BindingDB logo
myBDB logout

USPatent US9085555

Compile Data Set for Download or QSAR

Found 773 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Complement factor D


(Homo sapiens (Human))		BDBM50400274
PNG
(CHEMBL2180765 | US9085555, 373)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(OCC#N)ccc12 |r|
Show InChI InChI=1S/C25H22ClFN6O4/c26-17-3-1-2-13(22(17)27)11-30-23(34)21-9-14-8-20(14)33(21)25(36)31-18-12-32(24(29)35)19-5-4-15(10-16(18)19)37-7-6-28/h1-5,10,12,14,20-21H,7-9,11H2,(H2,29,35)(H,30,34)(H,31,36)/t14-,20-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM50400273
PNG
(CHEMBL2180764 | US9085555, 375)
Show SMILES C[C@@]1(F)C[C@H](N(C1)C(=O)Nc1cn(C(N)=O)c2ccc(OCC(O)=O)cc12)C(=O)NCc1cccc(Cl)c1F |r|
Show InChI InChI=1S/C25H24ClF2N5O6/c1-25(28)8-19(22(36)30-9-13-3-2-4-16(26)21(13)27)33(12-25)24(38)31-17-10-32(23(29)37)18-6-5-14(7-15(17)18)39-11-20(34)35/h2-7,10,19H,8-9,11-12H2,1H3,(H2,29,37)(H,30,36)(H,31,38)(H,34,35)/t19-,25+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170864
PNG
(US9085555, 292)
Show SMILES COc1ccc2n(cc(NC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(N)=O |r|
Show InChI InChI=1S/C23H22ClF2N5O4/c1-35-14-5-6-18-15(8-14)17(11-30(18)22(27)33)29-23(34)31-10-13(25)7-19(31)21(32)28-9-12-3-2-4-16(24)20(12)26/h2-6,8,11,13,19H,7,9-10H2,1H3,(H2,27,33)(H,28,32)(H,29,34)/t13-,19+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171262
PNG
(US9085555, 692)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc12 |r|
Show InChI InChI=1S/C23H21ClFN5O3/c24-15-6-3-4-12(20(15)25)10-27-23(33)18-9-13-8-17(13)30(18)19(31)11-29-16-7-2-1-5-14(16)21(28-29)22(26)32/h1-7,13,17-18H,8-11H2,(H2,26,32)(H,27,33)/t13-,17-,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171311
PNG
(US9085555, 741 | US9085555, 757)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cncc(Br)n2)c2ccccc12 |r|
Show InChI InChI=1S/C21H19BrN6O3/c1-11(29)20-13-4-2-3-5-14(13)27(26-20)10-19(30)28-15-6-12(15)7-16(28)21(31)25-18-9-23-8-17(22)24-18/h2-5,8-9,12,15-16H,6-7,10H2,1H3,(H,24,25,31)/t12-,15-,16+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171267
PNG
(US9085555, 697)
Show SMILES CCc1cc2c(nn(CC(=O)N3C[C@H](F)[C@@H](OC)[C@H]3C(=O)NCc3cccc(Cl)c3F)c2cn1)C(N)=O |r|
Show InChI InChI=1S/C24H25ClF2N6O4/c1-3-13-7-14-17(9-29-13)33(31-20(14)23(28)35)11-18(34)32-10-16(26)22(37-2)21(32)24(36)30-8-12-5-4-6-15(25)19(12)27/h4-7,9,16,21-22H,3,8,10-11H2,1-2H3,(H2,28,35)(H,30,36)/t16-,21-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170738
PNG
(US9085555, 166)
Show SMILES NC(=O)n1cc(NC(=O)N2C3CC3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc12 |r|
Show InChI InChI=1S/C23H21ClFN5O3/c24-15-6-3-4-12(20(15)25)10-27-21(31)19-9-13-8-18(13)30(19)23(33)28-16-11-29(22(26)32)17-7-2-1-5-14(16)17/h1-7,11,13,18-19H,8-10H2,(H2,26,32)(H,27,31)(H,28,33)/t13?,18?,19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM50400275
PNG
(CHEMBL2180766 | US9085555, 127)
Show SMILES CC(C)(C)OC(=O)Cc1ccc2c(NC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)NCc3cccc(Cl)c3F)cn(C(N)=O)c2c1 |r|
Show InChI InChI=1S/C29H31ClFN5O5/c1-29(2,3)41-24(37)10-15-7-8-18-20(14-35(27(32)39)22(18)9-15)34-28(40)36-21-11-17(21)12-23(36)26(38)33-13-16-5-4-6-19(30)25(16)31/h4-9,14,17,21,23H,10-13H2,1-3H3,(H2,32,39)(H,33,38)(H,34,40)/t17-,21-,23+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170945
