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PubMed code 18289848

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371914
PNG
(CHEMBL403661)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H18ClN3O/c1-3-13-4-6-14(7-5-13)19-16-10-15(22)8-9-17(16)25-21(26)20(19)18-11-23-12(2)24-18/h4-11H,3H2,1-2H3,(H,23,24)(H,25,26)
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n/an/a 2.10n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371915
PNG
(CHEMBL273198)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C22H18N4O/c1-3-14-4-7-16(8-5-14)20-17-10-15(11-23)6-9-18(17)26-22(27)21(20)19-12-24-13(2)25-19/h4-10,12H,3H2,1-2H3,(H,24,25)(H,26,27)
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n/an/a 2.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50371914
PNG
(CHEMBL403661)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H18ClN3O/c1-3-13-4-6-14(7-5-13)19-16-10-15(22)8-9-17(16)25-21(26)20(19)18-11-23-12(2)24-18/h4-11H,3H2,1-2H3,(H,23,24)(H,25,26)
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n/an/a 34n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50371915
PNG
(CHEMBL273198)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C22H18N4O/c1-3-14-4-7-16(8-5-14)20-17-10-15(11-23)6-9-18(17)26-22(27)21(20)19-12-24-13(2)25-19/h4-10,12H,3H2,1-2H3,(H,24,25)(H,26,27)
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n/an/a 47n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50371914
PNG
(CHEMBL403661)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H18ClN3O/c1-3-13-4-6-14(7-5-13)19-16-10-15(22)8-9-17(16)25-21(26)20(19)18-11-23-12(2)24-18/h4-11H,3H2,1-2H3,(H,23,24)(H,25,26)
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n/an/a 67n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of KIT


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371923
PNG
(CHEMBL255213)
Show SMILES CCc1ccc(cc1)-c1c(-c2cc(C)no2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H17ClN2O2/c1-3-13-4-6-14(7-5-13)19-16-11-15(22)8-9-17(16)23-21(25)20(19)18-10-12(2)24-26-18/h4-11H,3H2,1-2H3,(H,23,25)
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n/an/a 90n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371934
PNG
(CHEMBL272119)
Show SMILES Cc1cc(on1)-c1c(-c2ccccc2)c2cc(ccc2[nH]c1=O)C#N
Show InChI InChI=1S/C20H13N3O2/c1-12-9-17(25-23-12)19-18(14-5-3-2-4-6-14)15-10-13(11-21)7-8-16(15)22-20(19)24/h2-10H,1H3,(H,22,24)
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n/an/a 90n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371919
PNG
(CHEMBL436651)
Show SMILES Cc1cc(on1)-c1c(C2=CCCCCC2)c2cc(Cl)ccc2[nH]c1=O |t:9|
Show InChI InChI=1S/C20H19ClN2O2/c1-12-10-17(25-23-12)19-18(13-6-4-2-3-5-7-13)15-11-14(21)8-9-16(15)22-20(19)24/h6,8-11H,2-5,7H2,1H3,(H,22,24)
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n/an/a 90n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371937
PNG
(CHEMBL255215)
Show SMILES Cc1cc(on1)-c1c(-c2ccc(C)cc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C20H15ClN2O2/c1-11-3-5-13(6-4-11)18-15-10-14(21)7-8-16(15)22-20(24)19(18)17-9-12(2)23-25-17/h3-10H,1-2H3,(H,22,24)
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n/an/a 110n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371936
PNG
(CHEMBL270464)
Show SMILES COc1ccc(cc1)-c1c(-c2cc(C)no2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C20H15ClN2O3/c1-11-9-17(26-23-11)19-18(12-3-6-14(25-2)7-4-12)15-10-13(21)5-8-16(15)22-20(19)24/h3-10H,1-2H3,(H,22,24)
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n/an/a 140n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM17751
PNG
(6-chloro-3-(3-methyl-1,2-oxazol-5-yl)-4-phenyl-1,2...)
