Compile Data Set for Download or QSAR

Found 264 hits with Last Name = 'nabakka' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193944 (US9199981, F35) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(COC2CC(F)(F)C2(F)F)n1 Show InChI InChI=1S/C22H17F4N5O3/c1-12-5-6-13(8-14(12)28-20(32)15-10-27-17-4-2-3-7-31(15)17)19-29-18(34-30-19)11-33-16-9-21(23,24)22(16,25)26/h2-8,10,16H,9,11H2,1H3,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50224043 (CHEMBL36229) Show SMILES COCCN1C(=O)C(CC(=O)NO)Sc2ccccc12 Show InChI InChI=1S/C13H16N2O4S/c1-19-7-6-15-9-4-2-3-5-10(9)20-11(13(15)17)8-12(16)14-18/h2-5,11,18H,6-8H2,1H3,(H,14,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50141373 (CHEMBL37719 | N-Hydroxy-2-(3-oxo-3,4-dihydro-2H-be...) Show SMILES ONC(=O)CC1Sc2ccccc2NC1=O Show InChI InChI=1S/C10H10N2O3S/c13-9(12-15)5-8-10(14)11-6-3-1-2-4-7(6)16-8/h1-4,8,15H,5H2,(H,11,14)(H,12,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50224039 (CHEMBL36605) Show SMILES ONC(=O)CC1Sc2ccccc2N(CCc2ccccc2)C1=O Show InChI InChI=1S/C18H18N2O3S/c21-17(19-23)12-16-18(22)20(11-10-13-6-2-1-3-7-13)14-8-4-5-9-15(14)24-16/h1-9,16,23H,10-12H2,(H,19,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50224042 (CHEMBL36140) Show SMILES CC(C)CCN1C(=O)C(CC(=O)NO)Sc2ccccc12 Show InChI InChI=1S/C15H20N2O3S/c1-10(2)7-8-17-11-5-3-4-6-12(11)21-13(15(17)19)9-14(18)16-20/h3-6,10,13,20H,7-9H2,1-2H3,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50224038 (CHEMBL38016) Show SMILES ONC(=O)CC1Sc2ccccc2N(CCC2OCCO2)C1=O Show InChI InChI=1S/C15H18N2O5S/c18-13(16-20)9-12-15(19)17(6-5-14-21-7-8-22-14)10-3-1-2-4-11(10)23-12/h1-4,12,14,20H,5-9H2,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50224041 (CHEMBL34538) Show SMILES CC(C)CCCN1C(=O)C(CC(=O)NO)Sc2ccccc12 Show InChI InChI=1S/C16H22N2O3S/c1-11(2)6-5-9-18-12-7-3-4-8-13(12)22-14(16(18)20)10-15(19)17-21/h3-4,7-8,11,14,21H,5-6,9-10H2,1-2H3,(H,17,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50089194 ((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO Show InChI InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50224040 (CHEMBL286441) Show SMILES CCCCCN1C(=O)C(CC(=O)NO)Sc2ccccc12 Show InChI InChI=1S/C15H20N2O3S/c1-2-3-6-9-17-11-7-4-5-8-12(11)21-13(15(17)19)10-14(18)16-20/h4-5,7-8,13,20H,2-3,6,9-10H2,1H3,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193953 (US9199981, F44) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cnn(CC(C)(C)O)c1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C28H27F2N7O3/c1-16-4-5-17(24-34-26(40-35-24)19-9-28(29,30)10-19)8-21(16)33-25(38)22-12-31-23-7-6-18(14-37(22)23)20-11-32-36(13-20)15-27(2,3)39/h4-8,11-14,19,39H,9-10,15H2,1-3H3,(H,33,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193968 (US9199981, F59) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2cc(ccn12)N1CCOCC1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C25H24F2N6O3/c1-15-2-3-16(22-30-24(36-31-22)17-12-25(26,27)13-17)10-19(15)29-23(34)20-14-28-21-11-18(4-5-33(20)21)32-6-8-35-9-7-32/h2-5,10-11,14,17H,6-9,12-13H2,1H3,(H,29,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193951 (US9199981, F42) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cnn(C)c1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C25H21F2N7O2/c1-14-3-4-15(22-31-24(36-32-22)17-8-25(26,27)9-17)7-19(14)30-23(35)20-11-28-21-6-5-16(13-34(20)21)18-10-29-33(2)12-18/h3-7,10-13,17H,8-9H2,1-2H3,(H,30,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193923 (US9199981, F13 | US9199981, F92) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C21H17F2N5O2/c1-12-5-6-13(18-26-20(30-27-18)14-9-21(22,23)10-14)8-15(12)25-19(29)16-11-24-17-4-2-3-7-28(16)17/h2-8,11,14H,9-10H2,1H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193949 (US9199981, F40) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cn[nH]c1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C24H19F2N7O2/c1-13-2-3-14(21-31-23(35-32-21)16-7-24(25,26)8-16)6-18(13)30-22(34)19-11-27-20-5-4-15(12-33(19)20)17-9-28-29-10-17/h2-6,9-12,16H,7-8H2,1H3,(H,28,29)(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM194009 (US9199981, F102) Show SMILES Cc1ccn2c(cnc2c1)C(=O)Nc1cc(ccc1C)-c1noc(COC2CC(F)(F)C2(F)F)n1 Show InChI InChI=1S/C23H19F4N5O3/c1-12-5-6-32-16(10-28-18(32)7-12)21(33)29-15-8-14(4-3-13(15)2)20-30-19(35-31-20)11-34-17-9-22(24,25)23(17,26)27/h3-8,10,17H,9,11H2,1-2H3,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM194084 (US9199981, F19) Show SMILES CO[C@H]1C[C@H](C1)c1nc(no1)-c1ccc(C)c(NC(=O)c2cnc3ccccn23)c1 |r,wD:4.6,2.1,(7.85,-.09,;6.52,-.86,;5.18,-.09,;4.78,1.4,;3.3,1,;3.69,-.49,;1.96,1.77,;.5,1.29,;-.41,2.54,;.5,3.78,;1.96,3.31,;-1.95,2.54,;-2.72,3.87,;-4.26,3.87,;-5.03,2.54,;-6.57,2.54,;-4.26,1.2,;-5.03,-.13,;-6.57,-.13,;-7.34,1.2,;-7.34,-1.46,;-6.79,-2.9,;-7.98,-3.87,;-9.27,-3.03,;-10.76,-3.43,;-11.85,-2.34,;-11.45,-.85,;-9.96,-.46,;-8.88,-1.54,;-2.72,1.2,)| Show InChI InChI=1S/C22H21N5O3/c1-13-6-7-14(20-25-22(30-26-20)15-9-16(10-15)29-2)11-17(13)24-21(28)18-12-23-19-5-3-4-8-27(18)19/h3-8,11-12,15-16H,9-10H2,1-2H3,(H,24,28)/t15-,16+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193987 (US9199981, F78) Show SMILES CCC1CC(C1)c1nc(no1)-c1ccc(C)c(NC(=O)c2cnc3ccccn23)c1 |(9.22,-3.22,;8.14,-2.13,;6.65,-2.53,;5.88,-3.86,;4.54,-3.09,;5.31,-1.76,;3.06,-3.49,;1.81,-2.58,;.57,-3.49,;1.04,-4.95,;2.58,-4.95,;-.92,-3.09,;-2.01,-4.18,;-3.5,-3.78,;-3.9,-2.29,;-5.38,-1.9,;-2.81,-1.21,;-3.21,.28,;-4.69,.68,;-5.78,-.41,;-5.09,2.17,;-4.19,3.41,;-5.09,4.66,;-6.56,4.18,;-7.89,4.95,;-9.22,4.18,;-9.22,2.64,;-7.89,1.87,;-6.56,2.64,;-1.32,-1.6,)| Show InChI InChI=1S/C23H23N5O2/c1-3-15-10-17(11-15)23-26-21(27-30-23)16-8-7-14(2)18(12-16)25-22(29)19-13-24-20-6-4-5-9-28(19)20/h4-9,12-13,15,17H,3,10-11H2,1-2H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50141359 (CHEMBL285938 | N-Hydroxy-N-(3-oxo-3,4-dihydro-2H-b...) Show SMILES ON(CC1Sc2ccccc2NC1=O)C=O Show InChI InChI=1S/C10H10N2O3S/c13-6-12(15)5-9-10(14)11-7-3-1-2-4-8(7)16-9/h1-4,6,9,15H,5H2,(H,11,14)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193950 (US9199981, F41) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cnn(CCO)c1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C26H23F2N7O3/c1-15-2-3-16(23-32-25(38-33-23)18-9-26(27,28)10-18)8-20(15)31-24(37)21-12-29-22-5-4-17(14-35(21)22)19-11-30-34(13-19)6-7-36/h2-5,8,11-14,18,36H,6-7,9-10H2,1H3,(H,31,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193924 (US9199981, F14) Show SMILES [#6]-[#6]-[#8]\[#7]=[#6]-1/[#6]-[#6](-[#6]-1)-c1nc(no1)-c1ccc(-[#6])c(-[#7]-[#6](=O)-c2cnc3ccccn23)c1 Show InChI InChI=1S/C23H22N6O3/c1-3-31-27-17-10-16(11-17)23-26-21(28-32-23)15-8-7-14(2)18(12-15)25-22(30)19-13-24-20-6-4-5-9-29(19)20/h4-9,12-13,16H,3,10-11H2,1-2H3,(H,25,30)/b27-17-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50141360 (2-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin...) Show SMILES ONC(=O)CC1Sc2ccccc2N(Cc2ccccc2)C1=O Show InChI InChI=1S/C17H16N2O3S/c20-16(18-22)10-15-17(21)19(11-12-6-2-1-3-7-12)13-8-4-5-9-14(13)23-15/h1-9,15,22H,10-11H2,(H,18,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193922 (US9199981, F12) Show SMILES C[C@H]1COC2(CC(C2)c2nc(no2)-c2ccc(C)c(NC(=O)c3cnc4ccccn34)c2)O1 |r,wD:1.0,(8.07,-5.27,;8.07,-3.73,;9.31,-2.82,;8.84,-1.36,;7.3,-1.36,;7.3,.18,;5.76,.18,;5.76,-1.36,;4.99,1.52,;3.45,1.52,;2.97,2.98,;4.22,3.89,;5.46,2.98,;1.48,3.38,;1.08,4.87,;-.4,5.27,;-1.49,4.18,;-2.98,4.58,;-1.09,2.69,;-2.18,1.6,;-3.67,2,;-4.07,3.49,;-4.76,.91,;-4.28,-.55,;-5.53,-1.46,;-6.78,-.55,;-8.28,-.87,;-9.31,.27,;-8.84,1.73,;-7.33,2.06,;-6.3,.91,;.39,2.29,;6.82,-2.82,)| Show InChI InChI=1S/C24H23N5O4/c1-14-6-7-16(9-18(14)26-22(30)19-12-25-20-5-3-4-8-29(19)20)21-27-23(33-28-21)17-10-24(11-17)31-13-15(2)32-24/h3-9,12,15,17H,10-11,13H2,1-2H3,(H,26,30)/t15-,17?,24?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193952 (US9199981, F43) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1ccn(C)n1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C25H21F2N7O2/c1-14-3-4-15(22-30-24(36-32-22)17-10-25(26,27)11-17)9-19(14)29-23(35)20-12-28-21-6-5-16(13-34(20)21)18-7-8-33(2)31-18/h3-9,12-13,17H,10-11H2,1-2H3,(H,29,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193934 (US9199981, F25) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CC(O)(C1)C(F)(F)F |(-3.06,3.95,;-1.58,3.55,;-.49,4.64,;1,4.24,;1.4,2.75,;.31,1.66,;-1.18,2.06,;-2.27,.97,;-3.75,1.37,;-4.15,2.86,;-4.84,.28,;-4.68,-1.25,;-6.09,-1.87,;-7.12,-.73,;-8.66,-.73,;-9.43,.6,;-8.66,1.94,;-7.12,1.94,;-6.35,.6,;2.89,2.35,;4.13,3.26,;5.38,2.35,;4.9,.89,;3.36,.89,;5.67,-.44,;7.16,-.84,;6.76,-2.33,;6.76,-3.87,;5.27,-1.93,;8.1,-3.1,;9.43,-2.33,;8.1,-4.64,;9.43,-3.87,)| Show InChI InChI=1S/C22H18F3N5O3/c1-12-5-6-13(18-28-20(33-29-18)14-9-21(32,10-14)22(23,24)25)8-15(12)27-19(31)16-11-26-17-4-2-3-7-30(16)17/h2-8,11,14,32H,9-10H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193974 (US9199981, F65) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2cc(ccn12)-c1c[nH]nn1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C23H18F2N8O2/c1-12-2-3-14(20-29-22(35-31-20)15-8-23(24,25)9-15)6-16(12)28-21(34)18-11-26-19-7-13(4-5-33(18)19)17-10-27-32-30-17/h2-7,10-11,15H,8-9H2,1H3,(H,28,34)(H,27,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193955 (US9199981, F46) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cscn1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C24H18F2N6O2S/c1-13-2-3-14(21-30-23(34-31-21)16-7-24(25,26)8-16)6-17(13)29-22(33)19-9-27-20-5-4-15(10-32(19)20)18-11-35-12-28-18/h2-6,9-12,16H,7-8H2,1H3,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193917 (US9199981, F7) Show SMILES [#6]-[#8]\[#7]=[#6]-1/[#6]-[#6](-[#6]-1)-c1nc(no1)-c1ccc(-[#6])c(-[#7]-[#6](=O)-c2cnc3ccccn23)c1 Show InChI InChI=1S/C22H20N6O3/c1-13-6-7-14(20-25-22(31-27-20)15-9-16(10-15)26-30-2)11-17(13)24-21(29)18-12-23-19-5-3-4-8-28(18)19/h3-8,11-12,15H,9-10H2,1-2H3,(H,24,29)/b26-16-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM194010 (US9199981, F103) Show SMILES Cc1ccc2ncc(C(=O)Nc3cc(ccc3C)-c3noc(COC4CC(F)(F)C4(F)F)n3)n2c1 Show InChI InChI=1S/C23H19F4N5O3/c1-12-3-6-18-28-9-16(32(18)10-12)21(33)29-15-7-14(5-4-13(15)2)20-30-19(35-31-20)11-34-17-8-22(24,25)23(17,26)27/h3-7,9-10,17H,8,11H2,1-2H3,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193939 (US9199981, F30) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CC(=C)C1 Show InChI InChI=1S/C22H19N5O2/c1-13-9-16(10-13)22-25-20(26-29-22)15-7-6-14(2)17(11-15)24-21(28)18-12-23-19-5-3-4-8-27(18)19/h3-8,11-12,16H,1,9-10H2,2H3,(H,24,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193943 (US9199981, F34) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(CNC2CC(F)(F)C2)n1 Show InChI InChI=1S/C22H20F2N6O2/c1-13-5-6-14(20-28-19(32-29-20)12-25-15-9-22(23,24)10-15)8-16(13)27-21(31)17-11-26-18-4-2-3-7-30(17)18/h2-8,11,15,25H,9-10,12H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193957 (US9199981, F48) Show SMILES CC(C)(O)Cn1cc(cn1)-c1ccc2ncc(C(=O)Nc3cc(ccc3F)-c3noc(n3)C3CC(F)(F)C3)n2c1 Show InChI InChI=1S/C27H24F3N7O3/c1-26(2,39)14-36-12-18(10-32-36)16-4-6-22-31-11-21(37(22)13-16)24(38)33-20-7-15(3-5-19(20)28)23-34-25(40-35-23)17-8-27(29,30)9-17/h3-7,10-13,17,39H,8-9,14H2,1-2H3,(H,33,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193975 (US9199981, F66) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2cc(ccn12)-c1cn(CCO)nn1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C25H22F2N8O3/c1-14-2-3-16(22-30-24(38-32-22)17-10-25(26,27)11-17)8-18(14)29-23(37)20-12-28-21-9-15(4-5-35(20)21)19-13-34(6-7-36)33-31-19/h2-5,8-9,12-13,17,36H,6-7,10-11H2,1H3,(H,29,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193984 (US9199981, F75) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CC2(C1)CC(=O)C2 Show InChI InChI=1S/C24H21N5O3/c1-14-5-6-15(21-27-23(32-28-21)16-9-24(10-16)11-17(30)12-24)8-18(14)26-22(31)19-13-25-20-4-2-3-7-29(19)20/h2-8,13,16H,9-12H2,1H3,(H,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50141370 (CHEMBL34024 | N-Hydroxy-2-[3-oxo-4-(tetrahydro-pyr...) Show SMILES ONC(=O)CC1Sc2ccccc2N(CC2CCCCO2)C1=O Show InChI InChI=1S/C16H20N2O4S/c19-15(17-21)9-14-16(20)18(10-11-5-3-4-8-22-11)12-6-1-2-7-13(12)23-14/h1-2,6-7,11,14,21H,3-5,8-10H2,(H,17,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193978 (US9199981, F69 | US9199981, F80) Show SMILES