Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239048 (CHEMBL4067028) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Inhibition of cAMP PDE II enzyme | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239048 (CHEMBL4067028) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239045 (CHEMBL4083339) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | <0.850 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239040 (CHEMBL4086771) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239040 (CHEMBL4086771) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239049 (CHEMBL4086782) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Inhibition of cAMP PDE II enzyme | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM249124 (US9453038, 1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E.... | US Patent US9453038 (2016) BindingDB Entry DOI: 10.7270/Q23X85KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239049 (CHEMBL4086782) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM249145 (US9453038, 23) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E.... | US Patent US9453038 (2016) BindingDB Entry DOI: 10.7270/Q23X85KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239044 (CHEMBL4104680) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM249137 (US9453038, 15) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.80 | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E.... | US Patent US9453038 (2016) BindingDB Entry DOI: 10.7270/Q23X85KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239048 (CHEMBL4067028) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239048 (CHEMBL4067028) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM249148 (US9453038, 26) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4.30 | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E.... | US Patent US9453038 (2016) BindingDB Entry DOI: 10.7270/Q23X85KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239043 (CHEMBL4067037) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50008283 (CHEMBL3235148) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose by spectrophotometry | Bioorg Med Chem 22: 2280-93 (2014) Article DOI: 10.1016/j.bmc.2014.02.009 BindingDB Entry DOI: 10.7270/Q2959K3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239040 (CHEMBL4086771) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239040 (CHEMBL4086771) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260385 (US9527838, 13) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a |
Discovery, Preclinical and Early Development, Merck& Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. Electronic address: Jiayi_xu@merck.com. Curated by ChEMBL | Assay Description Inhibition of cAMP PDE II enzyme | Bioorg Med Chem Lett 27: 2063-2068 (2017) Article DOI: 10.1016/j.bmcl.2016.10.088 BindingDB Entry DOI: 10.7270/Q2F191V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50089134 (CHEMBL3577728) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assay | ACS Med Chem Lett 6: 296-301 (2015) Article DOI: 10.1021/ml5004712 BindingDB Entry DOI: 10.7270/Q2ZP47VT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50089108 (CHEMBL3577727) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assay | ACS Med Chem Lett 6: 296-301 (2015) Article DOI: 10.1021/ml5004712 BindingDB Entry DOI: 10.7270/Q2ZP47VT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50089139 (CHEMBL3577715) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assay | ACS Med Chem Lett 6: 296-301 (2015) Article DOI: 10.1021/ml5004712 BindingDB Entry DOI: 10.7270/Q2ZP47VT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50089135 (CHEMBL3577729) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assay | ACS Med Chem Lett 6: 296-301 (2015) Article DOI: 10.1021/ml5004712 BindingDB Entry DOI: 10.7270/Q2ZP47VT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50089180 (CHEMBL3577735) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assay | ACS Med Chem Lett 6: 296-301 (2015) Article DOI: 10.1021/ml5004712 BindingDB Entry DOI: 10.7270/Q2ZP47VT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260423 (US9527838, 51) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa... | US Patent US9527838 (2016) BindingDB Entry DOI: 10.7270/Q2RV0MN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50089181 (CHEMBL3577736) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assay | ACS Med Chem Lett 6: 296-301 (2015) Article DOI: 10.1021/ml5004712 BindingDB Entry DOI: 10.7270/Q2ZP47VT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260373 (US9527838, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa... | US Patent US9527838 (2016) BindingDB Entry DOI: 10.7270/Q2RV0MN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260425 (US9527838, 53) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa... | US Patent US9527838 (2016) BindingDB Entry DOI: 10.7270/Q2RV0MN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50008306 (CHEMBL3235155) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose by spectrophotometry | Bioorg Med Chem 22: 2280-93 (2014) Article DOI: 10.1016/j.bmc.2014.02.009 BindingDB Entry DOI: 10.7270/Q2959K3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260396 (US9527838, 24) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa... | US Patent US9527838 (2016) BindingDB Entry DOI: 10.7270/Q2RV0MN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239044 (CHEMBL4104680) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM249157 (US9453038, 35) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 8.90 | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E.... | US Patent US9453038 (2016) BindingDB Entry DOI: 10.7270/Q23X85KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50089177 (CHEMBL3577732) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assay | ACS Med Chem Lett 6: 296-301 (2015) Article DOI: 10.1021/ml5004712 BindingDB Entry DOI: 10.7270/Q2ZP47VT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260385 (US9527838, 13) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa... | US Patent US9527838 (2016) BindingDB Entry DOI: 10.7270/Q2RV0MN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239043 (CHEMBL4067037) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50540184 (CHEMBL4643627) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a |
