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Compile Data Set for Download or QSAR

Found 153 hits with Last Name = 'verzal' and Initial = 'mk'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152472
PNG
(CHEMBL182261 | N-[3-(2-Amino-quinolin-8-yloxy)-pro...)
Show SMILES Nc1ccc2cccc(OCCCNC(=O)c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C19H18ClN3O2/c20-15-6-1-5-14(12-15)19(24)22-10-3-11-25-16-7-2-4-13-8-9-17(21)23-18(13)16/h1-2,4-9,12H,3,10-11H2,(H2,21,23)(H,22,24)
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n/an/a 0.400n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152479
PNG
(1-[3-(2-Amino-quinolin-8-yloxy)-propyl]-3-(3-chlor...)
Show SMILES Nc1ccc2cccc(OCCCNC(=O)Nc3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C19H19ClN4O2/c20-14-5-2-6-15(12-14)23-19(25)22-10-3-11-26-16-7-1-4-13-8-9-17(21)24-18(13)16/h1-2,4-9,12H,3,10-11H2,(H2,21,24)(H2,22,23,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152486
PNG
(3-Chloro-N-[3-(2-{[5-(2-chloro-phenyl)-furan-2-ylm...)
Show SMILES Clc1cccc(c1)C(=O)NCCCOc1cccc2ccc(NCc3ccc(o3)-c3ccccc3Cl)nc12
Show InChI InChI=1S/C30H25Cl2N3O3/c31-22-8-3-7-21(18-22)30(36)33-16-5-17-37-27-11-4-6-20-12-15-28(35-29(20)27)34-19-23-13-14-26(38-23)24-9-1-2-10-25(24)32/h1-4,6-15,18H,5,16-17,19H2,(H,33,36)(H,34,35)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152481
PNG
(8-[2-(3-Methoxy-benzylamino)-1-methyl-ethoxy]-quin...)
Show SMILES COc1cccc(CNCC(C)Oc2cccc3ccc(N)nc23)c1
Show InChI InChI=1S/C20H23N3O2/c1-14(12-22-13-15-5-3-7-17(11-15)24-2)25-18-8-4-6-16-9-10-19(21)23-20(16)18/h3-11,14,22H,12-13H2,1-2H3,(H2,21,23)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152463
PNG
(8-[3-(2,2-Difluoro-benzo[1,3]dioxol-5-ylamino)-pro...)
Show SMILES Nc1ccc2cccc(OCCCNc3ccc4OC(F)(F)Oc4c3)c2n1
Show InChI InChI=1S/C19H17F2N3O3/c20-19(21)26-14-7-6-13(11-16(14)27-19)23-9-2-10-25-15-4-1-3-12-5-8-17(22)24-18(12)15/h1,3-8,11,23H,2,9-10H2,(H2,22,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152469
PNG
(CHEMBL182575 | N-[3-(2-{[5-(4-Chloro-phenyl)-furan...)
Show SMILES Clc1ccc(cc1)-c1ccc(CNc2ccc3cccc(OCCCNC(=O)c4cccc(c4)C#N)c3n2)o1
Show InChI InChI=1S/C31H25ClN4O3/c32-25-11-8-22(9-12-25)27-14-13-26(39-27)20-35-29-15-10-23-5-2-7-28(30(23)36-29)38-17-3-16-34-31(37)24-6-1-4-21(18-24)19-33/h1-2,4-15,18H,3,16-17,20H2,(H,34,37)(H,35,36)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152480
PNG
(CHEMBL184243 | N-[3-(2-Amino-quinolin-8-yloxy)-pro...)
Show SMILES COc1cccc(c1)C(=O)NCCCOc1cccc2ccc(N)nc12
Show InChI InChI=1S/C20H21N3O3/c1-25-16-7-2-6-15(13-16)20(24)22-11-4-12-26-17-8-3-5-14-9-10-18(21)23-19(14)17/h2-3,5-10,13H,4,11-12H2,1H3,(H2,21,23)(H,22,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152478
PNG
(CHEMBL184581 | N-[3-(2-Amino-quinolin-8-yloxy)-pro...)
Show SMILES Nc1ccc2cccc(OCCCNC(=O)c3cccc(c3)C#N)c2n1
Show InChI InChI=1S/C20H18N4O2/c21-13-14-4-1-6-16(12-14)20(25)23-10-3-11-26-17-7-2-5-15-8-9-18(22)24-19(15)17/h1-2,4-9,12H,3,10-11H2,(H2,22,24)(H,23,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Mus musculus)		BDBM50168509
PNG
(CHEMBL188937 | N-(1-Benzo[1,3]dioxol-5-ylmethyl-pi...)
Show SMILES COc1cc(cc(OC)c1C)C(=O)NC1CCCN(Cc2ccc3OCOc3c2)C1
Show InChI InChI=1S/C23H28N2O5/c1-15-20(27-2)10-17(11-21(15)28-3)23(26)24-18-5-4-8-25(13-18)12-16-6-7-19-22(9-16)30-14-29-19/h6-7,9-11,18H,4-5,8,12-14H2,1-3H3,(H,24,26)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration required for binding affinity against mouse MCHr1 competing human neuronal IMR32 cells receptor in a radiometric binding ass...

