Compile Data Set for Download or QSAR

Found 441 hits with Last Name = 'leonard' and Initial = 'n'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50343442 (CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methyl...) Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O Show InChI InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of CYP2C9				Bioorg Med Chem Lett 21: 3134-41 (2011) Article DOI: 10.1016/j.bmcl.2011.03.007 BindingDB Entry DOI: 10.7270/Q24T6JQF
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127310 (5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccc2ccccc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-27(34)29(22-8-6-20(15-30)7-9-22)35-18-25-12-13-26(16-31)33-28(25)24-11-10-21-4-2-3-5-23(21)14-24/h2-14,17,19,29H,18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP transfer to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127313 (5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-23(34)25(18-7-5-17(12-30)6-8-18)35-15-20-9-10-21(13-31)33-24(20)19-3-2-4-22(11-19)36-26(27,28)29/h2-11,14,16,25H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127321 (5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccc2OC(F)(F)Oc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H17F2N5O3/c1-33-15-31-13-21(33)25(17-4-2-16(11-29)3-5-17)34-14-19-6-8-20(12-30)32-24(19)18-7-9-22-23(10-18)36-26(27,28)35-22/h2-10,13,15,25H,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13390 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES COCc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O2/c1-32-19-31-16-27(32)28(23-9-6-20(14-29)7-10-23)34-18-25-11-8-21(15-30)13-26(25)24-5-3-4-22(12-24)17-33-2/h3-13,16,19,28H,17-18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM13389 (4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...) Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(35-19-22-11-9-21(16-31)10-12-22)24-13-14-25(17-32)28(15-24)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127318 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Cn1cncc1C(OCc1nc(N2CCOCC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C29H25ClN6O2/c1-35-19-33-17-27(35)28(21-7-5-20(15-31)6-8-21)38-18-26-25(22-3-2-4-24(30)13-22)14-23(16-32)29(34-26)36-9-11-37-12-10-36/h2-8,13-14,17,19,28H,9-12,18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13389 (4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...) Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(35-19-22-11-9-21(16-31)10-12-22)24-13-14-25(17-32)28(15-24)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13384 (4-{[(R)-(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)...) Show SMILES COc1cccc(c1)-c1cc(ccc1CO[C@@H](c1cncn1C)c1ccc(cc1)C#N)C#N |r| Show InChI InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(21-9-6-19(14-28)7-10-21)33-17-23-11-8-20(15-29)12-25(23)22-4-3-5-24(13-22)32-2/h3-13,16,18,27H,17H2,1-2H3/t27-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127306 (5-[(5-Cyano-3'-trifluoromethoxy-biphenyl-2-ylmetho...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(nc1)C#N Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-24(34)25(19-7-8-21(12-31)33-13-19)35-15-20-6-5-17(11-30)9-23(20)18-3-2-4-22(10-18)36-26(27,28)29/h2-10,13-14,16,25H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127315 (6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H...) Show SMILES Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-28(34)29(35-18-24-12-9-20(14-30)16-33-24)22-10-11-23(15-31)27(13-22)26-8-4-6-21-5-2-3-7-25(21)26/h2-13,16-17,19,29H,18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13405 (3-(3-chlorophenyl)-4-{[(4-cyano-3-fluorophenyl)(1-...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(C#N)c(F)c1 Show InChI InChI=1S/C26H18ClFN4O/c1-32-16-31-14-25(32)26(19-7-8-20(13-30)24(28)11-19)33-15-21-6-5-17(12-29)9-23(21)18-3-2-4-22(27)10-18/h2-11,14,16,26H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127324 (5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-23(32)25(17-4-2-16(11-28)3-5-17)33-14-18-6-7-22(12-29)31-24(18)19-8-20(26)10-21(27)9-19/h2-10,13,15,25H,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127311 (5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccc(OC(F)(F)F)cc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-23(34)25(19-4-2-17(12-30)3-5-19)35-15-20-6-9-21(13-31)33-24(20)18-7-10-22(11-8-18)36-26(27,28)29/h2-11,14,16,25H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127320 (5'-(3-Chloro-phenyl)-6'-[(4-cyano-phenyl)-(3-methy...) Show SMILES Cn1cncc1C(OCc1nc(N2CCC(O)CC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C30H27ClN6O2/c1-36-19-34-17-28(36)29(21-7-5-20(15-32)6-8-21)39-18-27-26(22-3-2-4-24(31)13-22)14-23(16-33)30(35-27)37-11-9-25(38)10-12-37/h2-8,13-14,17,19,25,29,38H,9-12,18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127304 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES CN1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc1C#N)-c1cccc(Cl)c1 Show InChI InChI=1S/C30H28ClN7O/c1-36-10-12-38(13-11-36)30-24(17-33)15-26(23-4-3-5-25(31)14-23)27(35-30)19-39-29(28-18-34-20-37(28)2)22-8-6-21(16-32)7-9-22/h3-9,14-15,18,20,29H,10-13,19H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13415 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1NCc1cc(F)cc(F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H21F2N5O/c1-34-17-32-15-26(34)27(21-5-2-18(12-30)3-6-21)35-16-22-7-4-19(13-31)10-25(22)33-14-20-8-23(28)11-24(29)9-20/h2-11,15,17,27,33H,14,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.610	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM13383 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(21-9-6-19(14-28)7-10-21)33-17-23-11-8-20(15-29)12-25(23)22-4-3-5-24(13-22)32-2/h3-13,16,18,27H,17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127300 (5-[(3',5'-Dichloro-5-cyano-biphenyl-2-ylmethoxy)-(...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(nc1)C#N Show InChI InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-24(32)25(17-4-5-22(11-29)31-12-17)33-14-18-3-2-16(10-28)6-23(18)19-7-20(26)9-21(27)8-19/h2-9,12-13,15,25H,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13388 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O2/c1-3-33-25-6-4-5-23(14-25)26-13-21(16-30)9-12-24(26)18-34-28(27-17-31-19-32(27)2)22-10-7-20(15-29)8-11-22/h4-14,17,19,28H,3,18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127322 (5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1cc(F)cc(F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H17F2N5O/c1-32-15-30-13-23(32)25(17-4-2-16(11-28)3-5-17)33-14-18-6-7-22(12-29)31-24(18)19-8-20(26)10-21(27)9-19/h2-10,13,15,25H,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127301 (5'-(3-Chloro-phenyl)-3'-cyano-6'-[(4-cyano-phenyl)...) Show SMILES Cn1cncc1C(OCc1nc(N2CCC(CC2)C(N)=O)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C31H28ClN7O2/c1-38-19-36-17-28(38)29(21-7-5-20(15-33)6-8-21)41-18-27-26(23-3-2-4-25(32)13-23)14-24(16-34)31(37-27)39-11-9-22(10-12-39)30(35)40/h2-8,13-14,17,19,22,29H,9-12,18H2,1H3,(H2,35,40)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13383 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(21-9-6-19(14-28)7-10-21)33-17-23-11-8-20(15-29)12-25(23)22-4-3-5-24(13-22)32-2/h3-13,16,18,27H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127323 (5-[(3'-Chloro-5-cyano-biphenyl-2-ylmethoxy)-(3-met...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(nc1)C#N Show InChI InChI=1S/C25H18ClN5O/c1-31-16-29-14-24(31)25(19-7-8-22(12-28)30-13-19)32-15-20-6-5-17(11-27)9-23(20)18-3-2-4-21(26)10-18/h2-10,13-14,16,25H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13418 (A313326 Analogue 65 | N-(3-chlorophenyl)-5-cyano-2...) Show SMILES Cn1cncc1C(OCc1ccc(cc1C(=O)Nc1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H20ClN5O2/c1-33-17-31-15-25(33)26(20-8-5-18(13-29)6-9-20)35-16-21-10-7-19(14-30)11-24(21)27(34)32-23-4-2-3-22(28)12-23/h2-12,15,17,26H,16H2,1H3,(H,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13406 (3-(3-chlorophenyl)-4-{[(4-cyano-2-fluorophenyl)(1-...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1F)C#N Show InChI InChI=1S/C26H18ClFN4O/c1-32-16-31-14-25(32)26(22-8-6-18(13-30)10-24(22)28)33-15-20-7-5-17(12-29)9-23(20)19-3-2-4-21(27)11-19/h2-11,14,16,26H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13375 (4-({[4-chloro-2-(3-chlorophenyl)phenyl]methoxy}(1-...) Show SMILES Cn1cncc1C(OCc1ccc(Cl)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C25H19Cl2N3O/c1-30-16-29-14-24(30)25(18-7-5-17(13-28)6-8-18)31-15-20-9-10-22(27)12-23(20)19-3-2-4-21(26)11-19/h2-12,14,16,25H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127312 (6-(3-Chloro-phenyl)-5-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H18ClN5O/c1-31-16-29-14-23(31)25(18-7-5-17(12-27)6-8-18)32-15-20-9-10-22(13-28)30-24(20)19-3-2-4-21(26)11-19/h2-11,14,16,25H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13393 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc(OC(F)(F)F)cc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19F3N4O2/c1-34-17-33-15-25(34)26(21-5-2-18(13-31)3-6-21)35-16-22-7-4-19(14-32)12-24(22)20-8-10-23(11-9-20)36-27(28,29)30/h2-12,15,17,26H,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127319 (5-[(2-Benzo[1,3]dioxol-5-yl-4-cyano-benzyloxy)-(3-...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc2OCOc2c1)C#N)c1ccc(nc1)C#N Show InChI InChI=1S/C26H19N5O3/c1-31-15-29-13-23(31)26(19-4-6-21(11-28)30-12-19)32-14-20-3-2-17(10-27)8-22(20)18-5-7-24-25(9-18)34-16-33-24/h2-9,12-13,15,26H,14,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13382 (3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19ClN4O/c1-31-17-30-15-25(31)26(20-8-5-18(13-28)6-9-20)32-16-22-10-7-19(14-29)11-24(22)21-3-2-4-23(27)12-21/h2-12,15,17,26H,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.870	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13386 (3-(2H-1,3-benzodioxol-5-yl)-4-{[(4-cyanophenyl)(1-...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc2OCOc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H20N4O3/c1-31-16-30-14-24(31)27(20-5-2-18(12-28)3-6-20)32-15-22-7-4-19(13-29)10-23(22)21-8-9-25-26(11-21)34-17-33-25/h2-11,14,16,27H,15,17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.870	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13412 (A313326 Analogue 60a | N-(5-cyano-2-{[(4-cyanophen...) Show SMILES Cn1cncc1C(OCc1ccc(cc1NS(=O)(=O)c1cccs1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C24H19N5O3S2/c1-29-16-27-14-22(29)24(19-7-4-17(12-25)5-8-19)32-15-20-9-6-18(13-26)11-21(20)28-34(30,31)23-3-2-10-33-23/h2-11,14,16,24,28H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127314 (5-[(5-Cyano-3'-methoxy-biphenyl-2-ylmethoxy)-(3-me...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(nc1)C#N)C#N Show InChI InChI=1S/C26H21N5O2/c1-31-17-29-15-25(31)26(20-8-9-22(13-28)30-14-20)33-16-21-7-6-18(12-27)10-24(21)19-4-3-5-23(11-19)32-2/h3-11,14-15,17,26H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127302 (2-Chloro-5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(...) Show SMILES Cn1cncc1C(OCc1nc(Cl)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-23(32)24(17-7-5-16(11-28)6-8-17)33-14-22-21(10-19(12-29)25(27)31-22)18-3-2-4-20(26)9-18/h2-10,13,15,24H,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13377 (4-({[4-chloro-2-(3-methoxyphenyl)phenyl]methoxy}(1...) Show SMILES COc1cccc(c1)-c1cc(Cl)ccc1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C26H22ClN3O2/c1-30-17-29-15-25(30)26(19-8-6-18(14-28)7-9-19)32-16-21-10-11-22(27)13-24(21)20-4-3-5-23(12-20)31-2/h3-13,15,17,26H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.910	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127316 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Cn1cncc1C(OCc1ncc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H18ClN5O/c1-31-16-29-14-24(31)25(19-7-5-17(11-27)6-8-19)32-15-23-22(9-18(12-28)13-30-23)20-3-2-4-21(26)10-20/h2-10,13-14,16,25H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.920	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13380 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc2ccccc12)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(24-12-9-21(16-31)10-13-24)35-19-25-14-11-22(17-32)15-28(25)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.940	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13391 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES COc1ccc(cc1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(22-6-3-19(14-28)4-7-22)33-17-23-8-5-20(15-29)13-25(23)21-9-11-24(32-2)12-10-21/h3-13,16,18,27H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13404 (4-{[(3-chloro-4-cyanophenyl)(1-methyl-1H-imidazol-...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(C#N)c(Cl)c1)C#N Show InChI InChI=1S/C27H21ClN4O2/c1-32-17-31-15-26(32)27(20-8-9-21(14-30)25(28)12-20)34-16-22-7-6-18(13-29)10-24(22)19-4-3-5-23(11-19)33-2/h3-12,15,17,27H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.970	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127317 (2-(4-Acetyl-piperazin-1-yl)-5-(3-chloro-phenyl)-6-...) Show SMILES CC(=O)N1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc1C#N)-c1cccc(Cl)c1 Show InChI InChI=1S/C31H28ClN7O2/c1-21(40)38-10-12-39(13-11-38)31-25(17-34)15-27(24-4-3-5-26(32)14-24)28(36-31)19-41-30(29-18-35-20-37(29)2)23-8-6-22(16-33)7-9-23/h3-9,14-15,18,20,30H,10-13,19H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13395 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cc(F)cc(F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H18F2N4O/c1-32-16-31-14-25(32)26(19-5-2-17(12-29)3-6-19)33-15-20-7-4-18(13-30)8-24(20)21-9-22(27)11-23(28)10-21/h2-11,14,16,26H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127307 (4-{5-(3-Chloro-phenyl)-3-cyano-6-[(4-cyano-phenyl)...) Show SMILES Cn1cncc1C(OCc1nc(N2CCN(CC2)C(=O)OC(C)(C)C)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C34H34ClN7O3/c1-34(2,3)45-33(43)42-14-12-41(13-15-42)32-26(19-37)17-28(25-6-5-7-27(35)16-25)29(39-32)21-44-31(30-20-38-22-40(30)4)24-10-8-23(18-36)9-11-24/h5-11,16-17,20,22,31H,12-15,21H2,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.990	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13413 (A313326 Analogue 60b) Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H23N5O3S/c1-19-3-11-24(12-4-19)36(33,34)31-25-13-21(15-29)7-10-23(25)17-35-27(26-16-30-18-32(26)2)22-8-5-20(14-28)6-9-22/h3-13,16,18,27,31H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50127303 (5-[(3'-Chloro-5-cyano-4'-fluoro-biphenyl-2-ylmetho...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc(F)c(Cl)c1)C#N)c1ccc(nc1)C#N Show InChI InChI=1S/C25H17ClFN5O/c1-32-15-30-13-24(32)25(18-4-6-20(11-29)31-12-18)33-14-19-3-2-16(10-28)8-21(19)17-5-7-23(27)22(26)9-17/h2-9,12-13,15,25H,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13407 (3-(3-chlorophenyl)-4-{[(1-methyl-1H-imidazol-5-yl)...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C26H19ClF3N3O/c1-33-16-32-14-24(33)25(18-7-9-21(10-8-18)26(28,29)30)34-15-20-6-5-17(13-31)11-23(20)19-3-2-4-22(27)12-19/h2-12,14,16,25H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13396 (4-({[2-(3-methoxyphenyl)-4-nitrophenyl]methoxy}(1-...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)[N+]([O-])=O Show InChI InChI=1S/C26H22N4O4/c1-29-17-28-15-25(29)26(19-8-6-18(14-27)7-9-19)34-16-21-10-11-22(30(31)32)13-24(21)20-4-3-5-23(12-20)33-2/h3-13,15,17,26H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13378 (4-({[4-chloro-2-(3-ethoxyphenyl)phenyl]methoxy}(1-...) Show SMILES CCOc1cccc(c1)-c1cc(Cl)ccc1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C27H24ClN3O2/c1-3-32-24-6-4-5-21(13-24)25-14-23(28)12-11-22(25)17-33-27(26-16-30-18-31(26)2)20-9-7-19(15-29)8-10-20/h4-14,16,18,27H,3,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13394 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cc1ccc(cc1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H22N4O/c1-19-3-8-22(9-4-19)25-13-21(15-29)7-12-24(25)17-32-27(26-16-30-18-31(26)2)23-10-5-20(14-28)6-11-23/h3-13,16,18,27H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13387 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc2OC(F)(F)Oc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H18F2N4O3/c1-33-16-32-14-23(33)26(19-5-2-17(12-30)3-6-19)34-15-21-7-4-18(13-31)10-22(21)20-8-9-24-25(11-20)36-27(28,29)35-24/h2-11,14,16,26H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair

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