The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28279845 |
54 |
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. |
Nanyang Normal University |
| 27876467 |
9 |
A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease. |
Tehran University of Medical Sciences |
| 27951485 |
59 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-ß-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. |
Sichuan University |
| 27552582 |
42 |
Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents. |
East China University of Science and Technology |
| 27392529 |
32 |
Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach. |
Universidade Federal Do Rio Grande Do Sul |
| 25678013 |
63 |
Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease. |
Sichuan University |
| 25082512 |
38 |
Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy. |
Zhejiang University |
| 25778991 |
116 |
Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. |
Sichuan University |
| 25614117 |
37 |
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. |
Sichuan University |
| 25205193 |
10 |
Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B. |
Hunan University |
| 23422935 |
29 |
Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors. |
Universidade Federal Do Rio Grande Do Sul |
| 23380475 |
7 |
Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors. |
Hainan University |
| 23273608 |
20 |
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. |
The Hong Kong University of Science and Technology |
| 18976927 |
83 |
Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. |
Universit£ |
| 3965704 |
22 |
Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase. |
TBA |
| 23033965 |
37 |
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. |
Istituto Italiano Di Tecnologia |
| 22172310 |
47 |
Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents. |
Punjabi University |
| 22831800 |
32 |
Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities. |
Meiji Pharmaceutical University |
| 18517184 |
47 |
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. |
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic) |
| 18479118 |
114 |
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. |
Universit£ |
| 15568781 |
2 |
Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors. |
Instituto De Qu£Mica Da Universidade Estadual Paulista |
| 17888667 |
33 |
Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate. |
University of Mysore |
| 15993600 |
54 |
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors. |
Zhejiang University |
| 15214773 |
76 |
Fragment-based drug discovery. |
Sunesis Pharmaceuticals |
| 10052979 |
45 |
Aminopyridazines as acetylcholinesterase inhibitors. |
Universit£ |
| 7658452 |
52 |
Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
| 1766006 |
8 |
Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity. |
Mayo Clinic |
| 11551765 |
7 |
Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives. |
Universit£T Wien |
| 10476864 |
22 |
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors. |
Hong Kong University of Science and Technology |
| 9873409 |
2 |
Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A. |
Chinese Academy of Sciences |
| | 32 |
Acetylcholinesterase inhibition by fused dihydroquinazoline compounds |
TBA |
| 21438612 |
4 |
Amidine-oximes: reactivators for organophosphate exposure. |
Human Biomolecular Research Institute |
| 22257528 |
5 |
A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease. |
Punjabi University |
| 22019465 |
28 |
Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities. |
Zhejiang University |
| 20144867 |
32 |
Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities. |
Zhejiang University |
| 19692250 |
52 |
Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors. |
Zhejiang University |
| 19954865 |
10 |
Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones. |
Universidade Federal Do Rio Grande Do Sul |
| 19493592 |
30 |
Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase. |
University of Mysore |
| | 18 |
Acetylcholinesterase inhibition by tacrine analogues |
TBA |
| | 11 |
Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitor |
TBA |
| | 7 |
Synthesis and in vitro gastrointestinal motility enhancing activity of 3-aryl-2-imidazolidinylidene propanedinitrile derivatives |
TBA |
| | 26 |
Synthesis and in vitro acetylcholinesterase inhibitory activity of some 1-substituted analogues of velnacrine |
TBA |
| | 27 |
Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds |
TBA |
| | 12 |
Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine |
TBA |
| | 15 |
Synthesis and biological activity of galanthamine derivatives as acetylcholinesterase (AChE) inhibitors |
TBA |
| 19485411 |
2 |
Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy. |
Institute of Science |
| 19162488 |
57 |
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase. |
Chinese Academy of Sciences |
| 18662884 |
56 |
2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity. |
Zhejiang University |
| 18550228 |
40 |
Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors. |
Zhejiang University |
| 18436348 |
68 |
Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives. |
Zhejiang University |
| 17624631 |
9 |
Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors. |
Università |
| 17126020 |
58 |
Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. |
Chinese Academy of Sciences |
| 16942022 |
20 |
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. |
Institute of Science |
| 16735118 |
23 |
Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease. |
University of Mysore |
| 15664805 |
15 |
Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B. |
Chinese Academy of Sciences |
| 12646025 |
12 |
Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors. |
Universidade Federal Do Rio De Janeiro |
| 10612585 |
4 |
Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound. |
Institute of Materia Medica |
| 30470598 |
75 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
Sichuan University |
| 31103902 |
41 |
Multi-target design strategies for the improved treatment of Alzheimer's disease. |
China Pharmaceutical University |
| 30744931 |
170 |
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
Csir-Central Drug Research Institute |
| 31401465 |
52 |
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
Julius Maximilian University of W£Rzburg |
| 9357518 |
74 |
Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. |
University of Strathclyde |
| 8709135 |
20 |
Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology. |
Warner-Lambert |
| 8558530 |
4 |
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
| 8558529 |
195 |
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
| 8126709 |
49 |
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity. |
Centre De Recherche Pierre Fabre MéDicament |
| 8057278 |
43 |
Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors. |
Takeda Chemical Industries |
| 7932538 |
54 |
Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety. |
Takeda Chemical Industries |
| 23466605 |
36 |
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors. |
Chinese Academy of Sciences |
| 23481643 |
1 |
Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. |
Complutense University of Madrid |
| 23453838 |
18 |
Synthesis and anti-acetylcholinesterase properties of novel ?- and ?-substituted alkoxy organophosphonates. |
The University of Montana |
| 7636858 |
25 |
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation. |
Centre De Recherche Pierre Fabre |
| 6827532 |
2 |
In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide. |
TBA |
| 3385720 |
2 |
(+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity. |
Hoechst-Roussel Pharmaceuticals |
| 29089261 |
18 |
Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer's disease: Design, synthesis and biological evaluations. |
Punjabi University |
| 29172081 |
68 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
East China University of Science and Technology |
| 29729987 |
66 |
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. |
East China University of Science and Technology |
| 28587871 |
34 |
Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety. |
Tehran University of Medical Sciences |
| 28458136 |
57 |
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. |
Sichuan University |
| 29033232 |
164 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease. |
Nanyang Normal University |
| 28487125 |
174 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease. |
Nanyang Normal University |
| 28371641 |
32 |
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease. |
China Pharmaceutical University |
| 14709324 |
20 |
Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. |
Yamanouchi Pharmaceutical |
| 19154150 |
19 |
Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease. |
Schering-Plough Research Institute |
| 17723305 |
34 |
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. |
Incyte |
| 18585390 |
20 |
The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. |
University of Alberta |
| 18287029 |
12 |
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. |
Plexxikon |
| 18473434 |
57 |
Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold. |
Cancer Research Uk Centre For Cancer Therapeutics |
| 18459730 |
144 |
Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. |
University of Namur |
| 14709046 |
4 |
A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization. |
Fujisawa Pharmaceutical |
| 17824681 |
55 |
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones. |
Irbm-Mrl |
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