The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28273563 |
59 |
Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one. |
Seoul National University |
28186757 |
66 |
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. |
European Institute of Oncology |
28186755 |
85 |
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration. |
European Institute of Oncology |
28131710 |
22 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-ß aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. |
Sichuan University |
27951485 |
59 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-ß-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. |
Sichuan University |
28188065 |
9 |
Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone. |
Sunchon National University |
28107736 |
53 |
Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors. |
Ntz Lab |
28237559 |
65 |
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases andß-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. |
Sichuan University |
2113950 |
1 |
Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl and (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain. |
Brookhaven National Laboratory |
4068012 |
3 |
1-Benzylcyclopropylamine and 1-(phenylcyclopropyl)methylamine: an inactivator and a substrate of monoamine oxidase. |
TBA |
28011206 |
36 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
Sichuan University |
27923535 |
39 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties. |
Sichuan University |
27908752 |
55 |
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. |
University of Ljubljana |
27692996 |
84 |
Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease. |
China Pharmaceutical University |
26471320 |
50 |
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation. |
Okayama University |
27267007 |
58 |
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties. |
Instituto De Qu£Mica M£Dica |
27578245 |
46 |
2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase. |
North-West University |
27135371 |
26 |
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors. |
Universit£ |
27079124 |
22 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
Sichuan University |
26710088 |
248 |
Recent Progress in Histone Demethylase Inhibitors. |
University of Oxford |
26819666 |
26 |
Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis. |
Birla Institute of Technology |
26702542 |
59 |
Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. |
European Institute of Oncology |
26974383 |
11 |
Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors. |
Qatar University |
26700437 |
32 |
Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators. |
Kyoto Prefectural University of Medicine |
26964672 |
26 |
Novel tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one: Design, synthesis, model and use as hMAO-B inhibitors. |
Anhui Medical University |
26717204 |
17 |
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold. |
Universit£ |
26917219 |
63 |
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease. |
China Pharmaceutical University |
26821818 |
25 |
Inhibition of monoamine oxidase by benzoxathiolone analogues. |
North-West University |
26652247 |
60 |
3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1. |
Baylor College of Medicine |
26432037 |
14 |
Monoamine oxidase inhibitory activities of heterocyclic chalcones. |
North-West University |
26352677 |
44 |
Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitors. |
Hefei University of Technology |
26086931 |
38 |
Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators. |
Shandong University |
26337020 |
69 |
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors. |
Korea Institute of Science and Technology |
26278660 |
90 |
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders. |
University of Jena |
25915162 |
12 |
New Frontiers in Selective Human MAO-B Inhibitors. |
Sapienza University of Rome |
25934229 |
21 |
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease. |
Sun Yat-Sen University |
26107513 |
172 |
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases. |
Universit£ |
25699146 |
13 |
Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies. |
Sapienza University of Rome |
25812965 |
80 |
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. |
China Pharmaceutical University |
25768700 |
30 |
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts. |
Sapienza University of Rome |
25627172 |
150 |
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease. |
A* Star |
25610955 |
53 |
Design, synthesis, and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents. |
Zhengzhou University |
25418133 |
51 |
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. |
Laboratorio De Quimica Medica (Iqog, Csic) |
25857942 |
30 |
The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase. |
North-West University |
25827526 |
33 |
Histone H3 peptide based LSD1-selective inhibitors. |
Waseda University |
25725609 |
18 |
Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. |
John Hopkins University |
25600407 |
26 |
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques. |
Dart Neuroscience |
25701250 |
32 |
Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives. |
Yaroslavl State Technical University |
25542589 |
23 |
Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-ß-amyloid (Aß) aggregation and metal chelation properties against Alzheimer's disease. |
China Pharmaceutical University |
25541201 |
55 |
Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors. |
Anhui Medical University |
24986657 |
56 |
Synthesis of some novel hydrazone and 2-pyrazoline derivatives: monoamine oxidase inhibitory activities and docking studies. |
Ministry of Health of Turkey |
24955776 |
166 |
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency. |
University of Bonn |
25532905 |
10 |
Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives. |
Universidad De Santiago De Compostela |
25488845 |
4 |
Radiosynthesis and ex vivo evaluation of [(18)F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET. |
University of Toronto |
25173853 |
50 |
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. |
European Institute of Oncology |
24904963 |
18 |
New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies. |
Sapienza University of Rome |
24856304 |
25 |
New coumarin derivatives: design, synthesis and use as inhibitors of hMAO. |
Anhui Medical University |
24794105 |
38 |
a-Tetralone derivatives as inhibitors of monoamine oxidase. |
North-West University |
24793878 |
25 |
New 2H-chromene-3-carboxamide derivatives: design, synthesis and use as inhibitors of hMAO. |
Anhui Medical University |
24746464 |
29 |
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors. |
Sapienza University of Rome |
24187998 |
96 |
Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. |
University of Copenhagen |
23454517 |
56 |
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease. |
Sun Yat-Sen University |
23211968 |
7 |
Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity. |
Karolinska Institutet |
23207410 |
42 |
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors. |
Sapienza University of Rome |
23337801 |
24 |
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema. |
Astellas Pharma |
23281824 |
118 |
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors. |
Universit£ |
15203146 |
30 |
Inhibition of monoamine oxidases by coumarin-3-acyl derivatives: biological activity and computational study. |
Sapienza University of Rome |
12443774 |
12 |
Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies. |
University of Bari |
22705191 |
45 |
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives. |
North-West University |
20934874 |
16 |
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors. |
Sapienza University of Rome |
17034132 |
122 |
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors. |
University of Geneva |
23122934 |
44 |
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues. |
North-West University |
23122857 |
49 |
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B. |
North-West University |
23102654 |
20 |
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease. |
Northeast Ohio Medical University |
22978824 |
17 |
Multitarget-directed benzylideneindanone derivatives: anti-ß-amyloid (Aß) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease. |
Sun Yat-Sen University |
23010267 |
23 |
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B. |
North-West University |
23153812 |
68 |
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines. |
Sapienza University of Rome |
22850212 |
30 |
Selected chromone derivatives as inhibitors of monoamine oxidase. |
North-West University |
22781190 |
102 |
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B. |
University of Mississippi |
22595173 |
68 |
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1). |
Pharmaxis |
22282722 |
10 |
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. |
TBA |
22436387 |
4 |
Synthesis and evaluation of [¹8F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B). |
Karolinska Institutet |
21742494 |
44 |
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B. |
Northeastern Ohio Universities Colleges of Medicine and Pharmacy |
21726069 |
98 |
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. |
University of Namur |
21175212 |
3 |
Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex. |
University of Pavia |
20875743 |
90 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela |
Pfizer |
20708306 |
68 |
Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies. |
Alexandria University |
20579890 |
111 |
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. |
Sapienza University of Rome |
20650633 |
12 |
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening. |
Northeastern Ohio Universities |
20123154 |
48 |
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. |
University of Chile |
18272363 |
7 |
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. |
Johnson & Johnson Pharmaceutical Research & Development |
18181565 |
71 |
Multi-target-directed ligands to combat neurodegenerative diseases. |
University of Bologna |
16570912 |
24 |
Design, synthesis, and biological evaluation of semicarbazide-sensitive amine oxidase (SSAO) inhibitors with anti-inflammatory activity. |
La Jolla Pharmaceutical |
15537343 |
4 |
Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxidase. |
Universit£T M£Nster |
15056004 |
36 |
Synthesis and selective inhibitory activity of 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives against monoamine oxidase. |
Sapienza University of Rome |
15027872 |
7 |
Fluorinated phenylcyclopropylamines. 1. Synthesis and effect of fluorine substitution at the cyclopropane ring on inhibition of microbial tyramine oxidase. |
National Institute of Diabetes and Digestive and Kidney Diseases |
2296014 |
42 |
Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. |
University of Texas |
22264472 |
30 |
Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs. |
University of Mississippi |
22309913 |
30 |
Inhibition of monoamine oxidase by selected C6-substituted chromone derivatives. |
North-West University |
22225638 |
18 |
A scaffold hopping approach to identify novel monoamine oxidase B inhibitors. |
Northeast Ohio Medical University |
22078410 |
31 |
Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines. |
West Virginia University |
21955276 |
60 |
Lysine demethylases inhibitors. |
Kyoto Prefectural University of Medicine |
22222137 |
13 |
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B. |
Universit£ |
22137786 |
9 |
Hydroxycoumarins as selective MAO-B inhibitors. |
Universit£ |
22071524 |
7 |
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO. |
Federal University of Rio De Janeiro |
22055712 |
33 |
Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase. |
North-West University |
22018876 |
4 |
Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives. |
Facult£S Universitaires Notre-Dame De Paix |
22005185 |
25 |
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins. |
University of Santiago De Compostela |
21923198 |
6 |
Synthesis of three novel fluorine-18 labeled analogues of L-deprenyl for positron emission tomography (PET) studies of monoamine oxidase B (MAO-B). |
Karolinska Institutet |
21923181 |
28 |
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors. |
University of Santiago De Compostela |
21899930 |
37 |
Monoamine oxidase inhibition by selected anilide derivatives. |
North-West University |
21872365 |
54 |
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives. |
Sapienza University of Rome |
21777011 |
15 |
3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: a new scaffold for the selective inhibition of monoamine oxidase B. |
University of Cagliari |
21778064 |
40 |
Inhibition of monoamine oxidase by C5-substituted phthalimide analogues. |
North-West University |
21696156 |
23 |
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors. |
Universidade Do Porto |
21621312 |
58 |
8-Aryl- and alkyloxycaffeine analogues as inhibitors of monoamine oxidase. |
North-West University |
21684743 |
12 |
MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins. |
Universidad De Santiago De Compostela |
21680183 |
48 |
Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies. |
Birla Institute of Technology |
19423346 |
8 |
A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors. |
Facultad De Farmacia |
21405131 |
39 |
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties. |
Sapienza University of Rome |
21377879 |
44 |
Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation. |
Birla Institute of Technology |
21316817 |
14 |
Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives. |
Universita Degli Studi Di Cagliari |
21134756 |
90 |
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues. |
North-West University |
21194943 |
9 |
Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors. |
Universidade Do Porto |
21183355 |
18 |
Synthesis and evaluation ofß-carboline derivatives as potential monoamine oxidase inhibitors. |
Facult£S Universitaires Notre-Dame De La Paix |
20843688 |
8 |
'Click' assembly of selective inhibitors for MAO-A. |
Zhejiang University |
20702005 |
17 |
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase. |
Dipartimento Farmaco Chimico Tecnologico |
20674099 |
48 |
Inhibition of monoamine oxidase by indole and benzofuran derivatives. |
North-West University |
20715818 |
78 |
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines. |
Sapienza University of Rome |
20659799 |
10 |
New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors. |
Universidad De Santiago De Compostela |
20615716 |
55 |
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors. |
Sapienza University of Rome |
20382016 |
8 |
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B. |
Universit£ |
19926363 |
29 |
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives. |
Universit£ |
20045650 |
56 |
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. |
Sapienza University of Rome |
20093036 |
28 |
Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. |
North-West University |
19628387 |
6 |
Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors. |
Universidad De Santiago De Compostela |
19321235 |
22 |
Knowledge based identification of MAO-B selective inhibitors using pharmacophore and structure based virtual screening models. |
Gvk Biosciences |
| 52 |
Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase |
TBA |
19342233 |
12 |
Inhibition of monoamine oxidase by (E)-styrylisatin analogues. |
North-West University |
19064321 |
37 |
Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. |
Universidade Federal De Santa Maria |
19053775 |
4 |
Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B. |
Emory University |
18834112 |
52 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
University of Santiago De Compostela |
18723354 |
12 |
Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues. |
North-West University |
18666768 |
39 |
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones. |
Sapienza University of Rome |
18640844 |
38 |
Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines. |
UniversitäT MüNster |
17521909 |
15 |
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. |
University of Santiago De Chile |
16137882 |
10 |
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds. |
Kadir Has University |
15974574 |
56 |
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors. |
Sapienza University of Rome |
14698188 |
13 |
Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites. |
Instituto De QuíMica MéDica |
12540239 |
3 |
Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity. |
Glaxosmithkline |
12467619 |
12 |
Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative. |
FacultéS Universitaires Notre-Dame De La Paix |
12443791 |
14 |
Inhibition of amine oxidases activity by 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives. |
Sapienza University of Rome |
32551003 |
53 |
Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors. |
Constellation Pharmaceuticals |
32089390 |
10 |
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease. |
Guizhou Medical University |
32945812 |
79 |
Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia. |
Convergence Pharmaceuticals |
32503694 |
27 |
Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity. |
Zhejiang University |
32299731 |
56 |
Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase. |
North-West University |
32146060 |
37 |
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. |
Guizhou Medical University |
32031378 |
17 |
Acetylene Group, Friend or Foe in Medicinal Chemistry. |
St. John'S University |
31864798 |
42 |
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy. |
Universidade De Lisboa |
31740200 |
10 |
Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities. |
Josai University |
30808606 |
240 |
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies. |
Jagiellonian University Medical College |
27396685 |
36 |
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors. |
Universitat De Barcelona |
27244485 |
52 |
Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors. |
University of Porto |
27575476 |
30 |
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens. |
Sunchon National University |
27658798 |
376 |
8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors. |
University of Bonn |
27347731 |
206 |
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. |
Universit£ |
30686752 |
35 |
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. |
Sunchon National University |
32038769 |
36 |
Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol |
Lieber Institute For Brain Development |
31430136 |
118 |
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth. |
University of Manchester |
30792039 |
44 |
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure. |
Hefei University of Technology |
31421966 |
20 |
Rasagiline derivatives combined with histamine H |
Heinrich Heine University D£Sseldorf |
30975503 |
99 |
Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors. |
Fudan University |
31362921 |
62 |
A fragment-like approach to PYCR1 inhibition. |
University of Strathclyde |
30522087 |
63 |
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons. |
Ntz Lab |
31599580 |
10 |
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2- |
University of Oxford |
30713023 |
51 |
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor. |
Liaoning Shihua University |
31325784 |
15 |
Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease. |
Zhejiang University |
31310916 |
37 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. |
Nanyang Normal University |
31229875 |
33 |
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
Nanyang Normal University |
31376564 |
13 |
Cinnamamide: An insight into the pharmacological advances and structure-activity relationships. |
National Institute of Pharmaceutical Education and Research (NIPER) |
31444085 |
85 |
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
Guizhou Medical University |
31265934 |
53 |
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors. |
Ntz Lab |
31151057 |
52 |
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase. |
Central University of Punjab |
31103902 |
41 |
Multi-target design strategies for the improved treatment of Alzheimer's disease. |
China Pharmaceutical University |
31005056 |
36 |
Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease. |
Institute of Materia Medica |
30744931 |
170 |
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
Csir-Central Drug Research Institute |
31401465 |
52 |
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
Julius Maximilian University of W£Rzburg |
30611617 |
15 |
Identification of selective and reversible LSD1 inhibitors with anti-metastasis activity by high-throughput docking. |
Taizhou People'S Hospital |
30529634 |
16 |
Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
School of Traditional Chinese Pharmacy |
30503945 |
28 |
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents. |
University of The Western Cape |
30404719 |
48 |
4-tert-Pentylphenoxyalkyl derivatives - Histamine H |
Jagiellonian University Medical College |
30366255 |
81 |
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors. |
Universit£ |
31917923 |
91 |
Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B. |
University of Ljubljana |
31580073 |
92 |
Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3. |
Pharmaxis |
30850265 |
6 |
Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma. |
West Virginia University |
30833108 |
31 |
Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors. |
Hefei University of Technology |
31711793 |
20 |
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies. |
University of Porto |
31627991 |
35 |
Design, synthesis and biological evaluation of curcumin analogues as novel LSD1 inhibitors. |
Shenyang Pharmaceutical University |
31581002 |
70 |
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease. |
Chinese Academy of Sciences |
30455149 |
73 |
Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework. |
Ushinsky Yaroslavl State Pedagogical University |
30448189 |
28 |
Design, synthesis and in vitro evaluation of stilbene derivatives as novel LSD1 inhibitors for AML therapy. |
Xinxiang Medical University |
31537422 |
34 |
1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B. |
