Compile Data Set for Download or QSAR

Found 404 hits with Last Name = 'ghai' and Initial = 'rd'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Rattus norvegicus (Rat))	BDBM50283607 (7-(2-Mercaptomethyl-3-phenyl-propionylamino)-hepta...) Show SMILES OC(=O)CCCCCCNC(=O)C(CS)Cc1ccccc1 Show InChI InChI=1S/C17H25NO3S/c19-16(20)10-6-1-2-7-11-18-17(21)15(13-22)12-14-8-4-3-5-9-14/h3-5,8-9,15,22H,1-2,6-7,10-13H2,(H,18,21)(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition against neutral endopeptidase 24.11 (NEP) in rat kidney cortex membrane				Bioorg Med Chem Lett 4: 2673-2676 (1994) Article DOI: 10.1016/S0960-894X(01)80694-6 BindingDB Entry DOI: 10.7270/Q2X34XXT
					More data for this Ligand-Target Pair
Neprilysin (Oryctolagus cuniculus (rabbit))	BDBM50251742 ((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...) Show SMILES CC(C)C[C@H](NP(O)(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r| Show InChI InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in membranes prepared from rabbit				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neprilysin (Rattus norvegicus (Rat))	BDBM50251742 ((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...) Show SMILES CC(C)C[C@H](NP(O)(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r| Show InChI InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatum				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neprilysin (Rattus norvegicus (Rat))	BDBM50034841 ((S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoyl)-p...) Show SMILES OC(=O)CCNC(=O)[C@@H](CCC(O)=O)Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H23NO5/c23-19(24)11-10-18(21(27)22-13-12-20(25)26)14-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-9,18H,10-14H2,(H,22,27)(H,23,24)(H,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034846 ((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...) Show SMILES C[C@H](C[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O)C(O)=O Show InChI InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50042828 (4-Hydroxy-1-(9-mercaptomethyl-10-oxo-azecane-2-car...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)C1CCCCCCC(CS)C(=O)N1)C(O)=O Show InChI InChI=1S/C16H26N2O5S/c19-11-7-13(16(22)23)18(8-11)15(21)12-6-4-2-1-3-5-10(9-24)14(20)17-12/h10-13,19,24H,1-9H2,(H,17,20)(H,22,23)/t10?,11-,12?,13+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of NEP 24.11 from rat kidney				J Med Chem 36: 3821-8 (1994) BindingDB Entry DOI: 10.7270/Q2ZS2X5D
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50056252 ((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...) Show SMILES OC(=O)[C@@H]1CCCCc2ccccc2C[C@H](CS)C(=O)N1 Show InChI InChI=1S/C16H21NO3S/c18-15-13(10-21)9-12-7-2-1-5-11(12)6-3-4-8-14(17-15)16(19)20/h1-2,5,7,13-14,21H,3-4,6,8-10H2,(H,17,18)(H,19,20)/t13-,14+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit neutral endopeptidase (NEP)				J Med Chem 40: 506-14 (1997) Article DOI: 10.1021/jm960583g BindingDB Entry DOI: 10.7270/Q2TM797S
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50056252 ((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...) Show SMILES OC(=O)[C@@H]1CCCCc2ccccc2C[C@H](CS)C(=O)N1 Show InChI InChI=1S/C16H21NO3S/c18-15-13(10-21)9-12-7-2-1-5-11(12)6-3-4-8-14(17-15)16(19)20/h1-2,5,7,13-14,21H,3-4,6,8-10H2,(H,17,18)(H,19,20)/t13-,14+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharmaceuticals Corporation Curated by ChEMBL					Assay Description Inhibition of neutral endopeptidase				J Med Chem 40: 495-505 (1997) Article DOI: 10.1021/jm960582o BindingDB Entry DOI: 10.7270/Q2ZC81Z3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) Show SMILES OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)c1nnn[nH]1 Show InChI InChI=1S/C16H18N5O3P/c22-25(23,24)11-17-15(16-18-20-21-19-16)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15,17H,10-11H2,(H2,22,23,24)(H,18,19,20,21)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	0.930	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP)				Bioorg Med Chem Lett 5: 145-150 (1995) Article DOI: 10.1016/0960-894X(94)00474-T BindingDB Entry DOI: 10.7270/Q2G160SW
