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PubMed code 26303893

Compile data set for download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))		BDBM50120365
PNG
(CHEMBL3616693)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C37H33F6N3O5/c1-3-4-5-30(23-6-8-24(9-7-23)35(49)44-19-18-33(47)48)46-31-20-25(22-10-14-27(15-11-22)51-37(41,42)43)12-16-28(31)34(45-46)29-21-26(36(38,39)40)13-17-32(29)50-2/h6-17,20-21,30H,3-5,18-19H2,1-2H3,(H,44,49)(H,47,48)
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n/an/a 0.800n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120319
PNG
(CHEMBL3616588)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C36H31F6N3O5/c1-3-4-29(22-5-7-23(8-6-22)34(48)43-18-17-32(46)47)45-30-19-24(21-9-13-26(14-10-21)50-36(40,41)42)11-15-27(30)33(44-45)28-20-25(35(37,38)39)12-16-31(28)49-2/h5-16,19-20,29H,3-4,17-18H2,1-2H3,(H,43,48)(H,46,47)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120342
PNG
(CHEMBL3616689)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(SC)cc1
Show InChI InChI=1S/C37H36F3N3O4S/c1-4-5-6-31(24-7-9-25(10-8-24)36(46)41-20-19-34(44)45)43-32-21-26(23-11-15-28(48-3)16-12-23)13-17-29(32)35(42-43)30-22-27(37(38,39)40)14-18-33(30)47-2/h7-18,21-22,31H,4-6,19-20H2,1-3H3,(H,41,46)(H,44,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120364
PNG
(CHEMBL3616692)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)c(F)c1
Show InChI InChI=1S/C37H35F4N3O5/c1-4-5-6-30(22-7-9-23(10-8-22)36(47)42-18-17-34(45)46)44-31-20-25(24-12-15-33(49-3)29(38)19-24)11-14-27(31)35(43-44)28-21-26(37(39,40)41)13-16-32(28)48-2/h7-16,19-21,30H,4-6,17-18H2,1-3H3,(H,42,47)(H,45,46)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120366
PNG
(CHEMBL3616694)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C37H33F6N3O4/c1-3-4-5-30(23-6-8-24(9-7-23)35(49)44-19-18-33(47)48)46-31-20-25(22-10-13-26(14-11-22)36(38,39)40)12-16-28(31)34(45-46)29-21-27(37(41,42)43)15-17-32(29)50-2/h6-17,20-21,30H,3-5,18-19H2,1-2H3,(H,44,49)(H,47,48)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120339
PNG
(CHEMBL3616687)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C37H36F3N3O5/c1-4-5-6-31(24-7-9-25(10-8-24)36(46)41-20-19-34(44)45)43-32-21-26(23-11-15-28(47-2)16-12-23)13-17-29(32)35(42-43)30-22-27(37(38,39)40)14-18-33(30)48-3/h7-18,21-22,31H,4-6,19-20H2,1-3H3,(H,41,46)(H,44,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120281
PNG
(CHEMBL3616584)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C36H34F3N3O4/c1-4-5-30(24-10-12-25(13-11-24)35(45)40-19-18-33(43)44)42-31-20-26(23-8-6-22(2)7-9-23)14-16-28(31)34(41-42)29-21-27(36(37,38)39)15-17-32(29)46-3/h6-17,20-21,30H,4-5,18-19H2,1-3H3,(H,40,45)(H,43,44)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120327
PNG
(CHEMBL3616675)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(Cl)ccc2C(N)=O)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H26ClF3N4O5/c1-18(19-2-4-21(5-3-19)32(45)39-15-14-29(42)43)41-28-16-22(20-6-10-24(11-7-20)46-33(35,36)37)8-12-26(28)30(40-41)27-17-23(34)9-13-25(27)31(38)44/h2-13,16-18H,14-15H2,1H3,(H2,38,44)(H,39,45)(H,42,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120374
PNG
(CHEMBL3616701)
Show SMILES COc1ccc(cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C34H30F3N3O4/c1-20-4-6-23(7-5-20)25-12-14-27-29(18-25)40(39-32(27)28-19-26(34(35,36)37)13-15-30(28)44-3)21(2)22-8-10-24(11-9-22)33(43)38-17-16-31(41)42/h4-15,18-19,21H,16-17H2,1-3H3,(H,38,43)(H,41,42)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120341
PNG
(CHEMBL3616688)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C37H36F3N3O4/c1-4-5-6-31(25-11-13-26(14-12-25)36(46)41-20-19-34(44)45)43-32-21-27(24-9-7-23(2)8-10-24)15-17-29(32)35(42-43)30-22-28(37(38,39)40)16-18-33(30)47-3/h7-18,21-22,31H,4-6,19-20H2,1-3H3,(H,41,46)(H,44,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120322
PNG
(CHEMBL3616591)
Show SMILES COc1ccc(Cl)cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H27ClF3N3O5/c1-19(20-3-5-22(6-4-20)32(43)38-16-15-30(41)42)40-28-17-23(21-7-11-25(12-8-21)45-33(35,36)37)9-13-26(28)31(39-40)27-18-24(34)10-14-29(27)44-2/h3-14,17-19H,15-16H2,1-2H3,(H,38,43)(H,41,42)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120362
PNG
(CHEMBL3616690)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C36H34F3N3O4/c1-3-4-10-30(24-11-13-25(14-12-24)35(45)40-20-19-33(43)44)42-31-21-26(23-8-6-5-7-9-23)15-17-28(31)34(41-42)29-22-27(36(37,38)39)16-18-32(29)46-2/h5-9,11-18,21-22,30H,3-4,10,19-20H2,1-2H3,(H,40,45)(H,43,44)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120333
PNG
(CHEMBL3616681)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(Cl)cc(c2)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H24ClF6N3O4/c1-18(19-2-4-21(5-3-19)31(46)41-13-12-29(44)45)43-28-16-22(20-6-9-26(10-7-20)47-33(38,39)40)8-11-27(28)30(42-43)23-14-24(32(35,36)37)17-25(34)15-23/h2-11,14-18H,12-13H2,1H3,(H,41,46)(H,44,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120367
