Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258546![]() (CHEMBL4087727) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Non-competitive inhibition of recombinant human N-terminal GST-tagged WNK1 (1 to 491 residues) expressed in baculovirus expression system using fluor... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [166-489] (Homo sapiens (Human)) | BDBM203827![]() (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258566![]() (CHEMBL4088706) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of recombinant human N-terminal GST-tagged WNK1 catalytic domain (1 to 491 residues) expressed in baculovirus expression system... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-491] (Homo sapiens (Human)) | BDBM203827![]() (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-434] (Homo sapiens (Human)) | BDBM203827![]() (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258547![]() (CHEMBL4098876) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-444] (Homo sapiens (Human)) | BDBM203827![]() (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258598![]() (CHEMBL4091128) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase WNK1 [1-491] (Homo sapiens (Human)) | BDBM203827![]() (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | 7.3 | 4 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK2 [166-489] (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258595![]() (CHEMBL4065531) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-491] (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 64 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258581![]() (CHEMBL4070177) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258567![]() (CHEMBL4060478) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-491] (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258546![]() (CHEMBL4087727) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 162 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-491] (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase WNK4 [1-444] (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 187 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK3 [1-434] (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 377 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258599![]() (CHEMBL4070968) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 623 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258568![]() (CHEMBL4083340) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase WNK1 [1-491] (Homo sapiens (Human)) | BDBM203826![]() ((R)-1-(1-(2-(4-methoxyphenyl)acetyl)pyrrolidin-3-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 856 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258597![]() (CHEMBL4061509) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 971 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258596![]() (CHEMBL4091817) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [198-401] (Homo sapiens (Human)) | BDBM49829![]() ((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 ... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [198-401] (Homo sapiens (Human)) | BDBM49829![]() ((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 ... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [198-401] (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 ... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [198-401] (Homo sapiens (Human)) | BDBM207990![]() ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. | Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 ... | ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258547![]() (CHEMBL4098876) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 589 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258581![]() (CHEMBL4070177) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.39E+3 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258566![]() (CHEMBL4088706) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 352 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair |