(13-15-23)29-27-28-19-21-18-24(20-10-8-7-9-11-20)26(33)32(6-3)25(21)30-27/h7-15,18-19H,4-6,16-17H2,1-3H3,(H,28,29,30)
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n/an/a 31n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4067
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C26H29N5O2/c1-4-31(5-2)15-16-33-22-13-11-21(12-14-22)28-26-27-18-20-17-23(19-9-7-6-8-10-19)25(32)30(3)24(20)29-26/h6-14,17-18H,4-5,15-16H2,1-3H3,(H,27,28,29)
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n/an/a 42n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3096
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)|
Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)
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n/an/a 43n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4059
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(3-dimethylaminop...)
Show SMILES CN(C)CCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(1.02,-7.41,;1.02,-5.87,;2.35,-5.1,;-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C18H19Cl2N5O/c1-24(2)7-4-8-25-16-11(10-22-18(21)23-16)9-12(17(25)26)15-13(19)5-3-6-14(15)20/h3,5-6,9-10H,4,7-8H2,1-2H3,(H2,21,22,23)
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n/an/a 50n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4068
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccsc4)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C24H27N5O2S/c1-4-29(5-2)11-12-31-20-8-6-19(7-9-20)26-24-25-15-18-14-21(17-10-13-32-16-17)23(30)28(3)22(18)27-24/h6-10,13-16H,4-5,11-12H2,1-3H3,(H,25,26,27)
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n/an/a 54n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4076
PNG
(8-Ethyl-6-phenyl-2-(pyridin-4-ylamino)-8H-pyrido[2...)
Show SMILES CCn1c2nc(Nc3ccncc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C20H17N5O/c1-2-25-18-15(12-17(19(25)26)14-6-4-3-5-7-14)13-22-20(24-18)23-16-8-10-21-11-9-16/h3-13H,2H2,1H3,(H,21,22,23,24)
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n/an/a 74n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3096
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)|
Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)
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n/an/a 79n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4077
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1
Show InChI InChI=1S/C27H31N5O2/c1-4-31(5-2)16-17-34-23-14-12-22(13-15-23)29-27-28-19-21-18-24(20-10-8-7-9-11-20)26(33)32(6-3)25(21)30-27/h7-15,18-19H,4-6,16-17H2,1-3H3,(H,28,29,30)
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n/an/a 88n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4067
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C26H29N5O2/c1-4-31(5-2)15-16-33-22-13-11-21(12-14-22)28-26-27-18-20-17-23(19-9-7-6-8-10-19)25(32)30(3)24(20)29-26/h6-14,17-18H,4-5,15-16H2,1-3H3,(H,27,28,29)
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n/an/a 140n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3097
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 64 | 6-(2,...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-1.48,-2.74,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)|
Show InChI InChI=1S/C27H29Cl2N5O2/c1-4-33(5-2)14-15-36-20-12-10-19(11-13-20)31-27-30-17-18-16-21(24-22(28)8-7-9-23(24)29)26(35)34(6-3)25(18)32-27/h7-13,16-17H,4-6,14-15H2,1-3H3,(H,30,31,32)
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n/an/a 150n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4057
PNG
(2-Amino-8-benzyl-6-(2,6-dichlorophenyl)-8H-pyrido-...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(Cc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;2.35,-5.1,;2.35,-3.56,;1.02,-2.79,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C20H14Cl2N4O/c21-15-7-4-8-16(22)17(15)14-9-13-10-24-20(23)25-18(13)26(19(14)27)11-12-5-2-1-3-6-12/h1-10H,11H2,(H2,23,24,25)
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n/an/a 160n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-ethyl-8H-pyrido[2...)
Show SMILES CCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C15H12Cl2N4O/c1-2-21-13-8(7-19-15(18)20-13)6-9(14(21)22)12-10(16)4-3-5-11(12)17/h3-7H,2H2,1H3,(H2,18,19,20)
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n/an/a 160n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4061
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(3-hydroxypropyl)...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCO)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C16H14Cl2N4O2/c17-11-3-1-4-12(18)13(11)10-7-9-8-20-16(19)21-14(9)22(15(10)24)5-2-6-23/h1,3-4,7-8,23H,2,5-6H2,(H2,19,20,21)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4074
PNG
(8-ethyl-6-phenyl-2-(phenylamino)-7H,8H-pyrido[2,3-...)
