Found 306 hits with Last Name = 'mitchell' and Initial = 'c' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Coagulation factor X
(Homo sapiens (Human)) | BDBM12557
(6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-...)Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C22H26ClN3O4S/c1-15(21(27)25-10-3-2-4-11-25)26-12-9-20(22(26)28)24-31(29,30)19-8-6-16-13-18(23)7-5-17(16)14-19/h5-8,13-15,20,24H,2-4,9-12H2,1H3/t15-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12569
(GTC000006A | N-(6-chloronaphthalen-2-yl)-N'-[(3S)-...)Show SMILES CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 |r| Show InChI InChI=1S/C25H30ClN3O6S/c1-3-21(30)16-29(36(33,34)22-7-5-18-14-20(26)6-4-19(18)15-22)23-8-9-28(25(23)32)17(2)24(31)27-10-12-35-13-11-27/h4-7,14-15,17,23H,3,8-13,16H2,1-2H3/t17-,23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12558
(6-chloro-N-methyl-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(p...)Show SMILES C[C@H](N1CC[C@H](N(C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C23H28ClN3O4S/c1-16(22(28)26-11-4-3-5-12-26)27-13-10-21(23(27)29)25(2)32(30,31)20-9-7-17-14-19(24)8-6-18(17)15-20/h6-9,14-16,21H,3-5,10-13H2,1-2H3/t16-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | -49.7 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12567
(2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpho...)Show SMILES C[C@H](N1CC[C@H](N(CC(O)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H26ClN3O7S/c1-15(22(30)25-8-10-34-11-9-25)26-7-6-20(23(26)31)27(14-21(28)29)35(32,33)19-5-3-16-12-18(24)4-2-17(16)13-19/h2-5,12-13,15,20H,6-11,14H2,1H3,(H,28,29)/t15-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | -49.7 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198573
((S)-1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydro...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccc(F)cc2)CC1=O Show InChI InChI=1S/C27H36FN3O/c1-3-29(4-2)19-22-5-8-24-18-26(12-9-23(24)17-22)31-16-15-30(20-27(31)32)14-13-21-6-10-25(28)11-7-21/h5-8,10-11,17,26H,3-4,9,12-16,18-20H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12568
(2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpho...)Show SMILES C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H27ClN4O6S/c1-15(22(30)26-8-10-34-11-9-26)27-7-6-20(23(27)31)28(14-21(25)29)35(32,33)19-5-3-16-12-18(24)4-2-17(16)13-19/h2-5,12-13,15,20H,6-11,14H2,1H3,(H2,25,29)/t15-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3 | -48.6 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12561
(N-[(3S)-1-[(2S)-1-{2-azabicyclo[2.2.2]octan-2-yl}-...)Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CC2CCC1CC2 |r,wD:1.0,5.5,(24.17,-11.35,;25.5,-12.12,;26.84,-11.35,;26.95,-9.81,;28.44,-9.44,;29.26,-10.75,;30.79,-10.86,;31.46,-12.25,;30.13,-13.02,;31.86,-13.74,;33,-12.25,;33.71,-10.88,;35.25,-10.81,;36.08,-12.11,;37.62,-12.04,;38.45,-13.34,;39.99,-13.27,;37.74,-14.71,;36.2,-14.78,;35.37,-13.48,;33.83,-13.55,;28.26,-11.93,;28.63,-13.42,;25.5,-13.66,;26.84,-14.43,;24.17,-14.43,;22.84,-13.66,;21.5,-14.43,;21.5,-15.97,;22.84,-16.74,;24.17,-15.97,;22.43,-15.88,;22.37,-15.08,)| Show InChI InChI=1S/C24H28ClN3O4S/c1-15(23(29)28-14-16-2-7-20(28)8-3-16)27-11-10-22(24(27)30)26-33(31,32)21-9-5-17-12-19(25)6-4-18(17)13-21/h4-6,9,12-13,15-16,20,22,26H,2-3,7-8,10-11,14H2,1H3/t15-,16?,20?,22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3 | -48.6 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198574
((S)-4-(4-chlorophenethyl)-1-(6-((diethylamino)-met...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccc(Cl)cc2)CC1=O Show InChI InChI=1S/C27H36ClN3O/c1-3-29(4-2)19-22-5-8-24-18-26(12-9-23(24)17-22)31-16-15-30(20-27(31)32)14-13-21-6-10-25(28)11-7-21/h5-8,10-11,17,26H,3-4,9,12-16,18-20H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 819-22 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.052
BindingDB Entry DOI: 10.7270/Q2736QKD |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198574
((S)-4-(4-chlorophenethyl)-1-(6-((diethylamino)-met...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccc(Cl)cc2)CC1=O Show InChI InChI=1S/C27H36ClN3O/c1-3-29(4-2)19-22-5-8-24-18-26(12-9-23(24)17-22)31-16-15-30(20-27(31)32)14-13-21-6-10-25(28)11-7-21/h5-8,10-11,17,26H,3-4,9,12-16,18-20H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50203064
((S)-4-(4-bromophenethyl)-1-(6-((diethylamino)-meth...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccc(Br)cc2)CC1=O Show InChI InChI=1S/C27H36BrN3O/c1-3-29(4-2)19-22-5-8-24-18-26(12-9-23(24)17-22)31-16-15-30(20-27(31)32)14-13-21-6-10-25(28)11-7-21/h5-8,10-11,17,26H,3-4,9,12-16,18-20H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12538
(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C21H24ClN3O5S/c1-14(20(26)24-8-10-30-11-9-24)25-7-6-19(21(25)27)23-31(28,29)18-5-3-15-12-17(22)4-2-16(15)13-18/h2-5,12-14,19,23H,6-11H2,1H3/t14-,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| 6 | -46.9 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50203054
(4'-fluoro-biphenyl-4-carboxylic acid [2-(4-dimethy...)Show SMILES CN(C)Cc1ccc(CCN(C)C(=O)c2ccc(cc2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C25H27FN2O/c1-27(2)18-20-6-4-19(5-7-20)16-17-28(3)25(29)23-10-8-21(9-11-23)22-12-14-24(26)15-13-22/h4-15H,16-18H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192169
((R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrr...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C24H26N2O3/c1-28-22-12-20(13-23(14-22)29-2)24(27)25-21-9-10-26(16-21)15-17-7-8-18-5-3-4-6-19(18)11-17/h3-8,11-14,21H,9-10,15-16H2,1-2H3,(H,25,27)/t21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50241095
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H29FN2O/c1-29(2)18-19-4-5-24-17-26(15-12-23(24)16-19)30(3)27(31)22-8-6-20(7-9-22)21-10-13-25(28)14-11-21/h4-11,13-14,16,26H,12,15,17-18H2,1-3H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 814-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192189
(3,4,5-trifluoro-N-(1-(naphthalen-2-ylmethyl)piperi...)Show SMILES Fc1cc(cc(F)c1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H21F3N2O/c24-20-12-18(13-21(25)22(20)26)23(29)27-19-7-9-28(10-8-19)14-15-5-6-16-3-1-2-4-17(16)11-15/h1-6,11-13,19H,7-10,14H2,(H,27,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12566
(6-chloro-N-methyl-N-[(3S)-1-[(2S)-1-(morpholin-4-y...)Show SMILES C[C@H](N1CC[C@H](N(C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C22H26ClN3O5S/c1-15(21(27)25-9-11-31-12-10-25)26-8-7-20(22(26)28)24(2)32(29,30)19-6-4-16-13-18(23)5-3-17(16)14-19/h3-6,13-15,20H,7-12H2,1-2H3/t15-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 10 | -45.7 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50203063
((S)-4-(3-fluorophenethyl)-1-(6-((diethylamino)-met...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2cccc(F)c2)CC1=O Show InChI InChI=1S/C27H36FN3O/c1-3-29(4-2)19-22-8-9-24-18-26(11-10-23(24)16-22)31-15-14-30(20-27(31)32)13-12-21-6-5-7-25(28)17-21/h5-9,16-17,26H,3-4,10-15,18-20H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
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UniChem
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| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50200748
(1-(4-(piperidin-1-ylmethyl)phenethyl)-4-phenethylp...)Show SMILES O=C1CN(CCc2ccccc2)CCN1CCc1ccc(CN2CCCCC2)cc1 Show InChI InChI=1S/C26H35N3O/c30-26-22-28(17-13-23-7-3-1-4-8-23)19-20-29(26)18-14-24-9-11-25(12-10-24)21-27-15-5-2-6-16-27/h1,3-4,7-12H,2,5-6,13-22H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 657-61 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.096
BindingDB Entry DOI: 10.7270/Q2QR4WS9 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198501
((S)-5-(4-chlorophenyl)-N-(6-((dimethylamino)methyl...)Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)25-13-9-22(16-28-25)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 814-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50200748
(1-(4-(piperidin-1-ylmethyl)phenethyl)-4-phenethylp...)Show SMILES O=C1CN(CCc2ccccc2)CCN1CCc1ccc(CN2CCCCC2)cc1 Show InChI InChI=1S/C26H35N3O/c30-26-22-28(17-13-23-7-3-1-4-8-23)19-20-29(26)18-14-24-9-11-25(12-10-24)21-27-15-5-2-6-16-27/h1,3-4,7-12H,2,5-6,13-22H2 | PDB
Reactome pathway
KEGG
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| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198502
((S)-6-(4-chlorophenyl)-N-(6-((dimethylamino)methyl...)Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(nc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)22-9-13-25(28-16-22)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 814-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50203055
((S)-4-(2-fluorophenethyl)-1-(6-((diethylamino)-met...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccccc2F)CC1=O Show InChI InChI=1S/C27H36FN3O/c1-3-29(4-2)19-21-9-10-24-18-25(12-11-23(24)17-21)31-16-15-30(20-27(31)32)14-13-22-7-5-6-8-26(22)28/h5-10,17,25H,3-4,11-16,18-20H2,1-2H3/t25-/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168507
((E)-N-(1-cinnamylpiperidin-4-yl)-3,5-dimethoxybenz...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(C\C=C\c2ccccc2)CC1 Show InChI InChI=1S/C23H28N2O3/c1-27-21-15-19(16-22(17-21)28-2)23(26)24-20-10-13-25(14-11-20)12-6-9-18-7-4-3-5-8-18/h3-9,15-17,20H,10-14H2,1-2H3,(H,24,26)/b9-6+ | PDB
Reactome pathway
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Similars
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PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192178
(3,5-dimethoxy-N-((3R)-1-(1-(naphthalen-2-yl)ethyl)...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C1)C(C)c1ccc2ccccc2c1 Show InChI InChI=1S/C25H28N2O3/c1-17(19-9-8-18-6-4-5-7-20(18)12-19)27-11-10-22(16-27)26-25(28)21-13-23(29-2)15-24(14-21)30-3/h4-9,12-15,17,22H,10-11,16H2,1-3H3,(H,26,28)/t17?,22-/m1/s1 | PDB
Reactome pathway
KEGG
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PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192174
(4-fluoro-3-methoxy-N-(1-(naphthalen-2-ylmethyl)pip...)Show SMILES COc1cc(ccc1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C24H25FN2O2/c1-29-23-15-20(8-9-22(23)25)24(28)26-21-10-12-27(13-11-21)16-17-6-7-18-4-2-3-5-19(18)14-17/h2-9,14-15,21H,10-13,16H2,1H3,(H,26,28) | PDB
Reactome pathway
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PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12562
(6-chloro-N-[(3S)-1-[(2S)-1-[(1R,5S)-3,7-diazabicyc...)Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1C[C@H]2CNC[C@H](C2)C1 |r| Show InChI InChI=1S/C24H29ClN4O4S/c1-15(23(30)28-13-16-8-17(14-28)12-26-11-16)29-7-6-22(24(29)31)27-34(32,33)21-5-3-18-9-20(25)4-2-19(18)10-21/h2-5,9-10,15-17,22,26-27H,6-8,11-14H2,1H3/t15-,16-,17+,22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 13 | -45.0 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50200742
(7-(4-fluorophenethyl)-2-(4-(piperidin-1-ylmethyl)p...)Show SMILES Fc1ccc(CCc2cc3C(=O)N(CCc4ccc(CN5CCCCC5)cc4)CCn3c2)cc1 Show InChI InChI=1S/C29H34FN3O/c30-27-12-10-23(11-13-27)6-9-26-20-28-29(34)32(18-19-33(28)22-26)17-14-24-4-7-25(8-5-24)21-31-15-2-1-3-16-31/h4-5,7-8,10-13,20,22H,1-3,6,9,14-19,21H2 | PDB
Reactome pathway
KEGG
