Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227653 (3-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.156 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227651 (6-(5-chloropyridin-3-yl)- 8-[1-fluoro-1-(2- fluoro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.176 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223046 (6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- m...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.202 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224125 (3-{6-[3-chloro-5- (hydroxymethyl)phen- yl]-7-[(tra...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.205 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224261 (3-{8-[(2r)-4-acetyl- 2-phenylpiperazin-1- yl]-6-{[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.215 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227665 (5-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.289 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227683 (3-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(3- flu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.315 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223705 (3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8- (hexahyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.344 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227669 (5-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(3- flu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.359 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223402 (6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- m...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.381 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM226428 (3-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(2- flu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.424 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227696 (2-{1-[6-(5-chloropyridin- 3-yl)-7-[(trans-4- methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.435 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227678 (3-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.452 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM226426 (5-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(2- flu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.453 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224176 (5-{6-(5- chloropyridin-3-yl)- 8-[(3r)-3-(2- fluoro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.494 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM333988 ((S)-1-(3-((9-ethyl-8-(6-methoxy- 5-methylpyridin-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio... | US Patent US9730940 (2017) BindingDB Entry DOI: 10.7270/Q2BP04WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM333882 (US9730940, Compound 1-35 | tert-butyl (3S)-3-{[8-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio... | US Patent US9730940 (2017) BindingDB Entry DOI: 10.7270/Q2BP04WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224216 (3-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylc...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.504 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223681 (3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8-[2-(1-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.507 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227695 (2-{1-[6-(5-chloropyridin- 3-yl)-7-[(trans-4- methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.515 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224107 (3-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylc...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.517 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM221499 (6-{[(1r)-1- cyclobutylethyl]amino}- 8-[(1-pyridin-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.526 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224295 (6-{[(1r)-1-cyclobutylethyl]amino}- 7-[(trans-4-eth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.548 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224851 (3-(6-{[(1r)-1- cyclobutylethyl]amino}-8-[1- fluoro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.563 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223674 (3-{8-[3-(2- chlorophenyl)morph- olin-4-yl]-6-{[(1r...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.568 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224214 (5-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylc...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.569 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224173 (3-{6-(5- chloropyridin-3-yl)- 8-[(3r)-3-(2- fluoro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.585 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223756 (6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- m...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.585 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224155 (3-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylc...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.585 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227673 (5-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.598 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM333992 ((S)-1-(3-((9-ethyl-8-(1-ethyl-5- methyl-1H-pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio... | US Patent US9730940 (2017) BindingDB Entry DOI: 10.7270/Q2BP04WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224239 (3-{6-(5-chloro-2- methylpyridin-3-yl)- 7-[(trans-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.601 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224288 (5-(6-(5-chloropyridin-3-yl)-7-(1- ((trans)-4-methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227658 (5-{8-[1-(3-chloro-2- fluorophenyl)-1- methoxyethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.623 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223200 (3-(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.626 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223702 (3-(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.642 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224146 (3-{6-(3- chlorophenyl)-8-[2- (1-methoxy-1- methyle...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.658 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224323 (3-{6-(5-chloropyridin-3-yl)-7-[1- (trans-4-methylc...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227671 (5-{6-(5-chloropyridin-3- yl)-8-[1-(3-fluoropyridin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.675 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224103 (6-(3-chlorophenyl)-7- [(trans-4- methylcyclohexyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.680 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM428786 ((R or S)-5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga... | US Patent US10544147 (2020) BindingDB Entry DOI: 10.7270/Q2G1637Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM333881 (US9730940, Compound 1-34 | tert-butyl (3S)-3-{[9-e...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio... | US Patent US9730940 (2017) BindingDB Entry DOI: 10.7270/Q2BP04WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224240 (5-{6-(5-chloro-2- methylpyridin-3-yl)- 7-[(trans-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.704 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM227694 (2-{[6-(5-chloropyridin-3- yl)-7-[(trans-4- methylc...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.707 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM221505 (6-{[(1r)-1- cyclobutylethyl]amino}- 8-{[(1s)-1-(3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.753 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM224650 (3-[6-{[(1r)-1- cyclobutylethyl]amino}-7- [(trans-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.763 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223736 (3-(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.767 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223714 (3-(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.774 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223703 (3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8-[(3r,5r)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.788 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human)) | BDBM223737 (5-(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re... | US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F | |||||||||||
More data for this Ligand-Target Pair |
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