Show SMILES CCn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C21H18N4O/c1-2-25-19-16(13-18(20(25)26)15-9-5-3-6-10-15)14-22-21(24-19)23-17-11-7-4-8-12-17/h3-14H,2H2,1H3,(H,22,23,24)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4068
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccsc4)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C24H27N5O2S/c1-4-29(5-2)11-12-31-20-8-6-19(7-9-20)26-24-25-15-18-14-21(17-10-13-32-16-17)23(30)28(3)22(18)27-24/h6-10,13-16H,4-5,11-12H2,1-3H3,(H,25,26,27)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)|
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19)
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n/an/a 260n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4063
PNG
(8-Methyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]py...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C20H16N4O/c1-24-18-15(12-17(19(24)25)14-8-4-2-5-9-14)13-21-20(23-18)22-16-10-6-3-7-11-16/h2-13H,1H3,(H,21,22,23)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4065
PNG
(8-Methyl-6-phenyl-2-(pyridin-4-ylamino)-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C19H15N5O/c1-24-17-14(11-16(18(24)25)13-5-3-2-4-6-13)12-21-19(23-17)22-15-7-9-20-10-8-15/h2-12H,1H3,(H,20,21,22,23)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4052
PNG
(2-Amino-8-butyl-6-(2,6-dichlorophenyl)-8H-pyrido[2...)
Show SMILES CCCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(1.02,-5.87,;-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C17H16Cl2N4O/c1-2-3-7-23-15-10(9-21-17(20)22-15)8-11(16(23)24)14-12(18)5-4-6-13(14)19/h4-6,8-9H,2-3,7H2,1H3,(H2,20,21,22)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4054
PNG
(2-Amino-6-(2,6-dichlorophenyl)-7-oxo-7H-pyrido[2,3...)
Show SMILES COC(=O)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.35,-3.56,;1.02,-2.79,;-.32,-3.56,;-.32,-5.1,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C16H12Cl2N4O3/c1-25-12(23)7-22-14-8(6-20-16(19)21-14)5-9(15(22)24)13-10(17)3-2-4-11(13)18/h2-6H,7H2,1H3,(H2,19,20,21)
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n/an/a 340n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4067
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C26H29N5O2/c1-4-31(5-2)15-16-33-22-13-11-21(12-14-22)28-26-27-18-20-17-23(19-9-7-6-8-10-19)25(32)30(3)24(20)29-26/h6-14,17-18H,4-5,15-16H2,1-3H3,(H,27,28,29)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4061
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(3-hydroxypropyl)...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCO)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C16H14Cl2N4O2/c17-11-3-1-4-12(18)13(11)10-7-9-8-20-16(19)21-14(9)22(15(10)24)5-2-6-23/h1,3-4,7-8,23H,2,5-6H2,(H2,19,20,21)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4076
PNG
(8-Ethyl-6-phenyl-2-(pyridin-4-ylamino)-8H-pyrido[2...)
Show SMILES CCn1c2nc(Nc3ccncc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C20H17N5O/c1-2-25-18-15(12-17(19(25)26)14-6-4-3-5-7-14)13-22-20(24-18)23-16-8-10-21-11-9-16/h3-13H,2H2,1H3,(H,21,22,23,24)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4075
PNG
(8-Ethyl-2-phenylamino-6-thiophene-3-yl-8H-pyrido-[...)