Ushinsky Yaroslavl State Pedagogical University |
27020523 |
73 |
An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase. |
Yaroslavl State Technical University |
26536532 |
19 |
Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives. |
Kuwait University |
25580204 |
10 |
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors. |
Medical University of South Carolina |
24560738 |
64 |
Alkynyl-coumarinyl ethers as MAO-B inhibitors. |
University of Bonn |
24325601 |
74 |
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. |
Sapienza University of Rome |
24169316 |
46 |
Chromenylchalcones with inhibitory effects on monoamine oxidase B. |
Konkuk University |
24139167 |
419 |
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases. |
University of Bonn |
24140951 |
19 |
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases. |
University of Padova |
24012376 |
5 |
Development of a novel fluorine-18 labeled deuterated fluororasagiline ([(18)F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B). |
Karolinska Institutet |
24099995 |
21 |
Monoamine oxidase inhibitory activity of 3,5-biaryl-4,5-dihydro-1H-pyrazole-1-carboxylate derivatives. |
Birla Institute of Technology |
24012182 |
28 |
Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives. |
North-West University |
23810676 |
13 |
Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease. |
Korea Institute of Science and Technology |
23927971 |
51 |
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles. |
Universit£ |
23860591 |
38 |
Selected furanochalcones as inhibitors of monoamine oxidase. |
North-West University |
23807114 |
12 |
Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors. |
Sapienza University of Rome |
23374869 |
49 |
Inhibition of monoamine oxidase by phthalide analogues. |
North-West University |
23631427 |
212 |
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones. |
University of Bonn |
23517722 |
13 |
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease. |
R.C. Patel Institute of Pharmaceutical Education and Research |
23474901 |
12 |
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study. |
University of Santiago De Compostela |
23207409 |
24 |
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors. |
Universidade Do Porto |
31070916 |
14 |
Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships. |
The Institute of Cancer Research |
15566287 |
106 |
alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype. |
Universit£ |
12747788 |
41 |
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
Universit£ |
11754577 |
26 |
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole. |
Universit£ |
11334568 |
16 |
Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity. |
Universit£ |
10425083 |
22 |
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors. |
Universit£ |
30096650 |
102 |
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. |
China Pharmaceutical University |
30025348 |
149 |
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease. |
Consejo Superior De Investigaciones Cient�Ficas (Iqm-Csic) |
30245401 |
61 |
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors. |
University of Porto |
30243151 |
23 |
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. |
China Pharmaceutical University |
29247860 |
80 |
Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation. |
University of Freiburg |
30153955 |
20 |
Optimization of 5-arylidene barbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia. |
Fudan University |
30016860 |
58 |
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases. |
The University of British Columbia |
29500132 |
59 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and ?-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. |
Sichuan University |
29331452 |
9 |
Design, synthesis and evaluation of ?-turn mimetics as LSD1-selective inhibitors. |
Kyoto Prefectural University of Medicine |
3260955 |
14 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues. Inactivation of monoamine oxidase by conformationally rigid analogues of N,N-dimethylcinnamylamine. |
Northwestern University |
29477889 |
36 |
Novel indanone derivatives as MAO B/H |
Heinrich Heine University Duesseldorf |
29459279 |
10 |
Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. |
Medical University of South Carolina |
28797883 |
56 |
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease. |
Shanghai University of Traditional Chinese Medicine |
28797881 |
20 |
Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors. |
Universidade De Vigo |
28728104 |
52 |
Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-? aggregation for the treatment of Alzheimer's disease. |
Shenyang Pharmaceutical University |
29409707 |
6 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. |
Sichuan University |
29395970 |
18 |
Selective inhibition of monoamine oxidase A by hispidol. |
Sunchon National University |
29648817 |
7 |
Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis. |
University of Porto |
29198865 |
9 |
Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors. |
Waseda University |
29198609 |
96 |
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy. |
Yonsei University |
28988627 |
22 |
Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease. |
Shenyang Pharmaceutical University |
28082069 |
41 |
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment. |
Charles University In Prague |
29339253 |
55 |
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline. |
Hefei University of Technology |
29248751 |
36 |
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors. |
Anadolu University |
