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Compile Data Set for Download or QSAR

Found 219 hits with Last Name = 'sofolarides' and Initial = 'm'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383459
PNG
(CHEMBL2031619)
Show SMILES O=c1ccnc2c(cccn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H24N6OS/c27-17-6-9-21-18-16(5-4-12-26(17)18)19-22-23-20(28-19)25-13-7-15(8-14-25)24-10-2-1-3-11-24/h4-6,9,12,15H,1-3,7-8,10-11,13-14H2
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 2.10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383442
PNG
(CHEMBL2031602)
Show SMILES Cc1nnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H25N7S/c1-14-20-21-17-6-5-15(13-26(14)17)18-22-23-19(27-18)25-11-7-16(8-12-25)24-9-3-2-4-10-24/h5-6,13,16H,2-4,7-12H2,1H3
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 2.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383459
PNG
(CHEMBL2031619)
Show SMILES O=c1ccnc2c(cccn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H24N6OS/c27-17-6-9-21-18-16(5-4-12-26(17)18)19-22-23-20(28-19)25-13-7-15(8-14-25)24-10-2-1-3-11-24/h4-6,9,12,15H,1-3,7-8,10-11,13-14H2
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 2.60n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383444
PNG
(CHEMBL2031604)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1cccc2ccnn12
Show InChI InChI=1S/C19H24N6S/c1-2-11-23(12-3-1)15-8-13-24(14-9-15)19-22-21-18(26-19)17-6-4-5-16-7-10-20-25(16)17/h4-7,10,15H,1-3,8-9,11-14H2
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 3.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383442
PNG
(CHEMBL2031602)
Show SMILES Cc1nnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H25N7S/c1-14-20-21-17-6-5-15(13-26(14)17)18-22-23-19(27-18)25-11-7-16(8-12-25)24-9-3-2-4-10-24/h5-6,13,16H,2-4,7-12H2,1H3
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 3.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333520
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(6-methoxypyridin-2-y...)
Show SMILES COc1cccc(n1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H25N5OS/c1-24-16-7-5-6-15(19-16)17-20-21-18(25-17)23-12-8-14(9-13-23)22-10-3-2-4-11-22/h5-7,14H,2-4,8-13H2,1H3
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 3.5n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333511
PNG
(1-(3-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-...)
Show SMILES CC(=O)c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H26N4OS/c1-15(25)16-6-5-7-17(14-16)19-21-22-20(26-19)24-12-8-18(9-13-24)23-10-3-2-4-11-23/h5-7,14,18H,2-4,8-13H2,1H3
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 4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383448
PNG
(CHEMBL2031608)
Show SMILES O=C(N1CCC1)c1cccc(n1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H28N6OS/c28-20(26-12-5-13-26)18-7-4-6-17(22-18)19-23-24-21(29-19)27-14-8-16(9-15-27)25-10-2-1-3-11-25/h4,6-7,16H,1-3,5,8-15H2
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 4.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383445
PNG
(CHEMBL2031605)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1cccc2cccnc12
Show InChI InChI=1S/C21H25N5S/c1-2-12-25(13-3-1)17-9-14-26(15-10-17)21-24-23-20(27-21)18-8-4-6-16-7-5-11-22-19(16)18/h4-8,11,17H,1-3,9-10,12-15H2
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 4.60n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333521
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(6-methylpyridin-2-yl...)
Show SMILES Cc1cccc(n1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H25N5S/c1-14-6-5-7-16(19-14)17-20-21-18(24-17)23-12-8-15(9-13-23)22-10-3-2-4-11-22/h5-7,15H,2-4,8-13H2,1H3
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 6.10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383445
PNG
(CHEMBL2031605)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1cccc2cccnc12
Show InChI InChI=1S/C21H25N5S/c1-2-12-25(13-3-1)17-9-14-26(15-10-17)21-24-23-20(27-21)18-8-4-6-16-7-5-11-22-19(16)18/h4-8,11,17H,1-3,9-10,12-15H2
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 7.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333534
PNG
(1-(2-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-...)