Show SMILES Cc1cc(on1)-c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C19H13ClN2O2/c1-11-9-16(24-22-11)18-17(12-5-3-2-4-6-12)14-10-13(20)7-8-15(14)21-19(18)23/h2-10H,1H3,(H,21,23)
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n/an/a 140n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50371915
PNG
(CHEMBL273198)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C22H18N4O/c1-3-14-4-7-16(8-5-14)20-17-10-15(11-23)6-9-18(17)26-22(27)21(20)19-12-24-13(2)25-19/h4-10,12H,3H2,1-2H3,(H,24,25)(H,26,27)
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n/an/a 170n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of KIT


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371921
PNG
(CHEMBL255634)
Show SMILES Cc1cc(on1)-c1c(-c2ccc(O)cc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C19H13ClN2O3/c1-10-8-16(25-22-10)18-17(11-2-5-13(23)6-3-11)14-9-12(20)4-7-15(14)21-19(18)24/h2-9,23H,1H3,(H,21,24)
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n/an/a 170n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371928
PNG
(CHEMBL258088)
Show SMILES Clc1ccc2[nH]c(=O)c(-c3c[nH]cn3)c(-c3ccccc3)c2c1
Show InChI InChI=1S/C18H12ClN3O/c19-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)17(18(23)22-14)15-9-20-10-21-15/h1-10H,(H,20,21)(H,22,23)
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n/an/a 180n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371922
PNG
(CHEMBL402429)
Show SMILES CC(C)c1ccc(cc1)-c1c(-c2cc(C)no2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C22H19ClN2O2/c1-12(2)14-4-6-15(7-5-14)20-17-11-16(23)8-9-18(17)24-22(26)21(20)19-10-13(3)25-27-19/h4-12H,1-3H3,(H,24,26)
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n/an/a 200n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371920
PNG
(CHEMBL270463)
Show SMILES Cc1cc(on1)-c1c(C2=CCCCC2)c2cc(Cl)ccc2[nH]c1=O |t:9|
Show InChI InChI=1S/C19H17ClN2O2/c1-11-9-16(24-22-11)18-17(12-5-3-2-4-6-12)14-10-13(20)7-8-15(14)21-19(18)23/h5,7-10H,2-4,6H2,1H3,(H,21,23)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371917
PNG
(CHEMBL403621)
Show SMILES Cc1cc(on1)-c1c(-c2cccc(C)c2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C20H15ClN2O2/c1-11-4-3-5-13(8-11)18-15-10-14(21)6-7-16(15)22-20(24)19(18)17-9-12(2)23-25-17/h3-10H,1-2H3,(H,22,24)
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n/an/a 240n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371941
PNG
(CHEMBL401691)
Show SMILES Cc1cc(on1)-c1c(-c2ccccc2)c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C19H13FN2O2/c1-11-9-16(24-22-11)18-17(12-5-3-2-4-6-12)14-10-13(20)7-8-15(14)21-19(18)23/h2-10H,1H3,(H,21,23)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371927
PNG
(CHEMBL401736)
Show SMILES O=c1[nH]c2ccc(cc2c(-c2ccccc2)c1-c1c[nH]cn1)C#N
Show InChI InChI=1S/C19H12N4O/c20-9-12-6-7-15-14(8-12)17(13-4-2-1-3-5-13)18(19(24)23-15)16-10-21-11-22-16/h1-8,10-11H,(H,21,22)(H,23,24)
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n/an/a 280n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371931
PNG
(CHEMBL271479)
Show SMILES CC(C)c1cc(on1)-c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C21H17ClN2O2/c1-12(2)17-11-18(26-24-17)20-19(13-6-4-3-5-7-13)15-10-14(22)8-9-16(15)23-21(20)25/h3-12H,1-2H3,(H,23,25)
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n/an/a 300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371930
PNG
(CHEMBL403097)
Show SMILES Nc1cc(on1)-c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H12ClN3O2/c19-11-6-7-13-12(8-11)16(10-4-2-1-3-5-10)17(18(23)21-13)14-9-15(20)22-24-14/h1-9H,(H2,20,22)(H,21,23)
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n/an/a 320n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371933
PNG
(CHEMBL256836)
Show SMILES Cc1cc([o+][n-]1)-c1c(-c2ccccc2)c2cc(ccc2[nH]c1=O)[N+]([O-])=O
Show InChI InChI=1S/C19H13N3O4/c1-11-9-16(26-21-11)18-17(12-5-3-2-4-6-12)14-10-13(22(24)25)7-8-15(14)20-19(18)23/h2-10H,1H3,(H,20,23)
