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PubMed code 26718844

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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4.90n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50191289
PNG
(7-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(Cl)cc2Oc2ccccc12 |t:8|
Show InChI InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-12-13(19)6-7-15(17)20-18/h2-7,12H,8-11H2,1H3
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8.30n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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35n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Binding affinity to histamine 4 receptor (unknown origin)


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50412494
PNG
(CHEMBL452847 | VUF-10497)
Show SMILES CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5S/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)
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43n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50191289
PNG
(7-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(Cl)cc2Oc2ccccc12 |t:8|
Show InChI InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-12-13(19)6-7-15(17)20-18/h2-7,12H,8-11H2,1H3
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102n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM26392
PNG
(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Show SMILES CN1CCN(CC1)c1nc(N)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C17H21N5/c1-21-8-10-22(11-9-21)16-14-7-6-12-4-2-3-5-13(12)15(14)19-17(18)20-16/h2-5H,6-11H2,1H3,(H2,18,19,20)
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186n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50412494
PNG
(CHEMBL452847 | VUF-10497)
Show SMILES CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5S/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)
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550n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137650
PNG
(CHEMBL3752885)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)c2CCc3ccccc3-c2n1
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)24-26-22-20-10-6-5-9-19(20)11-12-21(22)23(27-24)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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891n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137647
PNG
(CHEMBL3752085)
Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)
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955n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137640
PNG
(CHEMBL3752972)
Show SMILES COc1ccc(CNc2nc3CCc4ccccc4-c3c(n2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C25H29N5O/c1-29-13-15-30(16-14-29)24-23-21-6-4-3-5-19(21)9-12-22(23)27-25(28-24)26-17-18-7-10-20(31-2)11-8-18/h3-8,10-11H,9,12-17H2,1-2H3,(H,26,27,28)
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1.07E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137647
PNG
(CHEMBL3752085)
Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)
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1.12E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137638
PNG
(CHEMBL3753705)
Show SMILES CN1CCN(CC1)c1nc2CCc3ccccc3-c2c(n1)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6/c1-25-9-13-27(14-10-25)21-20-18-6-4-3-5-17(18)7-8-19(20)23-22(24-21)28-15-11-26(2)12-16-28/h3-6H,7-16H2,1-2H3
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1.18E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137655
PNG
(CHEMBL3752270)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)23-21-12-11-19-9-5-6-10-20(19)22(21)26-24(27-23)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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1.59E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137646
PNG
(CHEMBL3752195)
Show SMILES COc1ccc(CNc2nc(cc(n2)-c2ccccc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C23H27N5O/c1-27-12-14-28(15-13-27)22-16-21(19-6-4-3-5-7-19)25-23(26-22)24-17-18-8-10-20(29-2)11-9-18/h3-11,16H,12-15,17H2,1-2H3,(H,24,25,26)
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1.74E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137639
PNG
(CHEMBL3753985)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccccc2)nc2CCc3ccccc3-c12
Show InChI InChI=1S/C25H29N5/c1-29-15-17-30(18-16-29)24-23-21-10-6-5-9-20(21)11-12-22(23)27-25(28-24)26-14-13-19-7-3-2-4-8-19/h2-10H,11-18H2,1H3,(H,26,27,28)
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1.86E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137641
PNG
(CHEMBL3753967)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)nc2CCc3ccccc3-c12
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)23-22-20-10-6-5-9-19(20)11-12-21(22)26-24(27-23)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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1.91E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137642
PNG
(CHEMBL3752978)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccccc2)cc(n1)-c1ccccc1
Show InChI InChI=1S/C23H27N5/c1-27-14-16-28(17-15-27)23-25-21(20-10-6-3-7-11-20)18-22(26-23)24-13-12-19-8-4-2-5-9-19/h2-11,18H,12-17H2,1H3,(H,24,25,26)
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1.95E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137653
PNG
(CHEMBL3753334)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(F)cc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C24H26FN5/c1-29-12-14-30(15-13-29)23-21-11-8-18-4-2-3-5-20(18)22(21)27-24(28-23)26-16-17-6-9-19(25)10-7-17/h2-7,9-10H,8,11-16H2,1H3,(H,26,27,28)
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1.95E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137655
PNG
(CHEMBL3752270)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)23-21-12-11-19-9-5-6-10-20(19)22(21)26-24(27-23)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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2.09E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50137647
PNG
(CHEMBL3752085)
Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)
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2.51E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine 3 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137644
PNG
(CHEMBL3753849)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)cc(n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)22-24-20(19-10-6-3-7-11-19)16-21(25-22)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)
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PubMed
2.51E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137645
PNG
(CHEMBL3752383)
Show SMILES CN1CCN(CC1)c1cc(nc(NCCc2ccccc2)n1)-c1ccccc1
Show InChI InChI=1S/C23H27N5/c1-27-14-16-28(17-15-27)22-18-21(20-10-6-3-7-11-20)25-23(26-22)24-13-12-19-8-4-2-5-9-19/h2-11,18H,12-17H2,1H3,(H,24,25,26)
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3.31E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137654
PNG
(CHEMBL3754176)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(C)cc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C25H29N5/c1-18-7-9-19(10-8-18)17-26-25-27-23-21-6-4-3-5-20(21)11-12-22(23)24(28-25)30-15-13-29(2)14-16-30/h3-10H,11-17H2,1-2H3,(H,26,27,28)
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3.39E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137643
PNG
(CHEMBL3754008)
Show SMILES COc1ccc(CNc2cc(nc(n2)N2CCN(C)CC2)-c2ccccc2)cc1
Show InChI InChI=1S/C23H27N5O/c1-27-12-14-28(15-13-27)23-25-21(19-6-4-3-5-7-19)16-22(26-23)24-17-18-8-10-20(29-2)11-9-18/h3-11,16H,12-15,17H2,1-2H3,(H,24,25,26)
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4.17E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137652
PNG
(CHEMBL3752225)
Show SMILES COc1ccc(CNc2nc(N3CCN(C)CC3)c3CCc4ccccc4-c3n2)cc1
Show InChI InChI=1S/C25H29N5O/c1-29-13-15-30(16-14-29)24-22-12-9-19-5-3-4-6-21(19)23(22)27-25(28-24)26-17-18-7-10-20(31-2)11-8-18/h3-8,10-11H,9,12-17H2,1-2H3,(H,26,27,28)
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4.27E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137646
PNG
(CHEMBL3752195)
Show SMILES COc1ccc(CNc2nc(cc(n2)-c2ccccc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C23H27N5O/c1-27-12-14-28(15-13-27)22-16-21(19-6-4-3-5-7-19)25-23(26-22)24-17-18-8-10-20(29-2)11-9-18/h3-11,16H,12-15,17H2,1-2H3,(H,24,25,26)
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5.25E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137652
PNG
(CHEMBL3752225)
Show SMILES COc1ccc(CNc2nc(N3CCN(C)CC3)c3CCc4ccccc4-c3n2)cc1
Show InChI InChI=1S/C25H29N5O/c1-29-13-15-30(16-14-29)24-22-12-9-19-5-3-4-6-21(19)23(22)27-25(28-24)26-17-18-7-10-20(31-2)11-8-18/h3-8,10-11H,9,12-17H2,1-2H3,(H,26,27,28)
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5.75E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50137655
PNG
(CHEMBL3752270)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)23-21-12-11-19-9-5-6-10-20(19)22(21)26-24(27-23)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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6.03E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine 3 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137648
PNG
(CHEMBL3753784)
Show SMILES COc1ccc(CNc2nc(nc-3c2CCc2ccccc-32)N2CCN(C)CC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H32ClN5O/c1-36-15-17-37(18-16-36)31-34-29-25-6-4-3-5-22(25)10-13-26(29)30(35-31)33-20-21-7-14-28(38-2)27(19-21)23-8-11-24(32)12-9-23/h3-9,11-12,14,19H,10,13,15-18,20H2,1-2H3,(H,33,34,35)