PNG
(CHEMBL3616695)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)nc1
Show InChI InChI=1S/C36H35F3N4O5/c1-4-5-6-29(22-7-9-23(10-8-22)35(46)40-18-17-33(44)45)43-30-19-24(25-12-16-32(48-3)41-21-25)11-14-27(30)34(42-43)28-20-26(36(37,38)39)13-15-31(28)47-2/h7-16,19-21,29H,4-6,17-18H2,1-3H3,(H,40,46)(H,44,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120371
PNG
(CHEMBL3616698)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C36H31F6N3O4/c1-3-4-5-29(20-6-8-21(9-7-20)35(48)43-15-14-32(46)47)45-30-18-22(23-16-27(37)33(39)28(38)17-23)10-12-25(30)34(44-45)26-19-24(36(40,41)42)11-13-31(26)49-2/h6-13,16-19,29H,3-5,14-15H2,1-2H3,(H,43,48)(H,46,47)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120372
PNG
(CHEMBL3616699)
Show SMILES COc1ccc(cc1-c1nn(C(C(C)C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C36H34F3N3O4/c1-21(2)34(24-9-11-25(12-10-24)35(45)40-18-17-32(43)44)42-30-19-26(23-7-5-22(3)6-8-23)13-15-28(30)33(41-42)29-20-27(36(37,38)39)14-16-31(29)46-4/h5-16,19-21,34H,17-18H2,1-4H3,(H,40,45)(H,43,44)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120373
PNG
(CHEMBL3616700)
Show SMILES CCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C35H32F3N3O4/c1-4-29(23-9-11-24(12-10-23)34(44)39-18-17-32(42)43)41-30-19-25(22-7-5-21(2)6-8-22)13-15-27(30)33(40-41)28-20-26(35(36,37)38)14-16-31(28)45-3/h5-16,19-20,29H,4,17-18H2,1-3H3,(H,39,44)(H,42,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120334
PNG
(CHEMBL3616682)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2ccc(Cl)c(F)c2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H24ClF4N3O4/c1-18(19-2-4-21(5-3-19)31(43)38-15-14-29(41)42)40-28-17-22(20-6-10-24(11-7-20)44-32(35,36)37)8-12-25(28)30(39-40)23-9-13-26(33)27(34)16-23/h2-13,16-18H,14-15H2,1H3,(H,38,43)(H,41,42)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120318
PNG
(CHEMBL3616587)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1cc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C37H35F3N2O4/c1-4-5-32(25-10-12-26(13-11-25)36(45)41-19-18-35(43)44)42-22-31(30-21-28(37(38,39)40)15-17-34(30)46-3)29-16-14-27(20-33(29)42)24-8-6-23(2)7-9-24/h6-17,20-22,32H,4-5,18-19H2,1-3H3,(H,41,45)(H,43,44)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120212
PNG
(CHEMBL3616581)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C36H34F3N3O5/c1-4-5-30(23-6-8-24(9-7-23)35(45)40-19-18-33(43)44)42-31-20-25(22-10-14-27(46-2)15-11-22)12-16-28(31)34(41-42)29-21-26(36(37,38)39)13-17-32(29)47-3/h6-17,20-21,30H,4-5,18-19H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120363
PNG
(CHEMBL3616691)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1Cl
Show InChI InChI=1S/C37H35ClF3N3O5/c1-4-5-6-31(22-7-9-23(10-8-22)36(47)42-18-17-34(45)46)44-32-19-24(27-15-13-26(48-2)21-30(27)38)11-14-28(32)35(43-44)29-20-25(37(39,40)41)12-16-33(29)49-3/h7-16,19-21,31H,4-6,17-18H2,1-3H3,(H,42,47)(H,45,46)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120323
PNG
(CHEMBL3616592)
Show SMILES COc1cc(F)c(F)cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H26F5N3O5/c1-18(19-3-5-21(6-4-19)32(44)39-14-13-30(42)43)41-28-15-22(20-7-10-23(11-8-20)46-33(36,37)38)9-12-24(28)31(40-41)25-16-26(34)27(35)17-29(25)45-2/h3-12,15-18H,13-14H2,1-2H3,(H,39,44)(H,42,43)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120370
PNG
(CHEMBL3616697)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)s1
Show InChI InChI=1S/C35H34F3N3O4S/c1-4-5-6-28(22-8-10-23(11-9-22)34(44)39-18-17-32(42)43)41-29-19-24(31-16-7-21(2)46-31)12-14-26(29)33(40-41)27-20-25(35(36,37)38)13-15-30(27)45-3/h7-16,19-20,28H,4-6,17-18H2,1-3H3,(H,39,44)(H,42,43)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120324
PNG
(CHEMBL3616672)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2F)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H24F7N3O4/c1-18(19-2-4-21(5-3-19)31(46)41-15-14-29(44)45)43-28-16-22(20-6-10-24(11-7-20)47-33(38,39)40)8-12-25(28)30(42-43)26-17-23(32(35,36)37)9-13-27(26)34/h2-13,16-18H,14-15H2,1H3,(H,41,46)(H,44,45)
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120281
PNG
(CHEMBL3616584)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C36H34F3N3O4/c1-4-5-30(24-10-12-25(13-11-24)35(45)40-19-18-33(43)44)42-31-20-26(23-8-6-22(2)7-9-23)14-16-28(31)34(41-42)29-21-27(36(37,38)39)15-17-32(29)46-3/h6-17,20-21,30H,4-5,18-19H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120319
PNG
(CHEMBL3616588)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C36H31F6N3O5/c1-3-4-29(22-5-7-23(8-6-22)34(48)43-18-17-32(46)47)45-30-19-24(21-9-13-26(14-10-21)50-36(40,41)42)11-15-27(30)33(44-45)28-20-25(35(37,38)39)12-16-31(28)49-2/h5-16,19-20,29H,3-4,17-18H2,1-2H3,(H,43,48)(H,46,47)
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n/an/a 5.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120335
PNG