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048318 ((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](CCc1ccccc1)C(O)=O Show InChI InChI=1S/C21H30N2O4S/c1-14(2)17(28)18(24)23-21(12-6-7-13-21)20(27)22-16(19(25)26)11-10-15-8-4-3-5-9-15/h3-5,8-9,14,16-17,28H,6-7,10-13H2,1-2H3,(H,22,27)(H,23,24)(H,25,26)/t16-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Angiotensin-converting enzyme 2 (Homo sapiens (Human))	BDBM50017129 ((S)-1-((S)-2-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-y...) Show SMILES CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)/t14-,16-,17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition against angiotensin converting enzyme (ACE)				Bioorg Med Chem Lett 4: 2673-2676 (1994) Article DOI: 10.1016/S0960-894X(01)80694-6 BindingDB Entry DOI: 10.7270/Q2X34XXT
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50285328 (CHEMBL285747 | {[(S)-2-Biphenyl-4-yl-1-(1H-tetrazo...) Show SMILES OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)Nc1nnn[nH]1 Show InChI InChI=1S/C17H19N6O4P/c24-16(19-17-20-22-23-21-17)15(18-11-28(25,26)27)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15,18H,10-11H2,(H2,25,26,27)(H2,19,20,21,22,23,24)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP)				Bioorg Med Chem Lett 5: 145-150 (1995) Article DOI: 10.1016/0960-894X(94)00474-T BindingDB Entry DOI: 10.7270/Q2G160SW
					More data for this Ligand-Target Pair
Neprilysin (Oryctolagus cuniculus (rabbit))	BDBM50017742 (CHEMBL316180 | disodium 2-benzyl-4-(3-carboxylatop...) Show SMILES [O-]C(=O)CCCNC(=O)[C@@H](C[C@@H](Cc1ccccc1)C([O-])=O)Cc1ccccc1 Show InChI InChI=1S/C23H27NO5/c25-21(26)12-7-13-24-22(27)19(14-17-8-3-1-4-9-17)16-20(23(28)29)15-18-10-5-2-6-11-18/h1-6,8-11,19-20H,7,12-16H2,(H,24,27)(H,25,26)(H,28,29)/p-2/t19-,20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in membranes prepared from rabbit				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048312 ((S)-3-(4-Hydroxy-phenyl)-2-{[1-((S)-2-mercapto-3-m...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C20H28N2O5S/c1-12(2)16(28)17(24)22-20(9-3-4-10-20)19(27)21-15(18(25)26)11-13-5-7-14(23)8-6-13/h5-8,12,15-16,23,28H,3-4,9-11H2,1-2H3,(H,21,27)(H,22,24)(H,25,26)/t15-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM21641 (2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...) Show SMILES OC(=O)CNC(=O)C(CS)Cc1ccccc1 Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neprilysin (Rattus norvegicus (Rat))	BDBM50048320 ((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1cccs1)C(O)=O Show InChI InChI=1S/C18H26N2O4S2/c1-11(2)14(25)15(21)20-18(7-3-4-8-18)17(24)19-13(16(22)23)10-12-6-5-9-26-12/h5-6,9,11,13-14,25H,3-4,7-8,10H2,1-2H3,(H,19,24)(H,20,21)(H,22,23)/t13-,14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50285340 (CHEMBL290285 | {[(S)-2-(2-Methoxy-biphenyl-4-yl)-1...) Show SMILES COc1cc(C[C@H](NCP(O)(O)=O)c2nnn[nH]2)ccc1-c1ccccc1 Show InChI InChI=1S/C17H20N5O4P/c1-26-16-10-12(7-8-14(16)13-5-3-2-4-6-13)9-15(17-19-21-22-20-17)18-11-27(23,24)25/h2-8,10,15,18H,9,11H2,1H3,(H2,23,24,25)(H,19,20,21,22)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP)				Bioorg Med Chem Lett 5: 145-150 (1995) Article DOI: 10.1016/0960-894X(94)00474-T BindingDB Entry DOI: 10.7270/Q2G160SW
