Compile Data Set for Download or QSAR

Found 398 hits with Last Name = 'childers' and Initial = 'kk'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301997 (US9598405, 1.5 | US9598405, 1.6) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H24F3N5O3S/c1-21(2)11-22(34,5-3-14(21)19(32)33)20-29-10-16(35-20)15-8-13(27)9-18(30-15)31-17-7-12(4-6-28-17)23(24,25)26/h4,6-10,14,34H,3,5,11H2,1-2H3,(H,32,33)(H3,27,28,30,31)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0710	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302002 (US9598405, 2.1) Show SMILES Cc1cc(Nc2cc(ccn2)-c2c[nH]nn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O Show InChI InChI=1S/C23H23N7O3S/c1-13-8-16(18-12-25-22(34-18)23(33)5-2-14(3-6-23)21(31)32)27-20(9-13)28-19-10-15(4-7-24-19)17-11-26-30-29-17/h4,7-12,14,33H,2-3,5-6H2,1H3,(H,31,32)(H,24,27,28)(H,26,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0720	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302016 (US9598405, 3.1) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@]1(O)CC[C@@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t15-,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0730	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302034 (BDBM302035 | US9598405, 4.1) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2(CCCCC2)C1C(O)=O Show InChI InChI=1S/C25H25F3N4O3S/c1-14-9-16(31-19(10-14)32-18-11-15(5-8-29-18)25(26,27)28)17-12-30-22(36-17)24(35)13-23(20(24)21(33)34)6-3-2-4-7-23/h5,8-12,20,35H,2-4,6-7,13H2,1H3,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0860	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302018 (US9598405, 3.3 | US9598405, 3.7) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H23F3N4O3S/c1-21(2)12-22(33,8-6-14(21)19(31)32)20-28-11-16(34-20)15-4-3-5-17(29-15)30-18-10-13(7-9-27-18)23(24,25)26/h3-5,7,9-11,14,33H,6,8,12H2,1-2H3,(H,31,32)(H,27,29,30)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0920	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302028 (US9598405, 3.13) Show SMILES Cc1cc(Nc2cc(C)c(Cl)cn2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H27ClN4O3S/c1-13-7-17(28-20(8-13)29-19-9-14(2)16(25)10-26-19)18-11-27-22(33-18)24(32)6-5-15(21(30)31)23(3,4)12-24/h7-11,15,32H,5-6,12H2,1-4H3,(H,30,31)(H,26,28,29)/t15-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177763 (US9120785, Example 10 | US9120785, Example 11) Show SMILES Cc1cc(Nc2cc(C)c(F)cn2)nc(c1)-c1cnc(s1)C(C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:27.33,wD:24.26,(4.68,-7.21,;3.34,-6.44,;2.01,-7.21,;.68,-6.44,;-.66,-7.21,;-1.99,-6.44,;-1.99,-4.9,;-3.33,-4.13,;-3.33,-2.59,;-4.66,-4.9,;-5.99,-4.13,;-4.66,-6.44,;-3.33,-7.21,;.68,-4.9,;2.01,-4.13,;3.34,-4.9,;2.01,-2.59,;3.25,-1.68,;2.78,-.22,;1.24,-.22,;.76,-1.68,;.47,1.12,;-.86,1.89,;-.86,.35,;1.24,2.45,;2.73,2.05,;3.82,3.14,;3.42,4.63,;1.93,5.03,;.84,3.94,;4.51,5.72,;5.99,5.32,;4.11,7.21,)| Show InChI InChI=1S/C24H27FN4O3S/c1-13-8-18(28-21(9-13)29-20-10-14(2)17(25)11-26-20)19-12-27-23(33-19)24(3,32)16-6-4-15(5-7-16)22(30)31/h8-12,15-16,32H,4-7H2,1-3H3,(H,30,31)(H,26,28,29)/t15-,16-,24?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301993 (BDBM301994 | US9598405, 1.1) Show SMILES Cc1cc(Nc2cc(ccn2)C2CC2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C26H30N4O3S/c1-15-10-19(29-22(11-15)30-21-12-17(7-9-27-21)16-4-5-16)20-13-28-24(34-20)26(33)8-6-18(23(31)32)25(2,3)14-26/h7,9-13,16,18,33H,4-6,8,14H2,1-3H3,(H,31,32)(H,27,29,30)/t18-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.103	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302029 (US9598405, 3.14) Show SMILES COc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C24H28N4O4S/c1-14-9-17(27-20(10-14)28-19-11-15(32-4)6-8-25-19)18-12-26-22(33-18)24(31)7-5-16(21(29)30)23(2,3)13-24/h6,8-12,16,31H,5,7,13H2,1-4H3,(H,29,30)(H,25,27,28)/t16-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.104	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302032 (US9598405, 3.17) Show SMILES Cc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C24H28N4O3S/c1-14-6-8-25-19(10-14)28-20-11-15(2)9-17(27-20)18-12-26-22(32-18)24(31)7-5-16(21(29)30)23(3,4)13-24/h6,8-12,16,31H,5,7,13H2,1-4H3,(H,29,30)(H,25,27,28)/t16-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.113	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302000 (US9598405, 1.8) Show SMILES CC1(C)CC(O)(CCC1C(O)=O)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H24F3N5O3S/c1-21(2)11-22(34,5-3-14(21)19(32)33)20-29-10-16(35-20)15-8-13(27)9-18(30-15)31-17-7-12(4-6-28-17)23(24,25)26/h4,6-10,14,34H,3,5,11H2,1-2H3,(H,32,33)(H3,27,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.119	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302030 (US9598405, 3.15) Show SMILES Cc1cc(Nc2cc(C)c(F)cn2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H27FN4O3S/c1-13-7-17(28-20(8-13)29-19-9-14(2)16(25)10-26-19)18-11-27-22(33-18)24(32)6-5-15(21(30)31)23(3,4)12-24/h7-11,15,32H,5-6,12H2,1-4H3,(H,30,31)(H,26,28,29)/t15-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.127	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302013 (US9598405, 2.12) Show SMILES Cc1cc(Nc2cc(OC3CCNCC3)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(10.66,-14.61,;11.29,-13.2,;12.82,-13.04,;13.45,-11.63,;14.98,-11.47,;15.61,-10.06,;17.14,-9.9,;17.76,-8.5,;19.3,-8.33,;20.2,-9.58,;21.73,-9.42,;22.64,-10.66,;22.01,-12.07,;20.48,-12.23,;19.57,-10.99,;16.86,-7.25,;15.33,-7.41,;14.7,-8.82,;12.54,-10.38,;11.01,-10.55,;10.38,-11.95,;10.11,-9.3,;8.57,-9.3,;8.09,-7.84,;9.34,-6.93,;10.58,-7.84,;9.34,-5.39,;10.85,-5.66,;7.82,-5.66,;6.83,-4.48,;7.36,-3.03,;8.87,-2.76,;9.86,-3.94,;6.37,-1.85,;4.85,-2.12,;6.89,-.4,)| Show InChI InChI=1S/C26H31N5O4S/c1-16-12-20(21-15-29-25(36-21)26(34)7-2-17(3-8-26)24(32)33)30-23(13-16)31-22-14-19(6-11-28-22)35-18-4-9-27-10-5-18/h6,11-15,17-18,27,34H,2-5,7-10H2,1H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.152	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302017 (US9598405, 3.2 | US9598405, 3.6) Show SMILES CC(C)(C)c1ccnc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C26H32N4O3S/c1-24(2,3)16-10-12-27-21(13-16)30-20-8-6-7-18(29-20)19-14-28-23(34-19)26(33)11-9-17(22(31)32)25(4,5)15-26/h6-8,10,12-14,17,33H,9,11,15H2,1-5H3,(H,31,32)(H,27,29,30)/t17-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302033 (US9598405, 3.18) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t15-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302042 (US9598405, 5.1) Show SMILES C[C@@H]1C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(C)c(F)cn2)n1 Show InChI InChI=1S/C23H25FN4O3S/c1-12-6-17(27-20(7-12)28-19-8-13(2)16(24)10-25-19)18-11-26-22(32-18)23(31)5-4-15(21(29)30)14(3)9-23/h6-8,10-11,14-15,31H,4-5,9H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,15+,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.161	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301996 (US9598405, 1.4) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCC(C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.164	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302026 (US9598405, 3.11) Show SMILES Cc1cc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)ncc1Cl Show InChI InChI=1S/C23H25ClN4O3S/c1-13-9-19(25-10-15(13)24)28-18-6-4-5-16(27-18)17-11-26-21(32-17)23(31)8-7-14(20(29)30)22(2,3)12-23/h4-6,9-11,14,31H,7-8,12H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.208	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302036 (BDBM302037 | US9598405, 4.3) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2CCC(C1)C2C(O)=O |TLB:24:23:27.28:31,(13.28,-2.32,;11.96,-1.53,;11.98,.01,;10.66,.8,;10.68,2.34,;9.36,3.13,;9.38,4.67,;8.06,5.46,;6.71,4.71,;6.69,3.17,;8.01,2.38,;8.08,7,;8.1,8.54,;9.62,6.98,;6.54,7.02,;9.31,.05,;9.29,-1.49,;10.61,-2.28,;7.95,-2.24,;7.76,-3.77,;6.25,-4.07,;5.5,-2.72,;6.55,-1.59,;3.97,-2.54,;3.36,-3.95,;3.71,-1.01,;1.98,-1.04,;1.38,-2.36,;.22,-3.07,;1.19,-1.74,;3.01,-1.74,;.93,-.22,;.14,1.1,;.9,2.45,;-1.4,1.08,)| Show InChI InChI=1S/C24H23F3N4O3S/c1-12-6-16(30-19(7-12)31-18-8-15(4-5-28-18)24(25,26)27)17-11-29-22(35-17)23(34)9-13-2-3-14(10-23)20(13)21(32)33/h4-8,11,13-14,20,34H,2-3,9-10H2,1H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.228	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50590228 (CHEMBL5172416) Show SMILES CC(C)(O)[C@@H]1CCN(C1)c1cnc(c(NC(=O)c2cccc(n2)-c2cnn(CC3(CC3)C(F)(F)F)c2)c1)C(F)(F)F |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00097g BindingDB Entry DOI: 10.7270/Q2WH2TZ3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302006 (US9598405, 2.5) Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)-c2cn(C)nn2)n1 Show InChI InChI=1S/C26H29N7O3S/c1-4-36-24(34)17-5-8-26(35,9-6-17)25-28-14-21(37-25)19-11-16(2)12-23(29-19)30-22-13-18(7-10-27-22)20-15-33(3)32-31-20/h7,10-15,17,35H,4-6,8-9H2,1-3H3,(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302014 (US9598405, 2.13) Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)-c2c[nH]nn2)n1 Show InChI InChI=1S/C25H27N7O3S/c1-3-35-23(33)16-4-7-25(34,8-5-16)24-27-14-20(36-24)18-10-15(2)11-22(29-18)30-21-12-17(6-9-26-21)19-13-28-32-31-19/h6,9-14,16,34H,3-5,7-8H2,1-2H3,(H,26,29,30)(H,28,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.333	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302039 (US9598405, 4.6) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O Show InChI