PNG
(US9085555, 374)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(OCC(O)=O)ccc12 |r|
Show InChI InChI=1S/C25H23ClFN5O6/c26-16-3-1-2-12(22(16)27)9-29-23(35)20-7-13-6-19(13)32(20)25(37)30-17-10-31(24(28)36)18-5-4-14(8-15(17)18)38-11-21(33)34/h1-5,8,10,13,19-20H,6-7,9,11H2,(H2,28,36)(H,29,35)(H,30,37)(H,33,34)/t13-,19-,20+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171305
PNG
(US9085555, 735)
Show SMILES CCc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)Nc3cccc(Br)n3)c2cn1)C(N)=O |r|
Show InChI InChI=1S/C22H22BrN7O3/c1-2-12-8-13-16(9-25-12)29(28-20(13)21(24)32)10-19(31)30-14-6-11(14)7-15(30)22(33)27-18-5-3-4-17(23)26-18/h3-5,8-9,11,14-15H,2,6-7,10H2,1H3,(H2,24,32)(H,26,27,33)/t11-,14-,15+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170890
PNG
(US9085555, 318)
Show SMILES COC(=O)COc1ccc2n(cc(NC(=O)N3C[C@](C)(F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(N)=O |r|
Show InChI InChI=1S/C26H26ClF2N5O6/c1-26(29)9-20(23(36)31-10-14-4-3-5-17(27)22(14)28)34(13-26)25(38)32-18-11-33(24(30)37)19-7-6-15(8-16(18)19)40-12-21(35)39-2/h3-8,11,20H,9-10,12-13H2,1-2H3,(H2,30,37)(H,31,36)(H,32,38)/t20-,26+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170943
PNG
(US9085555, 371)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(O)ccc12 |r|
Show InChI InChI=1S/C23H21ClFN5O4/c24-15-3-1-2-11(20(15)25)9-27-21(32)19-7-12-6-18(12)30(19)23(34)28-16-10-29(22(26)33)17-5-4-13(31)8-14(16)17/h1-5,8,10,12,18-19,31H,6-7,9H2,(H2,26,33)(H,27,32)(H,28,34)/t12-,18-,19+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171304
PNG
(US9085555, 734)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)Nc3cccc(Br)n3)c2cn1)C(N)=O |r|
Show InChI InChI=1S/C21H20BrN7O3/c1-10-5-12-15(8-24-10)28(27-19(12)20(23)31)9-18(30)29-13-6-11(13)7-14(29)21(32)26-17-4-2-3-16(22)25-17/h2-5,8,11,13-14H,6-7,9H2,1H3,(H2,23,31)(H,25,26,32)/t11-,13-,14+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171318
PNG
(US9085555, 748)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(OCc3ncccn3)cc12 |r|
Show InChI InChI=1S/C27H24BrN7O4/c1-15(36)26-18-12-17(39-14-24-29-8-3-9-30-24)6-7-19(18)34(33-26)13-25(37)35-20-10-16(20)11-21(35)27(38)32-23-5-2-4-22(28)31-23/h2-9,12,16,20-21H,10-11,13-14H2,1H3,(H,31,32,38)/t16-,20-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171334
PNG
(US9085555, 764)
Show SMILES NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccccc12 |r|
Show InChI InChI=1S/C20H18BrFN6O3/c21-16-6-3-7-17(25-16)26-18(29)15-8-11(22)9-28(15)20(31)24-13-10-27(19(23)30)14-5-2-1-4-12(13)14/h1-7,10-11,15H,8-9H2,(H2,23,30)(H,24,31)(H,25,26,29)/t11-,15+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170872
PNG
(US9085555, 300)
Show SMILES COc1ccc2n(cc(NC(=O)N3C4CC4C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(N)=O |r|
Show InChI InChI=1S/C24H23ClFN5O4/c1-35-14-5-6-18-15(9-14)17(11-30(18)23(27)33)29-24(34)31-19-7-13(19)8-20(31)22(32)28-10-12-3-2-4-16(25)21(12)26/h2-6,9,11,13,19-20H,7-8,10H2,1H3,(H2,27,33)(H,28,32)(H,29,34)/t13?,19?,20-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170953
PNG
(US9085555, 383)
Show SMILES C[C@@]1(F)C[C@H](N(C1)C(=O)Nc1cn(C(N)=O)c2ccc(OCCO)cc12)C(=O)NCc1cccc(Cl)c1F |r|