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n/an/a 340n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371918
PNG
(CHEMBL270783)
Show SMILES Cc1cc(on1)-c1c(C2CCCCC2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C19H19ClN2O2/c1-11-9-16(24-22-11)18-17(12-5-3-2-4-6-12)14-10-13(20)7-8-15(14)21-19(18)23/h7-10,12H,2-6H2,1H3,(H,21,23)
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n/an/a 340n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371929
PNG
(CHEMBL257456)
Show SMILES Clc1ccc2[nH]c(=O)c(-c3ccc[nH]3)c(-c3ccccc3)c2c1
Show InChI InChI=1S/C19H13ClN2O/c20-13-8-9-15-14(11-13)17(12-5-2-1-3-6-12)18(19(23)22-15)16-7-4-10-21-16/h1-11,21H,(H,22,23)
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n/an/a 360n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371926
PNG
(CHEMBL273011)
Show SMILES Cn1cnc(c1)-c1c(-c2ccccc2)c2cc(ccc2[nH]c1=O)C#N
Show InChI InChI=1S/C20H14N4O/c1-24-11-17(22-12-24)19-18(14-5-3-2-4-6-14)15-9-13(10-21)7-8-16(15)23-20(19)25/h2-9,11-12H,1H3,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371925
PNG
(CHEMBL271259)
Show SMILES Cc1cc(on1)-c1c(-c2ccccc2)c2cc(Cl)ncc2[nH]c1=O
Show InChI InChI=1S/C18H12ClN3O2/c1-10-7-14(24-22-10)17-16(11-5-3-2-4-6-11)12-8-15(19)20-9-13(12)21-18(17)23/h2-9H,1H3,(H,21,23)
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n/an/a 720n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371939
PNG
(CHEMBL401738)
Show SMILES Cc1cc(n[nH]1)-c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C19H14ClN3O/c1-11-9-16(23-22-11)18-17(12-5-3-2-4-6-12)14-10-13(20)7-8-15(14)21-19(18)24/h2-10H,1H3,(H,21,24)(H,22,23)
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n/an/a 830n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371938
PNG
(CHEMBL401618)
Show SMILES Cc1cc(on1)-c1c(-c2ccccc2)c2cc(Cl)cnc2[nH]c1=O
Show InChI InChI=1S/C18H12ClN3O2/c1-10-7-14(24-22-10)16-15(11-5-3-2-4-6-11)13-8-12(19)9-20-17(13)21-18(16)23/h2-9H,1H3,(H,20,21,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50371914
PNG
(CHEMBL403661)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H18ClN3O/c1-3-13-4-6-14(7-5-13)19-16-10-15(22)8-9-17(16)25-21(26)20(19)18-11-23-12(2)24-18/h4-11H,3H2,1-2H3,(H,23,24)(H,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50371915
PNG
(CHEMBL273198)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C22H18N4O/c1-3-14-4-7-16(8-5-14)20-17-10-15(11-23)6-9-18(17)26-22(27)21(20)19-12-24-13(2)25-19/h4-10,12H,3H2,1-2H3,(H,24,25)(H,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371916
PNG
(CHEMBL257323)
Show SMILES CCOC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H14ClNO3/c1-2-23-18(22)16-15(11-6-4-3-5-7-11)13-10-12(19)8-9-14(13)20-17(16)21/h3-10H,2H2,1H3,(H,20,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371935
PNG
(CHEMBL270566)
Show SMILES Cc1cc(on1)-c1c(-c2ccncc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H12ClN3O2/c1-10-8-15(24-22-10)17-16(11-4-6-20-7-5-11)13-9-12(19)2-3-14(13)21-18(17)23/h2-9H,1H3,(H,21,23)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371932
PNG
(CHEMBL271523)
Show SMILES Cc1cc(on1)-c1c(-c2ccccc2)c2cc(N)ccc2[nH]c1=O
Show InChI InChI=1S/C19H15N3O2/c1-11-9-16(24-22-11)18-17(12-5-3-2-4-6-12)14-10-13(20)7-8-15(14)21-19(18)23/h2-10H,20H2,1H3,(H,21,23)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371940
PNG
(CHEMBL402635)
Show SMILES Cc1cc(on1)-c1c(-c2ccccc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C19H14N2O2/c1-12-11-16(23-21-12)18-17(13-7-3-2-4-8-13)14-9-5-6-10-15(14)20-19(18)22/h2-11H,1H3,(H,20,22)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371924
PNG
(CHEMBL403243)
Show SMILES Cc1cc(on1)-c1c(-c2ccccc2)c2ncccc2[nH]c1=O
Show InChI InChI=1S/C18H13N3O2/c1-11-10-14(23-21-11)16-15(12-6-3-2-4-7-12)17-13(20-18(16)22)8-5-9-19-17/h2-10H,1H3,(H,20,22)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%