Bioorg Med Chem Lett 15: 3412-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.023
BindingDB Entry DOI: 10.7270/Q26D5SHR
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152456
PNG
((S)-3-{3-[4-(3-Acetylamino-phenyl)-piperidin-1-yl]...)
Show SMILES COCC1=C([C@@H](N(C(=O)NCCCN2CCC(CC2)c2cccc(NC(C)=O)c2)C(=O)N1)c1ccc(F)c(F)c1)C(=O)OC |t:3|
Show InChI InChI=1S/C31H37F2N5O6/c1-19(39)35-23-7-4-6-21(16-23)20-10-14-37(15-11-20)13-5-12-34-30(41)38-28(22-8-9-24(32)25(33)17-22)27(29(40)44-3)26(18-43-2)36-31(38)42/h4,6-9,16-17,20,28H,5,10-15,18H2,1-3H3,(H,34,41)(H,35,39)(H,36,42)/t28-/m0/s1
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174908
PNG
(CHEMBL427367 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)
Show SMILES [O-][N+](=O)c1ccc2n(Cc3ccccc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C27H27N5O4/c33-32(34)22-7-8-24-23(15-22)27(29-31(24)17-19-4-2-1-3-5-19)28-21-10-12-30(13-11-21)16-20-6-9-25-26(14-20)36-18-35-25/h1-9,14-15,21H,10-13,16-18H2,(H,28,29)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152471
PNG
(CHEMBL363464 | N-[3-(2-{[5-(3-Chloro-phenyl)-furan...)
Show SMILES Clc1cccc(c1)-c1ccc(CNc2ccc3cccc(OCCCNC(=O)c4cccc(c4)C#N)c3n2)o1
Show InChI InChI=1S/C31H25ClN4O3/c32-25-9-2-7-23(18-25)27-13-12-26(39-27)20-35-29-14-11-22-6-3-10-28(30(22)36-29)38-16-4-15-34-31(37)24-8-1-5-21(17-24)19-33/h1-3,5-14,17-18H,4,15-16,20H2,(H,34,37)(H,35,36)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152458
PNG
(1-[3-(2-Amino-quinolin-8-yloxy)-propyl]-3-benzo[1,...)
Show SMILES Nc1ccc2cccc(OCCCNC(=O)Nc3ccc4OCOc4c3)c2n1
Show InChI InChI=1S/C20H20N4O4/c21-18-8-5-13-3-1-4-16(19(13)24-18)26-10-2-9-22-20(25)23-14-6-7-15-17(11-14)28-12-27-15/h1,3-8,11H,2,9-10,12H2,(H2,21,24)(H2,22,23,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152455
PNG
(8-[3-(4-Chloro-3-trifluoromethyl-benzylamino)-prop...)
Show SMILES Nc1ccc2cccc(OCCCNCc3ccc(Cl)c(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C20H19ClF3N3O/c21-16-7-5-13(11-15(16)20(22,23)24)12-26-9-2-10-28-17-4-1-3-14-6-8-18(25)27-19(14)17/h1,3-8,11,26H,2,9-10,12H2,(H2,25,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152470
PNG
(CHEMBL364210 | N-[3-(2-Amino-quinolin-8-yloxy)-pro...)
Show SMILES Nc1ccc2cccc(OCCCNC(=O)c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C20H18F3N3O3/c21-20(22,23)29-15-6-1-5-14(12-15)19(27)25-10-3-11-28-16-7-2-4-13-8-9-17(24)26-18(13)16/h1-2,4-9,12H,3,10-11H2,(H2,24,26)(H,25,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174921
PNG
(CHEMBL196973 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)
Show SMILES [O-][N+](=O)c1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C20H21N5O4/c26-25(27)15-2-3-17-16(10-15)20(23-22-17)21-14-5-7-24(8-6-14)11-13-1-4-18-19(9-13)29-12-28-18/h1-4,9-10,14H,5-8,11-12H2,(H2,21,22,23)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5893
PNG
(3-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]-1...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C22H16F3N3O2/c23-22(24,25)14-3-1-4-16(11-14)28-21(30)27-15-9-7-13(8-10-15)17-5-2-6-18-19(17)12-26-20(18)29/h1-11H,12H2,(H,26,29)(H2,27,28,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR in presence of 1 mM ATP