Show InChI InChI=1S/C25H26ClF2N5O5/c1-25(28)10-20(22(35)30-11-14-3-2-4-17(26)21(14)27)33(13-25)24(37)31-18-12-32(23(29)36)19-6-5-15(9-16(18)19)38-8-7-34/h2-6,9,12,20,34H,7-8,10-11,13H2,1H3,(H2,29,36)(H,30,35)(H,31,37)/t20-,25+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171314
PNG
(US9085555, 744)
Show SMILES C[C@]12C[C@H]1N([C@@H](C2)C(=O)Nc1cccc(Br)n1)C(=O)Cn1nc(C(N)=O)c2ccccc12 |r|
Show InChI InChI=1S/C22H21BrN6O3/c1-22-9-14(21(32)26-17-8-4-7-16(23)25-17)29(15(22)10-22)18(30)11-28-13-6-3-2-5-12(13)19(27-28)20(24)31/h2-8,14-15H,9-11H2,1H3,(H2,24,31)(H,25,26,32)/t14-,15+,22-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170878
PNG
(US9085555, 306)
Show SMILES CCOC(=O)Cc1ccc2n(cc(NC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(N)=O |r|
Show InChI InChI=1S/C27H27ClFN5O5/c1-2-39-23(35)9-14-6-7-20-17(8-14)19(13-33(20)26(30)37)32-27(38)34-21-10-16(21)11-22(34)25(36)31-12-15-4-3-5-18(28)24(15)29/h3-8,13,16,21-22H,2,9-12H2,1H3,(H2,30,37)(H,31,36)(H,32,38)/t16-,21-,22+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171319
PNG
(US9085555, 749)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(Br)n2)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C21H18BrClN6O3/c22-16-2-1-3-17(25-16)26-21(32)15-7-10-6-13(10)29(15)18(30)9-28-14-8-11(23)4-5-12(14)19(27-28)20(24)31/h1-5,8,10,13,15H,6-7,9H2,(H2,24,31)(H,25,26,32)/t10-,13-,15+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170701
PNG
(US9085555, 129)
Show SMILES CC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H](CO)c2cccc(Cl)c2F)c2ccccc12 |r|
Show InChI InChI=1S/C25H24ClFN4O4/c1-13(33)30-11-18(15-5-2-3-8-20(15)30)29-25(35)31-21-9-14(21)10-22(31)24(34)28-19(12-32)16-6-4-7-17(26)23(16)27/h2-8,11,14,19,21-22,32H,9-10,12H2,1H3,(H,28,34)(H,29,35)/t14-,19-,21-,22+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171311
PNG
(US9085555, 741 | US9085555, 757)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cncc(Br)n2)c2ccccc12 |r|
Show InChI InChI=1S/C21H19BrN6O3/c1-11(29)20-13-4-2-3-5-14(13)27(26-20)10-19(30)28-15-6-12(15)7-16(28)21(31)25-18-9-23-8-17(22)24-18/h2-5,8-9,12,15-16H,6-7,10H2,1H3,(H,24,25,31)/t12-,15-,16+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171332
PNG
(US9085555, 762)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccccc12 |r|
Show InChI InChI=1S/C21H19BrN6O3/c22-17-6-3-7-18(25-17)26-19(29)16-9-11-8-15(11)28(16)21(31)24-13-10-27(20(23)30)14-5-2-1-4-12(13)14/h1-7,10-11,15-16H,8-9H2,(H2,23,30)(H,24,31)(H,25,26,29)/t11-,15-,16+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171255
PNG
(US9085555, 685)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2cnccc12 |r|
Show InChI InChI=1S/C27H22ClFN6O3/c28-18-6-2-1-4-15(18)16-5-3-7-19(24(16)29)32-27(38)21-11-14-10-20(14)35(21)23(36)13-34-22-12-31-9-8-17(22)25(33-34)26(30)37/h1-9,12,14,20-21H,10-11,13H2,(H2,30,37)(H,32,38)/t14-,20-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171324
PNG
(US9085555, 754)
Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)Nc1cccc(Br)n1)C(=O)Cn1nc(C(N)=O)c2ccccc12 |r|
Show InChI InChI=1S/C21H20BrFN6O4/c1-33-19-12(23)9-28(18(19)21(32)26-15-8-4-7-14(22)25-15)16(30)10-29-13-6-3-2-5-11(13)17(27-29)20(24)31/h2-8,12,18-19H,9-10H2,1H3,(H2,24,31)(H,25,26,32)/t12-,18-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171208