Array BioPharma Inc. Curated by ChEMBL | Assay Description Activation of glucokinase (unknown origin) | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115232 BindingDB Entry DOI: 10.7270/Q2XW4PB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260404 (US9527838, 32) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a |
Discovery, Preclinical and Early Development, Merck& Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. Electronic address: Jiayi_xu@merck.com. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2063-2068 (2017) Article DOI: 10.1016/j.bmcl.2016.10.088 BindingDB Entry DOI: 10.7270/Q2F191V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239042 (CHEMBL4094511) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239046 (CHEMBL4068048) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Inhibition of cGMP PDE II enzyme | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50239046 (CHEMBL4068048) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a |
Merck& Co., Inc. Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple... | Bioorg Med Chem Lett 27: 2069-2073 (2017) Article DOI: 10.1016/j.bmcl.2016.10.085 BindingDB Entry DOI: 10.7270/Q2DZ0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50300593 (3-methyl-2-(4-(1-methyl-1H-pyrazol-3-ylamino)quina...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute Curated by ChEMBL | Assay Description Activation of N-terminal His-tagged human recombinant liver glucokinase expressed in Escherichia coli BL21 (DE3) by glucose-6-phosphate dehydrogenase... | Bioorg Med Chem Lett 19: 5531-8 (2009) Article DOI: 10.1016/j.bmcl.2009.08.064 BindingDB Entry DOI: 10.7270/Q2QR4X63 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260375 (US9527838, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 10.8 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa... | US Patent US9527838 (2016) BindingDB Entry DOI: 10.7270/Q2RV0MN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260383 (US9527838, 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 10.9 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa... | US Patent US9527838 (2016) BindingDB Entry DOI: 10.7270/Q2RV0MN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM249127 (US9453038, 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 11.4 | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E.... | US Patent US9453038 (2016) BindingDB Entry DOI: 10.7270/Q23X85KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50145874 (CHEMBL3764079) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
Servier Research Institute of Medicinal Chemistry Curated by ChEMBL | Assay Description Activation of recombinant human glucokinase assessed as NADPH formation using glucose as substrate incubated for 30 mins in presence of NADP+ and glu... | J Med Chem 59: 687-706 (2016) Article DOI: 10.1021/acs.jmedchem.5b01594 BindingDB Entry DOI: 10.7270/Q2CF9S0F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50089173 (CHEMBL3577720) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
Yuhan Research Institute Curated by ChEMBL | Assay Description Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assay | ACS Med Chem Lett 6: 296-301 (2015) Article DOI: 10.1021/ml5004712 BindingDB Entry DOI: 10.7270/Q2ZP47VT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM260390 (US9527838, 18) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 13.4 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa... | US Patent US9527838 (2016) BindingDB Entry DOI: 10.7270/Q2RV0MN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM249134 (US9453038, 10) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 13.9 | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E.... | US Patent US9453038 (2016) BindingDB Entry DOI: 10.7270/Q23X85KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50533163 (CHEMBL4528539) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activation of human recombinant glucokinase using 5 mM glucose monitored over 5 mins in presence of NAD+ by glucose 6-phosphate dehydrogenase coupled... | ACS Med Chem Lett 7: 714-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00140 BindingDB Entry DOI: 10.7270/Q2251NP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase-4 (Homo sapiens (Human)) | BDBM50533163 (CHEMBL4528539) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activation of human recombinant glucokinase using 5 mM glucose monitored over 5 mins in presence of NAD+ by glucose 6-phosphate dehydrogenase coupled... | ACS Med Chem Lett 7: 714-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00140 BindingDB Entry DOI: 10.7270/Q2251NP5 | |||||||||||
More data for this Ligand-Target Pair |
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