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PubMed code 12190315

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409560
PNG
(CHEMBL127065)
Show SMILES CC=C1C(=N)C2(OS1(=O)=O)C(CO)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O |w:1.0|
Show InChI InChI=1S/C20H31N3O8SSi/c1-8-12-14(21)20(31-32(12,27)28)13(10-24)29-17(15(20)30-33(6,7)19(3,4)5)23-9-11(2)16(25)22-18(23)26/h8-9,13,15,17,21,24H,10H2,1-7H3,(H,22,25,26)
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n/an/an/an/a 1.50E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409564
PNG
(CHEMBL129417)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(=CCCO)C3=N)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |w:22.22|
Show InChI InChI=1S/C28H49N3O9SSi2/c1-18-16-31(25(34)30(8)23(18)33)24-22(39-43(11,12)27(5,6)7)28(20(38-24)17-37-42(9,10)26(2,3)4)21(29)19(14-13-15-32)41(35,36)40-28/h14,16,20,22,24,29,32H,13,15,17H2,1-12H3
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n/an/an/an/a 5.90E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409557
PNG
(CHEMBL129381)
Show SMILES CC#CC1=C(N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |c:3|
Show InChI InChI=1S/C28H47N3O8SSi2/c1-14-15-19-21(29)28(39-40(19,34)35)20(17-36-41(10,11)26(3,4)5)37-24(22(28)38-42(12,13)27(6,7)8)31-16-18(2)23(32)30(9)25(31)33/h16,20,22,24H,17,29H2,1-13H3
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n/an/an/an/a>2.00E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409557
PNG
(CHEMBL129381)
Show SMILES CC#CC1=C(N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |c:3|
Show InChI InChI=1S/C28H47N3O8SSi2/c1-14-15-19-21(29)28(39-40(19,34)35)20(17-36-41(10,11)26(3,4)5)37-24(22(28)38-42(12,13)27(6,7)8)31-16-18(2)23(32)30(9)25(31)33/h16,20,22,24H,17,29H2,1-13H3
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n/an/an/an/a>2.00E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50169035
PNG
(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:21|
Show InChI InChI=1S/C24H43N3O8SSi2/c1-15-12-27(21(29)26-19(15)28)20-18(34-38(10,11)23(5,6)7)24(16(25)14-36(30,31)35-24)17(33-20)13-32-37(8,9)22(2,3)4/h12,14,17-18,20H,13,25H2,1-11H3,(H,26,28,29)/t17-,18+,20-,24-/m1/s1
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n/an/an/an/a 50n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50192293
PNG
(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(I)=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:22|
Show InChI InChI=1S/C24H42IN3O8SSi2/c1-14-12-28(21(30)27-19(14)29)20-17(35-39(10,11)23(5,6)7)24(16(26)18(25)37(31,32)36-24)15(34-20)13-33-38(8,9)22(2,3)4/h12,15,17,20H,13,26H2,1-11H3,(H,27,29,30)/t15-,17+,20-,24+/m1/s1
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n/an/an/an/a 120n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409569
PNG
(CHEMBL338643)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(=C3N)c3ccccc3)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:21|
Show InChI InChI=1S/C31H49N3O8SSi2/c1-20-18-34(28(36)33(8)26(20)35)27-25(41-45(11,12)30(5,6)7)31(22(40-27)19-39-44(9,10)29(2,3)4)24(32)23(43(37,38)42-31)21-16-14-13-15-17-21/h13-18,22,25,27H,19,32H2,1-12H3
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n/an/an/an/a 1.70E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50004536
PNG
(1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(t...)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:21|
Show InChI InChI=1S/C25H45N3O8SSi2/c1-16-13-28(22(30)27(8)20(16)29)21-19(35-39(11,12)24(5,6)7)25(17(26)15-37(31,32)36-25)18(34-21)14-33-38(9,10)23(2,3)4/h13,15,18-19,21H,14,26H2,1-12H3
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n/an/an/an/a 60n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409572
PNG
(CHEMBL340307)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(=C3N)c3ccccc3)C2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:21|
