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Compile Data Set for Download or QSAR

Found 1122 hits with Last Name = 'zhu' and Initial = 'hy'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495912
PNG
(CHEMBL3115255)
Show SMILES Cn1cncc1[C@@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(N)=O)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C25H27ClN6O2/c1-25(34,21-14-28-15-30(21)2)20-12-16-4-3-7-29-22(16)23(18-6-5-17(26)13-19(18)20)31-8-10-32(11-9-31)24(27)33/h3-7,12-15,23,34H,8-11H2,1-2H3,(H2,27,33)/t23-,25-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495899
PNG
(CHEMBL3115256)
Show SMILES Cn1cncc1[C@@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)NC2CCCCC2)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C31H37ClN6O2/c1-31(40,27-19-33-20-36(27)2)26-17-21-7-6-12-34-28(21)29(24-11-10-22(32)18-25(24)26)37-13-15-38(16-14-37)30(39)35-23-8-4-3-5-9-23/h6-7,10-12,17-20,23,29,40H,3-5,8-9,13-16H2,1-2H3,(H,35,39)/t29-,31-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495906
PNG
(CHEMBL3115258)
Show SMILES CC(C)OC(=O)N1CCN(CC1)[C@H]1c2ccc(Cl)cc2C(=Cc2cccnc12)[C@](C)(O)c1cncn1C |r,c:22|
Show InChI InChI=1S/C28H32ClN5O3/c1-18(2)37-27(35)34-12-10-33(11-13-34)26-21-8-7-20(29)15-22(21)23(14-19-6-5-9-31-25(19)26)28(3,36)24-16-30-17-32(24)4/h5-9,14-18,26,36H,10-13H2,1-4H3/t26-,28-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495911
PNG
(CHEMBL601202)
Show SMILES Cn1cncc1[C@H](O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC(C)(C)C)c2ccc(Cl)cc12 |r,t:9|
Show InChI InChI=1S/C28H32ClN5O3/c1-28(2,3)37-27(36)34-12-10-33(11-13-34)25-20-8-7-19(29)15-21(20)22(14-18-6-5-9-31-24(18)25)26(35)23-16-30-17-32(23)4/h5-9,14-17,25-26,35H,10-13H2,1-4H3/t25-,26+/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495918
PNG
(CHEMBL3115265)
Show SMILES Cn1cncc1[C@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)NC2CCCCC2)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C31H37ClN6O2/c1-31(40,27-19-33-20-36(27)2)26-17-21-7-6-12-34-28(21)29(24-11-10-22(32)18-25(24)26)37-13-15-38(16-14-37)30(39)35-23-8-4-3-5-9-23/h6-7,10-12,17-20,23,29,40H,3-5,8-9,13-16H2,1-2H3,(H,35,39)/t29-,31+/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495913
PNG
(CHEMBL3115261)
Show SMILES Cn1cncc1[C@@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC2CCCC2)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C30H34ClN5O3/c1-30(38,26-18-32-19-34(26)2)25-16-20-6-5-11-33-27(20)28(23-10-9-21(31)17-24(23)25)35-12-14-36(15-13-35)29(37)39-22-7-3-4-8-22/h5-6,9-11,16-19,22,28,38H,3-4,7-8,12-15H2,1-2H3/t28-,30-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495902
PNG
(CHEMBL3115429)
Show SMILES Cn1cncc1[C@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC2CCCC2)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C30H34ClN5O3/c1-30(38,26-18-32-19-34(26)2)25-16-20-6-5-11-33-27(20)28(23-10-9-21(31)17-24(23)25)35-12-14-36(15-13-35)29(37)39-22-7-3-4-8-22/h5-6,9-11,16-19,22,28,38H,3-4,7-8,12-15H2,1-2H3/t28-,30+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154612
PNG
(US8999957, Column 165-167, Compound 1)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NOCC1CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495905
PNG
(CHEMBL3115426)
Show SMILES CC(C)OC(=O)N1CCN(CC1)[C@H]1c2ccc(Cl)cc2C(=Cc2cccnc12)[C@@](C)(O)c1cncn1C |r,c:22|
Show InChI InChI=1S/C28H32ClN5O3/c1-18(2)37-27(35)34-12-10-33(11-13-34)26-21-8-7-20(29)15-22(21)23(14-19-6-5-9-31-25(19)26)28(3,36)24-16-30-17-32(24)4/h5-9,14-18,26,36H,10-13H2,1-4H3/t26-,28+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495907
PNG
(CHEMBL3115266)
Show SMILES Cn1cncc1[C@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)NC(C)(C)C)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C29H35ClN6O2/c1-28(2,3)33-27(37)36-13-11-35(12-14-36)26-21-9-8-20(30)16-22(21)23(15-19-7-6-10-32-25(19)26)29(4,38)24-17-31-18-34(24)5/h6-10,15-18,26,38H,11-14H2,1-5H3,(H,33,37)/t26-,29+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495922
PNG
(CHEMBL3115254)
Show SMILES Cn1cncc1[C@@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)Nc2ccc(cc2)C#N)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C32H30ClN7O2/c1-32(42,28-19-35-20-38(28)2)27-16-22-4-3-11-36-29(22)30(25-10-7-23(33)17-26(25)27)39-12-14-40(15-13-39)31(41)37-24-8-5-21(18-34)6-9-24/h3-11,16-17,19-20,30,42H,12-15H2,1-2H3,(H,37,41)/t30-,32-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM103302
PNG
(SCH772984 | US8546404, 6)
Show SMILES O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r|
Show InChI InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1
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US Patent
n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme

