The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28586221 |
139 |
The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors. |
Emory University |
| 28222314 |
3 |
Systematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201. |
University of M£Nster |
| 9873416 |
3 |
Unusual synthesis of new glycine antagonists via sequential aldol condensation-lactonization-elimination reaction. |
Glaxowellcome |
| 27064517 |
12 |
Neurosteroid-like Inhibitors of N-Methyl-d-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene. |
Academy of Sciences of The Czech Republic |
| 26525866 |
7 |
A novel class of negative allosteric modulators of NMDA receptor function. |
Emory University |
| 24824658 |
8 |
Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors. |
University of Copenhagen |
| 24512267 |
41 |
Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators. |
Emory University |
| 23627311 |
88 |
Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
Emory University |
| 23614571 |
20 |
Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists. |
University of Copenhagen |
| 23320429 |
48 |
Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors. |
University of Copenhagen |
| 23140383 |
12 |
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2. |
Universit£ |
| 21188966 |
2 |
Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata. |
University of Copenhagen |
| 20408529 |
32 |
4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. |
Universit£ |
| 19588945 |
55 |
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization. |
University of Copenhagen |
| 18800760 |
96 |
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. |
Emory University |
| 18578474 |
27 |
N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. |
University of Copenhagen |
| 16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
| 10715162 |
59 |
Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype. |
Cocensys |
| 10090790 |
131 |
Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs. |
Taisho Pharmaceutical |
| 9719603 |
39 |
Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. |
University of Oregon |
| 7562904 |
64 |
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity. |
Warner-Lambert |
| 1382133 |
18 |
Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones. |
Eli Lilly |
| 2155320 |
21 |
Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 9871605 |
43 |
5-Aminomethylquinoxaline-2,3-diones, Part III: Arylamide derivatives as highly potent and selective glycine-site NMDA receptor antagonists. |
Novartis Pharma |
| 9871630 |
5 |
5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists. |
Novartis Pharma |
| | 12 |
Synthesis and glutamate antagonist activity of 4-phosphonoalkylquinoline derivatives: A novel class of non-NMDA antagonist |
TBA |
| | 3 |
Synthesis and excitatory amino acid pharmacology of some novel quinoxalinediones |
TBA |
| 22111545 |
80 |
Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors. |
University of Bristol |
| 20684595 |
374 |
Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. |
Emory University |
| 19648014 |
11 |
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. |
Emory University |
| 19394821 |
4 |
3-(aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB. |
University of Berne |
| | 5 |
6,7,8,9-tetrahydro-3-hydroxy-1H-1-benzazepine-2,5-diones via a diels-alder reaction:antagonists with a non-planar hydrophobic region for NMDA receptor glycine sites |
TBA |
| | 6 |
Tetramic acids as novel glycine site antagonists |
TBA |
| | 6 |
5,6,7,8-Tetrahydroquinolones as antagonists at the glycine site of the NMDA receptor |
TBA |
| | 10 |
Structure-activity relationships of tricyclic quinoxalinediones as potent antagonists for the glycine binding site of the NMDA receptor 2 |
TBA |
| | 19 |
Structure-activity relationships of tricyclic quinoxalinediones as potent antagonists for the glycine binding site of the NMDA receptor 1 |
TBA |
| | 1 |
NS 257 (1,2,3,6,7,8-hexahydro-3(hydroxyimino)-N,N,7-trimethyl-2-oxobenzo[2,1-b:3,4-c']dipyrrole-5-sulfonamide) is a potent, systemically active ampa receptor antagonist |
TBA |
| | 10 |
Structure-activity relationships of a series of glycine antagonists related to 5,7-dichlorokynurenic acid and 3-(2-carboxy-6-chloroindol-3-yl)acetic acid |
TBA |
| | 20 |
Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor |
TBA |
| | 13 |
2-carboxy indolines and indoles as potential glycine/NMDA antagonists: effect of five-membered ring conformation on affinity. |
TBA |
| | 9 |
Design, synthesis and molecular modeling of 3-acylamino-2- Carboxyindole NMDA receptor glycine-site antagonists |
TBA |
| | 14 |
Tricyclic quinoxalines as ligands for the strychnine-insensitive glycine site |
TBA |
| 17985859 |
16 |
Design and synthesis of indole-based peptoids as potent noncompetitive antagonists of transient receptor potential vanilloid 1. |
University of Barcelona |
| 17602546 |
20 |
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. |
University Paris Descartes |
| 15837299 |
11 |
NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives. |
Ludwig-Maximilians-UniversitäT MüNchen |
| 15801853 |
62 |
Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. |
University Walk |
| 15081038 |
7 |
3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. |
Universita Degli Studi Di Firenze |
| 14980668 |
20 |
Subtype selective NMDA receptor antagonists: evaluation of some novel alkynyl analogues. |
Pfizer |
| 14695840 |
21 |
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. |
Universita Degli Studi Di Firenze |
| 12954059 |
55 |
Selectivity fields: comparative molecular field analysis (CoMFA) of the glycine/NMDA and AMPA receptors. |