Show InChI InChI=1S/C30H47N3O8SSi2/c1-19-17-33(27(35)32-25(19)34)26-24(40-44(10,11)29(5,6)7)30(21(39-26)18-38-43(8,9)28(2,3)4)23(31)22(42(36,37)41-30)20-15-13-12-14-16-20/h12-17,21,24,26H,18,31H2,1-11H3,(H,32,34,35)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409566
PNG
(CHEMBL129004)
Show SMILES CC1=C(N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |c:1|
Show InChI InChI=1S/C26H47N3O8SSi2/c1-16-14-29(23(31)28(9)21(16)30)22-20(36-40(12,13)25(6,7)8)26(19(27)17(2)38(32,33)37-26)18(35-22)15-34-39(10,11)24(3,4)5/h14,18,20,22H,15,27H2,1-13H3
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n/an/an/an/a 250n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409573
PNG
(CHEMBL340730)
Show SMILES COC(=O)CC=C1C(=N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |w:5.4|
Show InChI InChI=1S/C29H49N3O10SSi2/c1-18-16-32(26(35)31(8)24(18)34)25-23(41-45(12,13)28(5,6)7)29(20(40-25)17-39-44(10,11)27(2,3)4)22(30)19(43(36,37)42-29)14-15-21(33)38-9/h14,16,20,23,25,30H,15,17H2,1-13H3
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n/an/an/an/a 2.90E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409574
PNG
(CHEMBL413115)
Show SMILES CNC1=C(C)S(=O)(=O)OC11C(CO[Si](C)(C)C(C)(C)C)OC(C1O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |c:2|
Show InChI InChI=1S/C27H49N3O8SSi2/c1-17-15-30(24(32)29(10)22(17)31)23-21(37-41(13,14)26(6,7)8)27(20(28-9)18(2)39(33,34)38-27)19(36-23)16-35-40(11,12)25(3,4)5/h15,19,21,23,28H,16H2,1-14H3
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n/an/an/an/a>2.50E+5n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409559
PNG
(CHEMBL129067)
Show SMILES CC=C1C(=N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O |w:1.0|
Show InChI InChI=1S/C26H45N3O8SSi2/c1-13-17-19(27)26(37-38(17,32)33)18(15-34-39(9,10)24(3,4)5)35-22(20(26)36-40(11,12)25(6,7)8)29-14-16(2)21(30)28-23(29)31/h13-14,18,20,22,27H,15H2,1-12H3,(H,28,30,31)
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n/an/an/an/a 3.20E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409560
PNG
(CHEMBL127065)
Show SMILES CC=C1C(=N)C2(OS1(=O)=O)C(CO)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O |w:1.0|
Show InChI InChI=1S/C20H31N3O8SSi/c1-8-12-14(21)20(31-32(12,27)28)13(10-24)29-17(15(20)30-33(6,7)19(3,4)5)23-9-11(2)16(25)22-18(23)26/h8-9,13,15,17,21,24H,10H2,1-7H3,(H,22,25,26)
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n/an/an/an/a 2.30E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50169035
PNG
(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:21|
Show InChI InChI=1S/C24H43N3O8SSi2/c1-15-12-27(21(29)26-19(15)28)20-18(34-38(10,11)23(5,6)7)24(16(25)14-36(30,31)35-24)17(33-20)13-32-37(8,9)22(2,3)4/h12,14,17-18,20H,13,25H2,1-11H3,(H,26,28,29)/t17-,18+,20-,24-/m1/s1
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n/an/an/an/a 60n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409568
PNG
(CHEMBL339262)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(I)=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:22|
Show InChI InChI=1S/C25H44IN3O8SSi2/c1-15-13-29(22(31)28(8)20(15)30)21-18(36-40(11,12)24(5,6)7)25(17(27)19(26)38(32,33)37-25)16(35-21)14-34-39(9,10)23(2,3)4/h13,16,18,21H,14,27H2,1-12H3
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n/an/an/an/a 110n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409572
PNG
(CHEMBL340307)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(=C3N)c3ccccc3)C2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:21|
Show InChI InChI=1S/C30H47N3O8SSi2/c1-19-17-33(27(35)32-25(19)34)26-24(40-44(10,11)29(5,6)7)30(21(39-26)18-38-43(8,9)28(2,3)4)23(31)22(42(36,37)41-30)20-15-13-12-14-16-20/h12-17,21,24,26H,18,31H2,1-11H3,(H,32,34,35)
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n/an/an/an/a 6.70E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409559
PNG
(CHEMBL129067)
Show SMILES CC=C1C(=N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O |w:1.0|
Show InChI InChI=1S/C26H45N3O8SSi2/c1-13-17-19(27)26(37-38(17,32)33)18(15-34-39(9,10)24(3,4)5)35-22(20(26)36-40(11,12)25(6,7)8)29-14-16(2)21(30)28-23(29)31/h13-14,18,20,22,27H,15H2,1-12H3,(H,28,30,31)