US Patent


Assay Description
Activated ERK2 activity was determined in the IMAP assay format.

US Patent US8546404 (2013)


BindingDB Entry DOI: 10.7270/Q2959G61
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495917
PNG
(CHEMBL3115257)
Show SMILES Cn1cncc1[C@@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)NC(C)(C)C)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C29H35ClN6O2/c1-28(2,3)33-27(37)36-13-11-35(12-14-36)26-21-9-8-20(30)16-22(21)23(15-19-7-6-10-32-25(19)26)29(4,38)24-17-31-18-34(24)5/h6-10,15-18,26,38H,11-14H2,1-5H3,(H,33,37)/t26-,29-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154864
PNG
(US8999957, Table 3, Compound 137)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NN)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154863
PNG
(US8999957, Table 3, Compound 136)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(N)=O)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154874
PNG
(US8999957, Table 3, Compound 147)
Show SMILES CNC(=S)NNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154613
PNG
(US8999957, Column 165-167, Compound 2)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(C)(O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154600
PNG
(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Show SMILES Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r|
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n/an/a 1.10n/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154600
PNG
(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Show SMILES Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r|
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n/an/a 1.10n/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154614
PNG
(US8999957, Column 165-167, Compound 3)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC[C@H]1CC[C@H](O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154592
PNG
(US8999957, Column 143, Compound 1)
Show SMILES COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(C3=CCOCC3)c2c1 |r,t:28|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154897
PNG
(US8999957, Table 4, Compound 2)
Show SMILES CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495901
PNG
(CHEMBL3115253)
Show SMILES Cn1cncc1[C@@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC(C)(C)C)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C29H34ClN5O3/c1-28(2,3)38-27(36)35-13-11-34(12-14-35)26-21-9-8-20(30)16-22(21)23(15-19-7-6-10-32-25(19)26)29(4,37)24-17-31-18-33(24)5/h6-10,15-18,26,37H,11-14H2,1-5H3/t26-,29-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495904
PNG
(CHEMBL3115427)
Show SMILES Cn1cncc1[C@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC2CCCCC2)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C31H36ClN5O3/c1-31(39,27-19-33-20-35(27)2)26-17-21-7-6-12-34-28(21)29(24-11-10-22(32)18-25(24)26)36-13-15-37(16-14-36)30(38)40-23-8-4-3-5-9-23/h6-7,10-12,17-20,23,29,39H,3-5,8-9,13-16H2,1-2H3/t29-,31+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154900
PNG
(US8999957, Table 4, Compound 5)
Show SMILES CN1C[C@@H](Cc2c(F)cccc2F)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)nn4c3)c2c1 |r|
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n/an/a 1.45n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154617
PNG
(US8999957, Column 165-167, Compound 6)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC[C@@H]1CC[C@@H](O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154902
PNG
(US8999957, Table 4, Compound 7)
Show SMILES CN1C[C@H](Cc2c(F)cccc2F)C[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccn4ccnc4c3)c2c1 |r|
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n/an/a 1.59n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495914
PNG
(CHEMBL3115259)
Show SMILES Cn1cncc1[C@@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC2CCCCC2)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C31H36ClN5O3/c1-31(39,27-19-33-20-35(27)2)26-17-21-7-6-12-34-28(21)29(24-11-10-22(32)18-25(24)26)36-13-15-37(16-14-36)30(38)40-23-8-4-3-5-9-23/h6-7,10-12,17-20,23,29,39H,3-5,8-9,13-16H2,1-2H3/t29-,31-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154822
PNG
(US8999957, Table 3, Compound 94)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(N)=O)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495920
PNG
(CHEMBL3115251)
Show SMILES Cn1cncc1C(C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC(C)(C)C)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C29H34ClN5O3/c1-28(2,3)38-27(36)35-13-11-34(12-14-35)26-21-9-8-20(30)16-22(21)23(15-19-7-6-10-32-25(19)26)29(4,37)24-17-31-18-33(24)5/h6-10,15-18,26,37H,11-14H2,1-5H3/t26-,29?/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495900
PNG
(CHEMBL3115263)
Show SMILES Cn1cncc1[C@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)Nc2ccc(cc2)C#N)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C32H30ClN7O2/c1-32(42,28-19-35-20-38(28)2)27-16-22-4-3-11-36-29(22)30(25-10-7-23(33)17-26(25)27)39-12-14-40(15-13-39)31(41)37-24-8-5-21(18-34)6-9-24/h3-11,16-17,19-20,30,42H,12-15H2,1-2H3,(H,37,41)/t30-,32+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495909
PNG
(CHEMBL3115248)
Show SMILES [H][C@]12C[C@]1(c1cc(Cl)ccc1[C@H](N1CCN(CC1)C(=O)OC(C)(C)C)c1ncccc21)C(C)(O)c1cncn1C |r|
Show InChI InChI=1S/C30H36ClN5O3/c1-28(2,3)39-27(37)36-13-11-35(12-14-36)26-21-9-8-19(31)15-22(21)30(29(4,38)24-17-32-18-34(24)5)16-23(30)20-7-6-10-33-25(20)26/h6-10,15,17-18,23,26,38H,11-14,16H2,1-5H3/t23-,26+,29?,30-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM103295
PNG
(US8546404, 462)
Show SMILES CO[C@]1(CCN(CC(=O)N2CCN(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 |r|
Show InChI InChI=1S/C35H35FN8O3/c1-47-35(34(46)39-27-9-12-30-29(21-27)32(41-40-30)24-3-7-26(36)8-4-24)13-16-42(23-35)22-31(45)44-19-17-43(18-20-44)28-10-5-25(6-11-28)33-37-14-2-15-38-33/h2-12,14-15,21H,13,16-20,22-23H2,1H3,(H,39,46)(H,40,41)/t35-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Merck Sharp & Dohme