InChI=1S/C22H21F3N4O3S/c1-12-8-15(28-18(9-12)29-17-10-14(4-7-26-17)22(23,24)25)16-11-27-20(33-16)21(32)5-2-13(3-6-21)19(30)31/h4,7-11,13,32H,2-3,5-6H2,1H3,(H,30,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.392	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50590227 (CHEMBL5181104) Show SMILES CC(C)(O)[C@@H]1CCN(C1)c1cnc(c(NC(=O)c2cccc(n2)-c2cnn(CC3CC3)c2)c1)C(F)(F)F |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00097g BindingDB Entry DOI: 10.7270/Q2WH2TZ3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212230 (US9290490, 2-1) Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C(C)(O)C1CCC(CC1)C(O)=O |(1.74,-8.38,;.41,-7.61,;-.92,-8.38,;-2.26,-7.61,;-3.59,-8.38,;-4.93,-7.61,;-6.26,-8.38,;-7.59,-7.61,;-7.59,-6.07,;-6.26,-5.24,;-4.93,-6.07,;-6.26,-3.7,;-6.26,-2.16,;-4.72,-3.7,;-7.8,-3.7,;-2.26,-6.07,;-.92,-5.3,;.41,-6.07,;-.92,-3.76,;-2.17,-2.85,;-1.69,-1.39,;-.15,-1.39,;.32,-2.85,;.62,-.06,;1.39,1.28,;-.15,1.28,;2.16,-.06,;2.93,-1.39,;4.47,-1.39,;5.29,-.06,;4.47,1.28,;2.93,1.28,;6.83,-.06,;7.6,1.28,;7.6,-1.39,)| Show InChI InChI=1S/C24H25F3N4O3S/c1-13-9-15(11-17(10-13)30-22-28-8-7-19(31-22)24(25,26)27)18-12-29-21(35-18)23(2,34)16-5-3-14(4-6-16)20(32)33/h7-12,14,16,34H,3-6H2,1-2H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9290490 (2016) BindingDB Entry DOI: 10.7270/Q2Z0370B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212238 (US9290490, 2-77) Show SMILES CC(C)c1ccnc(Nc2cc(C)cc(c2)-c2cnc(s2)C(C)(O)C2CCC(CC2)C(O)=O)n1 |(-5.09,-3.04,;-6.42,-3.81,;-7.51,-2.72,;-6.42,-5.35,;-7.76,-6.18,;-7.76,-7.72,;-6.42,-8.49,;-5.09,-7.72,;-3.76,-8.49,;-2.42,-7.72,;-1.09,-8.49,;.24,-7.72,;1.58,-8.49,;.24,-6.18,;-1.09,-5.41,;-2.42,-6.18,;-1.09,-3.87,;-2.34,-2.96,;-1.86,-1.5,;-.32,-1.5,;.16,-2.96,;.45,-.17,;1.22,1.17,;-.32,1.17,;1.99,-.17,;2.76,-1.5,;4.3,-1.5,;5.13,-.17,;4.3,1.17,;2.76,1.17,;6.67,-.17,;7.44,1.17,;7.44,-1.5,;-5.09,-6.18,)| Show InChI InChI=1S/C26H32N4O3S/c1-15(2)21-9-10-27-25(30-21)29-20-12-16(3)11-18(13-20)22-14-28-24(34-22)26(4,33)19-7-5-17(6-8-19)23(31)32/h9-15,17,19,33H,5-8H2,1-4H3,(H,31,32)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9290490 (2016) BindingDB Entry DOI: 10.7270/Q2Z0370B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212258 (US9290490, Example 15) Show SMILES C[C@@](O)([C@H]1CC[C@@H](CC1)C(O)=O)c1ncc(s1)-c1cc(CO)cc(Nc2nccc(n2)C(F)(F)F)c1 |r,wU:1.1,6.9,wD:1.12,3.8,(-.42,-5.66,;.83,-4.75,;2.07,-3.85,;1.73,-6,;1.11,-7.4,;2.01,-8.65,;3.54,-8.49,;4.17,-7.08,;3.27,-5.84,;4.45,-9.73,;5.98,-9.57,;3.82,-11.14,;-.08,-3.5,;-1.62,-3.5,;-2.09,-2.04,;-.85,-1.13,;.4,-2.04,;-.85,.41,;.49,1.18,;.49,2.72,;1.82,3.49,;3.15,2.72,;-.85,3.49,;-2.18,2.72,;-3.51,3.49,;-3.51,5.03,;-2.18,5.8,;-2.18,7.34,;-3.51,8.11,;-4.85,7.34,;-4.85,5.8,;-6.18,8.11,;-7.51,8.88,;-5.41,9.44,;-6.95,6.77,;-2.18,1.18,)| Show InChI InChI=1S/C24H25F3N4O4S/c1-23(35,16-4-2-14(3-5-16)20(33)34)21-29-11-18(36-21)15-8-13(12-32)9-17(10-15)30-22-28-7-6-19(31-22)24(25,26)27/h6-11,14,16,32,35H,2-5,12H2,1H3,(H,33,34)(H,28,30,31)/t14-,16-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9290490 (2016) BindingDB Entry DOI: 10.7270/Q2Z0370B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212261 (US9290490, Example 18) Show SMILES