Show SMILES CCn1c2nc(Nc3ccccc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C19H16N4OS/c1-2-23-17-14(10-16(18(23)24)13-8-9-25-12-13)11-20-19(22-17)21-15-6-4-3-5-7-15/h3-12H,2H2,1H3,(H,20,21,22)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4065
PNG
(8-Methyl-6-phenyl-2-(pyridin-4-ylamino)-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C19H15N5O/c1-24-17-14(11-16(18(24)25)13-5-3-2-4-6-13)12-21-19(23-17)22-15-7-9-20-10-8-15/h2-12H,1H3,(H,20,21,22,23)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4066
PNG
(8-Methyl-2-(pyridin-4-ylamino)-6-thiophene-3-yl-8H...)
Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C17H13N5OS/c1-22-15-12(8-14(16(22)23)11-4-7-24-10-11)9-19-17(21-15)20-13-2-5-18-6-3-13/h2-10H,1H3,(H,18,19,20,21)
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n/an/a 480n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4053
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-isobutyl-8H-pyrid...)
Show SMILES CC(C)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-5.1,;-.32,-3.56,;1.02,-2.79,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C17H16Cl2N4O/c1-9(2)8-23-15-10(7-21-17(20)22-15)6-11(16(23)24)14-12(18)4-3-5-13(14)19/h3-7,9H,8H2,1-2H3,(H2,20,21,22)
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n/an/a 500n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4051
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-propyl-8H-pyrido-...)
Show SMILES CCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C16H14Cl2N4O/c1-2-6-22-14-9(8-20-16(19)21-14)7-10(15(22)23)13-11(17)4-3-5-12(13)18/h3-5,7-8H,2,6H2,1H3,(H2,19,20,21)
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n/an/a 510n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-ethyl-8H-pyrido[2...)
Show SMILES CCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C15H12Cl2N4O/c1-2-21-13-8(7-19-15(18)20-13)6-9(14(21)22)12-10(16)4-3-5-11(12)17/h3-7H,2H2,1H3,(H2,18,19,20)
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n/an/a 540n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4055
PNG
([2-Amino-6-(2,6-dichlorophenyl)-7-oxo-7H-pyrido[2,...)
Show SMILES CC(C)(C)OC(=O)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.69,-2.79,;2.35,-3.56,;2.35,-5.1,;3.69,-4.33,;1.02,-2.79,;-.32,-3.56,;-.32,-5.1,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C19H18Cl2N4O3/c1-19(2,3)28-14(26)9-25-16-10(8-23-18(22)24-16)7-11(17(25)27)15-12(20)5-4-6-13(15)21/h4-8H,9H2,1-3H3,(H2,22,23,24)
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n/an/a 560n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4052
PNG
(2-Amino-8-butyl-6-(2,6-dichlorophenyl)-8H-pyrido[2...)
Show SMILES CCCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(1.02,-5.87,;-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C17H16Cl2N4O/c1-2-3-7-23-15-10(9-21-17(20)22-15)8-11(16(23)24)14-12(18)5-4-6-13(14)19/h4-6,8-9H,2-3,7H2,1H3,(H2,20,21,22)
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n/an/a 580n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4051
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-propyl-8H-pyrido-...)
Show SMILES CCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C16H14Cl2N4O/c1-2-6-22-14-9(8-20-16(19)21-14)7-10(15(22)23)13-11(17)4-3-5-12(13)18/h3-5,7-8H,2,6H2,1H3,(H2,19,20,21)
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n/an/a 630n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4058
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(pyridin-4-ylmeth...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(Cc3ccncc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;2.35,-5.1,;2.35,-3.56,;1.02,-2.79,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C19H13Cl2N5O/c20-14-2-1-3-15(21)16(14)13-8-12-9-24-19(22)25-17(12)26(18(13)27)10-11-4-6-23-7-5-11/h1-9H,10H2,(H2,22,24,25)
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n/an/a 630n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4058
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(pyridin-4-ylmeth...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(Cc3ccncc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;2.35,-5.1,;2.35,-3.56,;1.02,-2.79,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C19H13Cl2N5O/c20-14-2-1-3-15(21)16(14)13-8-12-9-24-19(22)25-17(12)26(18(13)27)10-11-4-6-23-7-5-11/h1-9H,10H2,(H2,22,24,25)
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n/an/a 720n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4064
PNG
(8-Methyl-2-phenylamino-6-thiophene-3-yl-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C18H14N4OS/c1-22-16-13(9-15(17(22)23)12-7-8-24-11-12)10-19-18(21-16)20-14-5-3-2-4-6-14/h2-11H,1H3,(H,19,20,21)
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n/an/a 800n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4059
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(3-dimethylaminop...)
