Found 49 hits Enz. Inhib. hit(s) with all data for entry = 50030802 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301693
(5-(5-((4-(dimethylamino)piperidin-1-yl)methyl)fura...)Show SMILES CN(C)C1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C27H30N6O/c1-18-23-6-9-30-26(23)5-4-25(18)31-27-20(13-28)14-29-15-24(27)19-12-22(34-17-19)16-33-10-7-21(8-11-33)32(2)3/h4-6,9,12,14-15,17,21,30H,7-8,10-11,16H2,1-3H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301694
(5-(5-((4-isopropylpiperazin-1-yl)methyl)furan-3-yl...)Show SMILES CC(C)N1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C27H30N6O/c1-18(2)33-10-8-32(9-11-33)16-22-12-20(17-34-22)24-15-29-14-21(13-28)27(24)31-25-4-5-26-23(19(25)3)6-7-30-26/h4-7,12,14-15,17-18,30H,8-11,16H2,1-3H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301679
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-((4-methylpip...)Show SMILES CN1CCN(Cc2cccc(c2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C27H28N6/c1-19-23-8-9-30-26(23)7-6-25(19)31-27-22(15-28)16-29-17-24(27)21-5-3-4-20(14-21)18-33-12-10-32(2)11-13-33/h3-9,14,16-17,30H,10-13,18H2,1-2H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301695
(5-(5-((4-cyclopentylpiperazin-1-yl)methyl)furan-3-...)Show SMILES Cc1c(Nc2c(cncc2-c2coc(CN3CCN(CC3)C3CCCC3)c2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C29H32N6O/c1-20-25-8-9-32-28(25)7-6-27(20)33-29-22(15-30)16-31-17-26(29)21-14-24(36-19-21)18-34-10-12-35(13-11-34)23-4-2-3-5-23/h6-9,14,16-17,19,23,32H,2-5,10-13,18H2,1H3,(H,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301685
(1-((4-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2cc(cs2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2S/c1-4-22-7-5-10-28(25-17-26(32-20-25)19-31-15-13-30(3)14-16-31)29(22)18-24-12-11-23-8-6-9-27(23)21(24)2/h1,5-7,9-12,17,20H,8,13-16,18-19H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301678
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-((4-methylpip...)Show SMILES CN1CCN(Cc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C27H28N6/c1-19-23-9-10-30-26(23)8-7-25(19)31-27-22(15-28)16-29-17-24(27)21-5-3-20(4-6-21)18-33-13-11-32(2)12-14-33/h3-10,16-17,30H,11-14,18H2,1-2H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301684
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)Show SMILES CN1CCN(Cc2ccc(s2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C25H26N6S/c1-17-20-7-8-28-23(20)5-4-22(17)29-25-18(13-26)14-27-15-21(25)24-6-3-19(32-24)16-31-11-9-30(2)10-12-31/h3-8,14-15,28H,9-12,16H2,1-2H3,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301676
(5-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)Show SMILES CN(C)Cc1cccc(c1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C Show InChI InChI=1S/C24H23N5/c1-16-20-9-10-27-23(20)8-7-22(16)28-24-19(12-25)13-26-14-21(24)18-6-4-5-17(11-18)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301689
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(thiomorpholi...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCSCC3)o2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C24H23N5OS/c1-16-19-6-7-27-22(19)4-3-21(16)28-24-17(12-25)13-26-14-20(24)23-5-2-18(30-23)15-29-8-10-31-11-9-29/h2-7,13-14,27H,8-11,15H2,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301688
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(morpholinome...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCOCC3)o2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C24H23N5O2/c1-16-19-6-7-27-22(19)4-3-21(16)28-24-17(12-25)13-26-14-20(24)23-5-2-18(31-23)15-29-8-10-30-11-9-29/h2-7,13-14,27H,8-11,15H2,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301693
(5-(5-((4-(dimethylamino)piperidin-1-yl)methyl)fura...)Show SMILES CN(C)C1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C27H30N6O/c1-18-23-6-9-30-26(23)5-4-25(18)31-27-20(13-28)14-29-15-24(27)19-12-22(34-17-19)16-33-10-7-21(8-11-33)32(2)3/h4-6,9,12,14-15,17,21,30H,7-8,10-11,16H2,1-3H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301675
(5-(4-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)Show SMILES CN(C)Cc1ccc(cc1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C Show InChI InChI=1S/C24H23N5/c1-16-20-10-11-27-23(20)9-8-22(16)28-24-19(12-25)13-26-14-21(24)18-6-4-17(5-7-18)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301680
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(morpholinome...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCOCC3)cc2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C26H25N5O/c1-18-22-8-9-29-25(22)7-6-24(18)30-26-21(14-27)15-28-16-23(26)20-4-2-19(3-5-20)17-31-10-12-32-13-11-31/h2-9,15-16,29H,10-13,17H2,1H3,(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301685
(1-((4-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2cc(cs2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2S/c1-4-22-7-5-10-28(25-17-26(32-20-25)19-31-15-13-30(3)14-16-31)29(22)18-24-12-11-23-8-6-9-27(23)21(24)2/h1,5-7,9-12,17,20H,8,13-16,18-19H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301687
