Found 1188 hits with Last Name = 'hanney' and Initial = 'b' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM14775
(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
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| Purchase
CHEMBL
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MCE
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PDB
UniChem
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| PDB
Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111966
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-benz...)Show SMILES Nc1ncnc2cc(CN3CCN(CC3=O)S(=O)(=O)c3cc4ccc(Cl)cc4s3)ccc12 Show InChI InChI=1S/C21H18ClN5O3S2/c22-15-3-2-14-8-20(31-18(14)9-15)32(29,30)27-6-5-26(19(28)11-27)10-13-1-4-16-17(7-13)24-12-25-21(16)23/h1-4,7-9,12H,5-6,10-11H2,(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM14775
(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23) | PDB
UniProtKB/SwissProt
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| PDB
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rh£ne-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of Rolipram binding to Phosphodiesterase 4 |
Bioorg Med Chem Lett 8: 2737-42 (1998)
BindingDB Entry DOI: 10.7270/Q2GB267S |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12594
(4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXO...)Show SMILES NC(=N)c1ccc(CN2CCN(CC2=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)cc1 Show InChI InChI=1S/C20H19ClN4O3S2/c21-16-6-5-15-9-19(29-17(15)10-16)30(27,28)25-8-7-24(18(26)12-25)11-13-1-3-14(4-2-13)20(22)23/h1-6,9-10H,7-8,11-12H2,(H3,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12594
(4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXO...)Show SMILES NC(=N)c1ccc(CN2CCN(CC2=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)cc1 Show InChI InChI=1S/C20H19ClN4O3S2/c21-16-6-5-15-9-19(29-17(15)10-16)30(27,28)25-8-7-24(18(26)12-25)11-13-1-3-14(4-2-13)20(22)23/h1-6,9-10H,7-8,11-12H2,(H3,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
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Patents
Similars
| MMDB
PDB
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111958
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-1H-b...)Show SMILES Nc1ncnc2cc(CN3CCN(CC3=O)S(=O)(=O)c3nc4ccc(Cl)cc4[nH]3)ccc12 Show InChI InChI=1S/C20H18ClN7O3S/c21-13-2-4-15-17(8-13)26-20(25-15)32(30,31)28-6-5-27(18(29)10-28)9-12-1-3-14-16(7-12)23-11-24-19(14)22/h1-4,7-8,11H,5-6,9-10H2,(H,25,26)(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111955
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-1H-b...)Show SMILES Nc1ncnc2cc(CN3CCN(Cc4nc5ccc(Cl)cc5[nH]4)CC3=O)ccc12 Show InChI InChI=1S/C21H20ClN7O/c22-14-2-4-16-18(8-14)27-19(26-16)10-28-5-6-29(20(30)11-28)9-13-1-3-15-17(7-13)24-12-25-21(15)23/h1-4,7-8,12H,5-6,9-11H2,(H,26,27)(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471876
(CHEMBL134441)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccccc2C1=O Show InChI InChI=1S/C27H25NO4/c1-31-23-11-10-19(16-24(23)32-20-6-2-3-7-20)27(17-18-12-14-28-15-13-18)25(29)21-8-4-5-9-22(21)26(27)30/h4-5,8-16,20H,2-3,6-7,17H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090593
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Cn1cncc1CCNC(=O)CN1CCN(CC1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 Show InChI InChI=1S/C20H22ClN5O4S2/c1-24-13-22-10-16(24)4-5-23-18(27)11-25-6-7-26(12-19(25)28)32(29,30)20-8-14-2-3-15(21)9-17(14)31-20/h2-3,8-10,13H,4-7,11-12H2,1H3,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090593
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Cn1cncc1CCNC(=O)CN1CCN(CC1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 Show InChI InChI=1S/C20H22ClN5O4S2/c1-24-13-22-10-16(24)4-5-23-18(27)11-25-6-7-26(12-19(25)28)32(29,30)20-8-14-2-3-15(21)9-17(14)31-20/h2-3,8-10,13H,4-7,11-12H2,1H3,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111963