(CHEMBL3616683)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(F)c(F)c(F)c2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H23F6N3O4/c1-17(18-2-4-20(5-3-18)31(44)39-13-12-28(42)43)41-27-16-21(19-6-9-23(10-7-19)45-32(36,37)38)8-11-24(27)30(40-41)22-14-25(33)29(35)26(34)15-22/h2-11,14-17H,12-13H2,1H3,(H,39,44)(H,42,43)
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n/an/a 6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120341
PNG
(CHEMBL3616688)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C37H36F3N3O4/c1-4-5-6-31(25-11-13-26(14-12-25)36(46)41-20-19-34(44)45)43-32-21-27(24-9-7-23(2)8-10-24)15-17-29(32)35(42-43)30-22-28(37(38,39)40)16-18-33(30)47-3/h7-18,21-22,31H,4-6,19-20H2,1-3H3,(H,41,46)(H,44,45)
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n/an/a 6.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120326
PNG
(CHEMBL3616674)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(F)cc(F)c2F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H23F6N3O4/c1-17(18-2-4-20(5-3-18)31(44)39-13-12-28(42)43)41-27-14-21(19-6-9-23(10-7-19)45-32(36,37)38)8-11-24(27)30(40-41)25-15-22(33)16-26(34)29(25)35/h2-11,14-17H,12-13H2,1H3,(H,39,44)(H,42,43)
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n/an/a 7n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120280
PNG
(CHEMBL3616583)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2cc(ccc12)-c1ccc(C)cc1
Show InChI InChI=1S/C36H34F3N3O4/c1-4-5-30(24-10-12-25(13-11-24)35(45)40-19-18-33(43)44)42-31-16-14-26(23-8-6-22(2)7-9-23)20-28(31)34(41-42)29-21-27(36(37,38)39)15-17-32(29)46-3/h6-17,20-21,30H,4-5,18-19H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 7n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120321
PNG
(CHEMBL3616590)
Show SMILES COc1ccc(OC(F)(F)F)cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C34H27F6N3O6/c1-19(20-3-5-22(6-4-20)32(46)41-16-15-30(44)45)43-28-17-23(21-7-10-24(11-8-21)48-33(35,36)37)9-13-26(28)31(42-43)27-18-25(49-34(38,39)40)12-14-29(27)47-2/h3-14,17-19H,15-16H2,1-2H3,(H,41,46)(H,44,45)
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n/an/a 7n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120369
PNG
(CHEMBL3616696)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C36H32ClF4N3O4/c1-3-4-5-30(21-6-8-22(9-7-21)35(47)42-15-14-33(45)46)44-31-18-23(24-16-26(37)20-27(38)17-24)10-12-28(31)34(43-44)29-19-25(36(39,40)41)11-13-32(29)48-2/h6-13,16-20,30H,3-5,14-15H2,1-2H3,(H,42,47)(H,45,46)
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n/an/a 7n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120374
PNG
(CHEMBL3616701)
Show SMILES COc1ccc(cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C34H30F3N3O4/c1-20-4-6-23(7-5-20)25-12-14-27-29(18-25)40(39-32(27)28-19-26(34(35,36)37)13-15-30(28)44-3)21(2)22-8-10-24(11-9-22)33(43)38-17-16-31(41)42/h4-15,18-19,21H,16-17H2,1-3H3,(H,38,43)(H,41,42)
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n/an/a 7.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120365
PNG
(CHEMBL3616693)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C37H33F6N3O5/c1-3-4-5-30(23-6-8-24(9-7-23)35(49)44-19-18-33(47)48)46-31-20-25(22-10-14-27(15-11-22)51-37(41,42)43)12-16-28(31)34(45-46)29-21-26(36(38,39)40)13-17-32(29)50-2/h6-17,20-21,30H,3-5,18-19H2,1-2H3,(H,44,49)(H,47,48)
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n/an/a 8n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120317
PNG
(CHEMBL3616586)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1cc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C37H35F3N2O5/c1-4-5-32(24-6-8-25(9-7-24)36(45)41-19-18-35(43)44)42-22-31(30-21-27(37(38,39)40)13-17-34(30)47-3)29-16-12-26(20-33(29)42)23-10-14-28(46-2)15-11-23/h6-17,20-22,32H,4-5,18-19H2,1-3H3,(H,41,45)(H,43,44)
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n/an/a 8n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120332
PNG
(CHEMBL3616680)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2ccc(F)cc2F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H24F5N3O4/c1-18(19-2-4-21(5-3-19)31(43)38-15-14-29(41)42)40-28-16-22(20-6-10-24(11-7-20)44-32(35,36)37)8-12-26(28)30(39-40)25-13-9-23(33)17-27(25)34/h2-13,16-18H,14-15H2,1H3,(H,38,43)(H,41,42)
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n/an/a 8n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120342
PNG
(CHEMBL3616689)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(SC)cc1
Show InChI InChI=1S/C37H36F3N3O4S/c1-4-5-6-31(24-7-9-25(10-8-24)36(46)41-20-19-34(44)45)43-32-21-26(23-11-15-28(48-3)16-12-23)13-17-29(32)35(42-43)30-22-27(37(38,39)40)14-18-33(30)47-2/h7-18,21-22,31H,4-6,19-20H2,1-3H3,(H,41,46)(H,44,45)
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n/an/a 9n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120325
PNG
(CHEMBL3616673)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(F)ccc2Cl)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H24ClF4N3O4/c1-18(19-2-4-21(5-3-19)31(43)38-15-14-29(41)42)40-28-16-22(20-6-10-24(11-7-20)44-32(35,36)37)8-12-25(28)30(39-40)26-17-23(34)9-13-27(26)33/h2-13,16-18H,14-15H2,1H3,(H,38,43)(H,41,42)