Cc1ccn2c(cnc2c1)C(=O)Nc1cc(ccc1C)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C22H19F2N5O2/c1-12-5-6-29-17(11-25-18(29)7-12)20(30)26-16-8-14(4-3-13(16)2)19-27-21(31-28-19)15-9-22(23,24)10-15/h3-8,11,15H,9-10H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193978 (US9199981, F69 | US9199981, F80) Show SMILES Cc1ccn2c(cnc2c1)C(=O)Nc1cc(ccc1C)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C22H19F2N5O2/c1-12-5-6-29-17(11-25-18(29)7-12)20(30)26-16-8-14(4-3-13(16)2)19-27-21(31-28-19)15-9-22(23,24)10-15/h3-8,11,15H,9-10H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193967 (US9199981, F58) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CC(C)(C)C1 Show InChI InChI=1S/C23H23N5O2/c1-14-7-8-15(20-26-22(30-27-20)16-11-23(2,3)12-16)10-17(14)25-21(29)18-13-24-19-6-4-5-9-28(18)19/h4-10,13,16H,11-12H2,1-3H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193999 (US9199981, F110 | US9199981, F91) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)[C@H]1C[C@@H]1F |r| Show InChI InChI=1S/C20H16FN5O2/c1-11-5-6-12(18-24-20(28-25-18)13-9-14(13)21)8-15(11)23-19(27)16-10-22-17-4-2-3-7-26(16)17/h2-8,10,13-14H,9H2,1H3,(H,23,27)/t13-,14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193914 (US9199981, F4) Show SMILES [#6]-c1ccc(cc1-[#7]-[#6](=O)-c1cnc2ccccn12)-c1noc(n1)-[#6]-1-[#6]\[#6](-[#6]-1)=[#7]\[#8] Show InChI InChI=1S/C21H18N6O3/c1-12-5-6-13(19-24-21(30-26-19)14-8-15(9-14)25-29)10-16(12)23-20(28)17-11-22-18-4-2-3-7-27(17)18/h2-7,10-11,14,29H,8-9H2,1H3,(H,23,28)/b25-15-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193992 (US9199981, F84) Show SMILES COCc1n[nH]c(n1)-c1ccc2ncc(C(=O)Nc3cc(ccc3C)-c3noc(n3)C3CC(F)(F)C3)n2c1 Show InChI InChI=1S/C25H22F2N8O3/c1-13-3-4-14(22-31-24(38-34-22)16-8-25(26,27)9-16)7-17(13)29-23(36)18-10-28-20-6-5-15(11-35(18)20)21-30-19(12-37-2)32-33-21/h3-7,10-11,16H,8-9,12H2,1-2H3,(H,29,36)(H,30,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193966 (US9199981, F57) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CCC1 Show InChI InChI=1S/C21H19N5O2/c1-13-8-9-15(19-24-21(28-25-19)14-5-4-6-14)11-16(13)23-20(27)17-12-22-18-7-2-3-10-26(17)18/h2-3,7-12,14H,4-6H2,1H3,(H,23,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM19992 (2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...) Show SMILES OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1 Show InChI InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM194000 (US9199981, F93) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)C(=O)NC1CC(F)(F)C1 Show InChI InChI=1S/C20H18F2N4O2/c1-12-5-6-13(18(27)24-14-9-20(21,22)10-14)8-15(12)25-19(28)16-11-23-17-4-2-3-7-26(16)17/h2-8,11,14H,9-10H2,1H3,(H,24,27)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193915 (US9199981, F5) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CCC(F)(F)CC1 Show InChI InChI=1S/C23H21F2N5O2/c1-14-5-6-16(20-28-22(32-29-20)15-7-9-23(24,25)10-8-15)12-17(14)27-21(31)18-13-26-19-4-2-3-11-30(18)19/h2-6,11-13,15H,7-10H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193911 (US9199981, F1) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1nc(no1)C1CC(F)(F)C1 Show InChI