PNG
(US9085555, 638)
Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)Nc1cccc(OC(F)(F)F)c1F)C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12 |r|
Show InChI InChI=1S/C29H25F5N6O6/c1-15(41)25-17-11-16(45-14-22-35-9-4-10-36-22)7-8-20(17)40(38-25)13-23(42)39-12-18(30)27(44-2)26(39)28(43)37-19-5-3-6-21(24(19)31)46-29(32,33)34/h3-11,18,26-27H,12-14H2,1-2H3,(H,37,43)/t18-,26-,27+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170734
PNG
(US9085555, 162)
Show SMILES COCCOc1ccc2n(cc(NC(=O)N3C4CC4C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(N)=O |r|
Show InChI InChI=1S/C26H27ClFN5O5/c1-37-7-8-38-16-5-6-20-17(11-16)19(13-32(20)25(29)35)31-26(36)33-21-9-15(21)10-22(33)24(34)30-12-14-3-2-4-18(27)23(14)28/h2-6,11,13,15,21-22H,7-10,12H2,1H3,(H2,29,35)(H,30,34)(H,31,36)/t15?,21?,22-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170949
PNG
(US9085555, 379)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(OCCO)ccc12 |r|
Show InChI InChI=1S/C25H25ClFN5O5/c26-17-3-1-2-13(22(17)27)11-29-23(34)21-9-14-8-20(14)32(21)25(36)30-18-12-31(24(28)35)19-5-4-15(10-16(18)19)37-7-6-33/h1-5,10,12,14,20-21,33H,6-9,11H2,(H2,28,35)(H,29,34)(H,30,36)/t14-,20-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171313
PNG
(US9085555, 743)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)Nc3cccc(Br)n3)c2c(C)n1)C(N)=O |r|
Show InChI InChI=1S/C22H22BrN7O3/c1-10-6-13-19(21(24)32)28-29(20(13)11(2)25-10)9-18(31)30-14-7-12(14)8-15(30)22(33)27-17-5-3-4-16(23)26-17/h3-6,12,14-15H,7-9H2,1-2H3,(H2,24,32)(H,26,27,33)/t12-,14-,15+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171315
PNG
(US9085555, 745)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@]4(C)C[C@H]3C(=O)Nc3cccc(Br)n3)c2cn1)C(N)=O |r|
Show InChI InChI=1S/C22H22BrN7O3/c1-11-6-12-14(9-25-11)29(28-19(12)20(24)32)10-18(31)30-13(7-22(2)8-15(22)30)21(33)27-17-5-3-4-16(23)26-17/h3-6,9,13,15H,7-8,10H2,1-2H3,(H2,24,32)(H,26,27,33)/t13-,15+,22-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170866
PNG
(US9085555, 294)
Show SMILES NC(=O)n1cc(NC(=O)N2C3CC3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(F)ccc12 |r|
Show InChI InChI=1S/C23H20ClF2N5O3/c24-15-3-1-2-11(20(15)26)9-28-21(32)19-7-12-6-18(12)31(19)23(34)29-16-10-30(22(27)33)17-5-4-13(25)8-14(16)17/h1-5,8,10,12,18-19H,6-7,9H2,(H2,27,33)(H,28,32)(H,29,34)/t12?,18?,19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170934
PNG
(US9085555, 362)
Show SMILES NC(=O)n1cc(NC(=O)N2N=CC[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc12 |r,c:10|
Show InChI InChI=1S/C21H18ClFN6O3/c22-14-6-3-4-12(18(14)23)10-25-19(30)17-8-9-26-29(17)21(32)27-15-11-28(20(24)31)16-7-2-1-5-13(15)16/h1-7,9,11,17H,8,10H2,(H2,24,31)(H,25,30)(H,27,32)/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171236
PNG
(US9085555, 666)
Show SMILES CC(=O)c1cn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(OCc3ncccn3)cc12 |r|
Show InChI InChI=1S/C30H27ClFN5O4/c1-17(38)22-14-36(24-7-6-20(12-21(22)24)41-16-27-33-8-3-9-34-27)15-28(39)37-25-10-19(25)11-26(37)30(40)35-13-18-4-2-5-23(31)29(18)32/h2-9,12,14,19,25-26H,10-11,13,15-16H2,1H3,(H,35,40)/t19-,25-,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170705
PNG
(US9085555, 133)