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120211
PNG
(CHEMBL3616580)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2cc(ccc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C36H34F3N3O5/c1-4-5-30(23-6-8-24(9-7-23)35(45)40-19-18-33(43)44)42-31-16-12-25(22-10-14-27(46-2)15-11-22)20-28(31)34(41-42)29-21-26(36(37,38)39)13-17-32(29)47-3/h6-17,20-21,30H,4-5,18-19H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120321
PNG
(CHEMBL3616590)
Show SMILES COc1ccc(OC(F)(F)F)cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C34H27F6N3O6/c1-19(20-3-5-22(6-4-20)32(46)41-16-15-30(44)45)43-28-17-23(21-7-10-24(11-8-21)48-33(35,36)37)9-13-26(28)31(42-43)27-18-25(49-34(38,39)40)12-14-29(27)47-2/h3-14,17-19H,15-16H2,1-2H3,(H,41,46)(H,44,45)
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120212
PNG
(CHEMBL3616581)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C36H34F3N3O5/c1-4-5-30(23-6-8-24(9-7-23)35(45)40-19-18-33(43)44)42-31-20-25(22-10-14-27(46-2)15-11-22)12-16-28(31)34(41-42)29-21-26(36(37,38)39)13-17-32(29)47-3/h6-17,20-21,30H,4-5,18-19H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120320
PNG
(CHEMBL3616589)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1cc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(nc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C36H31F6N3O5/c1-3-4-30(22-5-7-23(8-6-22)34(48)43-18-17-32(46)47)45-20-28(27-19-24(35(37,38)39)11-16-31(27)49-2)26-14-15-29(44-33(26)45)21-9-12-25(13-10-21)50-36(40,41)42/h5-16,19-20,30H,3-4,17-18H2,1-2H3,(H,43,48)(H,46,47)
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n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120366
PNG
(CHEMBL3616694)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C37H33F6N3O4/c1-3-4-5-30(23-6-8-24(9-7-23)35(49)44-19-18-33(47)48)46-31-20-25(22-10-13-26(14-11-22)36(38,39)40)12-16-28(31)34(45-46)29-21-27(37(41,42)43)15-17-32(29)50-2/h6-17,20-21,30H,3-5,18-19H2,1-2H3,(H,44,49)(H,47,48)
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n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120339
PNG
(CHEMBL3616687)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C37H36F3N3O5/c1-4-5-6-31(24-7-9-25(10-8-24)36(46)41-20-19-34(44)45)43-32-21-26(23-11-15-28(47-2)16-12-23)13-17-29(32)35(42-43)30-22-27(37(38,39)40)14-18-33(30)48-3/h7-18,21-22,31H,4-6,19-20H2,1-3H3,(H,41,46)(H,44,45)
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n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120336
PNG
(CHEMBL3616684)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2ccc(cc2)C#N)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H25F3N4O4/c1-20(22-6-8-25(9-7-22)32(43)38-17-16-30(41)42)40-29-18-26(23-10-13-27(14-11-23)44-33(34,35)36)12-15-28(29)31(39-40)24-4-2-21(19-37)3-5-24/h2-15,18,20H,16-17H2,1H3,(H,38,43)(H,41,42)
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n/an/a 15n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120280
PNG
(CHEMBL3616583)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2cc(ccc12)-c1ccc(C)cc1
Show InChI InChI=1S/C36H34F3N3O4/c1-4-5-30(24-10-12-25(13-11-24)35(45)40-19-18-33(43)44)42-31-16-14-26(23-8-6-22(2)7-9-23)20-28(31)34(41-42)29-21-27(36(37,38)39)15-17-32(29)46-3/h6-17,20-21,30H,4-5,18-19H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120362
PNG
(CHEMBL3616690)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C36H34F3N3O4/c1-3-4-10-30(24-11-13-25(14-12-24)35(45)40-20-19-33(43)44)42-31-21-26(23-8-6-5-7-9-23)15-17-28(31)34(41-42)29-22-27(36(37,38)39)16-18-32(29)46-2/h5-9,11-18,21-22,30H,3-4,10,19-20H2,1-2H3,(H,40,45)(H,43,44)
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n/an/a 18n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120364
PNG
(CHEMBL3616692)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)c(F)c1
Show InChI InChI=1S/C37H35F4N3O5/c1-4-5-6-30(22-7-9-23(10-8-22)36(47)42-18-17-34(45)46)44-31-20-25(24-12-15-33(49-3)29(38)19-24)11-14-27(31)35(43-44)28-21-26(37(39,40)41)13-16-32(28)48-2/h7-16,19-21,30H,4-6,17-18H2,1-3H3,(H,42,47)(H,45,46)
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n/an/a 18n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120363
PNG
(CHEMBL3616691)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1Cl
Show InChI InChI=1S/C37H35ClF3N3O5/c1-4-5-6-31(22-7-9-23(10-8-22)36(47)42-18-17-34(45)46)44-32-19-24(27-15-13-26(48-2)21-30(27)38)11-14-28(32)35(43-44)29-20-25(37(39,40)41)12-16-33(29)49-3/h7-16,19-21,31H,4-6,17-18H2,1-3H3,(H,42,47)(H,45,46)
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n/an/a 18n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120370
PNG
(CHEMBL3616697)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)s1
Show InChI InChI=1S/C35H34F3N3O4S/c1-4-5-6-28(22-8-10-23(11-9-22)34(44)39-18-17-32(42)43)41-29-19-24(31-16-7-21(2)46-31)12-14-26(29)33(40-41)27-20-25(35(36,37)38)13-15-30(27)45-3/h7-16,19-20,28H,4-6,17-18H2,1-3H3,(H,39,44)(H,42,43)