CC(O)([C@H]1CC[C@@H](CC1)C(O)=O)c1ncc(s1)-c1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)C(F)F |r,wU:6.9,wD:3.2,(4.78,1.69,;3.3,1.29,;4.38,.2,;2.9,2.78,;3.99,3.87,;3.59,5.35,;2.1,5.75,;1.01,4.66,;1.41,3.18,;1.7,7.24,;2.79,8.33,;.21,7.64,;2.21,.2,;.67,.2,;.19,-1.26,;1.44,-2.17,;2.68,-1.26,;1.44,-3.71,;.1,-4.48,;.1,-6.02,;-1.23,-6.79,;-2.56,-6.02,;-3.9,-6.79,;-5.23,-6.02,;-5.23,-4.48,;-3.9,-3.65,;-2.56,-4.48,;-3.9,-2.11,;-3.9,-.57,;-2.36,-2.11,;-5.44,-2.11,;1.44,-6.79,;2.77,-6.02,;2.77,-4.48,;4.1,-6.79,;5.44,-6.02,;4.1,-8.33,)| Show InChI InChI=1S/C24H23F5N4O3S/c1-23(36,15-4-2-12(3-5-15)20(34)35)21-31-11-17(37-21)13-8-14(19(25)26)10-16(9-13)32-22-30-7-6-18(33-22)24(27,28)29/h6-12,15,19,36H,2-5H2,1H3,(H,34,35)(H,30,32,33)/t12-,15-,23?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9290490 (2016) BindingDB Entry DOI: 10.7270/Q2Z0370B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM124614 (US8759366, 4-{1-hydroxy-1-[5-(3-methyl-5-{[4-(trif...) Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O Show InChI InChI=1S/C24H19F3N4O3S/c1-13-9-15(11-17(10-13)30-22-28-8-7-19(31-22)24(25,26)27)18-12-29-21(35-18)23(2,34)16-5-3-14(4-6-16)20(32)33/h3-12,34H,1-2H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...				US Patent US8759366 (2014) BindingDB Entry DOI: 10.7270/Q21N7ZS1
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM124640 (US8759366, (1S,4R)-4-hydroxy-2,2-dimethyl-4-[5-(3-...) Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-14(10-15(9-13)30-21-28-7-5-18(31-21)24(25,26)27)17-11-29-20(35-17)23(34)6-4-16(19(32)33)22(2,3)12-23/h5,7-11,16,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t16-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...				US Patent US8759366 (2014) BindingDB Entry DOI: 10.7270/Q21N7ZS1
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM124651 (US8759366, (1S,2R,4R)-4-hydroxy-2-methyl-4-[5-(3-m...) Show SMILES C[C@@H]1C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1 Show InChI InChI=1S/C23H23F3N4O3S/c1-12-7-14(9-15(8-12)29-21-27-6-4-18(30-21)23(24,25)26)17-11-28-20(34-17)22(33)5-3-16(19(31)32)13(2)10-22/h4,6-9,11,13,16,33H,3,5,10H2,1-2H3,(H,31,32)(H,27,29,30)/t13-,16+,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...				US Patent US8759366 (2014) BindingDB Entry DOI: 10.7270/Q21N7ZS1
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM124659 (US8759366, (1S,4R)-4-{5-[3-({4-[(1S)-1-fluoroethyl...) Show SMILES C[C@H](F)c1ccnc(Nc2cc(C)cc(c2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)n1 Show InChI InChI=1S/C25H29FN4O3S/c1-14-9-16(11-17(10-14)29-23-27-8-6-19(30-23)15(2)26)20-12-28-22(34-20)25(33)7-5-18(21(31)32)24(3,4)13-25/h6,8-12,15,18,33H,5,7,13H2,1-4H3,(H,31,32)(H,27,29,30)/t15-,18+,25+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...				US Patent US8759366 (2014) BindingDB Entry DOI: 10.7270/Q21N7ZS1
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM124660 (US8759366, (1S,4R)-4-{5-[3-({4-[(1R)-1-fluoroethyl...) Show SMILES C[C@@H](F)c1ccnc(Nc2cc(C)cc(c2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)n1 Show InChI InChI=1S/C25H29FN4O3S/c1-14-9-16(11-17(10-14)29-23-27-8-6-19(30-23)15(2)26)20-12-28-22(34-20)25(33)7-5-18(21(31)32)24(3,4)13-25/h6,8-12,15,18,33H,5,7,13H2,1-4H3,(H,31,32)(H,27,29,30)/t15-,18-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...				US Patent US8759366 (2014) BindingDB Entry DOI: 10.7270/Q21N7ZS1