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n/an/an/an/a 4.00E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409562
PNG
(CHEMBL340029)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(Cl)=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:22|
Show InChI InChI=1S/C24H42ClN3O8SSi2/c1-14-12-28(21(30)27-19(14)29)20-17(35-39(10,11)23(5,6)7)24(16(26)18(25)37(31,32)36-24)15(34-20)13-33-38(8,9)22(2,3)4/h12,15,17,20H,13,26H2,1-11H3,(H,27,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409565
PNG
(CHEMBL129382)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(CC=C)=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:24|
Show InChI InChI=1S/C28H49N3O8SSi2/c1-14-15-19-21(29)28(39-40(19,34)35)20(17-36-41(10,11)26(3,4)5)37-24(22(28)38-42(12,13)27(6,7)8)31-16-18(2)23(32)30(9)25(31)33/h14,16,20,22,24H,1,15,17,29H2,2-13H3
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n/an/an/an/a>5.00E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409568
PNG
(CHEMBL339262)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(I)=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:22|
Show InChI InChI=1S/C25H44IN3O8SSi2/c1-15-13-29(22(31)28(8)20(15)30)21-18(36-40(11,12)24(5,6)7)25(17(27)19(26)38(32,33)37-25)16(35-21)14-34-39(9,10)23(2,3)4/h13,16,18,21H,14,27H2,1-12H3
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n/an/an/an/a 50n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50004536
PNG
(1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(t...)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:21|
Show InChI InChI=1S/C25H45N3O8SSi2/c1-16-13-28(22(30)27(8)20(16)29)21-19(35-39(11,12)24(5,6)7)25(17(26)15-37(31,32)36-25)18(34-21)14-33-38(9,10)23(2,3)4/h13,15,18-19,21H,14,26H2,1-12H3
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n/an/an/an/a 40n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409565
PNG
(CHEMBL129382)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(CC=C)=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:24|
Show InChI InChI=1S/C28H49N3O8SSi2/c1-14-15-19-21(29)28(39-40(19,34)35)20(17-36-41(10,11)26(3,4)5)37-24(22(28)38-42(12,13)27(6,7)8)31-16-18(2)23(32)30(9)25(31)33/h14,16,20,22,24H,1,15,17,29H2,2-13H3
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n/an/an/an/a>5.00E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409562
PNG
(CHEMBL340029)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(Cl)=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:22|
Show InChI InChI=1S/C24H42ClN3O8SSi2/c1-14-12-28(21(30)27-19(14)29)20-17(35-39(10,11)23(5,6)7)24(16(26)18(25)37(31,32)36-24)15(34-20)13-33-38(8,9)22(2,3)4/h12,15,17,20H,13,26H2,1-11H3,(H,27,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409563
PNG
(CHEMBL128199)
Show SMILES COC(=O)CC=C1C(=N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O |w:5.4|
Show InChI InChI=1S/C28H47N3O10SSi2/c1-17-15-31(25(34)30-23(17)33)24-22(40-44(11,12)27(5,6)7)28(19(39-24)16-38-43(9,10)26(2,3)4)21(29)18(42(35,36)41-28)13-14-20(32)37-8/h13,15,19,22,24,29H,14,16H2,1-12H3,(H,30,33,34)
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n/an/an/an/a 3.70E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409558
PNG
(CHEMBL339662)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(Br)=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:22|
Show InChI InChI=1S/C24H42BrN3O8SSi2/c1-14-12-28(21(30)27-19(14)29)20-17(35-39(10,11)23(5,6)7)24(16(26)18(25)37(31,32)36-24)15(34-20)13-33-38(8,9)22(2,3)4/h12,15,17,20H,13,26H2,1-11H3,(H,27,29,30)
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n/an/an/an/a 930n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409561
PNG
(CHEMBL265105)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(CC(N)=O)=C3NCC(N)=O)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:25|