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n/an/a 18n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120335
PNG
(CHEMBL3616683)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(F)c(F)c(F)c2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H23F6N3O4/c1-17(18-2-4-20(5-3-18)31(44)39-13-12-28(42)43)41-27-16-21(19-6-9-23(10-7-19)45-32(36,37)38)8-11-24(27)30(40-41)22-14-25(33)29(35)26(34)15-22/h2-11,14-17H,12-13H2,1H3,(H,39,44)(H,42,43)
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n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120373
PNG
(CHEMBL3616700)
Show SMILES CCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C35H32F3N3O4/c1-4-29(23-9-11-24(12-10-23)34(44)39-18-17-32(42)43)41-30-19-25(22-7-5-21(2)6-8-22)13-15-27(30)33(40-41)28-20-26(35(36,37)38)14-16-31(28)45-3/h5-16,19-20,29H,4,17-18H2,1-3H3,(H,39,44)(H,42,43)
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n/an/a 21n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120367
PNG
(CHEMBL3616695)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)nc1
Show InChI InChI=1S/C36H35F3N4O5/c1-4-5-6-29(22-7-9-23(10-8-22)35(46)40-18-17-33(44)45)43-30-19-24(25-12-16-32(48-3)41-21-25)11-14-27(30)34(42-43)28-20-26(36(37,38)39)13-15-31(28)47-2/h7-16,19-21,29H,4-6,17-18H2,1-3H3,(H,40,46)(H,44,45)
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n/an/a 24n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120330
PNG
(CHEMBL3616678)
Show SMILES COc1ccc(cn1)-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H27F3N4O5/c1-19(20-3-5-22(6-4-20)31(42)36-16-15-29(40)41)39-27-17-23(21-7-11-25(12-8-21)44-32(33,34)35)9-13-26(27)30(38-39)24-10-14-28(43-2)37-18-24/h3-14,17-19H,15-16H2,1-2H3,(H,36,42)(H,40,41)
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n/an/a 26n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120371
PNG
(CHEMBL3616698)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C36H31F6N3O4/c1-3-4-5-29(20-6-8-21(9-7-20)35(48)43-15-14-32(46)47)45-30-18-22(23-16-27(37)33(39)28(38)17-23)10-12-25(30)34(44-45)26-19-24(36(40,41)42)11-13-31(26)49-2/h6-13,16-19,29H,3-5,14-15H2,1-2H3,(H,43,48)(H,46,47)
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n/an/a 26n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120211
PNG
(CHEMBL3616580)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2cc(ccc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C36H34F3N3O5/c1-4-5-30(23-6-8-24(9-7-23)35(45)40-19-18-33(43)44)42-31-16-12-25(22-10-14-27(46-2)15-11-22)20-28(31)34(41-42)29-21-26(36(37,38)39)13-17-32(29)47-3/h6-17,20-21,30H,4-5,18-19H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 26n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120338
PNG
(CHEMBL3616686)
Show SMILES COc1nccc(n1)-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C31H26F3N5O5/c1-18(19-3-5-21(6-4-19)29(42)35-16-14-27(40)41)39-26-17-22(20-7-10-23(11-8-20)44-31(32,33)34)9-12-24(26)28(38-39)25-13-15-36-30(37-25)43-2/h3-13,15,17-18H,14,16H2,1-2H3,(H,35,42)(H,40,41)
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n/an/a 35n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120322
PNG
(CHEMBL3616591)
Show SMILES COc1ccc(Cl)cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H27ClF3N3O5/c1-19(20-3-5-22(6-4-20)32(43)38-16-15-30(41)42)40-28-17-23(21-7-11-25(12-8-21)45-33(35,36)37)9-13-26(28)31(39-40)27-18-24(34)10-14-29(27)44-2/h3-14,17-19H,15-16H2,1-2H3,(H,38,43)(H,41,42)
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n/an/a 36n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120323
PNG
(CHEMBL3616592)
Show SMILES COc1cc(F)c(F)cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H26F5N3O5/c1-18(19-3-5-21(6-4-19)32(44)39-14-13-30(42)43)41-28-15-22(20-7-10-23(11-8-20)46-33(36,37)38)9-12-24(28)31(40-41)25-16-26(34)27(35)17-29(25)45-2/h3-12,15-18H,13-14H2,1-2H3,(H,39,44)(H,42,43)
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n/an/a 37n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120375
PNG
(CHEMBL3616702)
Show SMILES COc1ccc(cc1-c1nn(Cc2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C33H28F3N3O4/c1-20-3-7-22(8-4-20)24-11-13-26-28(17-24)39(19-21-5-9-23(10-6-21)32(42)37-16-15-30(40)41)38-31(26)27-18-25(33(34,35)36)12-14-29(27)43-2/h3-14,17-18H,15-16,19H2,1-2H3,(H,37,42)(H,40,41)
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n/an/a 39n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120337
PNG
(CHEMBL3616685)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(C(=O)c2ccc(cc2)N(C)C)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C35H31F3N4O5/c1-21(22-4-6-25(7-5-22)34(46)39-19-18-31(43)44)42-30-20-26(23-10-15-28(16-11-23)47-35(36,37)38)12-17-29(30)32(40-42)33(45)24-8-13-27(14-9-24)41(2)3/h4-17,20-21H,18-19H2,1-3H3,(H,39,46)(H,43,44)
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n/an/a 40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120332