Moscow State University |
| 12593650 |
11 |
Tricyclic indole-2-carboxylic acids: highly in vivo active and selective antagonists for the glycine binding site of the NMDA receptor. |
Sumitomo Pharmaceuticals |
| 12565947 |
1 |
Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists. |
Università |
| 11855983 |
18 |
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. |
Universita' Di Firenze |
| 32538088 |
62 |
Discovery of Dihydropyrrolo[1,2- |
Emory University |
| 30622023 |
39 |
Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid. |
University of Bristol |
| 31390523 |
56 |
Neuroactive Steroid |
Sage Therapeutics |
| 10543883 |
25 |
Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor. |
Université |
| 10522697 |
36 |
Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists. |
Warner-Lambert |
| 10464027 |
118 |
Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists. |
University of Oregon |
| 10425109 |
24 |
4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. |
Cocensys |
| 10395489 |
47 |
4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones: excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity. |
Universita' Di Firenze |
| 10395488 |
114 |
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines. |
Cocensys |
| 10386947 |
9 |
Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: potent subtype-selective inhibitors of N-methyl-D-aspartate (NMDA) receptors. |
University of Oregon |
| 10360746 |
8 |
Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. |
Institut De Recherches Servier |
| 30943028 |
66 |
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. |
University of Turin |
| 30891121 |
26 |
Di-aryl Sulfonamide Motif Adds ?-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor. |
Emory University |
| 9526557 |
6 |
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. |
Università |
| 9357535 |
5 |
5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
Cocensys |
| 9240357 |
3 |
Synthesis of racemic 6,7,8,9-tetrahydro-3-hydroxy-1H-1-benzazepine-2,5-diones as antagonists of N-methyl-d-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors. |
Cocensys |
| 9057862 |
41 |
4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity. |
Merck Sharp and Dohme Research Laboratories |
| 9057859 |
37 |
Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor. |
Cocensys |
| 8831762 |
3 |
Novel AMPA receptor antagonists: synthesis and structure-activity relationships of 1-hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and related compounds. |
Yamanouchi Pharmaceutical |
| 8765507 |
20 |
Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. |
Cocensys |
| 8632440 |
2 |
Novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonists: synthesis and structure-activity relationships of 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and related compounds. |
Yamanouchi Pharmaceutical |
| 8230130 |
19 |
3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. |
Merck Sharp and Dohme Research Laboratories |
| 8182696 |
10 |
3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. |
Merck Sharp and Dohme Research Laboratories |
| 7783155 |
10 |
Identification of 3,5-dihydro-2-aryl-1H-pyrazolo[3,4-c]quinoline-1,4(2H)-diones as novel high-affinity glycine site N-methyl-D-aspartate antagonists. |
Merck Sharp and Dohme Research Laboratories |
| 7512140 |
5 |
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA]. |
Royal Danish School of Pharmacy |
| 9083472 |
35 |
Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site. |
Glaxo Wellcome |
| 29708744 |
27 |
Positive Modulators of the N-Methyl-d-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters. |
Institute of Physiology of The Czech Academy of Sciences |
| 30125106 |
4 |
Controlling Ca |
University of Copenhagen |
| 29277306 |
6 |
Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers. |
Hiroshima University |
| 2549245 |
1 |
Evaluation and synthesis of aminohydroxyisoxazoles and pyrazoles as potential glycine agonists. |
Warner-Lambert |
| 1875352 |
12 |
Synthesis, stereochemistry, and biological activity of the 1-(1-phenyl-2-methylcyclohexyl)piperidines and the 1-(1-phenyl-4-methylcyclohexyl)piperidines. Absolute configuration of the potent trans-(-)-1-(1-phenyl-2-methylcyclohexyl)piperidine. |
Istituto Superiore Di Sanità |
| 29397723 |
267 |
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. |
University of Paris |
| 1534584 |
59 |
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor. |
Merck Sharp and Dohme Research Laboratories |
| 1534125 |
1 |
3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site. |
Marion Merrell Dow Research Institute |
| 29205034 |
39 |
Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist. |
University of Eastern Finland |
| 1469699 |
12 |
Synthesis, configuration, and activity of isomeric 2-phenyl-2-(N-piperidinyl)bicyclo[3.1.0]hexanes at phencyclidine and sigma binding sites. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 1326635 |
11 |
3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex. |
Eli Lilly |
| 1310117 |
12 |
Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor. |
Warner-Lambert |
| 24072709 |
11 |
Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. |
University of Copenhagen |
| 26946324 |
14 |
Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules. |
University of Siena |
| 26691755 |
19 |
Identifying New Drug Targets for Potent Phospholipase D Inhibitors: Combining Sequence Alignment, Molecular Docking, and Enzyme Activity/Binding Assays. |
Roxbury Community College |
| 16807364 |
18 |
Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. |
Queen'S University |
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