Show SMILES CN(C)CCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(1.02,-7.41,;1.02,-5.87,;2.35,-5.1,;-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C18H19Cl2N5O/c1-24(2)7-4-8-25-16-11(10-22-18(21)23-16)9-12(17(25)26)15-13(19)5-3-6-14(15)20/h3,5-6,9-10H,4,7-8H2,1-2H3,(H2,21,22,23)
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n/an/a 880n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4053
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-isobutyl-8H-pyrid...)
Show SMILES CC(C)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-5.1,;-.32,-3.56,;1.02,-2.79,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C17H16Cl2N4O/c1-9(2)8-23-15-10(7-21-17(20)22-15)6-11(16(23)24)14-12(18)4-3-5-13(14)19/h3-7,9H,8H2,1-2H3,(H2,20,21,22)
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n/an/a 890n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4071
PNG
(8-Methyl-2-phenylamino-6-thiophene-2-yl-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2cccs2)c1=O
Show InChI InChI=1S/C18H14N4OS/c1-22-16-12(10-14(17(22)23)15-8-5-9-24-15)11-19-18(21-16)20-13-6-3-2-4-7-13/h2-11H,1H3,(H,19,20,21)
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n/an/a 950n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-ethyl-8H-pyrido[2...)
Show SMILES CCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C15H12Cl2N4O/c1-2-21-13-8(7-19-15(18)20-13)6-9(14(21)22)12-10(16)4-3-5-11(12)17/h3-7H,2H2,1H3,(H2,18,19,20)
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n/an/a 980n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4076
PNG
(8-Ethyl-6-phenyl-2-(pyridin-4-ylamino)-8H-pyrido[2...)
Show SMILES CCn1c2nc(Nc3ccncc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C20H17N5O/c1-2-25-18-15(12-17(19(25)26)14-6-4-3-5-7-14)13-22-20(24-18)23-16-8-10-21-11-9-16/h3-13H,2H2,1H3,(H,21,22,23,24)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4061
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(3-hydroxypropyl)...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCO)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C16H14Cl2N4O2/c17-11-3-1-4-12(18)13(11)10-7-9-8-20-16(19)21-14(9)22(15(10)24)5-2-6-23/h1,3-4,7-8,23H,2,5-6H2,(H2,19,20,21)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4052
PNG
(2-Amino-8-butyl-6-(2,6-dichlorophenyl)-8H-pyrido[2...)
Show SMILES CCCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(1.02,-5.87,;-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C17H16Cl2N4O/c1-2-3-7-23-15-10(9-21-17(20)22-15)8-11(16(23)24)14-12(18)5-4-6-13(14)19/h4-6,8-9H,2-3,7H2,1H3,(H2,20,21,22)
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n/an/a 1.20E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4051
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-propyl-8H-pyrido-...)