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PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 657-61 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.096
BindingDB Entry DOI: 10.7270/Q2QR4WS9 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198573
((S)-1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydro...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccc(F)cc2)CC1=O Show InChI InChI=1S/C27H36FN3O/c1-3-29(4-2)19-22-5-8-24-18-26(12-9-23(24)17-22)31-16-15-30(20-27(31)32)14-13-21-6-10-25(28)11-7-21/h5-8,10-11,17,26H,3-4,9,12-16,18-20H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
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UniChem
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of binding to MCH-R1 |
Bioorg Med Chem Lett 17: 819-22 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.052
BindingDB Entry DOI: 10.7270/Q2736QKD |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50203059
((S)-1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydro...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccccc2)CC1=O Show InChI InChI=1S/C27H37N3O/c1-3-28(4-2)20-23-10-11-25-19-26(13-12-24(25)18-23)30-17-16-29(21-27(30)31)15-14-22-8-6-5-7-9-22/h5-11,18,26H,3-4,12-17,19-21H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
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Similars
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PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12574
(6-chloro-N-[(3R)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-...)Show SMILES C[C@H](N1CC[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C22H26ClN3O4S/c1-15(21(27)25-10-3-2-4-11-25)26-12-9-20(22(26)28)24-31(29,30)19-8-6-16-13-18(23)7-5-17(16)14-19/h5-8,13-15,20,24H,2-4,9-12H2,1H3/t15-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
Similars
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PubMed
| 16 | -44.5 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192163
((R,E)-N-(1-cinnamylpyrrolidin-3-yl)-3,5-dimethoxyb...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C\C=C\c2ccccc2)C1 Show InChI InChI=1S/C22H26N2O3/c1-26-20-13-18(14-21(15-20)27-2)22(25)23-19-10-12-24(16-19)11-6-9-17-7-4-3-5-8-17/h3-9,13-15,19H,10-12,16H2,1-2H3,(H,23,25)/b9-6+/t19-/m1/s1 | PDB
Reactome pathway
KEGG
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Similars
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PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192161
(3,4-difluoro-N-(1-(naphthalen-2-ylmethyl)piperidin...)Show SMILES Fc1ccc(cc1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H22F2N2O/c24-21-8-7-19(14-22(21)25)23(28)26-20-9-11-27(12-10-20)15-16-5-6-17-3-1-2-4-18(17)13-16/h1-8,13-14,20H,9-12,15H2,(H,26,28) | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
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PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198499
((S)-4-(5-chloropyridin-2-yl)-N-(6-((dimethylamino)...)Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(Cl)cn1 Show InChI InChI=1S/C26H28ClN3O/c1-29(2)17-18-4-5-22-15-24(12-10-21(22)14-18)30(3)26(31)20-8-6-19(7-9-20)25-13-11-23(27)16-28-25/h4-9,11,13-14,16,24H,10,12,15,17H2,1-3H3/t24-/m0/s1 | PDB
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 814-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50203061
((S)-4-(3-chlorophenethyl)-1-(6-((diethylamino)-met...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2cccc(Cl)c2)CC1=O Show InChI InChI=1S/C27H36ClN3O/c1-3-29(4-2)19-22-8-9-24-18-26(11-10-23(24)16-22)31-15-14-30(20-27(31)32)13-12-21-6-5-7-25(28)17-21/h5-9,16-17,26H,3-4,10-15,18-20H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50203057