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6.31E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137639
PNG
(CHEMBL3753985)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccccc2)nc2CCc3ccccc3-c12
Show InChI InChI=1S/C25H29N5/c1-29-15-17-30(18-16-29)24-23-21-10-6-5-9-20(21)11-12-22(23)27-25(28-24)26-14-13-19-7-3-2-4-8-19/h2-10H,11-18H2,1H3,(H,26,27,28)
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6.76E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50137655
PNG
(CHEMBL3752270)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)23-21-12-11-19-9-5-6-10-20(19)22(21)26-24(27-23)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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6.92E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-DE257 from human histamine 2 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137638
PNG
(CHEMBL3753705)
Show SMILES CN1CCN(CC1)c1nc2CCc3ccccc3-c2c(n1)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6/c1-25-9-13-27(14-10-25)21-20-18-6-4-3-5-17(18)7-8-19(20)23-22(24-21)28-15-11-26(2)12-16-28/h3-6H,7-16H2,1-2H3
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7.76E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137649
PNG
(CHEMBL3753621)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccccc2)c2CCc3ccccc3-c2n1
Show InChI InChI=1S/C25H29N5/c1-29-15-17-30(18-16-29)25-27-23-21-10-6-5-9-20(21)11-12-22(23)24(28-25)26-14-13-19-7-3-2-4-8-19/h2-10H,11-18H2,1H3,(H,26,27,28)
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8.13E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM26392
PNG
(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Show SMILES CN1CCN(CC1)c1nc(N)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C17H21N5/c1-21-8-10-22(11-9-21)16-14-7-6-12-4-2-3-5-13(12)15(14)19-17(18)20-16/h2-5H,6-11H2,1H3,(H2,18,19,20)
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9.12E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137651
PNG
(CHEMBL3753962)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccccc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C25H29N5/c1-29-15-17-30(18-16-29)24-22-12-11-20-9-5-6-10-21(20)23(22)27-25(28-24)26-14-13-19-7-3-2-4-8-19/h2-10H,11-18H2,1H3,(H,26,27,28)
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9.12E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50137651
PNG
(CHEMBL3753962)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccccc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C25H29N5/c1-29-15-17-30(18-16-29)24-22-12-11-20-9-5-6-10-21(20)23(22)27-25(28-24)26-14-13-19-7-3-2-4-8-19/h2-10H,11-18H2,1H3,(H,26,27,28)
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9.33E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137645
PNG
(CHEMBL3752383)
Show SMILES CN1CCN(CC1)c1cc(nc(NCCc2ccccc2)n1)-c1ccccc1
Show InChI InChI=1S/C23H27N5/c1-27-14-16-28(17-15-27)22-18-21(20-10-6-3-7-11-20)25-23(26-22)24-13-12-19-8-4-2-5-9-19/h2-11,18H,12-17H2,1H3,(H,24,25,26)
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9.77E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM26392
PNG
(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Show SMILES CN1CCN(CC1)c1nc(N)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C17H21N5/c1-21-8-10-22(11-9-21)16-14-7-6-12-4-2-3-5-13(12)15(14)19-17(18)20-16/h2-5H,6-11H2,1H3,(H2,18,19,20)
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9.77E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine 3 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50137647
PNG
(CHEMBL3752085)
Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)
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1.02E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-DE257 from human histamine 2 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137653
PNG
(CHEMBL3753334)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(F)cc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C24H26FN5/c1-29-12-14-30(15-13-29)23-21-11-8-18-4-2-3-5-20(18)22(21)27-24(28-23)26-16-17-6-9-19(25)10-7-17/h2-7,9-10H,8,11-16H2,1H3,(H,26,27,28)
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1.10E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137640
PNG
(CHEMBL3752972)
Show SMILES COc1ccc(CNc2nc3CCc4ccccc4-c3c(n2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C25H29N5O/c1-29-13-15-30(16-14-29)24-23-21-6-4-3-5-19(21)9-12-22(23)27-25(28-24)26-17-18-7-10-20(31-2)11-8-18/h3-8,10-11H,9,12-17H2,1-2H3,(H,26,27,28)
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1.38E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137650
PNG
(CHEMBL3752885)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)c2CCc3ccccc3-c2n1