Show SMILES CC(=O)c1ccccc1-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H26N4OS/c1-15(25)17-7-3-4-8-18(17)19-21-22-20(26-19)24-13-9-16(10-14-24)23-11-5-2-6-12-23/h3-4,7-8,16H,2,5-6,9-14H2,1H3
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 8.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383453
PNG
(CHEMBL2031613)
Show SMILES O=c1ccc2cc(ccc2[nH]1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H25N5OS/c27-19-7-5-15-14-16(4-6-18(15)22-19)20-23-24-21(28-20)26-12-8-17(9-13-26)25-10-2-1-3-11-25/h4-7,14,17H,1-3,8-13H2,(H,22,27)
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 10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333515
PNG
(3-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Show SMILES COc1cc(cc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1)C#N
Show InChI InChI=1S/C20H25N5OS/c1-26-18-12-15(14-21)11-16(13-18)19-22-23-20(27-19)25-9-5-17(6-10-25)24-7-3-2-4-8-24/h11-13,17H,2-10H2,1H3
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 12n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333514
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3-chloro-5-methoxyph...)
Show SMILES COc1cc(Cl)cc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H25ClN4OS/c1-25-17-12-14(11-15(20)13-17)18-21-22-19(26-18)24-9-5-16(6-10-24)23-7-3-2-4-8-23/h11-13,16H,2-10H2,1H3
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 12n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383456
PNG
(CHEMBL2031616)
Show SMILES O=c1ccoc2ccc(cc12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H24N4O2S/c26-18-8-13-27-19-5-4-15(14-17(18)19)20-22-23-21(28-20)25-11-6-16(7-12-25)24-9-2-1-3-10-24/h4-5,8,13-14,16H,1-3,6-7,9-12H2
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 12n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383450
PNG
(CHEMBL2031610)
Show SMILES O=c1cccnn1-c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C22H26N6OS/c29-20-8-5-11-23-28(20)19-7-4-6-17(16-19)21-24-25-22(30-21)27-14-9-18(10-15-27)26-12-2-1-3-13-26/h4-8,11,16,18H,1-3,9-10,12-15H2
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 12n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383456
PNG
(CHEMBL2031616)
Show SMILES O=c1ccoc2ccc(cc12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H24N4O2S/c26-18-8-13-27-19-5-4-15(14-17(18)19)20-22-23-21(28-20)25-11-6-16(7-12-25)24-9-2-1-3-10-24/h4-5,8,13-14,16H,1-3,6-7,9-12H2
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 12.7n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383458
PNG
(CHEMBL2031618)
Show SMILES O=c1ccnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H24N6OS/c27-18-6-9-21-17-5-4-15(14-26(17)18)19-22-23-20(28-19)25-12-7-16(8-13-25)24-10-2-1-3-11-24/h4-6,9,14,16H,1-3,7-8,10-13H2
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 13n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333513
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)cc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H28N4O2S/c1-25-17-12-15(13-18(14-17)26-2)19-21-22-20(27-19)24-10-6-16(7-11-24)23-8-4-3-5-9-23/h12-14,16H,3-11H2,1-2H3
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 15n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333516
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3-fluoro-5-methoxyph...)
Show SMILES COc1cc(F)cc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H25FN4OS/c1-25-17-12-14(11-15(20)13-17)18-21-22-19(26-18)24-9-5-16(6-10-24)23-7-3-2-4-8-23/h11-13,16H,2-10H2,1H3
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 16n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383449
PNG
(CHEMBL2031609)
Show SMILES CC(=O)Nc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H27N5OS/c1-15(26)21-17-7-5-6-16(14-17)19-22-23-20(27-19)25-12-8-18(9-13-25)24-10-3-2-4-11-24/h5-7,14,18H,2-4,8-13H2,1H3,(H,21,26)
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 16.5n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383441
PNG
(CHEMBL2031601)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1cccc2cnccc12
Show InChI InChI=1S/C21H25N5S/c1-2-11-25(12-3-1)17-8-13-26(14-9-17)21-24-23-20(27-21)19-6-4-5-16-15-22-10-7-18(16)19/h4-7,10,15,17H,1-3,8-9,11-14H2
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 17.8n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383455
PNG
(CHEMBL2031615)
Show SMILES O=c1ccc2c(cccc2[nH]1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H25N5OS/c27-19-8-7-16-17(5-4-6-18(16)22-19)20-23-24-21(28-20)26-13-9-15(10-14-26)25-11-2-1-3-12-25/h4-8,15H,1-3,9-14H2,(H,22,27)
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 20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383452
PNG
(CHEMBL2031612)