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177763 (US9120785, Example 10 | US9120785, Example 11) Show SMILES Cc1cc(Nc2cc(C)c(F)cn2)nc(c1)-c1cnc(s1)C(C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:27.33,wD:24.26,(4.68,-7.21,;3.34,-6.44,;2.01,-7.21,;.68,-6.44,;-.66,-7.21,;-1.99,-6.44,;-1.99,-4.9,;-3.33,-4.13,;-3.33,-2.59,;-4.66,-4.9,;-5.99,-4.13,;-4.66,-6.44,;-3.33,-7.21,;.68,-4.9,;2.01,-4.13,;3.34,-4.9,;2.01,-2.59,;3.25,-1.68,;2.78,-.22,;1.24,-.22,;.76,-1.68,;.47,1.12,;-.86,1.89,;-.86,.35,;1.24,2.45,;2.73,2.05,;3.82,3.14,;3.42,4.63,;1.93,5.03,;.84,3.94,;4.51,5.72,;5.99,5.32,;4.11,7.21,)| Show InChI InChI=1S/C24H27FN4O3S/c1-13-8-18(28-21(9-13)29-20-10-14(2)17(25)11-26-20)19-12-27-23(33-19)24(3,32)16-6-4-15(5-7-16)22(30)31/h8-12,15-16,32H,4-7H2,1-3H3,(H,30,31)(H,26,28,29)/t15-,16-,24?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177765 (US9120785, Example 14 Step 2) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C(C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:29.35,wD:26.28,(1.87,-4.83,;.54,-4.06,;-.8,-4.83,;-2.13,-4.06,;-3.47,-4.83,;-4.8,-4.06,;-4.8,-2.52,;-6.13,-1.69,;-7.47,-2.52,;-7.47,-4.06,;-6.13,-4.83,;-6.13,-.15,;-6.13,1.39,;-4.59,-.15,;-7.67,-.15,;-2.13,-2.52,;-.8,-1.75,;.54,-2.52,;-.8,-.21,;-2.04,.7,;-1.57,2.16,;-.03,2.16,;.45,.7,;.74,3.49,;-.03,4.83,;1.51,4.83,;2.28,3.49,;3.05,2.16,;4.59,2.16,;5.36,3.49,;4.59,4.83,;3.05,4.83,;6.9,3.49,;7.67,2.16,;7.67,4.83,)| Show InChI InChI=1S/C24H25F3N4O3S/c1-13-9-17(30-20(10-13)31-19-11-16(7-8-28-19)24(25,26)27)18-12-29-22(35-18)23(2,34)15-5-3-14(4-6-15)21(32)33/h7-12,14-15,34H,3-6H2,1-2H3,(H,32,33)(H,28,30,31)/t14-,15-,23?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177767 (US9120785, Example 14-4) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1cnc(s1)C(C)(O)C1CCC(CC1)C(O)=O |(-2.34,-8.32,;-3.67,-7.55,;-5.01,-8.32,;-6.34,-7.55,;-7.67,-8.32,;-9.01,-7.55,;-9.01,-6.01,;-10.34,-5.19,;-11.67,-6.01,;-11.67,-7.55,;-10.34,-8.32,;-10.34,-3.65,;-11.67,-2.88,;-9.01,-2.88,;-6.34,-6.01,;-5.01,-5.24,;-3.67,-6.01,;-5.01,-3.7,;-6.25,-2.8,;-5.78,-1.33,;-4.24,-1.33,;-3.76,-2.8,;-3.47,,;-4.55,1.09,;-2.7,1.33,;-1.93,,;-1.15,-1.33,;.38,-1.33,;1.21,,;.38,1.33,;-1.15,1.33,;2.75,0,;3.52,-1.33,;3.52,1.33,)| Show InChI InChI=1S/C24H26F2N4O3S/c1-13-9-17(29-20(10-13)30-19-11-15(21(25)26)7-8-27-19)18-12-28-23(34-18)24(2,33)16-5-3-14(4-6-16)22(31)32/h7-12,14,16,21,33H,3-6H2,1-2H3,(H,31,32)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177768 (US9120785, Example 14-14) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C(C)(O)C1CCC(C1)C(O)=O Show InChI InChI=1S/C23H23F3N4O3S/c1-12-7-16(29-19(8-12)30-18-10-15(5-6-27-18)23(24,25)26)17-11-28-21(34-17)22(2,33)14-4-3-13(9-14)20(31)32/h5-8,10-11,13-14,33H,3-4,9H2,1-2H3,(H,31,32)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177769 (US9120785, Example 14-15) Show SMILES CCC(O)(C1CCC(CC1)C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1 |(-6.13,,;-4.8,.77,;-3.47,,;-2.7,1.33,;-1.93,,;-1.15,-1.33,;.38,-1.33,;1.21,,;.38,1.33,;-1.15,1.33,;2.75,0,;3.52,-1.33,;3.52,1.33,;-4.24,-1.33,;-5.78,-1.33,;-6.25,-2.8,;-5.01,-3.7,;-3.76,-2.8,;-5.01,-5.24,;-3.67,-6.01,;-3.67,-7.55,;-2.34,-8.32,;-5.01,-8.32,;-6.34,-7.55,;-7.67,-8.32,;-9.01,-7.55,;-9.01,-6.01,;-10.34,-5.19,;-11.67,-6.01,;-11.67,-7.55,;-10.34,-8.32,;-10.34,-3.65,;-11.67,-2.88,;-10.34,-2.11,;-9.01,-2.88,;-6.34,-6.01,)| Show InChI InChI=1S/C25H27F3N4O3S/c1-3-24(35,16-6-4-15(5-7-16)22(33)34)23-30-13-19(36-23)18-10-14(2)11-21(31-18)32-20-12-17(8-9-29-20)25(26,27)28/h8-13,15-16,35H,3-7H2,1-2H3,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212267 (US9290490, Example 1 (faster eluting isomer)) Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@](C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |wU:23.27,26.28,wD:29.35,23.25,(-.18,14.64,;1.16,13.87,;2.49,14.64,;3.82,13.87,;5.16,14.64,;5.16,16.18,;3.82,16.95,;3.82,18.49,;5.16,19.26,;6.49,18.49,;6.49,16.95,;7.82,19.26,;9.16,20.03,;8.59,17.93,;7.05,20.6,;3.82,12.33,;2.49,11.56,;1.16,12.33,;2.49,10.02,;1.24,9.12,;1.72,7.65,;3.26,7.65,;3.73,9.12,;4.16,6.41,;5.41,7.31,;2.92,5.5,;5.07,5.16,;6.6,5.32,;7.51,4.08,;6.88,2.67,;5.35,2.51,;4.44,3.75,;7.78,1.42,;9.32,1.58,;7.16,.02,)| Show InChI InChI=1S/C24H25F3N4O3S/c1-13-9-15(11-17(10-13)30-22-28-8-7-19(31-22)24(25,26)27)18-12-29-21(35-18)23(2,34)16-5-3-14(4-6-16)20(32)33/h7-12,14,16,34H,3-6H2,1-2H3,(H,32,33)(H,28,30,31)/t14-,16-,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9290490 (2016) BindingDB Entry DOI: 10.7270/Q2Z0370B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212229 (US9290490, 1-18) Show SMILES CC(O)(C1CCC(CC1)C(O)=O)c1ncc(s1)-c1cccc(Nc2ncc(F)c(n2)C2CC2)c1 |(.12,1.44,;.89,.11,;1.66,1.44,;2.43,.11,;3.2,-1.22,;4.74,-1.22,;5.57,.11,;4.74,1.44,;3.2,1.44,;7.11,.11,;7.88,1.44,;7.88,-1.22,;.12,-1.22,;-1.42,-1.22,;-1.9,-2.69,;-.65,-3.59,;.6,-2.69,;-.65,-5.13,;.68,-5.9,;.68,-7.44,;-.65,-8.21,;-1.98,-7.44,;-3.32,-8.21,;-4.65,-7.44,;-5.98,-8.21,;-7.32,-7.44,;-7.32,-5.9,;-8.81,-5.5,;-5.98,-5.13,;-4.65,-5.9,;-5.98,-3.59,;-7.32,-2.82,;-5.23,-2.82,;-1.98,-5.9,)| Show InChI InChI=1S/C25H27FN4O3S/c1-25(33,17-9-7-15(8-10-17)22(31)32)23-27-13-20(34-23)16-3-2-4-18(11-16)29-24-28-12-19(26)21(30-24)14-5-6-14/h2-4,11-15,17,33H,5-10H2,1H3,(H,31,32)(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9290490 (2016) BindingDB Entry DOI: 10.7270/Q2Z0370B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302034 (BDBM302035 | US9598405, 4.1) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2(CCCCC2)C1C(O)=O Show InChI InChI=1S/C25H25F3N4O3S/c1-14-9-16(31-19(10-14)32-18-11-15(5-8-29-18)25(26,27)28)17-12-30-22(36-17)24(35)13-23(20(24)21(33)34)6-3-2-4-7-23/h5,8-12,20,35H,2-4,6-7,13H2,1H3,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.508	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301997 (US9598405, 1.5 | US9598405, 1.6) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H24F3N5O3S/c1-21(2)11-22(34,5-3-14(21)19(32)33)20-29-10-16(35-20)15-8-13(27)9-18(30-15)31-17-7-12(4-6-28-17)23(24,25)26/h4,6-10,14,34H,3,5,11H2,1-2H3,(H,32,33)(H3,27,28,30,31)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.516	