Show SMILES CCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C16H14Cl2N4O/c1-2-6-22-14-9(8-20-16(19)21-14)7-10(15(22)23)13-11(17)4-3-5-12(13)18/h3-5,7-8H,2,6H2,1H3,(H2,19,20,21)
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n/an/a 1.20E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4058
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(pyridin-4-ylmeth...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(Cc3ccncc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;2.35,-5.1,;2.35,-3.56,;1.02,-2.79,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C19H13Cl2N5O/c20-14-2-1-3-15(21)16(14)13-8-12-9-24-19(22)25-17(12)26(18(13)27)10-11-4-6-23-7-5-11/h1-9H,10H2,(H2,22,24,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)|
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19)
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n/an/a 1.30E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4057
PNG
(2-Amino-8-benzyl-6-(2,6-dichlorophenyl)-8H-pyrido-...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(Cc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;2.35,-5.1,;2.35,-3.56,;1.02,-2.79,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C20H14Cl2N4O/c21-15-7-4-8-16(22)17(15)14-9-13-10-24-20(23)25-18(13)26(19(14)27)11-12-5-2-1-3-6-12/h1-10H,11H2,(H2,23,24,25)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4060
PNG
(2-Amino-8-(3-benzyloxypropyl)-6-(2,6-dichloropheny...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCOCc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;1.02,-7.41,;2.35,-8.18,;2.35,-9.72,;3.69,-10.49,;5.02,-9.72,;5.02,-8.18,;3.69,-7.41,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C23H20Cl2N4O2/c24-18-8-4-9-19(25)20(18)17-12-16-13-27-23(26)28-21(16)29(22(17)30)10-5-11-31-14-15-6-2-1-3-7-15/h1-4,6-9,12-13H,5,10-11,14H2,(H2,26,27,28)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4074
PNG
(8-ethyl-6-phenyl-2-(phenylamino)-7H,8H-pyrido[2,3-...)
Show SMILES CCn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C21H18N4O/c1-2-25-19-16(13-18(20(25)26)15-9-5-3-6-10-15)14-22-21(24-19)23-17-11-7-4-8-12-17/h3-14H,2H2,1H3,(H,22,23,24)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4053
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-isobutyl-8H-pyrid...)
Show SMILES CC(C)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-.32,-5.1,;-.32,-3.56,;1.02,-2.79,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C17H16Cl2N4O/c1-9(2)8-23-15-10(7-21-17(20)22-15)6-11(16(23)24)14-12(18)4-3-5-13(14)19/h3-7,9H,8H2,1-2H3,(H2,20,21,22)
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n/an/a 1.60E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4066
PNG
(8-Methyl-2-(pyridin-4-ylamino)-6-thiophene-3-yl-8H...)
Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C17H13N5OS/c1-22-15-12(8-14(16(22)23)11-4-7-24-10-11)9-19-17(21-15)20-13-2-5-18-6-3-13/h2-10H,1H3,(H,18,19,20,21)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4055
PNG
([2-Amino-6-(2,6-dichlorophenyl)-7-oxo-7H-pyrido[2,...)
Show SMILES CC(C)(C)OC(=O)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.69,-2.79,;2.35,-3.56,;2.35,-5.1,;3.69,-4.33,;1.02,-2.79,;-.32,-3.56,;-.32,-5.1,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C19H18Cl2N4O3/c1-19(2,3)28-14(26)9-25-16-10(8-23-18(22)24-16)7-11(17(25)27)15-12(20)5-4-6-13(15)21/h4-8H,9H2,1-3H3,(H2,22,23,24)
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n/an/a 1.70E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4054
PNG
(2-Amino-6-(2,6-dichlorophenyl)-7-oxo-7H-pyrido[2,3...)
Show SMILES COC(=O)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.35,-3.56,;1.02,-2.79,;-.32,-3.56,;-.32,-5.1,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C16H12Cl2N4O3/c1-25-12(23)7-22-14-8(6-20-16(19)21-14)5-9(15(22)24)13-10(17)3-2-4-11(13)18/h2-6H,7H2,1H3,(H2,19,20,21)
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n/an/a 1.70E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4074
PNG
(8-ethyl-6-phenyl-2-(phenylamino)-7H,8H-pyrido[2,3-...)
Show SMILES CCn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C21H18N4O/c1-2-25-19-16(13-18(20(25)26)15-9-5-3-6-10-15)14-22-21(24-19)23-17-11-7-4-8-12-17/h3-14H,2H2,1H3,(H,22,23,24)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4059
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-(3-dimethylaminop...)
