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USPatent US8653111

Compile data set for download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118338
PNG
(US8653111, 62)
Show SMILES CC(C)(C)OC(=O)c1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3
PDB

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n/an/a 50n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118341
PNG
(US8653111, 85)
Show SMILES CC(C)(C)COc1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H18N6O2/c1-15(2,3)10-23-11-4-5-13(16-8-11)21-14(22)12(9-18-21)20-7-6-17-19-20/h4-9,18H,10H2,1-3H3
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n/an/a 190n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118328
PNG
(US8653111, 7)
Show SMILES Cc1ccnc(c1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H10N6O/c1-8-2-3-12-10(6-8)17-11(18)9(7-14-17)16-5-4-13-15-16/h2-7,14H,1H3
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n/an/a 340n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118344
PNG
(US8653111, 103)
Show SMILES CCSc1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H11N7OS/c1-2-20-10-5-9(12-7-13-10)18-11(19)8(6-15-18)17-4-3-14-16-17/h3-7,15H,2H2,1H3
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n/an/a 350n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118346
PNG
(US8653111, 129)
Show SMILES CC1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H18N8O/c1-11-2-5-21(6-3-11)13-8-14(17-10-16-13)23-15(24)12(9-19-23)22-7-4-18-20-22/h4,7-11,19H,2-3,5-6H2,1H3
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n/an/a 360n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118339
PNG
(US8653111, 72)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-n1ccnn1
Show InChI InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2
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n/an/a 490n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118329
PNG
(US8653111, 10)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-n1ccnc1
Show InChI InChI=1S/C15H17N7O/c23-15-12(21-7-4-16-11-21)9-19-22(15)14-8-13(17-10-18-14)20-5-2-1-3-6-20/h4,7-11,19H,1-3,5-6H2
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n/an/a 500n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118331
PNG
(US8653111, 17)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)C1CC1)-n1ccnn1
Show InChI InChI=1S/C12H11N7O/c20-12-10(18-4-3-15-17-18)6-16-19(12)11-5-9(8-1-2-8)13-7-14-11/h3-8,16H,1-2H2
PDB

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n/an/a 560n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118347
PNG
(US8653111, 166)
Show SMILES COC1CCCN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O
Show InChI InChI=1S/C16H19N7O2/c1-25-12-3-2-5-21(9-12)14-7-15(19-10-18-14)23-16(24)13(8-20-23)22-6-4-17-11-22/h4,6-8,10-12,20H,2-3,5,9H2,1H3
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n/an/a 690n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118345
PNG
(US8653111, 113)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCSCC1)-n1ccnn1
Show InChI InChI=1S/C13H14N8OS/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2
PDB

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n/an/a 740n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118330
PNG
(US8653111, 12)
Show SMILES OCc1ccc(nc1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C13H10F3N5O2/c14-13(15,16)10-5-20(7-18-10)9-4-19-21(12(9)23)11-2-1-8(6-22)3-17-11/h1-5,7,19,22H,6H2
PDB

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n/an/a 750n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118333
PNG
(US8653111, 45)
Show SMILES CC(C)c1cn(nn1)-c1c[nH]n(-c2ccc(CO)cn2)c1=O
Show InChI InChI=1S/C14H16N6O2/c1-9(2)11-7-19(18-17-11)12-6-16-20(14(12)22)13-4-3-10(8-21)5-15-13/h3-7,9,16,21H,8H2,1-2H3
PDB

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n/an/a 780n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118337
PNG
(US8653111, 61)
Show SMILES Cc1cc(ncc1Br)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H9BrN6O/c1-7-4-10(13-5-8(7)12)18-11(19)9(6-15-18)17-3-2-14-16-17/h2-6,15H,1H3
PDB

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n/an/a 1.10E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118334
PNG
(US8653111, 50)
Show SMILES Cc1cc(on1)-c1c[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C12H10N4O2/c1-8-6-10(18-15-8)9-7-14-16(12(9)17)11-4-2-3-5-13-11/h2-7,14H,1H3
PDB

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n/an/a 1.40E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118336
PNG
(US8653111, 60)
Show SMILES CCc1cc(ncn1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C13H11F3N6O/c1-2-8-3-11(18-6-17-8)22-12(23)9(4-20-22)21-5-10(19-7-21)13(14,15)16/h3-7,20H,2H2,1H3
PDB

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n/an/a 1.40E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118343
PNG
(US8653111, 101)
Show SMILES OC1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O
Show InChI InChI=1S/C13H13N7O2/c21-9-5-19(6-9)11-3-12(16-7-15-11)20-13(22)10(4-17-20)18-2-1-14-8-18/h1-4,7-9,17,21H,5-6H2
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n/an/a 1.70E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118332
PNG
(US8653111, 43)
Show SMILES Cc1cn(nn1)-c1c[nH]n(-c2cnccn2)c1=O
Show InChI InChI=1S/C10H9N7O/c1-7-6-16(15-14-7)8-4-13-17(10(8)18)9-5-11-2-3-12-9/h2-6,13H,1H3
PDB

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n/an/a 1.80E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118340
PNG
(US8653111, 83)
Show SMILES FC(F)(F)c1ccnc(c1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H7F3N6O/c12-11(13,14)7-1-2-15-9(5-7)20-10(21)8(6-17-20)19-4-3-16-18-19/h1-6,17H
PDB

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n/an/a 1.90E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118335
PNG
(US8653111, 55)
Show SMILES Cc1cn(cn1)-c1c[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C12H11N5O/c1-9-7-16(8-14-9)10-6-15-17(12(10)18)11-4-2-3-5-13-11/h2-8,15H,1H3
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118342
PNG
(US8653111, 91)
Show SMILES Cc1cnc(cc1C)-n1[nH]cc(-n2ccnc2)c1=O
Show InChI InChI=1S/C13H13N5O/c1-9-5-12(15-6-10(9)2)18-13(19)11(7-16-18)17-4-3-14-8-17/h3-8,16H,1-2H3
PDB

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n/an/a 2.80E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%