(4'-fluoro-biphenyl-4-carboxylic acid [2-(4-dimethy...)Show SMILES CN(C)Cc1ccc(CCNC(=O)c2ccc(cc2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C24H25FN2O/c1-27(2)17-19-5-3-18(4-6-19)15-16-26-24(28)22-9-7-20(8-10-22)21-11-13-23(25)14-12-21/h3-14H,15-17H2,1-2H3,(H,26,28) | PDB
Reactome pathway
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198495
((S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydr...)Show SMILES CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H28FN3O/c1-29(2)17-18-4-5-21-15-24(12-8-20(21)14-18)30(3)26(31)25-13-9-22(16-28-25)19-6-10-23(27)11-7-19/h4-7,9-11,13-14,16,24H,8,12,15,17H2,1-3H3/t24-/m0/s1 | PDB
Reactome pathway
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 814-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50200744
(CHEMBL408198 | N-(3-fluorophenyl)-4-oxo-5-(4-(pipe...)Show SMILES Fc1cccc(NC(=O)c2cc3C(=O)N(CCc4ccc(CN5CCCCC5)cc4)CCn3n2)c1 Show InChI InChI=1S/C27H30FN5O2/c28-22-5-4-6-23(17-22)29-26(34)24-18-25-27(35)32(15-16-33(25)30-24)14-11-20-7-9-21(10-8-20)19-31-12-2-1-3-13-31/h4-10,17-18H,1-3,11-16,19H2,(H,29,34) | PDB
Reactome pathway
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| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 657-61 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.096
BindingDB Entry DOI: 10.7270/Q2QR4WS9 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192162
(3,5-dimethoxy-N-((3R)-1-((E)-4-phenylbut-3-en-2-yl...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C1)C(C)\C=C\c1ccccc1 Show InChI InChI=1S/C23H28N2O3/c1-17(9-10-18-7-5-4-6-8-18)25-12-11-20(16-25)24-23(26)19-13-21(27-2)15-22(14-19)28-3/h4-10,13-15,17,20H,11-12,16H2,1-3H3,(H,24,26)/b10-9+/t17?,20-/m1/s1 | PDB
Reactome pathway
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50200745
(7-(4-fluorophenyl)-2-(4-(piperidin-1-ylmethyl)phen...)Show SMILES Fc1ccc(cc1)-c1cc2C(=O)N(CCc3ccc(CN4CCCCC4)cc3)CCn2c1 Show InChI InChI=1S/C27H30FN3O/c28-25-10-8-23(9-11-25)24-18-26-27(32)30(16-17-31(26)20-24)15-12-21-4-6-22(7-5-21)19-29-13-2-1-3-14-29/h4-11,18,20H,1-3,12-17,19H2 | PDB
Reactome pathway
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 657-61 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.096
BindingDB Entry DOI: 10.7270/Q2QR4WS9 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198500
((S)-N-(6-(((2-(dimethylamino)-2-oxoethyl)(methyl)a...)Show SMILES CN(CC(=O)N(C)C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C30H34FN3O2/c1-32(2)29(35)20-33(3)19-21-5-6-26-18-28(16-13-25(26)17-21)34(4)30(36)24-9-7-22(8-10-24)23-11-14-27(31)15-12-23/h5-12,14-15,17,28H,13,16,18-20H2,1-4H3/t28-/m0/s1 | PDB
Reactome pathway
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| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 814-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.053
BindingDB Entry DOI: 10.7270/Q2R2111C |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192160
(3,5-dimethoxy-N-(1-(1-(naphthalen-2-yl)ethyl)piper...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(CC1)C(C)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H30N2O3/c1-18(20-9-8-19-6-4-5-7-21(19)14-20)28-12-10-23(11-13-28)27-26(29)22-15-24(30-2)17-25(16-22)31-3/h4-9,14-18,23H,10-13H2,1-3H3,(H,27,29) | PDB
Reactome pathway
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50203056
(CHEMBL388181 | N-(4'-fluoro-biphenyl-4-yl)-3-(4-pi...)Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)CCc2ccc(CN3CCCCC3)cc2)cc1 Show InChI InChI=1S/C27H29FN2O/c28-25-13-9-23(10-14-25)24-11-15-26(16-12-24)29-27(31)17-8-21-4-6-22(7-5-21)20-30-18-2-1-3-19-30/h4-7,9-16H,1-3,8,17-20H2,(H,29,31) | PDB
Reactome pathway
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity at MCHR1 by flash plate radioligand binding assay |
Bioorg Med Chem 15: 2092-105 (2007)