Show SMILES COC(=O)COc1ccc2n(cc(NC(=O)N3C4CC4C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(N)=O |r|
Show InChI InChI=1S/C26H25ClFN5O6/c1-38-22(34)12-39-15-5-6-19-16(9-15)18(11-32(19)25(29)36)31-26(37)33-20-7-14(20)8-21(33)24(35)30-10-13-3-2-4-17(27)23(13)28/h2-6,9,11,14,20-21H,7-8,10,12H2,1H3,(H2,29,36)(H,30,35)(H,31,37)/t14?,20?,21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171263
PNG
(US9085555, 693)
Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccnc(C)c12)c1cccc(Cl)c1F |r|
Show InChI InChI=1S/C24H24ClFN6O3/c1-11(14-4-3-5-16(25)20(14)26)29-24(35)18-9-13-8-17(13)32(18)19(33)10-31-22-12(2)28-7-6-15(22)21(30-31)23(27)34/h3-7,11,13,17-18H,8-10H2,1-2H3,(H2,27,34)(H,29,35)/t11-,13-,17-,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171270
PNG
(US9085555, 700)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cnc(cc12)C1CC1 |r|
Show InChI InChI=1S/C25H24ClFN6O3/c26-16-3-1-2-13(22(16)27)9-30-25(36)19-7-14-6-18(14)33(19)21(34)11-32-20-10-29-17(12-4-5-12)8-15(20)23(31-32)24(28)35/h1-3,8,10,12,14,18-19H,4-7,9,11H2,(H2,28,35)(H,30,36)/t14-,18-,19+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170750
PNG
(US9085555, 178)
Show SMILES NC(=O)n1cc(NC(=O)N2CCS[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc12 |r|
Show InChI InChI=1S/C21H19ClFN5O3S/c22-14-6-3-4-12(17(14)23)10-25-18(29)19-27(8-9-32-19)21(31)26-15-11-28(20(24)30)16-7-2-1-5-13(15)16/h1-7,11,19H,8-10H2,(H2,24,30)(H,25,29)(H,26,31)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170775
PNG
(US9085555, 203)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H](CO)c2cccc(Cl)c2F)c2ccccc12 |r|
Show InChI InChI=1S/C24H23ClFN5O4/c25-15-6-3-5-14(21(15)26)17(11-32)28-22(33)20-9-12-8-19(12)31(20)24(35)29-16-10-30(23(27)34)18-7-2-1-4-13(16)18/h1-7,10,12,17,19-20,32H,8-9,11H2,(H2,27,34)(H,28,33)(H,29,35)/t12-,17-,19-,20+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171342
PNG
(US9085555, 772)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(OC(F)(F)F)c2F)c2ccc(OCC3CCCO3)cc12 |r|
Show InChI InChI=1S/C29H28F4N4O6/c1-15(38)27-19-12-17(42-14-18-4-3-9-41-18)7-8-21(19)36(35-27)13-25(39)37-22-10-16(22)11-23(37)28(40)34-20-5-2-6-24(26(20)30)43-29(31,32)33/h2,5-8,12,16,18,22-23H,3-4,9-11,13-14H2,1H3,(H,34,40)/t16-,18?,22-,23+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170586
PNG
(US9085555, 11)
Show SMILES NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2ccc(Cl)s2)c2ccccc12 |r|
Show InChI InChI=1S/C20H19ClFN5O3S/c21-17-6-5-12(31-17)8-24-18(28)16-7-11(22)9-27(16)20(30)25-14-10-26(19(23)29)15-4-2-1-3-13(14)15/h1-6,10-11,16H,7-9H2,(H2,23,29)(H,24,28)(H,25,30)/t11-,16+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170870
PNG
(US9085555, 298)
Show SMILES COc1ccc2n(cc(NC(=O)N3C[C@H](F)C[C@H]3C(=O)Nc3cccc(OC(F)(F)F)c3F)c2c1)C(N)=O |r|
Show InChI InChI=1S/C23H20F5N5O5/c1-37-12-5-6-16-13(8-12)15(10-32(16)21(29)35)31-22(36)33-9-11(24)7-17(33)20(34)30-14-3-2-4-18(19(14)25)38-23(26,27)28/h2-6,8,10-11,17H,7,9H2,1H3,(H2,29,35)(H,30,34)(H,31,36)/t11-,17+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170962
PNG
(US9085555, 392)
Show SMILES NC(=O)n1cc(NC(=O)N2C3CC3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(O)cc12 |r|