Bioorg Med Chem Lett 22: 4502-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.009
BindingDB Entry DOI: 10.7270/Q2K35VQK
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152454
PNG
(Benzo[1,3]dioxole-5-carboxylic acid [3-(2-amino-qu...)
Show SMILES Nc1ccc2cccc(OCCCNC(=O)c3ccc4OCOc4c3)c2n1
Show InChI InChI=1S/C20H19N3O4/c21-18-8-6-13-3-1-4-16(19(13)23-18)25-10-2-9-22-20(24)14-5-7-15-17(11-14)27-12-26-15/h1,3-8,11H,2,9-10,12H2,(H2,21,23)(H,22,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174920
PNG
(CHEMBL199025 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)
Show SMILES Clc1ccc2n(Cc3ccncc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C26H26ClN5O2/c27-20-2-3-23-22(14-20)26(30-32(23)16-18-5-9-28-10-6-18)29-21-7-11-31(12-8-21)15-19-1-4-24-25(13-19)34-17-33-24/h1-6,9-10,13-14,21H,7-8,11-12,15-17H2,(H,29,30)
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n/an/a 7n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174919
PNG
(CHEMBL371222 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)
Show SMILES COc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C21H24N4O3/c1-26-16-3-4-18-17(11-16)21(24-23-18)22-15-6-8-25(9-7-15)12-14-2-5-19-20(10-14)28-13-27-19/h2-5,10-11,15H,6-9,12-13H2,1H3,(H2,22,23,24)
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n/an/a 8n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174913
PNG
(CHEMBL197232 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)
Show SMILES Clc1ccc2n(Cc3ccccn3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C26H26ClN5O2/c27-19-5-6-23-22(14-19)26(30-32(23)16-21-3-1-2-10-28-21)29-20-8-11-31(12-9-20)15-18-4-7-24-25(13-18)34-17-33-24/h1-7,10,13-14,20H,8-9,11-12,15-17H2,(H,29,30)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50207480
PNG
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-(triflu...)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)13-3-1-4-15(11-13)27-20(30)26-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(25)29-28-17/h1-11H,(H3,25,28,29)(H2,26,27,30)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR in presence of 1 mM ATP

Bioorg Med Chem Lett 22: 4502-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.009
BindingDB Entry DOI: 10.7270/Q2K35VQK
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Mus musculus)		BDBM50168517
PNG
(CHEMBL187916 | N-(1-Benzo[1,3]dioxol-5-ylmethyl-pi...)
Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCCN(Cc2ccc3OCOc3c2)C1
Show InChI InChI=1S/C22H26N2O5/c1-26-18-9-16(10-19(11-18)27-2)22(25)23-17-4-3-7-24(13-17)12-15-5-6-20-21(8-15)29-14-28-20/h5-6,8-11,17H,3-4,7,12-14H2,1-2H3,(H,23,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration required for binding affinity against mouse MCHr1 competing human neuronal IMR32 cells receptor in a radiometric binding ass...