Show SMILES O=C1COc2ccc(cc2N1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H25N5O2S/c26-18-13-27-17-5-4-14(12-16(17)21-18)19-22-23-20(28-19)25-10-6-15(7-11-25)24-8-2-1-3-9-24/h4-5,12,15H,1-3,6-11,13H2,(H,21,26)
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 22.1n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383440
PNG
(CHEMBL2031600)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H26N6OS/c1-15-22-23-19(28-15)16-6-5-7-17(14-16)20-24-25-21(29-20)27-12-8-18(9-13-27)26-10-3-2-4-11-26/h5-7,14,18H,2-4,8-13H2,1H3
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 22.8n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333518
PNG
(5-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Show SMILES N#Cc1cc(cc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1)C#N
Show InChI InChI=1S/C20H22N6S/c21-13-15-10-16(14-22)12-17(11-15)19-23-24-20(27-19)26-8-4-18(5-9-26)25-6-2-1-3-7-25/h10-12,18H,1-9H2
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 23n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383443
PNG
(CHEMBL2031603)
Show SMILES Cc1nc2cc(ccc2o1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H25N5OS/c1-14-21-17-13-15(5-6-18(17)26-14)19-22-23-20(27-19)25-11-7-16(8-12-25)24-9-3-2-4-10-24/h5-6,13,16H,2-4,7-12H2,1H3
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 24.5n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383458
PNG
(CHEMBL2031618)
Show SMILES O=c1ccnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H24N6OS/c27-18-6-9-21-17-5-4-15(14-26(17)18)19-22-23-20(28-19)25-12-7-16(8-13-25)24-10-2-1-3-11-24/h4-6,9,14,16H,1-3,7-8,10-13H2
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 25n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333524
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(2-methoxythiazol-5-y...)
Show SMILES COc1ncc(s1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C16H23N5OS2/c1-22-16-17-11-13(23-16)14-18-19-15(24-14)21-9-5-12(6-10-21)20-7-3-2-4-8-20/h11-12H,2-10H2,1H3
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 28n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383439
PNG
(CHEMBL2031599)
Show SMILES CC(O)c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H28N4OS/c1-15(25)16-6-5-7-17(14-16)19-21-22-20(26-19)24-12-8-18(9-13-24)23-10-3-2-4-11-23/h5-7,14-15,18,25H,2-4,8-13H2,1H3
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 29n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333519
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(pyridin-2-yl)-1,3,4-...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1ccccn1
Show InChI InChI=1S/C17H23N5S/c1-4-10-21(11-5-1)14-7-12-22(13-8-14)17-20-19-16(23-17)15-6-2-3-9-18-15/h2-3,6,9,14H,1,4-5,7-8,10-13H2
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 30n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333506
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3-methoxyphenyl)-1,3...)
Show SMILES COc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H26N4OS/c1-24-17-7-5-6-15(14-17)18-20-21-19(25-18)23-12-8-16(9-13-23)22-10-3-2-4-11-22/h5-7,14,16H,2-4,8-13H2,1H3
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 31.9n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383454
PNG
(CHEMBL2031614)
Show SMILES O=c1ccc2ccc(cc2[nH]1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H25N5OS/c27-19-7-6-15-4-5-16(14-18(15)22-19)20-23-24-21(28-20)26-12-8-17(9-13-26)25-10-2-1-3-11-25/h4-7,14,17H,1-3,8-13H2,(H,22,27)
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 35.9n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333533
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-o-tolyl-1,3,4-thiadia...)
Show SMILES Cc1ccccc1-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H26N4S/c1-15-7-3-4-8-17(15)18-20-21-19(24-18)23-13-9-16(10-14-23)22-11-5-2-6-12-22/h3-4,7-8,16H,2,5-6,9-14H2,1H3
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 36n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333531
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(2-fluorophenyl)-1,3,...)
Show SMILES Fc1ccccc1-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23FN4S/c19-16-7-3-2-6-15(16)17-20-21-18(24-17)23-12-8-14(9-13-23)22-10-4-1-5-11-22/h2-3,6-7,14H,1,4-5,8-13H2
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 36n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333535
PNG
(4-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Show SMILES N#Cc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H23N5S/c20-14-15-4-6-16(7-5-15)18-21-22-19(25-18)24-12-8-17(9-13-24)23-10-2-1-3-11-23/h4-7,17H,1-3,8-13H2
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 36.4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333536
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(4-fluorophenyl)-1,3,...)