Show SMILES CN(C)CCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(1.02,-7.41,;1.02,-5.87,;2.35,-5.1,;-.32,-5.1,;-.32,-3.56,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C18H19Cl2N5O/c1-24(2)7-4-8-25-16-11(10-22-18(21)23-16)9-12(17(25)26)15-13(19)5-3-6-14(15)20/h3,5-6,9-10H,4,7-8H2,1-2H3,(H2,21,22,23)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4063
PNG
(8-Methyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]py...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C20H16N4O/c1-24-18-15(12-17(19(24)25)14-8-4-2-5-9-14)13-21-20(23-18)22-16-10-6-3-7-11-16/h2-13H,1H3,(H,21,22,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4068
PNG
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccsc4)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C24H27N5O2S/c1-4-29(5-2)11-12-31-20-8-6-19(7-9-20)26-24-25-15-18-14-21(17-10-13-32-16-17)23(30)28(3)22(18)27-24/h6-10,13-16H,4-5,11-12H2,1-3H3,(H,25,26,27)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4060
PNG
(2-Amino-8-(3-benzyloxypropyl)-6-(2,6-dichloropheny...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCOCc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;1.02,-7.41,;2.35,-8.18,;2.35,-9.72,;3.69,-10.49,;5.02,-9.72,;5.02,-8.18,;3.69,-7.41,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C23H20Cl2N4O2/c24-18-8-4-9-19(25)20(18)17-12-16-13-27-23(26)28-21(16)29(22(17)30)10-5-11-31-14-15-6-2-1-3-7-15/h1-4,6-9,12-13H,5,10-11,14H2,(H2,26,27,28)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)|
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19)
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n/an/a 3.80E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4057
PNG
(2-Amino-8-benzyl-6-(2,6-dichlorophenyl)-8H-pyrido-...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(Cc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;2.35,-5.1,;2.35,-3.56,;1.02,-2.79,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C20H14Cl2N4O/c21-15-7-4-8-16(22)17(15)14-9-13-10-24-20(23)25-18(13)26(19(14)27)11-12-5-2-1-3-6-12/h1-10H,11H2,(H2,23,24,25)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4065
PNG
(8-Methyl-6-phenyl-2-(pyridin-4-ylamino)-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C19H15N5O/c1-24-17-14(11-16(18(24)25)13-5-3-2-4-6-13)12-21-19(23-17)22-15-7-9-20-10-8-15/h2-12H,1H3,(H,20,21,22,23)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4054
PNG
(2-Amino-6-(2,6-dichlorophenyl)-7-oxo-7H-pyrido[2,3...)
Show SMILES COC(=O)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.35,-3.56,;1.02,-2.79,;-.32,-3.56,;-.32,-5.1,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C16H12Cl2N4O3/c1-25-12(23)7-22-14-8(6-20-16(19)21-14)5-9(15(22)24)13-10(17)3-2-4-11(13)18/h2-6H,7H2,1H3,(H2,19,20,21)
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n/an/a 5.00E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4063
PNG
(8-Methyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]py...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C20H16N4O/c1-24-18-15(12-17(19(24)25)14-8-4-2-5-9-14)13-21-20(23-18)22-16-10-6-3-7-11-16/h2-13H,1H3,(H,21,22,23)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4060
PNG
(2-Amino-8-(3-benzyloxypropyl)-6-(2,6-dichloropheny...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCOCc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;1.02,-7.41,;2.35,-8.18,;2.35,-9.72,;3.69,-10.49,;5.02,-9.72,;5.02,-8.18,;3.69,-7.41,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C23H20Cl2N4O2/c24-18-8-4-9-19(25)20(18)17-12-16-13-27-23(26)28-21(16)29(22(17)30)10-5-11-31-14-15-6-2-1-3-7-15/h1-4,6-9,12-13H,5,10-11,14H2,(H2,26,27,28)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4055
PNG
([2-Amino-6-(2,6-dichlorophenyl)-7-oxo-7H-pyrido[2,...)