Article DOI: 10.1016/j.bmc.2006.12.028
BindingDB Entry DOI: 10.7270/Q23R0SK8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192177
(3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidi...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C25H28N2O3/c1-29-23-14-21(15-24(16-23)30-2)25(28)26-22-9-11-27(12-10-22)17-18-7-8-19-5-3-4-6-20(19)13-18/h3-8,13-16,22H,9-12,17H2,1-2H3,(H,26,28) | PDB
Reactome pathway
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192165
(3-methoxy-N-(1-(naphthalen-2-ylmethyl)piperidin-4-...)Show SMILES COc1cccc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C24H26N2O2/c1-28-23-8-4-7-21(16-23)24(27)25-22-11-13-26(14-12-22)17-18-9-10-19-5-2-3-6-20(19)15-18/h2-10,15-16,22H,11-14,17H2,1H3,(H,25,27) | PDB
Reactome pathway
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191756
(4'-fluoro-biphenyl-4-carboxylic acid methyl-(3-pip...)Show SMILES CN(Cc1cccc2cc(CN3CCCCC3)cnc12)C(=O)c1ccc(cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C30H30FN3O/c1-33(30(35)25-10-8-23(9-11-25)24-12-14-28(31)15-13-24)21-27-7-5-6-26-18-22(19-32-29(26)27)20-34-16-3-2-4-17-34/h5-15,18-19H,2-4,16-17,20-21H2,1H3 | PDB
Reactome pathway
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| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192182
(CHEMBL214778 | N-(1-((6-fluoronaphthalen-2-yl)meth...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 Show InChI InChI=1S/C25H27FN2O3/c1-30-23-13-20(14-24(15-23)31-2)25(29)27-22-7-9-28(10-8-22)16-17-3-4-19-12-21(26)6-5-18(19)11-17/h3-6,11-15,22H,7-10,16H2,1-2H3,(H,27,29) | PDB
Reactome pathway
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198582
((S)-4-(2-cyclohexylethyl)-1-(6-((diethylamino)meth...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCC2CCCCC2)CC1=O Show InChI InChI=1S/C27H43N3O/c1-3-28(4-2)20-23-10-11-25-19-26(13-12-24(25)18-23)30-17-16-29(21-27(30)31)15-14-22-8-6-5-7-9-22/h10-11,18,22,26H,3-9,12-17,19-21H2,1-2H3/t26-/m0/s1 | PDB
Reactome pathway
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 819-22 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.052
BindingDB Entry DOI: 10.7270/Q2736QKD |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192157
(4-fluoro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show InChI InChI=1S/C23H23FN2O/c24-21-9-7-19(8-10-21)23(27)25-22-11-13-26(14-12-22)16-17-5-6-18-3-1-2-4-20(18)15-17/h1-10,15,22H,11-14,16H2,(H,25,27) | PDB
Reactome pathway
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| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM12573
(6-chloro-N-[(3R)-2-oxo-1-[(2R)-1-oxo-1-(piperidin-...)Show SMILES C[C@@H](N1CC[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C22H26ClN3O4S/c1-15(21(27)25-10-3-2-4-11-25)26-12-9-20(22(26)28)24-31(29,30)19-8-6-16-13-18(23)7-5-17(16)14-19/h5-8,13-15,20,24H,2-4,9-12H2,1H3/t15-,20-/m1/s1 | PDB
MMDB
Reactome pathway
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| 40 | -42.2 | n/a | n/a | n/a | n/a | n/a | 7.8 | 25 |
GlaxoSmithKline
| Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate... |
Bioorg Med Chem Lett 16: 3784-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.053
BindingDB Entry DOI: 10.7270/Q2416V9V |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192173
((1R,5S,6r)-N-(3,4-difluorobenzyl)-3-(naphthalen-2-...)Show SMILES Fc1ccc(CNC(=O)[C@@H]2[C@H]3CN(Cc4ccc5ccccc5c4)C[C@@H]23)cc1F Show InChI InChI=1S/C24H22F2N2O/c25-21-8-6-15(10-22(21)26)11-27-24(29)23-19-13-28(14-20(19)23)12-16-5-7-17-3-1-2-4-18(17)9-16/h1-10,19-20,23H,11-14H2,(H,27,29)/t19-,20+,23+ | PDB
Reactome pathway
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| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
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