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)Show SMILES CN1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C25H26N6O/c1-17-21-5-6-28-24(21)4-3-23(17)29-25-19(12-26)13-27-14-22(25)18-11-20(32-16-18)15-31-9-7-30(2)8-10-31/h3-6,11,13-14,16,28H,7-10,15H2,1-2H3,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C epsilon type
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of PKCepsilon by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301694
(5-(5-((4-isopropylpiperazin-1-yl)methyl)furan-3-yl...)Show SMILES CC(C)N1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C27H30N6O/c1-18(2)33-10-8-32(9-11-33)16-22-12-20(17-34-22)24-15-29-14-21(13-28)27(24)31-25-4-5-26-23(19(25)3)6-7-30-26/h4-7,12,14-15,17-18,30H,8-11,16H2,1-3H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301695
(5-(5-((4-cyclopentylpiperazin-1-yl)methyl)furan-3-...)Show SMILES Cc1c(Nc2c(cncc2-c2coc(CN3CCN(CC3)C3CCCC3)c2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C29H32N6O/c1-20-25-8-9-32-28(25)7-6-27(20)33-29-22(15-30)16-31-17-26(29)21-14-24(36-19-21)18-34-10-12-35(13-11-34)23-4-2-3-5-23/h6-9,14,16-17,19,23,32H,2-5,10-13,18H2,1H3,(H,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301679
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-((4-methylpip...)Show SMILES CN1CCN(Cc2cccc(c2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C27H28N6/c1-19-23-8-9-30-26(23)7-6-25(19)31-27-22(15-28)16-29-17-24(27)21-5-3-4-20(14-21)18-33-12-10-32(2)11-13-33/h3-9,14,16-17,30H,10-13,18H2,1-2H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301681
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(morpholinome...)Show SMILES Cc1c(Nc2c(cncc2-c2cccc(CN3CCOCC3)c2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C26H25N5O/c1-18-22-7-8-29-25(22)6-5-24(18)30-26-21(14-27)15-28-16-23(26)20-4-2-3-19(13-20)17-31-9-11-32-12-10-31/h2-8,13,15-16,29H,9-12,17H2,1H3,(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301678
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-((4-methylpip...)Show SMILES CN1CCN(Cc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C27H28N6/c1-19-23-9-10-30-26(23)8-7-25(19)31-27-22(15-28)16-29-17-24(27)21-5-3-20(4-6-21)18-33-13-11-32(2)12-14-33/h3-10,16-17,30H,11-14,18H2,1-2H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301676
(5-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)Show SMILES CN(C)Cc1cccc(c1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C Show InChI InChI=1S/C24H23N5/c1-16-20-9-10-27-23(20)8-7-22(16)28-24-19(12-25)13-26-14-21(24)18-6-4-5-17(11-18)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301691
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCCC3)o2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C24H23N5O/c1-16-19-8-9-27-22(19)6-5-21(16)28-24-17(12-25)13-26-14-20(24)23-7-4-18(30-23)15-29-10-2-3-11-29/h4-9,13-14,27H,2-3,10-11,15H2,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301687
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)Show SMILES CN1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C25H26N6O/c1-17-21-5-6-28-24(21)4-3-23(17)29-25-19(12-26)13-27-14-22(25)18-11-20(32-16-18)15-31-9-7-30(2)8-10-31/h3-6,11,13-14,16,28H,7-10,15H2,1-2H3,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301682
(4-(4-methyl-1H-indol-5-ylamino)-6'-((4-methylpiper...)Show SMILES CN1CCN(Cc2ccc(cn2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C26H27N7/c1-18-22-7-8-29-25(22)6-5-24(18)31-26-20(13-27)14-28-16-23(26)19-3-4-21(30-15-19)17-33-11-9-32(2)10-12-33/h3-8,14-16,29H,9-12,17H2,1-2H3,(H,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301690
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(piperidin-1-...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCCCC3)o2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C25H25N5O/c1-17-20-9-10-28-23(20)7-6-22(17)29-25-18(13-26)14-27-15-21(25)24-8-5-19(31-24)16-30-11-3-2-4-12-30/h5-10,14-15,28H,2-4,11-12,16H2,1H3,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301692
(5-(5-((diethylamino)methyl)furan-2-yl)-4-(4-methyl...)Show SMILES CCN(CC)Cc1ccc(o1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C Show InChI InChI=1S/C24H25N5O/c1-4-29(5-2)15-18-6-9-23(30-18)20-14-26-13-17(12-25)24(20)28-21-7-8-22-19(16(21)3)10-11-27-22/h6-11,13-14,27H,4-5,15H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301684
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)Show SMILES CN1CCN(Cc2ccc(s2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C25H26N6S/c1-17-20-7-8-28-23(20)5-4-22(17)29-25-18(13-26)14-27-15-21(25)24-6-3-19(32-24)16-31-11-9-30(2)10-12-31/h3-8,14-15,28H,9-12,16H2,1-2H3,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301675
(5-(4-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)Show SMILES CN(C)Cc1ccc(cc1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C Show InChI InChI=1S/C24H23N5/c1-16-20-10-11-27-23(20)9-8-22(16)28-24-19(12-25)13-26-14-21(24)18-6-4-17(5-7-18)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301680
