BindingDB PrimarySearch

Found 1114 hits Enz. Inhib. hit(s) with Target = 'Arginase'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	8.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Binding affinity to human arginase 2				J Med Chem 54: 5432-43 (2011) Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	8.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Arg2 at pH 7.5				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50561046 (CHEMBL4790798) Show SMILES NC(CCCCB(O)O)(CCCNCCc1ccccc1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Arg2 using L-arginine as substrate after 60 mins by spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50561046 (CHEMBL4790798) Show SMILES NC(CCCCB(O)O)(CCCNCCc1ccccc1)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Arg1 using L-arginine as substrate after 60 mins by spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50561045 (CHEMBL4758805) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Arg2 using L-arginine as substrate after 60 mins by spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50561045 (CHEMBL4758805) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Arg1 using L-arginine as substrate after 60 mins by spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50561034 (CHEMBL4244287) Show SMILES N[C@@H](CSCCB(O)O)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Arg2 at pH 7.5				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Arg2 at pH 7.5				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of arginase 2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.bmcl.2017.12.044 BindingDB Entry DOI: 10.7270/Q2736THR
TBA					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50294581 (3-phenylprop-1-enylboronic acid \| CHEMBL539140) Show SMILES OB(O)\C=C\Cc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents		89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM23417 (α-CA inhibitor, 4 \| (-)-Epicatechin \| (2R,3R)...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...				J Nat Prod 77: 392-6 (2014) Article DOI: 10.1021/np400717m BindingDB Entry DOI: 10.7270/Q2VX0J09
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50561034 (CHEMBL4244287) Show SMILES N[C@@H](CSCCB(O)O)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem		310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM23416 (α-CA inhibitor, 3 \| (+)-Catechin \| (2R,3S)-2-...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...				J Nat Prod 77: 392-6 (2014) Article DOI: 10.1021/np400717m BindingDB Entry DOI: 10.7270/Q2VX0J09
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM50241867 (((2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hy...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Competitive inhibition of Leishmania amazonensis arginase assessed as inhibition constant for enzyme-inhibitor complex using L-arginine as substrate ...				J Nat Prod 79: 1459-63 (2016) Article DOI: 10.1021/acs.jnatprod.5b00875 BindingDB Entry DOI: 10.7270/Q2G73J78
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM50446567 (CHEMBL3109443) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...				J Nat Prod 77: 392-6 (2014) Article DOI: 10.1021/np400717m BindingDB Entry DOI: 10.7270/Q2VX0J09
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM15236 (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...				J Nat Prod 77: 392-6 (2014) Article DOI: 10.1021/np400717m BindingDB Entry DOI: 10.7270/Q2VX0J09
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM50521944 (CHEMBL4204512) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Competitive inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production by measu...				Bioorg Med Chem 27: 3853-3859 (2019) Article DOI: 10.1016/j.bmc.2019.07.022 BindingDB Entry DOI: 10.7270/Q27D2ZJF
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50230418 (CHEMBL260629 \| N(gamma)-hydroxy-L-arginine \| N-OME...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Arg2 at pH 7.5				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase (Schistosoma mansoni (flatworms))	BDBM130378 (2(S)-amino-6-boronohexanoic acid (ABH)) Show SMILES N[C@@H](CCCCB(O)O)C(O)=O Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	8.5	n/a
University of Pennsylvania					Assay Description Briefly, 0.5-50 mM L-arginine (pH 8.5) was added to a solution of 50 mM 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (EPPS) (pH 8.5) and 100 &...				Biochemistry 53: 4671-4684 (2014) Article DOI: 10.1021/bi5004519 BindingDB Entry DOI: 10.7270/Q2RR1WZQ
University of Pennsylvania					More data for this Ligand-Target Pair
Arginase (Schistosoma mansoni (flatworms))	BDBM130379 (N-hydroxy-L-arginine (NOHA)) Show SMILES NC(=N)NCCC[C@H](NO)C(O)=O Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	8.5	n/a
University of Pennsylvania					Assay Description Briefly, 0.5-50 mM L-arginine (pH 8.5) was added to a solution of 50 mM 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (EPPS) (pH 8.5) and 100 &...				Biochemistry 53: 4671-4684 (2014) Article DOI: 10.1021/bi5004519 BindingDB Entry DOI: 10.7270/Q2RR1WZQ