US Patent


Assay Description
Activated ERK2 activity was determined in the IMAP assay format.

US Patent US8546404 (2013)


BindingDB Entry DOI: 10.7270/Q2959G61
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154811
PNG
(BDBM154818 | US8999957, Table 3, Compound 83)
Show SMILES CNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r|
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n/an/a 2.41n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154616
PNG
(US8999957, Column 165-167, Compound 5)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)C1CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM103292
PNG
(US8546404, 1729 | US8546404, 469)
Show SMILES CO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1 |r,c:12|
Show InChI InChI=1S/C38H38N8O3/c1-49-38(37(48)42-30-9-10-32-31(22-30)35(44-43-32)29-11-17-39-33(21-29)27-5-6-27)14-20-45(24-38)23-34(47)46-18-12-26(13-19-46)25-3-7-28(8-4-25)36-40-15-2-16-41-36/h2-4,7-12,15-17,21-22,27H,5-6,13-14,18-20,23-24H2,1H3,(H,42,48)(H,43,44)/t38-/m0/s1
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Merck Sharp & Dohme

US Patent


Assay Description
Activated ERK2 activity was determined in the IMAP assay format.

US Patent US8546404 (2013)


BindingDB Entry DOI: 10.7270/Q2959G61
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM34531
PNG
(US8546404, 459)
Show SMILES CO[C@]1(CCN(CC(=O)N2CCC(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1 |r|
Show InChI InChI=1S/C17H13N3O3S/c21-16(15-9-22-13-3-1-2-4-14(13)23-15)20-17-19-12(10-24-17)11-5-7-18-8-6-11/h1-8,10,15H,9H2,(H,19,20,21)
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Merck Sharp & Dohme

US Patent


Assay Description
Activated ERK2 activity was determined in the IMAP assay format.

