Compile Data Set for Download or QSAR

Found 120 hits with Last Name = 'mingardi' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (RAT)	BDBM50204428 ((S)-4-(3,3-dimethylbutan-2-yl) 2-propyl 3,5-dimeth...) Show SMILES CCCOC(=O)c1[nH]c(C)c(C(=O)O[C@@H](C)C(C)(C)C)c1C Show InChI InChI=1S/C17H27NO4/c1-8-9-21-16(20)14-10(2)13(11(3)18-14)15(19)22-12(4)17(5,6)7/h12,18H,8-9H2,1-7H3/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50116105 (3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...) Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)| Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412811 (CHEMBL458810) Show SMILES Cc1cc(c2CCN(c2n1)c1ccc(cc1C(F)(F)F)C#N)-n1ccc(n1)N1CCNC1=O Show InChI InChI=1S/C22H18F3N7O/c1-13-10-18(32-8-5-19(29-32)31-9-6-27-21(31)33)15-4-7-30(20(15)28-13)17-3-2-14(12-26)11-16(17)22(23,24)25/h2-3,5,8,10-11H,4,6-7,9H2,1H3,(H,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32.4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50084875 (8-(2,4-dichlorophenyl)-N-(1,3-dimethoxypropan-2-yl...) Show SMILES COCC(COC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(-3.04,-6.69,;-3.03,-8.23,;-4.37,-9,;-4.37,-10.54,;-3.03,-11.31,;-1.7,-10.54,;-1.7,-9.01,;-5.7,-11.31,;-5.7,-12.85,;-7.03,-13.63,;-7.03,-15.17,;-8.36,-15.94,;-5.7,-15.93,;-4.37,-15.17,;-2.91,-15.64,;-2,-14.4,;-.46,-14.4,;-2.91,-13.15,;-4.37,-13.63,;-2.18,-17.01,;-3.01,-18.3,;-2.29,-19.67,;-.75,-19.73,;-.03,-21.08,;.06,-18.41,;-.65,-17.05,;.16,-15.75,)| Show InChI InChI=1S/C18H21Cl2N5O2/c1-10-16(14-6-5-12(19)7-15(14)20)17-21-11(2)22-18(25(17)24-10)23-13(8-26-3)9-27-4/h5-7,13H,8-9H2,1-4H3,(H,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39.8	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412814 (CHEMBL456660) Show SMILES CCc1cc(ccc1N1CCc2c1nc(C)cc2-n1ccc(n1)N1CCNC1=O)C#N Show InChI InChI=1S/C23H23N7O/c1-3-17-13-16(14-24)4-5-19(17)28-9-6-18-20(12-15(2)26-22(18)28)30-10-7-21(27-30)29-11-8-25-23(29)31/h4-5,7,10,12-13H,3,6,8-9,11H2,1-2H3,(H,25,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50.1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412812 (CHEMBL459173) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCNC2=O)c(c1)C(F)F Show InChI InChI=1S/C22H22F2N6O2/c1-13-11-18(30-9-6-19(27-30)29-10-7-25-22(29)31)15-5-8-28(21(15)26-13)17-4-3-14(32-2)12-16(17)20(23)24/h3-4,6,9,11-12,20H,5,7-8,10H2,1-2H3,(H,25,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412798 (EMICERFONT) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCNC2=O)c(C)c1 Show InChI InChI=1S/C22H24N6O2/c1-14-12-16(30-3)4-5-18(14)26-9-6-17-19(13-15(2)24-21(17)26)28-10-7-20(25-28)27-11-8-23-22(27)29/h4-5,7,10,12-13H,6,8-9,11H2,1-3H3,(H,23,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66.1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412808 (CHEMBL456640) Show SMILES Cc1cc(c2CCN(c2n1)c1ccc(OC(F)(F)F)cc1C)-n1ccc(n1)N1CCNC1=O Show InChI InChI=1S/C22H21F3N6O2/c1-13-11-15(33-22(23,24)25)3-4-17(13)29-8-5-16-18(12-14(2)27-20(16)29)31-9-6-19(28-31)30-10-7-26-21(30)32/h3-4,6,9,11-12H,5,7-8,10H2,1-2H3,(H,26,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67.6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412809 (CHEMBL516170) Show SMILES Cc1cc(c2CCN(c2n1)c1ccc(cc1C)C#N)-n1ccc(n1)N1CCNC1=O Show InChI InChI=1S/C22H21N7O/c1-14-11-16(13-23)3-4-18(14)27-8-5-17-19(12-15(2)25-21(17)27)29-9-6-20(26-29)28-10-7-24-22(28)30/h3-4,6,9,11-12H,5,7-8,10H2,1-2H3,(H,24,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67.6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204429 (CHEMBL388669 | adamantane-1-carboxylic acid (1-oxo...) Show SMILES O=C(Nc1ccc2[nH]c3c(CCNC3=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:20:21:25:19.24.18,THB:18:19:22:25.26.17,18:17:20.19.24:22,20:19:25:21.22.26| Show InChI InChI=1S/C22H25N3O2/c26-20-19-16(3-4-23-20)17-8-15(1-2-18(17)25-19)24-21(27)22-9-12-5-13(10-22)7-14(6-12)11-22/h1-2,8,12-14,25H,3-7,9-11H2,(H,23,26)(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204434 (1-oxo-2,3,4,9-tetrahydro-1H-beta-carboline-6-carbo...) Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1ccc2[nH]c3c(CCNC3=O)c2c1 |THB:2:3:6:10.8.9,8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9| Show InChI InChI=1S/C22H25N3O2/c26-20(25-22-9-12-5-13(10-22)7-14(6-12)11-22)15-1-2-18-17(8-15)16-3-4-23-21(27)19(16)24-18/h1-2,8,12-14,24H,3-7,9-11H2,(H,23,27)(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412817 (CHEMBL464185) Show SMILES Cc1cc(c2CCN(c2n1)c1ccc(cc1C(F)(F)F)C(F)(F)F)-n1ccc(n1)-n1cc[nH]c1=O Show InChI InChI=1S/C22H16F6N6O/c1-12-10-17(34-8-5-18(31-34)33-9-6-29-20(33)35)14-4-7-32(19(14)30-12)16-3-2-13(21(23,24)25)11-15(16)22(26,27)28/h2-3,5-6,8-11H,4,7H2,1H3,(H,29,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89.1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204446 (1-oxo-2,3,4,9-tetrahydro-1H-beta-carboline-6-carbo...) Show SMILES O=C(NC1C2CC3CC(C2)CC1C3)c1ccc2[nH]c3c(CCNC3=O)c2c1 |TLB:9:8:12:5.4.3,9:4:7.8.10:12,THB:3:4:7:10.11.12,3:11:7:5.9.4,2:3:7.8.10:12,(-2.07,-19.86,;-2.06,-21.41,;-3.4,-22.18,;-4.74,-21.42,;-6.1,-22.09,;-7.03,-21,;-7.2,-19.6,;-8.87,-19.1,;-7.82,-20.25,;-7.69,-21.76,;-6.41,-19.53,;-4.85,-19.91,;-5.88,-18.92,;-.72,-22.17,;-.72,-23.71,;.62,-24.48,;1.95,-23.69,;3.42,-24.16,;4.28,-22.89,;3.41,-21.67,;4.03,-20.27,;5.56,-20.09,;6.46,-21.34,;5.85,-22.75,;6.76,-23.99,;1.94,-22.16,;.6,-21.39,)| Show InChI InChI=1S/C22H25N3O2/c26-21(25-19-14-6-11-5-12(8-14)9-15(19)7-11)13-1-2-18-17(10-13)16-3-4-23-22(27)20(16)24-18/h1-2,10-12,14-15,19,24H,3-9H2,(H,23,27)(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204435 (6-(benzyloxy)-3,4-dihydro-2H-pyrido[3,4-b]indol-1(...) Show SMILES O=C1NCCc2c1[nH]c1ccc(OCc3ccccc3)cc21 Show InChI InChI=1S/C18H16N2O2/c21-18-17-14(8-9-19-18)15-10-13(6-7-16(15)20-17)22-11-12-4-2-1-3-5-12/h1-7,10,20H,8-9,11H2,(H,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204445 (CHEMBL234960 | N-(3,3-dimethylbutan-2-yl)-N-methyl...) Show SMILES CC(N(C)C(=O)c1ccc2[nH]c3c(CCNC3=O)c2c1)C(C)(C)C |w:1.0| Show InChI