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302018 (US9598405, 3.3 | US9598405, 3.7) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H23F3N4O3S/c1-21(2)12-22(33,8-6-14(21)19(31)32)20-28-11-16(34-20)15-4-3-5-17(29-15)30-18-10-13(7-9-27-18)23(24,25)26/h3-5,7,9-11,14,33H,6,8,12H2,1-2H3,(H,31,32)(H,27,29,30)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.574	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302043 (US9598405, 5.2) Show SMILES C[C@H]1C[C@@](O)(CC[C@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(C)c(F)cn2)n1 Show InChI InChI=1S/C23H25FN4O3S/c1-12-6-17(27-20(7-12)28-19-8-13(2)16(24)10-25-19)18-11-26-22(32-18)23(31)5-4-15(21(29)30)14(3)9-23/h6-8,10-11,14-15,31H,4-5,9H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,15+,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301993 (BDBM301994 | US9598405, 1.1) Show SMILES Cc1cc(Nc2cc(ccn2)C2CC2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C26H30N4O3S/c1-15-10-19(29-22(11-15)30-21-12-17(7-9-27-21)16-4-5-16)20-13-28-24(34-20)26(33)8-6-18(23(31)32)25(2,3)14-26/h7,9-13,16,18,33H,4-6,8,14H2,1-3H3,(H,31,32)(H,27,29,30)/t18-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.581	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302027 (US9598405, 3.12) Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C23H26N4O3S/c1-14-8-10-24-19(11-14)27-18-6-4-5-16(26-18)17-12-25-21(31-17)23(30)9-7-15(20(28)29)22(2,3)13-23/h4-6,8,10-12,15,30H,7,9,13H2,1-3H3,(H,28,29)(H,24,26,27)/t15-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50590229 (CHEMBL5197547) Show SMILES CC(C)(O)[C@@H]1CCN(C1)c1cnc(c(NC(=O)c2cccc(n2)-c2cnn(CC(F)(F)F)c2)c1)C(F)(F)F |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00097g BindingDB Entry DOI: 10.7270/Q2WH2TZ3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302020 (US9598405, 3.5 | US9598405, 3.9) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(Cl)ccn2)n1 Show InChI InChI=1S/C22H23ClN4O3S/c1-21(2)12-22(30,8-6-14(21)19(28)29)20-25-11-16(31-20)15-4-3-5-17(26-15)27-18-10-13(23)7-9-24-18/h3-5,7,9-11,14,30H,6,8,12H2,1-2H3,(H,28,29)(H,24,26,27)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.733	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302019 (BDBM302023 | US9598405, 3.4) Show SMILES Cc1cc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)ncc1F Show InChI InChI=1S/C23H25FN4O3S/c1-13-9-19(25-10-15(13)24)28-18-6-4-5-16(27-18)17-11-26-21(32-17)23(31)8-7-14(20(29)30)22(2,3)12-23/h4-6,9-11,14,31H,7-8,12H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.784	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302005 (US9598405, 2.4) Show SMILES Cc1cc(Nc2cc(ccn2)-c2cn(C)nn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O Show InChI InChI=1S/C24H25N7O3S/c1-14-9-17(19-12-26-23(35-19)24(34)6-3-15(4-7-24)22(32)33)27-21(10-14)28-20-11-16(5-8-25-20)18-13-31(2)30-29-18/h5,8-13,15,34H,3-4,6-7H2,1-2H3,(H,32,33)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.808	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair

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