PNG
(CHEMBL3616680)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2ccc(F)cc2F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H24F5N3O4/c1-18(19-2-4-21(5-3-19)31(43)38-15-14-29(41)42)40-28-16-22(20-6-10-24(11-7-20)44-32(35,36)37)8-12-26(28)30(39-40)25-13-9-23(33)17-27(25)34/h2-13,16-18H,14-15H2,1H3,(H,38,43)(H,41,42)
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n/an/a 41n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120336
PNG
(CHEMBL3616684)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2ccc(cc2)C#N)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H25F3N4O4/c1-20(22-6-8-25(9-7-22)32(43)38-17-16-30(41)42)40-29-18-26(23-10-13-27(14-11-23)44-33(34,35)36)12-15-28(29)31(39-40)24-4-2-21(19-37)3-5-24/h2-15,18,20H,16-17H2,1H3,(H,38,43)(H,41,42)
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n/an/a 43n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120334
PNG
(CHEMBL3616682)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2ccc(Cl)c(F)c2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H24ClF4N3O4/c1-18(19-2-4-21(5-3-19)31(43)38-15-14-29(41)42)40-28-17-22(20-6-10-24(11-7-20)44-32(35,36)37)8-12-25(28)30(39-40)23-9-13-26(33)27(34)16-23/h2-13,16-18H,14-15H2,1H3,(H,38,43)(H,41,42)
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n/an/a 44n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120369
PNG
(CHEMBL3616696)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C36H32ClF4N3O4/c1-3-4-5-30(21-6-8-22(9-7-21)35(47)42-15-14-33(45)46)44-31-18-23(24-16-26(37)20-27(38)17-24)10-12-28(31)34(43-44)29-19-25(36(39,40)41)11-13-32(29)48-2/h6-13,16-20,30H,3-5,14-15H2,1-2H3,(H,42,47)(H,45,46)
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n/an/a 46n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120318
PNG
(CHEMBL3616587)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1cc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C37H35F3N2O4/c1-4-5-32(25-10-12-26(13-11-25)36(45)41-19-18-35(43)44)42-22-31(30-21-28(37(38,39)40)15-17-34(30)46-3)29-16-14-27(20-33(29)42)24-8-6-23(2)7-9-24/h6-17,20-22,32H,4-5,18-19H2,1-3H3,(H,41,45)(H,43,44)
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n/an/a 48n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120329
PNG
(CHEMBL3616677)
Show SMILES COc1cncc(c1)-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H27F3N4O5/c1-19(20-3-5-22(6-4-20)31(42)37-14-13-29(40)41)39-28-16-23(21-7-10-25(11-8-21)44-32(33,34)35)9-12-27(28)30(38-39)24-15-26(43-2)18-36-17-24/h3-12,15-19H,13-14H2,1-2H3,(H,37,42)(H,40,41)
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n/an/a 50n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120326
PNG
(CHEMBL3616674)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(F)cc(F)c2F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H23F6N3O4/c1-17(18-2-4-20(5-3-18)31(44)39-13-12-28(42)43)41-27-14-21(19-6-9-23(10-7-19)45-32(36,37)38)8-11-24(27)30(40-41)25-15-22(33)16-26(34)29(25)35/h2-11,14-17H,12-13H2,1H3,(H,39,44)(H,42,43)
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n/an/a 52n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120333
PNG
(CHEMBL3616681)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(Cl)cc(c2)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H24ClF6N3O4/c1-18(19-2-4-21(5-3-19)31(46)41-13-12-29(44)45)43-28-16-22(20-6-9-26(10-7-20)47-33(38,39)40)8-11-27(28)30(42-43)23-14-24(32(35,36)37)17-25(34)15-23/h2-11,14-18H,12-13H2,1H3,(H,41,46)(H,44,45)
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n/an/a 56n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120330
PNG
(CHEMBL3616678)
Show SMILES COc1ccc(cn1)-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H27F3N4O5/c1-19(20-3-5-22(6-4-20)31(42)36-16-15-29(40)41)39-27-17-23(21-7-11-25(12-8-21)44-32(33,34)35)9-13-26(27)30(38-39)24-10-14-28(43-2)37-18-24/h3-14,17-19H,15-16H2,1-2H3,(H,36,42)(H,40,41)
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n/an/a 65n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120372
PNG
(CHEMBL3616699)
Show SMILES COc1ccc(cc1-c1nn(C(C(C)C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C36H34F3N3O4/c1-21(2)34(24-9-11-25(12-10-24)35(45)40-18-17-32(43)44)42-30-19-26(23-7-5-22(3)6-8-23)13-15-28(30)33(41-42)29-20-27(36(37,38)39)14-16-31(29)46-4/h5-16,19-21,34H,17-18H2,1-4H3,(H,40,45)(H,43,44)
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n/an/a 69n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120331
PNG
(CHEMBL3616679)
Show SMILES COc1ncccc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H27F3N4O5/c1-19(20-5-7-22(8-6-20)30(42)36-17-15-28(40)41)39-27-18-23(21-9-12-24(13-10-21)44-32(33,34)35)11-14-25(27)29(38-39)26-4-3-16-37-31(26)43-2/h3-14,16,18-19H,15,17H2,1-2H3,(H,36,42)(H,40,41)
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n/an/a 72n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120331
PNG
(CHEMBL3616679)