Show SMILES CC(C)(C)OC(=O)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.69,-2.79,;2.35,-3.56,;2.35,-5.1,;3.69,-4.33,;1.02,-2.79,;-.32,-3.56,;-.32,-5.1,;-1.65,-2.79,;-1.65,-1.25,;-2.98,-.48,;-4.32,-1.25,;-5.65,-.48,;-6.98,-1.25,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,)|
Show InChI InChI=1S/C19H18Cl2N4O3/c1-19(2,3)28-14(26)9-25-16-10(8-23-18(22)24-16)7-11(17(25)27)15-12(20)5-4-6-13(15)21/h4-8H,9H2,1-3H3,(H2,22,23,24)
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n/an/a 7.20E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4056
PNG
(2-[2-amino-6-(2,6-dichlorophenyl)-7-oxo-7H,8H-pyri...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CC(O)=O)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;1.02,-2.79,;-.32,-5.1,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C15H10Cl2N4O3/c16-9-2-1-3-10(17)12(9)8-4-7-5-19-15(18)20-13(7)21(14(8)24)6-11(22)23/h1-5H,6H2,(H,22,23)(H2,18,19,20)
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n/an/a 7.90E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4064
PNG
(8-Methyl-2-phenylamino-6-thiophene-3-yl-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C18H14N4OS/c1-22-16-13(9-15(17(22)23)12-7-8-24-11-12)10-19-18(21-16)20-14-5-3-2-4-6-14/h2-11H,1H3,(H,19,20,21)
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n/an/a 8.10E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4066
PNG
(8-Methyl-2-(pyridin-4-ylamino)-6-thiophene-3-yl-8H...)
Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C17H13N5OS/c1-22-15-12(8-14(16(22)23)11-4-7-24-10-11)9-19-17(21-15)20-13-2-5-18-6-3-13/h2-10H,1H3,(H,18,19,20,21)
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n/an/a 2.26E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4069
PNG
(2-Amino-8-methyl-6-thiophene-3-yl-8H-pyrido[2,3-d]...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C12H10N4OS/c1-16-10-8(5-14-12(13)15-10)4-9(11(16)17)7-2-3-18-6-7/h2-6H,1H3,(H2,13,14,15)
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n/an/a 2.44E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4075
PNG
(8-Ethyl-2-phenylamino-6-thiophene-3-yl-8H-pyrido-[...)
Show SMILES CCn1c2nc(Nc3ccccc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C19H16N4OS/c1-2-23-17-14(10-16(18(23)24)13-8-9-25-12-13)11-20-19(22-17)21-15-6-4-3-5-7-15/h3-12H,2H2,1H3,(H,20,21,22)
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n/an/a 4.10E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4072
PNG
(6-(Biphenyl-4-yl)-8-methyl-2-phenylamino-8H-pyrido...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccc(cc2)-c2ccccc2)c1=O
Show InChI InChI=1S/C26H20N4O/c1-30-24-21(17-27-26(29-24)28-22-10-6-3-7-11-22)16-23(25(30)31)20-14-12-19(13-15-20)18-8-4-2-5-9-18/h2-17H,1H3,(H,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4070
PNG
(8-Methyl-2-methylamino-6-thiophene-3-yl-8H-pyrido-...)
Show SMILES CNc1ncc2cc(-c3ccsc3)c(=O)n(C)c2n1
Show InChI InChI=1S/C13H12N4OS/c1-14-13-15-6-9-5-10(8-3-4-19-7-8)12(18)17(2)11(9)16-13/h3-7H,1-2H3,(H,14,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4075
PNG
(8-Ethyl-2-phenylamino-6-thiophene-3-yl-8H-pyrido-[...)
Show SMILES CCn1c2nc(Nc3ccccc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C19H16N4OS/c1-2-23-17-14(10-16(18(23)24)13-8-9-25-12-13)11-20-19(22-17)21-15-6-4-3-5-7-15/h3-12H,2H2,1H3,(H,20,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4072
PNG
(6-(Biphenyl-4-yl)-8-methyl-2-phenylamino-8H-pyrido...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccc(cc2)-c2ccccc2)c1=O
Show InChI InChI=1S/C26H20N4O/c1-30-24-21(17-27-26(29-24)28-22-10-6-3-7-11-22)16-23(25(30)31)20-14-12-19(13-15-20)18-8-4-2-5-9-18/h2-17H,1H3,(H,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4070
PNG
(8-Methyl-2-methylamino-6-thiophene-3-yl-8H-pyrido-...)