Show InChI InChI=1S/C29H51N5O10SSi2/c1-17-15-34(26(38)33(8)24(17)37)25-23(43-47(11,12)28(5,6)7)29(19(42-25)16-41-46(9,10)27(2,3)4)22(32-14-21(31)36)18(13-20(30)35)45(39,40)44-29/h15,19,23,25,32H,13-14,16H2,1-12H3,(H2,30,35)(H2,31,36)
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n/an/an/an/a>2.00E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409564
PNG
(CHEMBL129417)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(=CCCO)C3=N)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |w:22.22|
Show InChI InChI=1S/C28H49N3O9SSi2/c1-18-16-31(25(34)30(8)23(18)33)24-22(39-43(11,12)27(5,6)7)28(20(38-24)17-37-42(9,10)26(2,3)4)21(29)19(14-13-15-32)41(35,36)40-28/h14,16,20,22,24,29,32H,13,15,17H2,1-12H3
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n/an/an/an/a 2.80E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409566
PNG
(CHEMBL129004)
Show SMILES CC1=C(N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |c:1|
Show InChI InChI=1S/C26H47N3O8SSi2/c1-16-14-29(23(31)28(9)21(16)30)22-20(36-40(12,13)25(6,7)8)26(19(27)17(2)38(32,33)37-26)18(35-22)15-34-39(10,11)24(3,4)5/h14,18,20,22H,15,27H2,1-13H3
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n/an/an/an/a 2.20E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409567
PNG
(CHEMBL445582)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(=C3N)c3ccsc3)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:21|
Show InChI InChI=1S/C29H47N3O8S2Si2/c1-18-15-32(26(34)31(8)24(18)33)25-23(39-44(11,12)28(5,6)7)29(20(38-25)16-37-43(9,10)27(2,3)4)22(30)21(42(35,36)40-29)19-13-14-41-17-19/h13-15,17,20,23,25H,16,30H2,1-12H3
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n/an/an/an/a 2.30E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409567
PNG
(CHEMBL445582)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(=C3N)c3ccsc3)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:21|
Show InChI InChI=1S/C29H47N3O8S2Si2/c1-18-15-32(26(34)31(8)24(18)33)25-23(39-44(11,12)28(5,6)7)29(20(38-25)16-37-43(9,10)27(2,3)4)22(30)21(42(35,36)40-29)19-13-14-41-17-19/h13-15,17,20,23,25H,16,30H2,1-12H3
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n/an/an/an/a>2.00E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409571
PNG
(CHEMBL340603)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C=C3NCC=C)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:21|
Show InChI InChI=1S/C28H49N3O8SSi2/c1-14-15-29-20-18-40(34,35)39-28(20)21(17-36-41(10,11)26(3,4)5)37-24(22(28)38-42(12,13)27(6,7)8)31-16-19(2)23(32)30(9)25(31)33/h14,16,18,21-22,24,29H,1,15,17H2,2-13H3
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n/an/an/an/a>5.00E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409570
PNG
(CHEMBL128354)
Show SMILES CCOC(=O)CC=C1C(=N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O |w:6.5|
Show InChI InChI=1S/C29H49N3O10SSi2/c1-13-38-21(33)15-14-19-22(30)29(42-43(19,36)37)20(17-39-44(9,10)27(3,4)5)40-25(23(29)41-45(11,12)28(6,7)8)32-16-18(2)24(34)31-26(32)35/h14,16,20,23,25,30H,13,15,17H2,1-12H3,(H,31,34,35)
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n/an/an/an/a 3.50E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50192294
PNG
(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(=CCCO)C3=N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |w:22.22|
Show InChI InChI=1S/C27H47N3O9SSi2/c1-17-15-30(24(33)29-22(17)32)23-21(38-42(10,11)26(5,6)7)27(19(37-23)16-36-41(8,9)25(2,3)4)20(28)18(13-12-14-31)40(34,35)39-27/h13,15,19,21,23,28,31H,12,14,16H2,1-11H3,(H,29,32,33)/t19-,21+,23-,27+/m1/s1
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n/an/an/an/a 6.60E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409563
PNG
(CHEMBL128199)
Show SMILES COC(=O)CC=C1C(=N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O |w:5.4|
Show InChI InChI=1S/C28H47N3O10SSi2/c1-17-15-31(25(34)30-23(17)33)24-22(40-44(11,12)27(5,6)7)28(19(39-24)16-38-43(9,10)26(2,3)4)21(29)18(42(35,36)41-28)13-14-20(32)37-8/h13,15,19,22,24,29H,14,16H2,1-12H3,(H,30,33,34)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409558
PNG