Bioorg Med Chem Lett 15: 3412-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.023
BindingDB Entry DOI: 10.7270/Q26D5SHR
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152487
PNG
(3-Chloro-N-[3-(2-propylamino-quinolin-8-yloxy)-pro...)
Show SMILES CCCNc1ccc2cccc(OCCCNC(=O)c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C22H24ClN3O2/c1-2-12-24-20-11-10-16-6-4-9-19(21(16)26-20)28-14-5-13-25-22(27)17-7-3-8-18(23)15-17/h3-4,6-11,15H,2,5,12-14H2,1H3,(H,24,26)(H,25,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152465
PNG
(8-{2-[(Furan-3-ylmethyl)-amino]-1-methyl-ethoxy}-q...)
Show SMILES CC(CNCc1ccoc1)Oc1cccc2ccc(N)nc12
Show InChI InChI=1S/C17H19N3O2/c1-12(9-19-10-13-7-8-21-11-13)22-15-4-2-3-14-5-6-16(18)20-17(14)15/h2-8,11-12,19H,9-10H2,1H3,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152475
PNG
(8-[3-(4-Isopropyl-benzylamino)-propoxy]-quinolin-2...)
Show SMILES CC(C)c1ccc(CNCCCOc2cccc3ccc(N)nc23)cc1
Show InChI InChI=1S/C22H27N3O/c1-16(2)18-9-7-17(8-10-18)15-24-13-4-14-26-20-6-3-5-19-11-12-21(23)25-22(19)20/h3,5-12,16,24H,4,13-15H2,1-2H3,(H2,23,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152474
PNG
(8-[3-(Benzo[1,3]dioxol-5-ylamino)-propoxy]-quinoli...)
Show SMILES Nc1ccc2cccc(OCCCNc3ccc4OCOc4c3)c2n1
Show InChI InChI=1S/C19H19N3O3/c20-18-8-5-13-3-1-4-16(19(13)22-18)23-10-2-9-21-14-6-7-15-17(11-14)25-12-24-15/h1,3-8,11,21H,2,9-10,12H2,(H2,20,22)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152467
PNG
(8-{1-Methyl-2-[(thiophen-3-ylmethyl)-amino]-ethoxy...)
Show SMILES CC(CNCc1ccsc1)Oc1cccc2ccc(N)nc12
Show InChI InChI=1S/C17H19N3OS/c1-12(9-19-10-13-7-8-22-11-13)21-15-4-2-3-14-5-6-16(18)20-17(14)15/h2-8,11-12,19H,9-10H2,1H3,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50387359
PNG
(CHEMBL2046840)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH][nH]c(=O)c23)c1
Show InChI InChI=1S/C21H15F3N4O2/c22-21(23,24)13-3-1-4-15(11-13)26-20(30)25-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(29)28-27-17/h1-11H,(H2,25,26,30)(H2,27,28,29)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR in presence of 1 mM ATP