Show SMILES Fc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23FN4S/c19-15-6-4-14(5-7-15)17-20-21-18(24-17)23-12-8-16(9-13-23)22-10-2-1-3-11-22/h4-7,16H,1-3,8-13H2
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 39n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383440
PNG
(CHEMBL2031600)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H26N6OS/c1-15-22-23-19(28-15)16-6-5-7-17(14-16)20-24-25-21(29-20)27-12-8-18(9-13-27)26-10-3-2-4-11-26/h5-7,14,18H,2-4,8-13H2,1H3
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 40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333530
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(2-methoxyphenyl)-1,3...)
Show SMILES COc1ccccc1-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H26N4OS/c1-24-17-8-4-3-7-16(17)18-20-21-19(25-18)23-13-9-15(10-14-23)22-11-5-2-6-12-22/h3-4,7-8,15H,2,5-6,9-14H2,1H3
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 40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333525
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(4-methoxyphenyl)-1,3...)
Show SMILES COc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H26N4OS/c1-24-17-7-5-15(6-8-17)18-20-21-19(25-18)23-13-9-16(10-14-23)22-11-3-2-4-12-22/h5-8,16H,2-4,9-14H2,1H3
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 40.1n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333507
PNG
(3-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Show SMILES N#Cc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H23N5S/c20-14-15-5-4-6-16(13-15)18-21-22-19(25-18)24-11-7-17(8-12-24)23-9-2-1-3-10-23/h4-6,13,17H,1-3,7-12H2
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 42.6n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333504
PNG
(1-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Show SMILES O=C(NC1CCCC1)Nc1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H30N6OS/c25-16(19-14-6-2-3-7-14)20-17-21-22-18(26-17)24-12-8-15(9-13-24)23-10-4-1-5-11-23/h14-15H,1-13H2,(H2,19,20,21,25)
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 48.6n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333509
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3-chlorophenyl)-1,3,...)
Show SMILES Clc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23ClN4S/c19-15-6-4-5-14(13-15)17-20-21-18(24-17)23-11-7-16(8-12-23)22-9-2-1-3-10-22/h4-6,13,16H,1-3,7-12H2
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 49n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333517
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3,5-difluorophenyl)-...)
Show SMILES Fc1cc(F)cc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H22F2N4S/c19-14-10-13(11-15(20)12-14)17-21-22-18(25-17)24-8-4-16(5-9-24)23-6-2-1-3-7-23/h10-12,16H,1-9H2
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 50n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333510
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-m-tolyl-1,3,4-thiadia...)
Show SMILES Cc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H26N4S/c1-15-6-5-7-16(14-15)18-20-21-19(24-18)23-12-8-17(9-13-23)22-10-3-2-4-11-22/h5-7,14,17H,2-4,8-13H2,1H3
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 60n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333508
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3-fluorophenyl)-1,3,...)
Show SMILES Fc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23FN4S/c19-15-6-4-5-14(13-15)17-20-21-18(24-17)23-11-7-16(8-12-23)22-9-2-1-3-10-22/h4-6,13,16H,1-3,7-12H2
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 62n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383451
PNG
(CHEMBL2031611)
Show SMILES O=C1Cc2cc(ccc2N1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H25N5OS/c26-18-13-15-12-14(4-5-17(15)21-18)19-22-23-20(27-19)25-10-6-16(7-11-25)24-8-2-1-3-9-24/h4-5,12,16H,1-3,6-11,13H2,(H,21,26)
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 64.4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333539
PNG
(1-(4-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-...)
Show SMILES CC(=O)c1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H26N4OS/c1-15(25)16-5-7-17(8-6-16)19-21-22-20(26-19)24-13-9-18(10-14-24)23-11-3-2-4-12-23/h5-8,18H,2-4,9-14H2,1H3
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 65n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50333532
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(2-chlorophenyl)-1,3,...)
Show SMILES Clc1ccccc1-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23ClN4S/c19-16-7-3-2-6-15(16)17-20-21-18(24-17)23-12-8-14(9-13-23)22-10-4-1-5-11-22/h2-3,6-7,14H,1,4-5,8-13H2
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 69n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...

Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
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