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-bromo-1H-be...)Show SMILES Nc1ncnc2cc(CN3CCN(Cc4nc5ccc(Br)cc5[nH]4)CC3=O)ccc12 Show InChI InChI=1S/C21H20BrN7O/c22-14-2-4-16-18(8-14)27-19(26-16)10-28-5-6-29(20(30)11-28)9-13-1-3-15-17(7-13)24-12-25-21(15)23/h1-4,7-8,12H,5-6,9-11H2,(H,26,27)(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471867
(CHEMBL135621)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccc(OCc3ccccc3)cc2C1=O Show InChI InChI=1S/C34H31NO5/c1-38-30-14-11-25(19-31(30)40-26-9-5-6-10-26)34(21-23-15-17-35-18-16-23)32(36)28-13-12-27(20-29(28)33(34)37)39-22-24-7-3-2-4-8-24/h2-4,7-8,11-20,26H,5-6,9-10,21-22H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471867
(CHEMBL135621)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccc(OCc3ccccc3)cc2C1=O Show InChI InChI=1S/C34H31NO5/c1-38-30-14-11-25(19-31(30)40-26-9-5-6-10-26)34(21-23-15-17-35-18-16-23)32(36)28-13-12-27(20-29(28)33(34)37)39-22-24-7-3-2-4-8-24/h2-4,7-8,11-20,26H,5-6,9-10,21-22H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471871
(CHEMBL135304)Show SMILES CCOc1ccc2C(=O)C(Cc3ccncc3)(C(=O)c2c1)c1ccc(OC)c(OC2CCCC2)c1 Show InChI InChI=1S/C29H29NO5/c1-3-34-22-9-10-23-24(17-22)28(32)29(27(23)31,18-19-12-14-30-15-13-19)20-8-11-25(33-2)26(16-20)35-21-6-4-5-7-21/h8-17,21H,3-7,18H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471861
(CHEMBL423897)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2cc[n+]([O-])cc2)C(=O)c2ccccc2C1=O Show InChI InChI=1S/C27H25NO5/c1-32-23-11-10-19(16-24(23)33-20-6-2-3-7-20)27(17-18-12-14-28(31)15-13-18)25(29)21-8-4-5-9-22(21)26(27)30/h4-5,8-16,20H,2-3,6-7,17H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471872
(CHEMBL134261)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccc(OCC(O)=O)cc2C1=O Show InChI InChI=1S/C29H27NO7/c1-35-24-9-6-19(14-25(24)37-20-4-2-3-5-20)29(16-18-10-12-30-13-11-18)27(33)22-8-7-21(36-17-26(31)32)15-23(22)28(29)34/h6-15,20H,2-5,16-17H2,1H3,(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471873
(CHEMBL334488)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc2C1=O Show InChI InChI=1S/C38H43N3O6/c1-45-33-12-9-27(23-34(33)46-29-7-3-4-8-29)38(25-26-13-17-39-18-14-26)35(42)31-11-10-30(24-32(31)36(38)43)47-37(44)41-21-15-28(16-22-41)40-19-5-2-6-20-40/h9-14,17-18,23-24,28-29H,2-8,15-16,19-22,25H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471867
(CHEMBL135621)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccc(OCc3ccccc3)cc2C1=O Show InChI InChI=1S/C34H31NO5/c1-38-30-14-11-25(19-31(30)40-26-9-5-6-10-26)34(21-23-15-17-35-18-16-23)32(36)28-13-12-27(20-29(28)33(34)37)39-22-24-7-3-2-4-8-24/h2-4,7-8,11-20,26H,5-6,9-10,21-22H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090592
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)NCCc2cnc[nH]2)C(=O)C1 Show InChI InChI=1S/C19H20ClN5O4S2/c20-14-2-1-13-7-19(30-16(13)8-14)31(28,29)25-6-5-24(18(27)11-25)10-17(26)22-4-3-15-9-21-12-23-15/h1-2,7-9,12H,3-6,10-11H2,(H,21,23)(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111957
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(5-chloro-1H-i...)Show SMILES Nc1ncnc2cc(CN3CCN(Cc4cc5cc(Cl)ccc5[nH]4)CC3=O)ccc12 Show InChI InChI=1S/C22H21ClN6O/c23-16-2-4-19-15(8-16)9-17(27-19)11-28-5-6-29(21(30)12-28)10-14-1-3-18-20(7-14)25-13-26-22(18)24/h1-4,7-9,13,27H,5-6,10-12H2,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471863
(CHEMBL422972)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccc(OCc3ccncc3)cc2C1=O Show InChI InChI=1S/C33H30N2O5/c1-38-29-9-6-24(18-30(29)40-25-4-2-3-5-25)33(20-22-10-14-34-15-11-22)31(36)27-8-7-26(19-28(27)32(33)37)39-21-23-12-16-35-17-13-23/h6-19,25H,2-5,20-21H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111965