Show SMILES COc1ncccc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H27F3N4O5/c1-19(20-5-7-22(8-6-20)30(42)36-17-15-28(40)41)39-27-18-23(21-9-12-24(13-10-21)44-32(33,34)35)11-14-25(27)29(38-39)26-4-3-16-37-31(26)43-2/h3-14,16,18-19H,15,17H2,1-2H3,(H,36,42)(H,40,41)
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n/an/a 77n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120338
PNG
(CHEMBL3616686)
Show SMILES COc1nccc(n1)-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C31H26F3N5O5/c1-18(19-3-5-21(6-4-19)29(42)35-16-14-27(40)41)39-26-17-22(20-7-10-23(11-8-20)44-31(32,33)34)9-12-24(26)28(38-39)25-13-15-36-30(37-25)43-2/h3-13,15,17-18H,14,16H2,1-2H3,(H,35,42)(H,40,41)
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n/an/a 84n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120329
PNG
(CHEMBL3616677)
Show SMILES COc1cncc(c1)-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H27F3N4O5/c1-19(20-3-5-22(6-4-20)31(42)37-14-13-29(40)41)39-28-16-23(21-7-10-25(11-8-21)44-32(33,34)35)9-12-27(28)30(38-39)24-15-26(43-2)18-36-17-24/h3-12,15-19H,13-14H2,1-2H3,(H,37,42)(H,40,41)
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n/an/a 100n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120328
PNG
(CHEMBL3616676)
Show SMILES COc1ccncc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H27F3N4O5/c1-19(20-3-5-22(6-4-20)31(42)37-16-14-29(40)41)39-27-17-23(21-7-10-24(11-8-21)44-32(33,34)35)9-12-25(27)30(38-39)26-18-36-15-13-28(26)43-2/h3-13,15,17-19H,14,16H2,1-2H3,(H,37,42)(H,40,41)
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n/an/a 110n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120324
PNG
(CHEMBL3616672)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2F)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H24F7N3O4/c1-18(19-2-4-21(5-3-19)31(46)41-15-14-29(44)45)43-28-16-22(20-6-10-24(11-7-20)47-33(38,39)40)8-12-25(28)30(42-43)26-17-23(32(35,36)37)9-13-27(26)34/h2-13,16-18H,14-15H2,1H3,(H,41,46)(H,44,45)
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n/an/a 120n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120317
PNG
(CHEMBL3616586)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1cc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C37H35F3N2O5/c1-4-5-32(24-6-8-25(9-7-24)36(45)41-19-18-35(43)44)42-22-31(30-21-27(37(38,39)40)13-17-34(30)47-3)29-16-12-26(20-33(29)42)23-10-14-28(46-2)15-11-23/h6-17,20-22,32H,4-5,18-19H2,1-3H3,(H,41,45)(H,43,44)
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120325
PNG
(CHEMBL3616673)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(F)ccc2Cl)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H24ClF4N3O4/c1-18(19-2-4-21(5-3-19)31(43)38-15-14-29(41)42)40-28-16-22(20-6-10-24(11-7-20)44-32(35,36)37)8-12-25(28)30(39-40)26-17-23(34)9-13-27(26)33/h2-13,16-18H,14-15H2,1H3,(H,38,43)(H,41,42)
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n/an/a 140n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120375
PNG
(CHEMBL3616702)
Show SMILES COc1ccc(cc1-c1nn(Cc2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C33H28F3N3O4/c1-20-3-7-22(8-4-20)24-11-13-26-28(17-24)39(19-21-5-9-23(10-6-21)32(42)37-16-15-30(40)41)38-31(26)27-18-25(33(34,35)36)12-14-29(27)43-2/h3-14,17-18H,15-16,19H2,1-2H3,(H,37,42)(H,40,41)
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n/an/a 140n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120337
PNG
(CHEMBL3616685)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(C(=O)c2ccc(cc2)N(C)C)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C35H31F3N4O5/c1-21(22-4-6-25(7-5-22)34(46)39-19-18-31(43)44)42-30-20-26(23-10-15-28(16-11-23)47-35(36,37)38)12-17-29(30)32(40-42)33(45)24-8-13-27(14-9-24)41(2)3/h4-17,20-21H,18-19H2,1-3H3,(H,39,46)(H,43,44)
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n/an/a 210n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120327
PNG
(CHEMBL3616675)
Show SMILES CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(Cl)ccc2C(N)=O)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C33H26ClF3N4O5/c1-18(19-2-4-21(5-3-19)32(45)39-15-14-29(42)43)41-28-16-22(20-6-10-24(11-7-20)46-33(35,36)37)8-12-26(28)30(40-41)27-17-23(34)9-13-25(27)31(38)44/h2-13,16-18H,14-15H2,1H3,(H2,38,44)(H,39,45)(H,42,43)
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n/an/a 220n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120320
PNG
(CHEMBL3616589)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1cc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(nc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C36H31F6N3O5/c1-3-4-30(22-5-7-23(8-6-22)34(48)43-18-17-32(46)47)45-20-28(27-19-24(35(37,38)39)11-16-31(27)49-2)26-14-15-29(44-33(26)45)21-9-12-25(13-10-21)50-36(40,41)42/h5-16,19-20,30H,3-4,17-18H2,1-2H3,(H,43,48)(H,46,47)
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n/an/a 360n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens (Human))		BDBM50120365
PNG