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(morpholinome...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCOCC3)cc2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C26H25N5O/c1-18-22-8-9-29-25(22)7-6-24(18)30-26-21(14-27)15-28-16-23(26)20-4-2-19(3-5-20)17-31-10-12-32-13-11-31/h2-9,15-16,29H,10-13,17H2,1H3,(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301681
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(morpholinome...)Show SMILES Cc1c(Nc2c(cncc2-c2cccc(CN3CCOCC3)c2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C26H25N5O/c1-18-22-7-8-29-25(22)6-5-24(18)30-26-21(14-27)15-28-16-23(26)20-4-2-3-19(13-20)17-31-9-11-32-12-10-31/h2-8,13,15-16,29H,9-12,17H2,1H3,(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301688
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(morpholinome...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCOCC3)o2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C24H23N5O2/c1-16-19-6-7-27-22(19)4-3-21(16)28-24-17(12-25)13-26-14-20(24)23-5-2-18(31-23)15-29-8-10-30-11-9-29/h2-7,13-14,27H,8-11,15H2,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301689
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(thiomorpholi...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCSCC3)o2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C24H23N5OS/c1-16-19-6-7-27-22(19)4-3-21(16)28-24-17(12-25)13-26-14-20(24)23-5-2-18(30-23)15-29-8-10-31-11-9-29/h2-7,13-14,27H,8-11,15H2,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C eta type
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of PKCeta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301692
(5-(5-((diethylamino)methyl)furan-2-yl)-4-(4-methyl...)Show SMILES CCN(CC)Cc1ccc(o1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C Show InChI InChI=1S/C24H25N5O/c1-4-29(5-2)15-18-6-9-23(30-18)20-14-26-13-17(12-25)24(20)28-21-7-8-22-19(16(21)3)10-11-27-22/h6-11,13-14,27H,4-5,15H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301683
(4-(4-methyl-1H-indol-5-ylamino)-5'-((4-methylpiper...)Show SMILES CN1CCN(Cc2cncc(c2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C26H27N7/c1-18-22-5-6-30-25(22)4-3-24(18)31-26-21(12-27)15-29-16-23(26)20-11-19(13-28-14-20)17-33-9-7-32(2)8-10-33/h3-6,11,13-16,30H,7-10,17H2,1-2H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50301677
(5-(2-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)Show SMILES CN(C)Cc1ccccc1-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C Show InChI InChI=1S/C24H23N5/c1-16-19-10-11-27-23(19)9-8-22(16)28-24-18(12-25)13-26-14-21(24)20-7-5-4-6-17(20)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCtheta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301682
(4-(4-methyl-1H-indol-5-ylamino)-6'-((4-methylpiper...)Show SMILES CN1CCN(Cc2ccc(cn2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C26H27N7/c1-18-22-7-8-29-25(22)6-5-24(18)31-26-20(13-27)14-28-16-23(26)19-3-4-21(30-15-19)17-33-11-9-32(2)10-12-33/h3-8,14-16,29H,9-12,17H2,1-2H3,(H,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301691
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCCC3)o2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C24H23N5O/c1-16-19-8-9-27-22(19)6-5-21(16)28-24-17(12-25)13-26-14-20(24)23-7-4-18(30-23)15-29-10-2-3-11-29/h4-9,13-14,27H,2-3,10-11,15H2,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301690
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(piperidin-1-...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCCCC3)o2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C25H25N5O/c1-17-20-9-10-28-23(20)7-6-22(17)29-25-18(13-26)14-27-15-21(25)24-8-5-19(31-24)16-30-11-3-2-4-12-30/h5-10,14-15,28H,2-4,11-12,16H2,1H3,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Lck |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50301677
(5-(2-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)Show SMILES CN(C)Cc1ccccc1-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C Show InChI InChI=1S/C24H23N5/c1-16-19-10-11-27-23(19)9-8-22(16)28-24-18(12-25)13-26-14-21(24)20-7-5-4-6-17(20)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKCdelta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of PKCbeta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lyn
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Lyn |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of MK2 |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ROCK1 |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50301686
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27| Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of PKCzeta by IMAP kinase assay |
Bioorg Med Chem Lett 19: 5423-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.109
BindingDB Entry DOI: 10.7270/Q2V69JPF |
More data for this
Ligand-Target Pair | |
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