Bioorg Med Chem Lett 22: 4502-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.009
BindingDB Entry DOI: 10.7270/Q2K35VQK
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174911
PNG
(1-(3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-...)
Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)CN1CCOCC1
Show InChI InChI=1S/C26H30ClN5O4/c27-19-2-3-22-21(14-19)26(29-32(22)25(33)16-31-9-11-34-12-10-31)28-20-5-7-30(8-6-20)15-18-1-4-23-24(13-18)36-17-35-23/h1-4,13-14,20H,5-12,15-17H2,(H,28,29)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174899
PNG
((3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-...)
Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)c1cscn1
Show InChI InChI=1S/C24H22ClN5O3S/c25-16-2-3-20-18(10-16)23(28-30(20)24(31)19-12-34-13-26-19)27-17-5-7-29(8-6-17)11-15-1-4-21-22(9-15)33-14-32-21/h1-4,9-10,12-13,17H,5-8,11,14H2,(H,27,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174895
PNG
((1-benzo{1,3}dioxol-5-ylmethyl-piperidin-4-yl)(5-c...)
Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C20H21ClN4O2/c21-14-2-3-17-16(10-14)20(24-23-17)22-15-5-7-25(8-6-15)11-13-1-4-18-19(9-13)27-12-26-18/h1-4,9-10,15H,5-8,11-12H2,(H2,22,23,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174893
PNG
(CHEMBL197497 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)
Show SMILES Clc1ccc2n(Cc3cccnc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C26H26ClN5O2/c27-20-4-5-23-22(13-20)26(30-32(23)16-19-2-1-9-28-14-19)29-21-7-10-31(11-8-21)15-18-3-6-24-25(12-18)34-17-33-24/h1-6,9,12-14,21H,7-8,10-11,15-17H2,(H,29,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174906
PNG
((3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-...)
Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)c1cccnc1
Show InChI InChI=1S/C26H24ClN5O3/c27-19-4-5-22-21(13-19)25(30-32(22)26(33)18-2-1-9-28-14-18)29-20-7-10-31(11-8-20)15-17-3-6-23-24(12-17)35-16-34-23/h1-6,9,12-14,20H,7-8,10-11,15-16H2,(H,29,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174916
PNG
(5-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)
Show SMILES Clc1ccc2n(Cc3ccccn3)nc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1
Show InChI InChI=1S/C29H28ClN5/c30-24-10-11-28-27(18-24)29(33-35(28)20-26-7-3-4-14-31-26)32-25-12-15-34(16-13-25)19-21-8-9-22-5-1-2-6-23(22)17-21/h1-11,14,17-18,25H,12-13,15-16,19-20H2,(H,32,33)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152425
PNG
(8-(1,3,3-Trimethyl-butoxy)-quinolin-2-ylamine | CH...)
Show SMILES CC(CC(C)(C)C)Oc1cccc2ccc(N)nc12
Show InChI InChI=1S/C16H22N2O/c1-11(10-16(2,3)4)19-13-7-5-6-12-8-9-14(17)18-15(12)13/h5-9,11H,10H2,1-4H3,(H2,17,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152425
PNG
(8-(1,3,3-Trimethyl-butoxy)-quinolin-2-ylamine | CH...)
Show SMILES CC(CC(C)(C)C)Oc1cccc2ccc(N)nc12
Show InChI InChI=1S/C16H22N2O/c1-11(10-16(2,3)4)19-13-7-5-6-12-8-9-14(17)18-15(12)13/h5-9,11H,10H2,1-4H3,(H2,17,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Mus musculus)		BDBM50168519
PNG
(CHEMBL186825 | N-(1-Benzo[1,3]dioxol-5-ylmethyl-pi...)
Show SMILES COc1cccc(c1)-c1ccc(CC(=O)NC2CCN(Cc3ccc4OCOc4c3)CC2)cc1
Show InChI InChI=1S/C28H30N2O4/c1-32-25-4-2-3-23(17-25)22-8-5-20(6-9-22)16-28(31)29-24-11-13-30(14-12-24)18-21-7-10-26-27(15-21)34-19-33-26/h2-10,15,17,24H,11-14,16,18-19H2,1H3,(H,29,31)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration required for binding affinity against mouse MCHr1 competing human neuronal IMR32 cells receptor in a radiometric binding ass...

Bioorg Med Chem Lett 15: 3412-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.023
BindingDB Entry DOI: 10.7270/Q26D5SHR
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152460
PNG
(8-(2-Cyclopentylamino-1-methyl-ethoxy)-quinolin-2-...)
Show SMILES CC(CNC1CCCC1)Oc1cccc2ccc(N)nc12
Show InChI InChI=1S/C17H23N3O/c1-12(11-19-14-6-2-3-7-14)21-15-8-4-5-13-9-10-16(18)20-17(13)15/h4-5,8-10,12,14,19H,2-3,6-7,11H2,1H3,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152477
PNG
(8-{2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-1-methy...)
Show SMILES CC(CNCc1ccc2OCOc2c1)Oc1cccc2ccc(N)nc12
Show InChI InChI=1S/C20H21N3O3/c1-13(10-22-11-14-5-7-16-18(9-14)25-12-24-16)26-17-4-2-3-15-6-8-19(21)23-20(15)17/h2-9,13,22H,10-12H2,1H3,(H2,21,23)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Mus musculus)		BDBM50168536
PNG
(CHEMBL189496 | N-(1-Benzo[1,3]dioxol-5-ylmethyl-pi...)
Show SMILES Clc1cc(Cl)cc(c1)C(=O)NC1CCCN(Cc2ccc3OCOc3c2)C1
Show InChI InChI=1S/C20H20Cl2N2O3/c21-15-7-14(8-16(22)9-15)20(25)23-17-2-1-5-24(11-17)10-13-3-4-18-19(6-13)27-12-26-18/h3-4,6-9,17H,1-2,5,10-12H2,(H,23,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration required for binding affinity against mouse MCHr1 competing human neuronal IMR32 cells receptor in a radiometric binding ass...