(CHEMBL3616693)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C37H33F6N3O5/c1-3-4-5-30(23-6-8-24(9-7-23)35(49)44-19-18-33(47)48)46-31-20-25(22-10-14-27(15-11-22)51-37(41,42)43)12-16-28(31)34(45-46)29-21-26(36(38,39)40)13-17-32(29)50-2/h6-17,20-21,30H,3-5,18-19H2,1-2H3,(H,44,49)(H,47,48)
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n/an/a 750n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucose dependent insulinotropic peptide receptor by cAMP accumulation assay

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120328
PNG
(CHEMBL3616676)
Show SMILES COc1ccncc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H27F3N4O5/c1-19(20-3-5-22(6-4-20)31(42)37-16-14-29(40)41)39-27-17-23(21-7-10-24(11-8-21)44-32(33,34)35)9-12-25(27)30(38-39)26-18-36-15-13-28(26)43-2/h3-13,15,17-19H,14,16H2,1-2H3,(H,37,42)(H,40,41)
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n/an/a 760n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120282
PNG
(CHEMBL3616585)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2cccc(-c3ccc(C)cc3)c12
Show InChI InChI=1S/C36H34F3N3O4/c1-4-6-30(24-13-15-25(16-14-24)35(45)40-20-19-32(43)44)42-34-27(23-11-9-22(2)10-12-23)7-5-8-28(34)33(41-42)29-21-26(36(37,38)39)17-18-31(29)46-3/h5,7-18,21,30H,4,6,19-20H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 780n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens (Human))		BDBM50120341
PNG
(CHEMBL3616688)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C37H36F3N3O4/c1-4-5-6-31(25-11-13-26(14-12-25)36(46)41-20-19-34(44)45)43-32-21-27(24-9-7-23(2)8-10-24)15-17-29(32)35(42-43)30-22-28(37(38,39)40)16-18-33(30)47-3/h7-18,21-22,31H,4-6,19-20H2,1-3H3,(H,41,46)(H,44,45)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucose dependent insulinotropic peptide receptor by cAMP accumulation assay

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens (Human))		BDBM50120339
PNG
(CHEMBL3616687)
Show SMILES CCCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C37H36F3N3O5/c1-4-5-6-31(24-7-9-25(10-8-24)36(46)41-20-19-34(44)45)43-32-21-26(23-11-15-28(47-2)16-12-23)13-17-29(32)35(42-43)30-22-27(37(38,39)40)14-18-33(30)48-3/h7-18,21-22,31H,4-6,19-20H2,1-3H3,(H,41,46)(H,44,45)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucose dependent insulinotropic peptide receptor by cAMP accumulation assay

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens (Human))		BDBM50120374
PNG
(CHEMBL3616701)
Show SMILES COc1ccc(cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C34H30F3N3O4/c1-20-4-6-23(7-5-20)25-12-14-27-29(18-25)40(39-32(27)28-19-26(34(35,36)37)13-15-30(28)44-3)21(2)22-8-10-24(11-9-22)33(43)38-17-16-31(41)42/h4-15,18-19,21H,16-17H2,1-3H3,(H,38,43)(H,41,42)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucose dependent insulinotropic peptide receptor by cAMP accumulation assay

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens (Human))		BDBM50120319
PNG
(CHEMBL3616588)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C36H31F6N3O5/c1-3-4-29(22-5-7-23(8-6-22)34(48)43-18-17-32(46)47)45-30-19-24(21-9-13-26(14-10-21)50-36(40,41)42)11-15-27(30)33(44-45)28-20-25(35(37,38)39)12-16-31(28)49-2/h5-16,19-20,29H,3-4,17-18H2,1-2H3,(H,43,48)(H,46,47)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucose dependent insulinotropic peptide receptor by cAMP accumulation assay

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120279
PNG
(CHEMBL3616582)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2cccc(-c3ccc(OC)cc3)c12
Show InChI InChI=1S/C36H34F3N3O5/c1-4-6-30(23-9-11-24(12-10-23)35(45)40-20-19-32(43)44)42-34-27(22-13-16-26(46-2)17-14-22)7-5-8-28(34)33(41-42)29-21-25(36(37,38)39)15-18-31(29)47-3/h5,7-18,21,30H,4,6,19-20H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from human glucagon receptor expressed in CHO cell membranes

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120279
PNG
(CHEMBL3616582)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2cccc(-c3ccc(OC)cc3)c12
Show InChI InChI=1S/C36H34F3N3O5/c1-4-6-30(23-9-11-24(12-10-23)35(45)40-20-19-32(43)44)42-34-27(22-13-16-26(46-2)17-14-22)7-5-8-28(34)33(41-42)29-21-25(36(37,38)39)15-18-31(29)47-3/h5,7-18,21,30H,4,6,19-20H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50120282
PNG
(CHEMBL3616585)
Show SMILES CCCC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(-c2cc(ccc2OC)C(F)(F)F)c2cccc(-c3ccc(C)cc3)c12
Show InChI InChI=1S/C36H34F3N3O4/c1-4-6-30(24-13-15-25(16-14-24)35(45)40-20-19-32(43)44)42-34-27(23-11-9-22(2)10-12-23)7-5-8-28(34)33(41-42)29-21-26(36(37,38)39)17-18-31(29)46-3/h5,7-18,21,30H,4,6,19-20H2,1-3H3,(H,40,45)(H,43,44)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human glucagon receptor expressed in CHO cells assessed as reduction in glucagon-induced cAMP production

Bioorg Med Chem Lett 25: 4143-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.015
BindingDB Entry DOI: 10.7270/Q23F4RGX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%