Show InChI InChI=1S/C23H21ClFN5O4/c24-15-3-1-2-11(20(15)25)9-27-21(32)19-7-12-6-17(12)30(19)23(34)28-16-10-29(22(26)33)18-8-13(31)4-5-14(16)18/h1-5,8,10,12,17,19,31H,6-7,9H2,(H2,26,33)(H,27,32)(H,28,34)/t12?,17?,19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171326
PNG
(US9085555, 756)
Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)Nc1cccc(Br)n1)C(=O)Cn1nc(C(C)=O)c2ccccc12 |r|
Show InChI InChI=1S/C22H21BrFN5O4/c1-12(30)19-13-6-3-4-7-15(13)29(27-19)11-18(31)28-10-14(24)21(33-2)20(28)22(32)26-17-9-5-8-16(23)25-17/h3-9,14,20-21H,10-11H2,1-2H3,(H,25,26,32)/t14-,20-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170955
PNG
(US9085555, 385)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(CCO)ccc12 |r|
Show InChI InChI=1S/C25H25ClFN5O4/c26-17-3-1-2-14(22(17)27)11-29-23(34)21-10-15-9-20(15)32(21)25(36)30-18-12-31(24(28)35)19-5-4-13(6-7-33)8-16(18)19/h1-5,8,12,15,20-21,33H,6-7,9-11H2,(H2,28,35)(H,29,34)(H,30,36)/t15-,20-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170576
PNG
(US9085555, 1)
Show SMILES NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc12 |r|
Show InChI InChI=1S/C22H20ClF2N5O3/c23-15-6-3-4-12(19(15)25)9-27-20(31)18-8-13(24)10-30(18)22(33)28-16-11-29(21(26)32)17-7-2-1-5-14(16)17/h1-7,11,13,18H,8-10H2,(H2,26,32)(H,27,31)(H,28,33)/t13-,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170776
PNG
(US9085555, 204)
Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)NCc1cccc(Cl)c1F)C(=O)Nc1cn(C(N)=O)c2ccccc12 |r|
Show InChI InChI=1S/C23H22ClF2N5O4/c1-35-20-15(25)10-31(19(20)21(32)28-9-12-5-4-7-14(24)18(12)26)23(34)29-16-11-30(22(27)33)17-8-3-2-6-13(16)17/h2-8,11,15,19-20H,9-10H2,1H3,(H2,27,33)(H,28,32)(H,29,34)/t15-,19-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170963
PNG
(US9085555, 393)
Show SMILES NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(O)cc12 |r|
Show InChI InChI=1S/C22H20ClF2N5O4/c23-15-3-1-2-11(19(15)25)8-27-20(32)18-6-12(24)9-30(18)22(34)28-16-10-29(21(26)33)17-7-13(31)4-5-14(16)17/h1-5,7,10,12,18,31H,6,8-9H2,(H2,26,33)(H,27,32)(H,28,34)/t12-,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM170892
PNG
(US9085555, 320)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H](CO)c2cccc(Cl)c2)c2ccccc12 |r|
Show InChI InChI=1S/C24H24ClN5O4/c25-15-5-3-4-13(8-15)18(12-31)27-22(32)21-10-14-9-20(14)30(21)24(34)28-17-11-29(23(26)33)19-7-2-1-6-16(17)19/h1-8,11,14,18,20-21,31H,9-10,12H2,(H2,26,33)(H,27,32)(H,28,34)/t14-,18-,20-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171316
PNG
(US9085555, 746)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H]3C[C@H]3[C@H]2C(=O)Nc2cccc(Br)n2)c2ccccc12 |r|
Show InChI InChI=1S/C21H19BrN6O3/c22-15-6-3-7-16(24-15)25-21(31)19-13-8-11(13)9-27(19)17(29)10-28-14-5-2-1-4-12(14)18(26-28)20(23)30/h1-7,11,13,19H,8-10H2,(H2,23,30)(H,24,25,31)/t11-,13-,19+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM171002
PNG
(US9085555, 432)
Show SMILES NC(=O)n1cc(NC(=O)N2NCC[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc12 |r|
Show InChI InChI=1S/C21H20ClFN6O3/c22-14-6-3-4-12(18(14)23)10-25-19(30)17-8-9-26-29(17)21(32)27-15-11-28(20(24)31)16-7-2-1-5-13(15)16/h1-7,11,17,26H,8-10H2,(H2,24,31)(H,25,30)(H,27,32)/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...

US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 773 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%