29172081 |
68 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
East China University of Science and Technology |
29126727 |
75 |
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents. |
"G. D'Annunzio" University of Chieti-Pescara |
29969030 |
24 |
Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
Iqog, Csic |
29031059 |
61 |
Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors. |
East China Normal University |
28987602 |
38 |
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment. |
Xinxiang Medical University |
30017112 |
36 |
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery. |
Abbottabad University of Science and Technology |
29925480 |
26 |
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid. |
Sunchon National University |
30279044 |
16 |
Synthesis and evaluation of 2-substituted 4(3H)-quinazolinone thioether derivatives as monoamine oxidase inhibitors. |
North-West University |
29792714 |
32 |
Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson's Disease. |
Uppsala University |
28549891 |
50 |
Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. |
China Pharmaceutical University |
28456030 |
20 |
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase. |
North-West University |
29033233 |
56 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
Nanyang Normal University |
29033232 |
164 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease. |
Nanyang Normal University |
28927796 |
42 |
Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1. |
University of Manchester |
28368606 |
5 |
Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens. |
Yunnan University |
27855360 |
23 |
Benzyloxynitrostyrene analogues - A novel class of selective and highly potent inhibitors of monoamine oxidase B. |
North-West University |
27754693 |
16 |
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B. |
Temple University |
27744252 |
102 |
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease. |
University of The Western Cape |
28753307 |
35 |
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis? |
University of Porto |
28301816 |
22 |
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains. |
Anadolu University |
28487125 |
174 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease. |
Nanyang Normal University |
29316397 |
47 |
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists. |
Bristol-Myers Squibb |
28537720 |
5 |
Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances. |
University of Porto |
21985377 |
42 |
Synthesis and biological evaluation of novel N, N'-disubstituted urea and thiourea derivatives as potential anti-melanoma agents. |
Nanjing University |
21815772 |
22 |
Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds. |
Artvin Coruh University |
20030512 |
1 |
New antihyperglycemic, alpha-glucosidase inhibitory, and cytotoxic derivatives of benzimidazoles. |
Indian Institute of Chemical Technology |
28525735 |
2 |
Structure-based rational design of self-inhibitory peptides to disrupt the intermolecular interaction between the troponin subunits C and I in neuropathic pain. |
The Affiliated Hospital of Qingdao University |
28481076 |
7 |
Heme Proximal Hydrogen Bonding between His170 and Asp132 Plays an Essential Role in the Heme Degradation Reaction of HutZ from Vibrio cholerae. |
Hokkaido University |
28387506 |
3 |
Interaction of Azole-Based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: A Molecular Basis for Toxicity. |
North Carolina State University |
14500740 |
13 |
Differential activation of formyl peptide receptor signaling by peptide ligands. |
Pohang University of Science and Technology |
11093776 |
5 |
Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists. |
University of Alabama At Birmingham |
8813598 |
34 |
Affinity of various ligands for GABAA receptors containing alpha 4 beta 3 gamma 2, alpha 4 gamma 2, or alpha 1 beta 3 gamma 2 subunits. |
University Clinic For Psychiatry |
8788493 |
64 |
Novel discriminatory ligands for 5-HT2B receptors. |
Smithkline Beecham Pharmaceuticals |
3014519 |
39 |
Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. |
Merck Sharp & Dohme Research Laboratories |
19113826 |
12 |
Rigid duplex alpha-cyclodextrin reversibly connected with disulfide bonds. Synthesis and inclusion complexes. |
Institute of Organic Chemistry and Biochemistry As Cr |
17416521 |
67 |
Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists. |
Tanabe Research Laboratories Usa |
19143565 |
58 |
Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases. |
University of Tartu |
19128055 |
24 |
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue. |
Universite De Lyon |
18790643 |
42 |
A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. |
University of Wisconsin-Milwaukee |
18578471 |
16 |
Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors. |
Astrazeneca |
12951118 |
24 |
HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent. |
Merck Research Laboratories |
12941332 |
27 |
6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3). |
Glaxosmithkline |
12941338 |
18 |
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. |
University of Newcastle |
12646019 |
48 |
Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. |
Sugen |
2552117 |
68 |
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. |
Hebrew University of Jerusalem |
18589438 |
10 |
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. |
University of Otago |
8523406 |
59 |
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs. |
Eli Lilly |
1588552 |
30 |
HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity. |
Merck Research Laboratories |