Show SMILES CNc1ncc2cc(-c3ccsc3)c(=O)n(C)c2n1
Show InChI InChI=1S/C13H12N4OS/c1-14-13-15-6-9-5-10(8-3-4-19-7-8)12(18)17(2)11(9)16-13/h3-7H,1-2H3,(H,14,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4071
PNG
(8-Methyl-2-phenylamino-6-thiophene-2-yl-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2cccs2)c1=O
Show InChI InChI=1S/C18H14N4OS/c1-22-16-12(10-14(17(22)23)15-8-5-9-24-15)11-19-18(21-16)20-13-6-3-2-4-7-13/h2-11H,1H3,(H,19,20,21)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4056
PNG
(2-[2-amino-6-(2,6-dichlorophenyl)-7-oxo-7H,8H-pyri...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CC(O)=O)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;1.02,-2.79,;-.32,-5.1,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C15H10Cl2N4O3/c16-9-2-1-3-10(17)12(9)8-4-7-5-19-15(18)20-13(7)21(14(8)24)6-11(22)23/h1-5H,6H2,(H,22,23)(H2,18,19,20)
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4070
PNG
(8-Methyl-2-methylamino-6-thiophene-3-yl-8H-pyrido-...)
Show SMILES CNc1ncc2cc(-c3ccsc3)c(=O)n(C)c2n1
Show InChI InChI=1S/C13H12N4OS/c1-14-13-15-6-9-5-10(8-3-4-19-7-8)12(18)17(2)11(9)16-13/h3-7H,1-2H3,(H,14,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4072
PNG
(6-(Biphenyl-4-yl)-8-methyl-2-phenylamino-8H-pyrido...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccc(cc2)-c2ccccc2)c1=O
Show InChI InChI=1S/C26H20N4O/c1-30-24-21(17-27-26(29-24)28-22-10-6-3-7-11-22)16-23(25(30)31)20-14-12-19(13-15-20)18-8-4-2-5-9-18/h2-17H,1H3,(H,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4071
PNG
(8-Methyl-2-phenylamino-6-thiophene-2-yl-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2cccs2)c1=O
Show InChI InChI=1S/C18H14N4OS/c1-22-16-12(10-14(17(22)23)15-8-5-9-24-15)11-19-18(21-16)20-13-6-3-2-4-7-13/h2-11H,1H3,(H,19,20,21)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4069
PNG
(2-Amino-8-methyl-6-thiophene-3-yl-8H-pyrido[2,3-d]...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C12H10N4OS/c1-16-10-8(5-14-12(13)15-10)4-9(11(16)17)7-2-3-18-6-7/h2-6H,1H3,(H2,13,14,15)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4069
PNG
(2-Amino-8-methyl-6-thiophene-3-yl-8H-pyrido[2,3-d]...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C12H10N4OS/c1-16-10-8(5-14-12(13)15-10)4-9(11(16)17)7-2-3-18-6-7/h2-6H,1H3,(H2,13,14,15)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4056
PNG
(2-[2-amino-6-(2,6-dichlorophenyl)-7-oxo-7H,8H-pyri...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CC(O)=O)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;1.02,-2.79,;-.32,-5.1,;-2.98,-.48,;-4.32,-1.25,)|
Show InChI InChI=1S/C15H10Cl2N4O3/c16-9-2-1-3-10(17)12(9)8-4-7-5-19-15(18)20-13(7)21(14(8)24)6-11(22)23/h1-5H,6H2,(H,22,23)(H2,18,19,20)
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4064
PNG
(8-Methyl-2-phenylamino-6-thiophene-3-yl-8H-pyrido-...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccsc2)c1=O
Show InChI InChI=1S/C18H14N4OS/c1-22-16-13(9-15(17(22)23)12-7-8-24-11-12)10-19-18(21-16)20-14-5-3-2-4-6-14/h2-11H,1H3,(H,19,20,21)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%