InChI=1S/C21H17F2N5O2/c1-12-5-6-13(20-26-18(27-30-20)14-9-21(22,23)10-14)8-15(12)25-19(29)16-11-24-17-4-2-3-7-28(16)17/h2-8,11,14H,9-10H2,1H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193997 (US9199981, F89) Show SMILES Cc1ccn2c(cnc2c1)C(=O)Nc1cc(ccc1C)-c1noc(n1)[C@H]1C[C@@](O)(C1)C(F)(F)F |r,wU:25.28,27.31,wD:27.34,(-10.09,4.95,;-8.76,4.18,;-8.76,2.64,;-7.42,1.87,;-6.09,2.64,;-4.63,2.17,;-3.72,3.41,;-4.63,4.66,;-6.09,4.18,;-7.42,4.95,;-4.23,.68,;-5.32,-.41,;-2.74,.28,;-2.34,-1.21,;-.85,-1.6,;-.45,-3.09,;-1.54,-4.18,;-3.03,-3.78,;-3.43,-2.29,;-4.92,-1.9,;1.03,-3.49,;1.51,-4.95,;3.05,-4.95,;3.52,-3.49,;2.28,-2.58,;5.01,-3.09,;5.78,-1.76,;7.12,-2.53,;8.2,-1.44,;6.35,-3.86,;8.6,-2.93,;9.69,-1.84,;9,-4.41,;10.09,-3.32,)| Show InChI InChI=1S/C23H20F3N5O3/c1-12-5-6-31-17(11-27-18(31)7-12)20(32)28-16-8-14(4-3-13(16)2)19-29-21(34-30-19)15-9-22(33,10-15)23(24,25)26/h3-8,11,15,33H,9-10H2,1-2H3,(H,28,32)/t15-,22+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193947 (US9199981, F38) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(COCCO)cn12)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C24H23F2N5O4/c1-14-2-4-16(21-29-23(35-30-21)17-9-24(25,26)10-17)8-18(14)28-22(33)19-11-27-20-5-3-15(12-31(19)20)13-34-7-6-32/h2-5,8,11-12,17,32H,6-7,9-10,13H2,1H3,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193941 (US9199981, F32) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CC(C1)=CCCO |(-6.58,-1.9,;-5.09,-2.29,;-4.69,-3.78,;-3.2,-4.18,;-2.12,-3.09,;-2.51,-1.6,;-4,-1.21,;-4.4,.28,;-5.89,.68,;-6.98,-.41,;-6.29,2.17,;-5.38,3.41,;-6.29,4.66,;-7.75,4.18,;-9.08,4.95,;-10.42,4.18,;-10.42,2.64,;-9.08,1.87,;-7.75,2.64,;-.63,-3.49,;-.15,-4.95,;1.39,-4.95,;1.86,-3.49,;.62,-2.58,;3.2,-2.72,;4.68,-3.12,;5.08,-1.63,;3.6,-1.23,;6.42,-.86,;7.75,-1.63,;9.08,-.86,;10.42,-1.63,)| Show InChI InChI=1S/C24H23N5O3/c1-15-7-8-17(22-27-24(32-28-22)18-11-16(12-18)5-4-10-30)13-19(15)26-23(31)20-14-25-21-6-2-3-9-29(20)21/h2-3,5-9,13-14,18,30H,4,10-12H2,1H3,(H,26,31)/b16-5-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193928 (US9199981, F18) Show SMILES COCCO[C@H]1C[C@H](C1)c1nc(no1)-c1ccc(C)c(NC(=O)c2cnc3ccccn23)c1 |r,wD:7.9,5.4,(11.85,-.86,;10.52,-.09,;9.18,-.86,;7.85,-.09,;6.52,-.86,;5.18,-.09,;4.78,1.4,;3.3,1,;3.69,-.49,;1.96,1.77,;.5,1.29,;-.41,2.54,;.5,3.78,;1.96,3.31,;-1.95,2.54,;-2.72,3.87,;-4.26,3.87,;-5.03,2.54,;-6.57,2.54,;-4.26,1.2,;-5.03,-.13,;-6.57,-.13,;-7.34,1.2,;-7.34,-1.46,;-6.79,-2.9,;-7.98,-3.87,;-9.27,-3.03,;-10.76,-3.43,;-11.85,-2.34,;-11.45,-.85,;-9.96,-.46,;-8.88,-1.54,;-2.72,1.2,)| Show InChI InChI=1S/C24H25N5O4/c1-15-6-7-16(22-27-24(33-28-22)17-11-18(12-17)32-10-9-31-2)13-19(15)26-23(30)20-14-25-21-5-3-4-8-29(20)21/h3-8,13-14,17-18H,9-12H2,1-2H3,(H,26,30)/t17-,18+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193979 (US9199981, F70) Show SMILES Cc1ccc2ncc(C(=O)Nc3cc(ccc3C)-c3noc(n3)C3CC(F)(F)C3)n2c1 Show InChI InChI=1S/C22H19F2N5O2/c1-12-3-6-18-25-10-17(29(18)11-12)20(30)26-16-7-14(5-4-13(16)2)19-27-21(31-28-19)15-8-22(23,24)9-15/h3-7,10-11,15H,8-9H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair

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