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048304 ((S)-3-(4-Fluoro-phenyl)-2-{[1-((S)-2-mercapto-3-me...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(O)=O Show InChI InChI=1S/C20H27FN2O4S/c1-12(2)16(28)17(24)23-20(9-3-4-10-20)19(27)22-15(18(25)26)11-13-5-7-14(21)8-6-13/h5-8,12,15-16,28H,3-4,9-11H2,1-2H3,(H,22,27)(H,23,24)(H,25,26)/t15-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description In vitro inhibition of Neutral endopeptidase (NEP) enzyme				J Med Chem 37: 498-511 (1994) BindingDB Entry DOI: 10.7270/Q2H70GF9
					More data for this Ligand-Target Pair
Angiotensin-converting enzyme (Oryctolagus cuniculus)	BDBM50021127 (2-(1-Carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-ben...) Show SMILES OC(=O)CN1c2ccccc2CC[C@H](N[C@@H](CCc2ccccc2)C(O)=O)C1=O Show InChI InChI=1S/C22H24N2O5/c25-20(26)14-24-19-9-5-4-8-16(19)11-13-17(21(24)27)23-18(22(28)29)12-10-15-6-2-1-3-7-15/h1-9,17-18,23H,10-14H2,(H,25,26)(H,28,29)/t17-,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Tested in vitro for the inhibition against neutral endopeptidase (NEP) from rat kidney				J Med Chem 36: 3829-33 (1994) BindingDB Entry DOI: 10.7270/Q2125RRG
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048303 ((S)-3-(5-Hydroxy-1H-indol-3-yl)-2-{[1-((S)-2-merca...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(O)=O Show InChI InChI=1S/C22H29N3O5S/c1-12(2)18(31)19(27)25-22(7-3-4-8-22)21(30)24-17(20(28)29)9-13-11-23-16-6-5-14(26)10-15(13)16/h5-6,10-12,17-18,23,26,31H,3-4,7-9H2,1-2H3,(H,24,30)(H,25,27)(H,28,29)/t17-,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Oryctolagus cuniculus (rabbit))	BDBM50017736 (2-Benzyl-4-(3-carboxy-propionylamino)-5-phenyl-pen...) Show SMILES OC(=O)CCC(=O)NC(C[C@@H](Cc1ccccc1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C22H25NO5/c24-20(11-12-21(25)26)23-19(14-17-9-5-2-6-10-17)15-18(22(27)28)13-16-7-3-1-4-8-16/h1-10,18-19H,11-15H2,(H,23,24)(H,25,26)(H,27,28)/t18-,19?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in membranes prepared from rabbit				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50034851 (3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50042835 (1-(9-Mercaptomethyl-10-oxo-azecane-2-carbonyl)-pyr...) Show SMILES OC(=O)[C@@H]1CCCN1C(=O)C1CCCCCCC(CS)C(=O)N1 Show InChI InChI=1S/C16H26N2O4S/c19-14-11(10-23)6-3-1-2-4-7-12(17-14)15(20)18-9-5-8-13(18)16(21)22/h11-13,23H,1-10H2,(H,17,19)(H,21,22)/t11?,12?,13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of NEP 24.11 from rat kidney				J Med Chem 36: 3821-8 (1994) BindingDB Entry DOI: 10.7270/Q2ZS2X5D
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50283642 ((S)-3-Biphenyl-4-yl-2-{(S)-3-methyl-2-[((R)-phosph...) Show SMILES CC[C@@H](C)[C@H](NCP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C22H29N2O6P/c1-3-15(2)20(23-14-31(28,29)30)21(25)24-19(22(26)27)13-16-9-11-18(12-10-16)17-7-5-4-6-8-17/h4-12,15,19-20,23H,3,13-14H2,1-2H3,(H,24,25)(H,26,27)(H2,28,29,30)/t15-,19+,20+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory concentration against neutral endopeptidase				Bioorg Med Chem Lett 4: 2715-2720 (1994) Article DOI: 10.1016/S0960-894X(01)80703-4 BindingDB Entry DOI: 10.7270/Q2SB467B
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50040401 ((S)-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-pro...) Show SMILES OC(=O)[C@@H](NC(=O)C(Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O)c1ccccc1 Show InChI InChI=1S/C24H25N2O6P/c27-23(26-22(24(28)29)20-9-5-2-6-10-20)21(25-16-33(30,31)32)15-17-11-13-19(14-12-17)18-7-3-1-4-8-18/h1-14,21-22,25H,15-16H2,(H,26,27)(H,28,29)(H2,30,31,32)/t21?,22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description In vitro inhibition of Neutral endopeptidase (NEP) enzyme				J Med Chem 37: 498-511 (1994) BindingDB Entry DOI: 10.7270/Q2H70GF9