US Patent US8546404 (2013)


BindingDB Entry DOI: 10.7270/Q2959G61
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM103292
PNG
(US8546404, 1729 | US8546404, 469)
Show SMILES CO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1 |r,c:12|
Show InChI InChI=1S/C38H38N8O3/c1-49-38(37(48)42-30-9-10-32-31(22-30)35(44-43-32)29-11-17-39-33(21-29)27-5-6-27)14-20-45(24-38)23-34(47)46-18-12-26(13-19-46)25-3-7-28(8-4-25)36-40-15-2-16-41-36/h2-4,7-12,15-17,21-22,27H,5-6,13-14,18-20,23-24H2,1H3,(H,42,48)(H,43,44)/t38-/m0/s1
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Merck Sharp & Dohme

US Patent


Assay Description
Activated ERK2 activity was determined in the IMAP assay format.

US Patent US8546404 (2013)


BindingDB Entry DOI: 10.7270/Q2959G61
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495919
PNG
(CHEMBL3115262)
Show SMILES Cn1cncc1[C@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC(C)(C)C)c2ccc(Cl)cc12 |r,t:10|
Show InChI InChI=1S/C29H34ClN5O3/c1-28(2,3)38-27(36)35-13-11-34(12-14-35)26-21-9-8-20(30)16-22(21)23(15-19-7-6-10-32-25(19)26)29(4,37)24-17-31-18-33(24)5/h6-10,15-18,26,37H,11-14H2,1-5H3/t26-,29+/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154601
PNG
(US8999957, Column 155, Compound 1 | US8999957, Tab...)
Show SMILES CN1CC(CC(C1)c1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1
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n/an/a 2.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154601
PNG
(US8999957, Column 155, Compound 1 | US8999957, Tab...)
Show SMILES CN1CC(CC(C1)c1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1
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n/an/a 2.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154873
PNG
(US8999957, Table 3, Compound 146)
Show SMILES CNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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n/an/a 2.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154908
PNG
(US8999957, Table 4, Compound 13)
Show SMILES CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1
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n/an/a 2.71n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154599
PNG
(US8999957, Column 153, Compound 4 | US8999957, Tab...)
Show SMILES O=C(N[C@@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r|
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n/an/a 2.90n/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154599
PNG
(US8999957, Column 153, Compound 4 | US8999957, Tab...)
Show SMILES O=C(N[C@@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r|
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n/an/a 2.90n/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154618
PNG
(US8999957, Column 165-167, Compound 7)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1ccncc1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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n/an/a 3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154898
PNG
(US8999957, Table 4, Compound 3)
Show SMILES CCN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1
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n/an/a 3.09n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495923
PNG
(CHEMBL3115430)
Show SMILES [H][C@]12C[C@@]1(C(=O)c1cncn1C)c1cc(Cl)ccc1[C@H](N1CCN(CC1)C(=O)OC(C)(C)C)c1ncccc21 |r|
Show InChI InChI=1S/C29H32ClN5O3/c1-28(2,3)38-27(37)35-12-10-34(11-13-35)25-20-8-7-18(30)14-21(20)29(26(36)23-16-31-17-33(23)4)15-22(29)19-6-5-9-32-24(19)25/h5-9,14,16-17,22,25H,10-13,15H2,1-4H3/t22-,25+,29-/m1/s1
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n/an/a 3.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))		BDBM154811
PNG
(BDBM154818 | US8999957, Table 3, Compound 83)
Show SMILES CNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r|
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n/an/a 3.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...

US Patent US8999957 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22S9
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50495915
PNG
(CHEMBL3115431)
Show SMILES [H][C@@]12C[C@]1(C(=O)c1cncn1C)c1cc(Cl)ccc1[C@H](N1CCN(CC1)C(=O)OC(C)(C)C)c1ncccc21 |r|
Show InChI InChI=1S/C29H32ClN5O3/c1-28(2,3)38-27(37)35-12-10-34(11-13-35)25-20-8-7-18(30)14-21(20)29(26(36)23-16-31-17-33(23)4)15-22(29)19-6-5-9-32-24(19)25/h5-9,14,16-17,22,25H,10-13,15H2,1-4H3/t22-,25-,29-/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...

Bioorg Med Chem Lett 24: 1228-31 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.046
BindingDB Entry DOI: 10.7270/Q26H4MCJ
More data for this
Ligand-Target Pair
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