(4-[4-(6-Chloro-1H-benzoimidazol-2-ylmethyl)-2-oxo-...)Show SMILES NC(=N)c1ccc(CN2CCN(Cc3nc4ccc(Cl)cc4[nH]3)CC2=O)cc1 Show InChI InChI=1S/C20H21ClN6O/c21-15-5-6-16-17(9-15)25-18(24-16)11-26-7-8-27(19(28)12-26)10-13-1-3-14(4-2-13)20(22)23/h1-6,9H,7-8,10-12H2,(H3,22,23)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111955
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-1H-b...)Show SMILES Nc1ncnc2cc(CN3CCN(Cc4nc5ccc(Cl)cc5[nH]4)CC3=O)ccc12 Show InChI InChI=1S/C21H20ClN7O/c22-14-2-4-16-18(8-14)27-19(26-16)10-28-5-6-29(20(30)11-28)9-13-1-3-15-17(7-13)24-12-25-21(15)23/h1-4,7-8,12H,5-6,9-11H2,(H,26,27)(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Tested for inhibitory activity against Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471870
(CHEMBL337194)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccc(O)cc2C1=O Show InChI InChI=1S/C27H25NO5/c1-32-23-9-6-18(14-24(23)33-20-4-2-3-5-20)27(16-17-10-12-28-13-11-17)25(30)21-8-7-19(29)15-22(21)26(27)31/h6-15,20,29H,2-5,16H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090605
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)NCCc2ccncc2)C(=O)C1 Show InChI InChI=1S/C21H21ClN4O4S2/c22-17-2-1-16-11-21(31-18(16)12-17)32(29,30)26-10-9-25(20(28)14-26)13-19(27)24-8-5-15-3-6-23-7-4-15/h1-4,6-7,11-12H,5,8-10,13-14H2,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471874
(CHEMBL335169)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccc(OC3CCN(C)CC3)cc2C1=O Show InChI InChI=1S/C33H36N2O5/c1-35-17-13-25(14-18-35)39-26-8-9-27-28(20-26)32(37)33(31(27)36,21-22-11-15-34-16-12-22)23-7-10-29(38-2)30(19-23)40-24-5-3-4-6-24/h7-12,15-16,19-20,24-25H,3-6,13-14,17-18,21H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471875
(CHEMBL335970)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)Cc2cc(OCc3ccccc3)ccc2C1=O Show InChI InChI=1S/C34H33NO4/c1-37-31-14-11-27(20-32(31)39-28-9-5-6-10-28)34(21-24-15-17-35-18-16-24)22-26-19-29(12-13-30(26)33(34)36)38-23-25-7-3-2-4-8-25/h2-4,7-8,11-20,28H,5-6,9-10,21-23H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090600
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)Nc2ccncn2)C(=O)C1 Show InChI InChI=1S/C18H16ClN5O4S2/c19-13-2-1-12-7-18(29-14(12)8-13)30(27,28)24-6-5-23(17(26)10-24)9-16(25)22-15-3-4-20-11-21-15/h1-4,7-8,11H,5-6,9-10H2,(H,20,21,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111960
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-methyl-1H-b...)Show SMILES Cc1ccc2nc(CN3CCN(Cc4ccc5c(N)ncnc5c4)C(=O)C3)[nH]c2c1 Show InChI InChI=1S/C22H23N7O/c1-14-2-5-17-19(8-14)27-20(26-17)11-28-6-7-29(21(30)12-28)10-15-3-4-16-18(9-15)24-13-25-22(16)23/h2-5,8-9,13H,6-7,10-12H2,1H3,(H,26,27)(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090595
(CHEMBL47654 | N-[2-(2-Amino-pyridin-4-yl)-ethyl]-2...)Show SMILES Nc1cc(CCNC(=O)CN2CCN(CC2=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)ccn1 Show InChI InChI=1S/C21H22ClN5O4S2/c22-16-2-1-15-10-21(32-17(15)11-16)33(30,31)27-8-7-26(20(29)13-27)12-19(28)25-6-4-14-3-5-24-18(23)9-14/h1-3,5,9-11H,4,6-8,12-13H2,(H2,23,24)(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090597
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)NCCc2ccccn2)C(=O)C1 Show InChI InChI=1S/C21H21ClN4O4S2/c22-16-5-4-15-11-21(31-18(15)12-16)32(29,30)26-10-9-25(20(28)14-26)13-19(27)24-8-6-17-3-1-2-7-23-17/h1-5,7,11-12H,6,8-10,13-14H2,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090604