(CHEMBL339662)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(Br)=C3N)C2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:22|
Show InChI InChI=1S/C24H42BrN3O8SSi2/c1-14-12-28(21(30)27-19(14)29)20-17(35-39(10,11)23(5,6)7)24(16(26)18(25)37(31,32)36-24)15(34-20)13-33-38(8,9)22(2,3)4/h12,15,17,20H,13,26H2,1-11H3,(H,27,29,30)
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n/an/an/an/a 850n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50192293
PNG
(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(I)=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |c:22|
Show InChI InChI=1S/C24H42IN3O8SSi2/c1-14-12-28(21(30)27-19(14)29)20-17(35-39(10,11)23(5,6)7)24(16(26)18(25)37(31,32)36-24)15(34-20)13-33-38(8,9)22(2,3)4/h12,15,17,20H,13,26H2,1-11H3,(H,27,29,30)/t15-,17+,20-,24+/m1/s1
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n/an/an/an/a 60n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409570
PNG
(CHEMBL128354)
Show SMILES CCOC(=O)CC=C1C(=N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O |w:6.5|
Show InChI InChI=1S/C29H49N3O10SSi2/c1-13-38-21(33)15-14-19-22(30)29(42-43(19,36)37)20(17-39-44(9,10)27(3,4)5)40-25(23(29)41-45(11,12)28(6,7)8)32-16-18(2)24(34)31-26(32)35/h14,16,20,23,25,30H,13,15,17H2,1-12H3,(H,31,34,35)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409561
PNG
(CHEMBL265105)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C(CC(N)=O)=C3NCC(N)=O)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:25|
Show InChI InChI=1S/C29H51N5O10SSi2/c1-17-15-34(26(38)33(8)24(17)37)25-23(43-47(11,12)28(5,6)7)29(19(42-25)16-41-46(9,10)27(2,3)4)22(32-14-21(31)36)18(13-20(30)35)45(39,40)44-29/h15,19,23,25,32H,13-14,16H2,1-12H3,(H2,30,35)(H2,31,36)
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n/an/an/an/a>2.00E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409574
PNG
(CHEMBL413115)
Show SMILES CNC1=C(C)S(=O)(=O)OC11C(CO[Si](C)(C)C(C)(C)C)OC(C1O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |c:2|
Show InChI InChI=1S/C27H49N3O8SSi2/c1-17-15-30(24(32)29(10)22(17)31)23-21(37-41(13,14)26(6,7)8)27(20(28-9)18(2)39(33,34)38-27)19(36-23)16-35-40(11,12)25(3,4)5/h15,19,21,23,28H,16H2,1-14H3
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n/an/an/an/a>1.00E+5n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50192294
PNG
(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(=CCCO)C3=N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |w:22.22|
Show InChI InChI=1S/C27H47N3O9SSi2/c1-17-15-30(24(33)29-22(17)32)23-21(38-42(10,11)26(5,6)7)27(19(37-23)16-36-41(8,9)25(2,3)4)20(28)18(13-12-14-31)40(34,35)39-27/h13,15,19,21,23,28,31H,12,14,16H2,1-11H3,(H,29,32,33)/t19-,21+,23-,27+/m1/s1
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n/an/an/an/a>2.00E+3n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409573
PNG
(CHEMBL340730)
Show SMILES COC(=O)CC=C1C(=N)C2(OS1(=O)=O)C(CO[Si](C)(C)C(C)(C)C)OC(C2O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |w:5.4|
Show InChI InChI=1S/C29H49N3O10SSi2/c1-18-16-32(26(35)31(8)24(18)34)25-23(41-45(12,13)28(5,6)7)29(20(40-25)17-39-44(10,11)27(2,3)4)22(30)19(43(36,37)42-29)14-15-21(33)38-9/h14,16,20,23,25,30H,15,17H2,1-13H3
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n/an/an/an/a 980n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50409571
PNG
(CHEMBL340603)
Show SMILES Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C=C3NCC=C)C2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O |c:21|
Show InChI InChI=1S/C28H49N3O8SSi2/c1-14-15-29-20-18-40(34,35)39-28(20)21(17-36-41(10,11)26(3,4)5)37-24(22(28)38-42(12,13)27(6,7)8)31-16-19(2)23(32)30(9)25(31)33/h14,16,18,21-22,24,29H,1,15,17H2,2-13H3
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n/an/an/an/a>5.00E+4n/an/an/an/a



Instituto de Qu£mica M£dica (C.S.I.C.)

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.

J Med Chem 45: 3934-45 (2002)


BindingDB Entry DOI: 10.7270/Q2639QXQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%