InChI=1S/C19H25N3O2/c1-11(19(2,3)4)22(5)18(24)12-6-7-15-14(10-12)13-8-9-20-17(23)16(13)21-15/h6-7,10-11,21H,8-9H2,1-5H3,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412802 (CHEMBL515363) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)-n2cc[nH]c2=O)c(C)c1 Show InChI InChI=1S/C22H22N6O2/c1-14-12-16(30-3)4-5-18(14)26-9-6-17-19(13-15(2)24-21(17)26)28-10-7-20(25-28)27-11-8-23-22(27)29/h4-5,7-8,10-13H,6,9H2,1-3H3,(H,23,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412813 (CHEMBL513937) Show SMILES Cc1cc(c2CCN(c2n1)c1ccc(cc1OC(F)(F)F)C#N)-n1ccc(n1)N1CCNC1=O Show InChI InChI=1S/C22H18F3N7O2/c1-13-10-17(32-8-5-19(29-32)31-9-6-27-21(31)33)15-4-7-30(20(15)28-13)16-3-2-14(12-26)11-18(16)34-22(23,24)25/h2-3,5,8,10-11H,4,6-7,9H2,1H3,(H,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412799 (CHEMBL458599) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCCC2=O)c(C)c1 Show InChI InChI=1S/C23H25N5O2/c1-15-13-17(30-3)6-7-19(15)26-11-8-18-20(14-16(2)24-23(18)26)28-12-9-21(25-28)27-10-4-5-22(27)29/h6-7,9,12-14H,4-5,8,10-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	123	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412803 (CHEMBL456448) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCCNC2=O)c(C)c1 Show InChI InChI=1S/C23H26N6O2/c1-15-13-17(31-3)5-6-19(15)27-11-7-18-20(14-16(2)25-22(18)27)29-12-8-21(26-29)28-10-4-9-24-23(28)30/h5-6,8,12-14H,4,7,9-11H2,1-3H3,(H,24,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412816 (CHEMBL464184) Show SMILES Cc1cc(c2CCN(c2n1)c1ccc(Cl)cc1Cl)-n1ccc(n1)-n1cc[nH]c1=O Show InChI InChI=1S/C20H16Cl2N6O/c1-12-10-17(28-8-5-18(25-28)27-9-6-23-20(27)29)14-4-7-26(19(14)24-12)16-3-2-13(21)11-15(16)22/h2-3,5-6,8-11H,4,7H2,1H3,(H,23,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204433 (6-(benzyloxy)-7-methyl-3,4-dihydro-2H-pyrido[3,4-b...) Show SMILES Cc1cc2[nH]c3c(CCNC3=O)c2cc1OCc1ccccc1 Show InChI InChI=1S/C19H18N2O2/c1-12-9-16-15(14-7-8-20-19(22)18(14)21-16)10-17(12)23-11-13-5-3-2-4-6-13/h2-6,9-10,21H,7-8,11H2,1H3,(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204427 (CHEMBL243020 | N-(bicyclo[2.2.1]heptan-2-yl)-1-oxo...) Show SMILES O=C(NC1CC2CCC1C2)c1ccc2[nH]c3c(CCNC3=O)c2c1 |w:8.7,5.5,3.2,TEB:2:3:6.7:9| Show InChI InChI=1S/C19H21N3O2/c23-18(22-16-8-10-1-2-11(16)7-10)12-3-4-15-14(9-12)13-5-6-20-19(24)17(13)21-15/h3-4,9-11,16,21H,1-2,5-8H2,(H,20,24)(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204439 (6-(3,3-dimethylbutan-2-yloxy)-3,4-dihydro-2H-pyrid...) Show SMILES CC(Oc1ccc2[nH]c3c(CCNC3=O)c2c1)C(C)(C)C |w:1.0| Show InChI InChI=1S/C17H22N2O2/c1-10(17(2,3)4)21-11-5-6-14-13(9-11)12-7-8-18-16(20)15(12)19-14/h5-6,9-10,19H,7-8H2,1-4H3,(H,18,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	239	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412804 (CHEMBL456449) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCNS2(=O)=O)c(C)c1 Show InChI InChI=1S/C21H24N6O3S/c1-14-12-16(30-3)4-5-18(14)25-9-6-17-19(13-15(2)23-21(17)25)26-10-7-20(24-26)27-11-8-22-31(27,28)29/h4-5,7,10,12-13,22H,6,8-9,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	309	