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)NCCc2cscn2)C(=O)C1 Show InChI InChI=1S/C19H19ClN4O4S3/c20-14-2-1-13-7-19(30-16(13)8-14)31(27,28)24-6-5-23(18(26)10-24)9-17(25)21-4-3-15-11-29-12-22-15/h1-2,7-8,11-12H,3-6,9-10H2,(H,21,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090596
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)Nc2ccncc2)C(=O)C1 Show InChI InChI=1S/C19H17ClN4O4S2/c20-14-2-1-13-9-19(29-16(13)10-14)30(27,28)24-8-7-23(18(26)12-24)11-17(25)22-15-3-5-21-6-4-15/h1-6,9-10H,7-8,11-12H2,(H,21,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090613
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)NCCc2cccnc2)C(=O)C1 Show InChI InChI=1S/C21H21ClN4O4S2/c22-17-4-3-16-10-21(31-18(16)11-17)32(29,30)26-9-8-25(20(28)14-26)13-19(27)24-7-5-15-2-1-6-23-12-15/h1-4,6,10-12H,5,7-9,13-14H2,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50471868
(CHEMBL335255)Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccc(O)cc2)C(=O)c2ccccc2C1=O Show InChI InChI=1S/C28H26O5/c1-32-24-15-12-19(16-25(24)33-21-6-2-3-7-21)28(17-18-10-13-20(29)14-11-18)26(30)22-8-4-5-9-23(22)27(28)31/h4-5,8-16,21,29H,2-3,6-7,17H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SW 8 Rh£ne-Poulenc Rorer Central Research
Curated by ChEMBL
| Assay Description
Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes. |
J Med Chem 41: 4216-23 (1998)
Article DOI: 10.1021/jm970575f
BindingDB Entry DOI: 10.7270/Q2K35XCX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090615
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Cc1ncsc1CCNC(=O)CN1CCN(CC1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 Show InChI InChI=1S/C20H21ClN4O4S3/c1-13-16(30-12-23-13)4-5-22-18(26)10-24-6-7-25(11-19(24)27)32(28,29)20-8-14-2-3-15(21)9-17(14)31-20/h2-3,8-9,12H,4-7,10-11H2,1H3,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111961
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-1-me...)Show SMILES Cn1c(CN2CCN(Cc3ccc4c(N)ncnc4c3)C(=O)C2)nc2ccc(Cl)cc12 Show InChI InChI=1S/C22H22ClN7O/c1-28-19-9-15(23)3-5-17(19)27-20(28)11-29-6-7-30(21(31)12-29)10-14-2-4-16-18(8-14)25-13-26-22(16)24/h2-5,8-9,13H,6-7,10-12H2,1H3,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090594
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Cc1nc[nH]c1CCNC(=O)CN1CCN(CC1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 Show InChI InChI=1S/C20H22ClN5O4S2/c1-13-16(24-12-23-13)4-5-22-18(27)10-25-6-7-26(11-19(25)28)32(29,30)20-8-14-2-3-15(21)9-17(14)31-20/h2-3,8-9,12H,4-7,10-11H2,1H3,(H,22,27)(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50111956
(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-1H-i...)Show SMILES Nc1ncnc2cc(CN3CCN(Cc4cc5ccc(Cl)cc5[nH]4)CC3=O)ccc12 Show InChI InChI=1S/C22H21ClN6O/c23-16-3-2-15-8-17(27-19(15)9-16)11-28-5-6-29(21(30)12-28)10-14-1-4-18-20(7-14)25-13-26-22(18)24/h1-4,7-9,13,27H,5-6,10-12H2,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Coagulation factor Xa |
Bioorg Med Chem Lett 12: 919-22 (2002)
BindingDB Entry DOI: 10.7270/Q28C9VJT |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090609
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Cn1cnc(CCNC(=O)CN2CCN(CC2=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)c1 Show InChI InChI=1S/C20H22ClN5O4S2/c1-24-10-16(23-13-24)4-5-22-18(27)11-25-6-7-26(12-19(25)28)32(29,30)20-8-14-2-3-15(21)9-17(14)31-20/h2-3,8-10,13H,4-7,11-12H2,1H3,(H,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090603
(CHEMBL295515 | N-[2-(2-Amino-thiazol-4-yl)-ethyl]-...)Show SMILES Nc1nc(CCNC(=O)CN2CCN(CC2=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)cs1 Show InChI InChI=1S/C19H20ClN5O4S3/c20-13-2-1-12-7-18(31-15(12)8-13)32(28,29)25-6-5-24(17(27)10-25)9-16(26)22-4-3-14-11-30-19(21)23-14/h1-2,7-8,11H,3-6,9-10H2,(H2,21,23)(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090611