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)24-26-22-20-10-6-5-9-19(20)11-12-21(22)23(27-24)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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1.45E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137649
PNG
(CHEMBL3753621)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccccc2)c2CCc3ccccc3-c2n1
Show InChI InChI=1S/C25H29N5/c1-29-15-17-30(18-16-29)25-27-23-21-10-6-5-9-20(21)11-12-22(23)24(28-25)26-14-13-19-7-3-2-4-8-19/h2-10H,11-18H2,1H3,(H,26,27,28)
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1.51E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137648
PNG
(CHEMBL3753784)
Show SMILES COc1ccc(CNc2nc(nc-3c2CCc2ccccc-32)N2CCN(C)CC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H32ClN5O/c1-36-15-17-37(18-16-36)31-34-29-25-6-4-3-5-22(25)10-13-26(29)30(35-31)33-20-21-7-14-28(38-2)27(19-21)23-8-11-24(32)12-9-23/h3-9,11-12,14,19H,10,13,15-18,20H2,1-2H3,(H,33,34,35)
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1.95E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137654
PNG
(CHEMBL3754176)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(C)cc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C25H29N5/c1-18-7-9-19(10-8-18)17-26-25-27-23-21-6-4-3-5-20(21)11-12-22(23)24(28-25)30-15-13-29(2)14-16-30/h3-10H,11-17H2,1-2H3,(H,26,27,28)
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2.00E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137641
PNG
(CHEMBL3753967)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)nc2CCc3ccccc3-c12
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)23-22-20-10-6-5-9-19(20)11-12-21(22)26-24(27-23)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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2.63E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137644
PNG
(CHEMBL3753849)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)cc(n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)22-24-20(19-10-6-3-7-11-19)16-21(25-22)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)
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3.16E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM26392
PNG
(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Show SMILES CN1CCN(CC1)c1nc(N)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C17H21N5/c1-21-8-10-22(11-9-21)16-14-7-6-12-4-2-3-5-13(12)15(14)19-17(18)20-16/h2-5H,6-11H2,1H3,(H2,18,19,20)
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3.16E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-DE257 from human histamine 2 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137642
PNG
(CHEMBL3752978)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccccc2)cc(n1)-c1ccccc1
Show InChI InChI=1S/C23H27N5/c1-27-14-16-28(17-15-27)23-25-21(20-10-6-3-7-11-20)18-22(26-23)24-13-12-19-8-4-2-5-9-19/h2-11,18H,12-17H2,1H3,(H,24,25,26)
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3.63E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137643
PNG
(CHEMBL3754008)
Show SMILES COc1ccc(CNc2cc(nc(n2)N2CCN(C)CC2)-c2ccccc2)cc1
Show InChI InChI=1S/C23H27N5O/c1-27-12-14-28(15-13-27)23-25-21(19-6-4-3-5-7-19)16-22(26-23)24-17-18-8-10-20(29-2)11-9-18/h3-11,16H,12-15,17H2,1-2H3,(H,24,25,26)
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7.24E+4n/an/an/an/an/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137655
PNG
(CHEMBL3752270)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccccc2)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C24H27N5/c1-28-13-15-29(16-14-28)23-21-12-11-19-9-5-6-10-20(19)22(21)26-24(27-23)25-17-18-7-3-2-4-8-18/h2-10H,11-17H2,1H3,(H,25,26,27)
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n/an/an/an/a 933n/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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n/an/an/an/a 417n/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50137647
PNG
(CHEMBL3752085)
Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)
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n/an/an/an/a 912n/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM26392
PNG
(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Show SMILES CN1CCN(CC1)c1nc(N)nc-2c1CCc1ccccc-21
Show InChI InChI=1S/C17H21N5/c1-21-8-10-22(11-9-21)16-14-7-6-12-4-2-3-5-13(12)15(14)19-17(18)20-16/h2-5H,6-11H2,1H3,(H2,18,19,20)
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n/an/an/an/a 295n/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 7.90n/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...


Bioorg Med Chem Lett 26: 292-300 (2016)


BindingDB Entry DOI: 10.7270/Q2Z03B0K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%