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204444 (1-oxo-2,3,4,9-tetrahydro-1H-beta-carboline-6-carbo...) Show SMILES O=C(NCC12CC3CC(CC(C3)C1)C2)c1ccc2[nH]c3c(CCNC3=O)c2c1 |TLB:3:4:7:11.9.10,THB:9:8:5:11.10.12,9:10:7.8.13:5,12:10:7:13.4.5,12:4:7:11.9.10| Show InChI InChI=1S/C23H27N3O2/c27-21(25-12-23-9-13-5-14(10-23)7-15(6-13)11-23)16-1-2-19-18(8-16)17-3-4-24-22(28)20(17)26-19/h1-2,8,13-15,26H,3-7,9-12H2,(H,24,28)(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	312	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412806 (CHEMBL457710) Show SMILES CCOc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCNC2=O)c(C)c1 Show InChI InChI=1S/C23H26N6O2/c1-4-31-17-5-6-19(15(2)13-17)27-10-7-18-20(14-16(3)25-22(18)27)29-11-8-21(26-29)28-12-9-24-23(28)30/h5-6,8,11,13-14H,4,7,9-10,12H2,1-3H3,(H,24,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412815 (CHEMBL457742) Show SMILES COc1cc(ccc1N1CCc2c1nc(C)cc2-n1ccc(n1)-n1cc[nH]c1=O)-n1cccn1 Show InChI InChI=1S/C24H22N8O2/c1-16-14-20(32-12-7-22(28-32)30-13-9-25-24(30)33)18-6-11-29(23(18)27-16)19-5-4-17(15-21(19)34-2)31-10-3-8-26-31/h3-5,7-10,12-15H,6,11H2,1-2H3,(H,25,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	363	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412810 (CHEMBL458626) Show SMILES Cc1cc(c2CCN(c2n1)c1ccc(cc1C)-n1cccn1)-n1ccc(n1)N1CCNC1=O Show InChI InChI=1S/C24H24N8O/c1-16-14-18(31-10-3-8-26-31)4-5-20(16)29-11-6-19-21(15-17(2)27-23(19)29)32-12-7-22(28-32)30-13-9-25-24(30)33/h3-5,7-8,10,12,14-15H,6,9,11,13H2,1-2H3,(H,25,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	372	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204443 (6-(1-phenylethoxy)-3,4-dihydro-2H-pyrido[3,4-b]ind...) Show SMILES CC(Oc1ccc2[nH]c3c(CCNC3=O)c2c1)c1ccccc1 |w:1.0| Show InChI InChI=1S/C19H18N2O2/c1-12(13-5-3-2-4-6-13)23-14-7-8-17-16(11-14)15-9-10-20-19(22)18(15)21-17/h2-8,11-12,21H,9-10H2,1H3,(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50323798 (CHEMBL1214336 | N-[5-(3-pyridinyl)-2,3-dihydro-1H-...) Show SMILES CC(C)S(=O)(=O)NC1Cc2ccc(cc2C1)-c1cccnc1 Show InChI InChI=1S/C17H20N2O2S/c1-12(2)22(20,21)19-17-9-14-6-5-13(8-16(14)10-17)15-4-3-7-18-11-15/h3-8,11-12,17,19H,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human CYP1A2 after 10 mins				J Med Chem 53: 5801-12 (2010) Article DOI: 10.1021/jm1005429 BindingDB Entry DOI: 10.7270/Q2FT8N0T
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204442 (7-(benzyloxy)-1,2-dihydropyrrolo[3,4-b]indol-3(4H)...) Show SMILES O=C1NCc2c1[nH]c1ccc(OCc3ccccc3)cc21 Show InChI InChI=1S/C17H14N2O2/c20-17-16-14(9-18-17)13-8-12(6-7-15(13)19-16)21-10-11-4-2-1-3-5-11/h1-8,19H,9-10H2,(H,18,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	683	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412800 (CHEMBL515532) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCN(C)C2=O)c(C)c1 Show InChI InChI=1S/C23H26N6O2/c1-15-13-17(31-4)5-6-19(15)27-9-7-18-20(14-16(2)24-22(18)27)29-10-8-21(25-29)28-12-11-26(3)23(28)30/h5-6,8,10,13-14H,7,9,11-12H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204431 (8-benzyloxy-3,4a,5,9b-tetrahydro-pyridazino[4,5-b]...) Show SMILES O=C1NNCc2c1[nH]c1ccc(OCc3ccccc3)cc21 Show InChI InChI=1S/C17H15N3O2/c21-17-16-14(9-18-20-17)13-8-12(6-7-15(13)19-16)22-10-11-4-2-1-3-5-11/h1-8,18-19H,9-10H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204430 (1-oxo-N-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]...) Show SMILES O=C(Nc1ccccc1)c1ccc2[nH]c3c(CCNC3=O)c2c1 Show InChI InChI=1S/C18H15N3O2/c22-17(20-12-4-2-1-3-5-12)11-6-7-15-14(10-11)13-8-9-19-18(23)16(13)21-15/h1-7,10,21H,8-9H2,(H,19,23)(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412807 (CHEMBL457975) Show SMILES CC(C)Oc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCNC2=O)c(C)c1 Show InChI InChI=1S/C24H28N6O2/c1-15(2)32-18-5-6-20(16(3)13-18)28-10-7-19-21(14-17(4)26-23(19)28)30-11-8-22(27-30)29-12-9-25-24(29)31/h5-6,8,11,13-15H,7,9-10,12H2,1-4H3,(H,25,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204432 (6-benzyloxy-2,3,4,4a,9,9a-hexahydro-beta-carbolin-...) Show SMILES O=C1NCCC2C1Nc1ccc(OCc3ccccc3)cc21 |w:5.4,6.7| Show InChI InChI=1S/C18H18N2O2/c21-18-17-14(8-9-19-18)15-10-13(6-7-16(15)20-17)22-11-12-4-2-1-3-5-12/h1-7,10,14,17,20H,8-9,11H2,(H,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412801 (CHEMBL458600) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCOC2=O)c(C)c1 Show InChI InChI=1S/C22H23N5O3/c1-14-12-16(29-3)4-5-18(14)25-8-6-17-19(13-15(2)23-21(17)25)27-9-7-20(24-27)26-10-11-30-22(26)28/h4-5,7,9,12-13H,6,8,10-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204437 (7-(benzyloxy)-3,4-dihydro-2H-pyrido[3,4-b]indol-1(...) Show SMILES O=C1NCCc2c1[nH]c1cc(OCc3ccccc3)ccc21 Show InChI InChI=1S/C18H16N2O2/c21-18-17-15(8-9-19-18)14-7-6-13(10-16(14)20-17)22-11-12-4-2-1-3-5-12/h1-7,10,20H,8-9,11H2,(H,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412805 (CHEMBL515503) Show SMILES COc1ccc(N2CCc3c2nc(C)cc3-n2ccc(n2)N2CCCS2(=O)=O)c(C)c1 Show InChI InChI=1S/C22H25N5O3S/c1-15-13-17(30-3)5-6-19(15)25-10-7-18-20(14-16(2)23-22(18)25)26-11-8-21(24-26)27-9-4-12-31(27,28)29/h5-6,8,11,13-14H,4,7,9-10,12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204441 (5-(benzyloxy)-3,4-dihydro-2H-pyrido[3,4-b]indol-1(...) Show SMILES O=C1NCCc2c1[nH]c1cccc(OCc3ccccc3)c21 Show InChI InChI=1S/C18H16N2O2/c21-18-17-13(9-10-19-18)16-14(20-17)7-4-8-15(16)22-11-12-5-2-1-3-6-12/h1-8,20H,9-11H2,(H,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204447 (6-phenoxy-3,4-dihydro-2H-pyrido[3,4-b]indol-1(9H)-...) Show SMILES O=C1NCCc2c1[nH]c1ccc(Oc3ccccc3)cc21 Show InChI InChI=1S/C17H14N2O2/c20-17-16-13(8-9-18-17)14-10-12(6-7-15(14)19-16)21-11-4-2-1-3-5-11/h1-7,10,19H,8-9H2,(H,18,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204436 (1-adamantan-1-yl-3-(1-oxo-2,3,4,9-tetrahydro-1H-be...) Show SMILES O=C(Nc1ccc2[nH]c3c(CCNC3=O)c2c1)NC12CC3CC(CC(C3)C1)C2 |TLB:21:22:26:20.25.19,THB:21:20:26:22.23.27,23:22:26.25.24:19,23:24:21.22.27:19| Show InChI InChI=1S/C22H26N4O2/c27-20-19-16(3-4-23-20)17-8-15(1-2-18(17)25-19)24-21(28)26-22-9-12-5-13(10-22)7-14(6-12)11-22/h1-2,8,12-14,25H,3-7,9-11H2,(H,23,27)(H2,24,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204426 (6-(cyclohexylmethoxy)-3,4-dihydro-2H-pyrido[3,4-b]...) Show SMILES O=C1NCCc2c1[nH]c1ccc(OCC3CCCCC3)cc21 Show InChI InChI=1S/C18H22N2O2/c21-18-17-14(8-9-19-18)15-10-13(6-7-16(15)20-17)22-11-12-4-2-1-3-5-12/h6-7,10,12,20H,1-5,8-9,11H2,(H,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50323794 (CHEMBL1214396 | N-[5-(4-methyl-3-pyridinyl)-2,3-di...) Show SMILES CC(C)S(=O)(=O)NC1Cc2ccc(cc2C1)-c1cnccc1C Show InChI InChI=1S/C18H22N2O2S/c1-12(2)23(21,22)20-17-9-14-4-5-15(8-16(14)10-17)18-11-19-7-6-13(18)3/h4-8,11-12,17,20H,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human CYP3A4 after 10 mins				J Med Chem 53: 5801-12 (2010) Article DOI: 10.1021/jm1005429 BindingDB Entry DOI: 10.7270/Q2FT8N0T
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50323797 (CHEMBL1214337 | N-[5-(2-fluoro-3-pyridinyl)-2,3-di...) Show SMILES CC(C)S(=O)(=O)NC1Cc2ccc(cc2C1)-c1cccnc1F Show InChI InChI=1S/C17H19FN2O2S/c1-11(2)23(21,22)20-15-9-12-5-6-13(8-14(12)10-15)16-4-3-7-19-17(16)18/h3-8,11,15,20H,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human CYP2C19 after 10 mins				J Med Chem 53: 5801-12 (2010) Article DOI: 10.1021/jm1005429 BindingDB Entry DOI: 10.7270/Q2FT8N0T
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204448 (6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]i...) Show SMILES C(Oc1ccc2[nH]c3CNCCc3c2c1)c1ccccc1 Show InChI InChI=1S/C18H18N2O/c1-2-4-13(5-3-1)12-21-14-6-7-17-16(10-14)15-8-9-19-11-18(15)20-17/h1-7,10,19-20H,8-9,11-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204424 (6-benzyloxy-2,3,4,4a,9,9a-hexahydro-1H-beta-carbol...) Show SMILES C(Oc1ccc2NC3CNCCC3c2c1)c1ccccc1 |w:12.11,7.7| Show InChI InChI=1S/C18H20N2O/c1-2-4-13(5-3-1)12-21-14-6-7-17-16(10-14)15-8-9-19-11-18(15)20-17/h1-7,10,15,18-20H,8-9,11-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204425 (CHEMBL234959 | N-(3,3-dimethylbutan-2-yl)-1-oxo-2,...) Show SMILES CC(NC(=O)c1ccc2[nH]c3c(CCNC3=O)c2c1)C(C)(C)C |w:1.0| Show InChI InChI=1S/C18H23N3O2/c1-10(18(2,3)4)20-16(22)11-5-6-14-13(9-11)12-7-8-19-17(23)15(12)21-14/h5-6,9-10,21H,7-8H2,1-4H3,(H,19,23)(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50058672 (6-Methoxy-2,3,4,9-tetrahydro-beta-carbolin-1-one |...) Show SMILES COc1ccc2[nH]c3c(CCNC3=O)c2c1 Show InChI InChI=1S/C12H12N2O2/c1-16-7-2-3-10-9(6-7)8-4-5-13-12(15)11(8)14-10/h2-3,6,14H,4-5H2,1H3,(H,13,15)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50204438 (6-hydroxy-3,4-dihydro-1-oxo-beta-carboline | 6-hyd...) Show SMILES Oc1ccc2[nH]c3c(CCNC3=O)c2c1 Show InChI InChI=1S/C11H10N2O2/c14-6-1-2-9-8(5-6)7-3-4-12-11(15)10(7)13-9/h1-2,5,13-14H,3-4H2,(H,12,15)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicine Research Centre Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 2254-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.055 BindingDB Entry DOI: 10.7270/Q2FT8KPZ
					More data for this Ligand-Target Pair

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