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)NCCc2c[nH]c(=S)[nH]2)C(=O)C1 Show InChI InChI=1S/C19H20ClN5O4S3/c20-13-2-1-12-7-18(31-15(12)8-13)32(28,29)25-6-5-24(17(27)11-25)10-16(26)21-4-3-14-9-22-19(30)23-14/h1-2,7-9H,3-6,10-11H2,(H,21,26)(H2,22,23,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090598
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)NCc2cccnc2)C(=O)C1 Show InChI InChI=1S/C20H19ClN4O4S2/c21-16-4-3-15-8-20(30-17(15)9-16)31(28,29)25-7-6-24(19(27)13-25)12-18(26)23-11-14-2-1-5-22-10-14/h1-5,8-10H,6-7,11-13H2,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| >1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090599
((S)-2-{2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl...)Show SMILES COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CN1CCN(CC1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 Show InChI InChI=1S/C21H22ClN5O6S2/c1-33-21(30)16(8-15-9-23-12-24-15)25-18(28)10-26-4-5-27(11-19(26)29)35(31,32)20-6-13-2-3-14(22)7-17(13)34-20/h2-3,6-7,9,12,16H,4-5,8,10-11H2,1H3,(H,23,24)(H,25,28)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| >1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090606
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)NCCCn2ccnc2)C(=O)C1 Show InChI InChI=1S/C20H22ClN5O4S2/c21-16-3-2-15-10-20(31-17(15)11-16)32(29,30)26-9-8-25(19(28)13-26)12-18(27)23-4-1-6-24-7-5-22-14-24/h2-3,5,7,10-11,14H,1,4,6,8-9,12-13H2,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| >1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090601
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)Nc2ccccc2)C(=O)C1 Show InChI InChI=1S/C20H18ClN3O4S2/c21-15-7-6-14-10-20(29-17(14)11-15)30(27,28)24-9-8-23(19(26)13-24)12-18(25)22-16-4-2-1-3-5-16/h1-7,10-11H,8-9,12-13H2,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| >1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090602
((R)-2-{2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl...)Show SMILES COC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)CN1CCN(CC1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 Show InChI InChI=1S/C21H22ClN5O6S2/c1-33-21(30)16(8-15-9-23-12-24-15)25-18(28)10-26-4-5-27(11-19(26)29)35(31,32)20-6-13-2-3-14(22)7-17(13)34-20/h2-3,6-7,9,12,16H,4-5,8,10-11H2,1H3,(H,23,24)(H,25,28)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| >1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090607
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES CN(C(=O)CN1CCN(CC1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1)c1ccncc1 Show InChI InChI=1S/C20H19ClN4O4S2/c1-23(16-4-6-22-7-5-16)18(26)12-24-8-9-25(13-19(24)27)31(28,29)20-10-14-2-3-15(21)11-17(14)30-20/h2-7,10-11H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| >1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090610
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N1CCN(CC(=O)Nc2cccnc2)C(=O)C1 Show InChI InChI=1S/C19H17ClN4O4S2/c20-14-4-3-13-8-19(29-16(13)9-14)30(27,28)24-7-6-23(18(26)12-24)11-17(25)22-15-2-1-5-21-10-15/h1-5,8-10H,6-7,11-12H2,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| >1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50090608
(2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo...)Show SMILES Cn1cccc1CCNC(=O)CN1CCN(CC1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 Show InChI InChI=1S/C21H23ClN4O4S2/c1-24-8-2-3-17(24)6-7-23-19(27)13-25-9-10-26(14-20(25)28)32(29,30)21-11-15-4-5-16(22)12-18(15)31-21/h2-5,8,11-12H,6-7,9-10,13-14H2,1H3,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| >1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 10: 1737-9 (2000)
BindingDB Entry DOI: 10.7270/Q23777Z2 |
More data for this
Ligand-Target Pair | |
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