University of Pennsylvania					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM50446568 (CHEMBL3109439) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...				J Nat Prod 77: 392-6 (2014) Article DOI: 10.1021/np400717m BindingDB Entry DOI: 10.7270/Q2VX0J09
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50316603 (2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid...) Show SMILES N[C@@H](CCCn1ccnc1N)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay				J Med Chem 53: 4266-76 (2010) Article DOI: 10.1021/jm100306a BindingDB Entry DOI: 10.7270/Q2SQ90JK
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM50521942 (CHEMBL4216180) Show SMILES CC(=O)Nc1ccccc1C(F)(F)C(=O)NNc1ccccc1 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Competitive inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production by measu...				Bioorg Med Chem 27: 3853-3859 (2019) Article DOI: 10.1016/j.bmc.2019.07.022 BindingDB Entry DOI: 10.7270/Q27D2ZJF
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM84978 (Quercitrin \| cid_5280459) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	KEGG MMDB PC cid PC sid UniChem Similars	Article PubMed	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...				J Nat Prod 77: 392-6 (2014) Article DOI: 10.1021/np400717m BindingDB Entry DOI: 10.7270/Q2VX0J09
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Plasmodium falciparum)	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assay				J Med Chem 54: 5432-43 (2011) Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM50510706 (CHEMBL4515068) Show SMILES Cc1cc(NNC(N)=S)n2nc(nc2n1)C(F)(F)F Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Tecnologia em Farmacos Curated by ChEMBL					Assay Description Non-competitive inhibition of Leishmania amazonensis arginase using L-arginine as substrate incubated for 15 mins				Bioorg Med Chem 27: 3061-3069 (2019) Article DOI: 10.1016/j.bmc.2019.05.026 BindingDB Entry DOI: 10.7270/Q2SX6HJQ
Instituto de Tecnologia em Farmacos Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50375814 (CHEMBL260628) Show SMILES CN(CCC[C@H](N)C(O)=O)C(NO)N=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.71E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Christian-Albrechts-University of Kiel Curated by ChEMBL					Assay Description Inhibition of bovine liver arginase				Bioorg Med Chem 16: 2305-12 (2008) Article DOI: 10.1016/j.bmc.2007.11.066 BindingDB Entry DOI: 10.7270/Q2KW5GXN
Christian-Albrechts-University of Kiel Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM50521943 (CHEMBL4574177) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Competitive inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production by measu...				Bioorg Med Chem 27: 3853-3859 (2019) Article DOI: 10.1016/j.bmc.2019.07.022 BindingDB Entry DOI: 10.7270/Q27D2ZJF
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50230418 (CHEMBL260629 \| N(gamma)-hydroxy-L-arginine \| N-OME...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Christian-Albrechts-University of Kiel Curated by ChEMBL					Assay Description Inhibition of bovine liver arginase				Bioorg Med Chem 16: 2305-12 (2008) Article DOI: 10.1016/j.bmc.2007.11.066 BindingDB Entry DOI: 10.7270/Q2KW5GXN
Christian-Albrechts-University of Kiel Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Leishmania amazonensis)	BDBM50521947 (CHEMBL4530523) Show SMILES CC(=O)Nc1ccccc1C(F)(F)C(=O)NCc1ccccc1 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Competitive inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production by measu...				Bioorg Med Chem 27: 3853-3859 (2019) Article DOI: 10.1016/j.bmc.2019.07.022 BindingDB Entry DOI: 10.7270/Q27D2ZJF
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Rattus norvegicus)	BDBM50354832 (CHEMBL1834160) Show SMILES N[C@@H](CCCCC=O)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars		6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50553165 (CHEMBL4754674) Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Lineweaver-Burk plot analysis				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50553165 (CHEMBL4754674) Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50553165 (CHEMBL4754674) Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Cornish-Bowden plot analysis				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50608139 (CHEMBL5287570) Show SMILES N[C@@H](CCCCS(N)(=O)=O)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem		9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50045936 ((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol \| (E)-...) Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Cornish-Bowden plot analysis				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50045936 ((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol \| (E)-...) Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Lineweaver-Burk plot analysis				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair
Arginase-1 (Bos taurus)	BDBM50045936 ((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol \| (E)-...) Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair
Arginase (Plasmodium falciparum)	BDBM50350309 (CHEMBL1812662) Show SMILES CC([NH3+])(CCCCB(O)O)C([O-])=O Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assay				J Med Chem 54: 5432-43 (2011) Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50462601 (CHEMBL4250607) Show SMILES NC(=N)Nc1ccc(cc1)C(F)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.75E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Brown University Curated by ChEMBL					Assay Description Irreversible inhibition of human arginase 1 using thioarginine as substrate measured up to 360 mins by UV micro plate method				Bioorg Med Chem 26: 3939-3946 (2018) Article DOI: 10.1016/j.bmc.2018.06.015 BindingDB Entry DOI: 10.7270/Q2TX3J1K
Brown University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50316607 (2-amino-L-histidine \| CHEMBL1099167 \| L-2-aminohis...) Show SMILES N[C@@H](Cc1cnc(N)[nH]1)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay				J Med Chem 53: 4266-76 (2010) Article DOI: 10.1021/jm100306a BindingDB Entry DOI: 10.7270/Q2SQ90JK
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50462601 (CHEMBL4250607) Show SMILES NC(=N)Nc1ccc(cc1)C(F)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.22E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Brown University Curated by ChEMBL					Assay Description Irreversible inhibition of human arginase 2 using thioarginine as substrate measured up to 360 mins by UV micro plate method				Bioorg Med Chem 26: 3939-3946 (2018) Article DOI: 10.1016/j.bmc.2018.06.015 BindingDB Entry DOI: 10.7270/Q2TX3J1K
Brown University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50462600 (CHEMBL4238387) Show SMILES CC(=O)OC(C(O)=O)c1ccc(NC(N)=N)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.82E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Brown University Curated by ChEMBL					Assay Description Irreversible inhibition of human arginase 1 using thioarginine as substrate measured up to 360 mins by UV micro plate method				Bioorg Med Chem 26: 3939-3946 (2018) Article DOI: 10.1016/j.bmc.2018.06.015 BindingDB Entry DOI: 10.7270/Q2TX3J1K
Brown University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM50462600 (CHEMBL4238387) Show SMILES CC(=O)OC(C(O)=O)c1ccc(NC(N)=N)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.37E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Brown University Curated by ChEMBL					Assay Description Irreversible inhibition of human arginase 2 using thioarginine as substrate measured up to 360 mins by UV micro plate method				Bioorg Med Chem 26: 3939-3946 (2018) Article DOI: 10.1016/j.bmc.2018.06.015 BindingDB Entry DOI: 10.7270/Q2TX3J1K
Brown University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50316604 ((S)-2-amino-5-(imidazol-2-ylamino)pentanoic acid \|...) Show SMILES N[C@@H](CCCNc1ncc[nH]1)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay				J Med Chem 53: 4266-76 (2010) Article DOI: 10.1021/jm100306a BindingDB Entry DOI: 10.7270/Q2SQ90JK
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase (Plasmodium falciparum)	BDBM50350310 (CHEMBL1812663) Show SMILES [NH3+]C(CCCCB(O)O)(C(F)F)C([O-])=O Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assay				J Med Chem 54: 5432-43 (2011) Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50316606 ((2S)-2-amino-4-(2-amino-1H-imidazol-5-yl)butanoic ...) Show SMILES N[C@@H](CCc1cnc(N)[nH]1)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	3.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay				J Med Chem 53: 4266-76 (2010) Article DOI: 10.1021/jm100306a BindingDB Entry DOI: 10.7270/Q2SQ90JK
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Homo sapiens (Human))	BDBM50316608 (1H-Imidazol-2-yl-ammonium \| 1H-Imidazol-2-ylamine ...) Show SMILES Nc1ncc[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	MMDB Article PubMed	3.60E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay				J Med Chem 53: 4266-76 (2010) Article DOI: 10.1021/jm100306a BindingDB Entry DOI: 10.7270/Q2SQ90JK
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50316603 (2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid...) Show SMILES N[C@@H](CCCn1ccnc1N)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem		3.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50316605 (2-amino-5-(2-aminoimidazol-4-yl)pentanoic acid \| C...) Show SMILES NC(CCCc1cnc(N)[nH]1)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>8.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay				J Med Chem 53: 4266-76 (2010) Article DOI: 10.1021/jm100306a BindingDB Entry DOI: 10.7270/Q2SQ90JK
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair

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