Bioorg Med Chem Lett 15: 3412-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.023
BindingDB Entry DOI: 10.7270/Q26D5SHR
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174915
PNG
(CHEMBL199222 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)
Show SMILES COc1ccc2n(C)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C22H26N4O3/c1-25-19-5-4-17(27-2)12-18(19)22(24-25)23-16-7-9-26(10-8-16)13-15-3-6-20-21(11-15)29-14-28-20/h3-6,11-12,16H,7-10,13-14H2,1-2H3,(H,23,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174892
PNG
(CHEMBL381013 | N-(1-((2,3-dihydrobenzo[b][1,4]diox...)
Show SMILES [O-][N+](=O)c1ccc2[nH]nc(NC3CCN(Cc4ccc5OCCOc5c4)CC3)c2c1
Show InChI InChI=1S/C21H23N5O4/c27-26(28)16-2-3-18-17(12-16)21(24-23-18)22-15-5-7-25(8-6-15)13-14-1-4-19-20(11-14)30-10-9-29-19/h1-4,11-12,15H,5-10,13H2,(H2,22,23,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174897
PNG
(CHEMBL370576 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)
Show SMILES Clc1ccc2n(Cc3ccccc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1
Show InChI InChI=1S/C27H27ClN4O2/c28-21-7-8-24-23(15-21)27(30-32(24)17-19-4-2-1-3-5-19)29-22-10-12-31(13-11-22)16-20-6-9-25-26(14-20)34-18-33-25/h1-9,14-15,22H,10-13,16-18H2,(H,29,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50387358
PNG
(CHEMBL2046839)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3c2[nH][nH]c3=O)c1
Show InChI InChI=1S/C21H15F3N4O2/c22-21(23,24)13-3-1-4-15(11-13)26-20(30)25-14-9-7-12(8-10-14)16-5-2-6-17-18(16)27-28-19(17)29/h1-11H,(H2,25,26,30)(H2,27,28,29)
PDB
MMDB

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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR in presence of 1 mM ATP

Bioorg Med Chem Lett 22: 4502-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.009
BindingDB Entry DOI: 10.7270/Q2K35VQK
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174904
PNG
((3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-...)
Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)C1CC1
Show InChI InChI=1S/C24H25ClN4O3/c25-17-4-5-20-19(12-17)23(27-29(20)24(30)16-2-3-16)26-18-7-9-28(10-8-18)13-15-1-6-21-22(11-15)32-14-31-21/h1,4-6,11-12,16,18H,2-3,7-10,13-14H2,(H,26,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50174901
PNG
(5-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)
Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1
Show InChI InChI=1S/C23H23ClN4/c24-19-7-8-22-21(14-19)23(27-26-22)25-20-9-11-28(12-10-20)15-16-5-6-17-3-1-2-4-18(17)13-16/h1-8,13-14,20H,9-12,15H2,(H2,25,26,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells

Bioorg Med Chem Lett 15: 5293-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152473
PNG
(8-(1-Methyl-2-piperidin-1-yl-ethoxy)-quinolin-2-yl...)
Show SMILES CC(CN1CCCCC1)Oc1cccc2ccc(N)nc12
Show InChI InChI=1S/C17H23N3O/c1-13(12-20-10-3-2-4-11-20)21-15-7-5-6-14-8-9-16(18)19-17(14)15/h5-9,13H,2-4,10-12H2,1H3,(H2,18,19)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152476
PNG
(1-Benzo[1,3]dioxol-5-yl-3-[3-(2-{[5-(2-chloro-phen...)
Show SMILES Clc1ccccc1-c1ccc(CNc2ccc3cccc(OCCCNC(=O)Nc4ccc5OCOc5c4)c3n2)o1
Show InChI InChI=1S/C31H27ClN4O5/c32-24-7-2-1-6-23(24)25-13-11-22(41-25)18-34-29-14-9-20-5-3-8-27(30(20)36-29)38-16-4-15-33-31(37)35-21-10-12-26-28(17-21)40-19-39-26/h1-3,5-14,17H,4,15-16,18-19H2,(H,34,36)(H2,33,35,37)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50152483
PNG
(8-(2-Cyclopropylamino-1-methyl-ethoxy)-quinolin-2-...)
Show SMILES CC(CNC1CC1)Oc1cccc2ccc(N)nc12
Show InChI InChI=1S/C15H19N3O/c1-10(9-17-12-6-7-12)19-13-4-2-3-11-5-8-14(16)18-15(11)13/h2-5,8,10,12,17H,6-7,9H2,1H3,(H2,16,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes

Bioorg Med Chem Lett 14: 4879-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61
More data for this
Ligand-Target Pair
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