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048314 ((S)-3-(1H-Indol-3-yl)-2-{[1-((S)-2-mercapto-3-meth...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C22H29N3O4S/c1-13(2)18(30)19(26)25-22(9-5-6-10-22)21(29)24-17(20(27)28)11-14-12-23-16-8-4-3-7-15(14)16/h3-4,7-8,12-13,17-18,23,30H,5-6,9-11H2,1-2H3,(H,24,29)(H,25,26)(H,27,28)/t17-,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048315 ((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...) Show SMILES COc1ccc(C[C@H](NC(=O)C2(CCCC2)NC(=O)[C@@H](S)C(C)C)C(O)=O)cc1 Show InChI InChI=1S/C21H30N2O5S/c1-13(2)17(29)18(24)23-21(10-4-5-11-21)20(27)22-16(19(25)26)12-14-6-8-15(28-3)9-7-14/h6-9,13,16-17,29H,4-5,10-12H2,1-3H3,(H,22,27)(H,23,24)(H,25,26)/t16-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048305 ((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccsc1)C(O)=O Show InChI InChI=1S/C18H26N2O4S2/c1-11(2)14(25)15(21)20-18(6-3-4-7-18)17(24)19-13(16(22)23)9-12-5-8-26-10-12/h5,8,10-11,13-14,25H,3-4,6-7,9H2,1-2H3,(H,19,24)(H,20,21)(H,22,23)/t13-,14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50056249 ((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...) Show SMILES OC(=O)[C@@H]1CCCCCc2ccccc2C[C@H](CS)C(=O)N1 Show InChI InChI=1S/C17H23NO3S/c19-16-14(11-22)10-13-8-5-4-7-12(13)6-2-1-3-9-15(18-16)17(20)21/h4-5,7-8,14-15,22H,1-3,6,9-11H2,(H,18,19)(H,20,21)/t14-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharmaceuticals Corporation Curated by ChEMBL					Assay Description Inhibition of neutral endopeptidase				J Med Chem 40: 495-505 (1997) Article DOI: 10.1021/jm960582o BindingDB Entry DOI: 10.7270/Q2ZC81Z3
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50042827 (9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid ...) Show SMILES OC(=O)C1CCCCCCC(CS)C(=O)N1 Show InChI InChI=1S/C11H19NO3S/c13-10-8(7-16)5-3-1-2-4-6-9(12-10)11(14)15/h8-9,16H,1-7H2,(H,12,13)(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of NEP 24.11 from rat kidney				J Med Chem 36: 3821-8 (1994) BindingDB Entry DOI: 10.7270/Q2ZS2X5D
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50042827 (9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid ...) Show SMILES OC(=O)C1CCCCCCC(CS)C(=O)N1 Show InChI InChI=1S/C11H19NO3S/c13-10-8(7-16)5-3-1-2-4-6-9(12-10)11(14)15/h8-9,16H,1-7H2,(H,12,13)(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of NEP 24.11 from rat kidney				J Med Chem 36: 3821-8 (1994) BindingDB Entry DOI: 10.7270/Q2ZS2X5D
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50040409 ((S)-2-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...) Show SMILES C[C@H](NC(=O)C(Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C19H23N2O6P/c1-13(19(23)24)21-18(22)17(20-12-28(25,26)27)11-14-7-9-16(10-8-14)15-5-3-2-4-6-15/h2-10,13,17,20H,11-12H2,1H3,(H,21,22)(H,23,24)(H2,25,26,27)/t13-,17?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description In vitro inhibition of Neutral endopeptidase (NEP) enzyme				J Med Chem 37: 498-511 (1994) BindingDB Entry DOI: 10.7270/Q2H70GF9
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM21641 (2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...) Show SMILES OC(=O)CNC(=O)C(CS)Cc1ccccc1 Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatum				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neprilysin (Rattus norvegicus (Rat))	BDBM50048317 ((S)-3-(4-Hydroxy-phenyl)-2-{[1-((S)-2-mercapto-3-p...) Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C1(CCCC1)NC(=O)[C@@H](S)Cc1ccccc1 Show InChI InChI=1S/C24H28N2O5S/c27-18-10-8-17(9-11-18)14-19(22(29)30)25-23(31)24(12-4-5-13-24)26-21(28)20(32)15-16-6-2-1-3-7-16/h1-3,6-11,19-20,27,32H,4-5,12-15H2,(H,25,31)(H,26,28)(H,29,30)/t19-,20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048310 ((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccccn1)C(O)=O Show InChI InChI=1S/C19H27N3O4S/c1-12(2)15(27)16(23)22-19(8-4-5-9-19)18(26)21-14(17(24)25)11-13-7-3-6-10-20-13/h3,6-7,10,12,14-15,27H,4-5,8-9,11H2,1-2H3,(H,21,26)(H,22,23)(H,24,25)/t14-,15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50056249 ((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...) Show SMILES OC(=O)[C@@H]1CCCCCc2ccccc2C[C@H](CS)C(=O)N1 Show InChI InChI=1S/C17H23NO3S/c19-16-14(11-22)10-13-8-5-4-7-12(13)6-2-1-3-9-15(18-16)17(20)21/h4-5,7-8,14-15,22H,1-3,6,9-11H2,(H,18,19)(H,20,21)/t14-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit neutral endopeptidase (NEP)				J Med Chem 40: 506-14 (1997) Article DOI: 10.1021/jm960583g BindingDB Entry DOI: 10.7270/Q2TM797S
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50085459 ((S)-3-Biphenyl-4-yl-2-[(S)-3-methyl-2-(phosphonome...) Show SMILES CC(C)[C@H](NCP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C21H27N2O6P/c1-14(2)19(22-13-30(27,28)29)20(24)23-18(21(25)26)12-15-8-10-17(11-9-15)16-6-4-3-5-7-16/h3-11,14,18-19,22H,12-13H2,1-2H3,(H,23,24)(H,25,26)(H2,27,28,29)/t18-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory concentration against neutral endopeptidase				Bioorg Med Chem Lett 4: 2715-2720 (1994) Article DOI: 10.1016/S0960-894X(01)80703-4 BindingDB Entry DOI: 10.7270/Q2SB467B
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50048316 ((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...) Show SMILES CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1cccnc1)C(O)=O Show InChI InChI=1S/C19H27N3O4S/c1-12(2)15(27)16(23)22-19(7-3-4-8-19)18(26)21-14(17(24)25)10-13-6-5-9-20-11-13/h5-6,9,11-12,14-15,27H,3-4,7-8,10H2,1-2H3,(H,21,26)(H,22,23)(H,24,25)/t14-,15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase				J Med Chem 38: 5023-30 (1996) BindingDB Entry DOI: 10.7270/Q26D5TMH
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50056251 ((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...) Show SMILES OC(=O)[C@@H]1CCCCCc2ccccc2C[C@@H](CS)C(=O)N1 Show InChI InChI=1S/C17H23NO3S/c19-16-14(11-22)10-13-8-5-4-7-12(13)6-2-1-3-9-15(18-16)17(20)21/h4-5,7-8,14-15,22H,1-3,6,9-11H2,(H,18,19)(H,20,21)/t14-,15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharmaceuticals Corporation Curated by ChEMBL					Assay Description Inhibition of neutral endopeptidase				J Med Chem 40: 495-505 (1997) Article DOI: 10.1021/jm960582o BindingDB Entry DOI: 10.7270/Q2ZC81Z3
					More data for this Ligand-Target Pair
Angiotensin-converting enzyme (Homo sapiens (Human))	BDBM50056262 ((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[10.3....) Show SMILES OC(=O)[C@@H]1CCCCCc2cccc(C[C@H](CS)C(=O)N1)c2 Show InChI InChI=1S/C17H23NO3S/c19-16-14(11-22)10-13-7-4-6-12(9-13)5-2-1-3-8-15(18-16)17(20)21/h4,6-7,9,14-15,22H,1-3,5,8,10-11H2,(H,18,19)(H,20,21)/t14-,15+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit Angiotensin I converting enzyme (ACE)				J Med Chem 40: 506-14 (1997) Article DOI: 10.1021/jm960583g BindingDB Entry DOI: 10.7270/Q2TM797S
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50040405 (3-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-propi...) Show SMILES OC(=O)CCNC(=O)C(Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O Show InChI InChI=1S/C19H23N2O6P/c22-18(23)10-11-20-19(24)17(21-13-28(25,26)27)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,21H,10-13H2,(H,20,24)(H,22,23)(H2,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description In vitro inhibition of Neutral endopeptidase (NEP) enzyme				J Med Chem 37: 498-511 (1994) BindingDB Entry DOI: 10.7270/Q2H70GF9
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50017755 (2-Benzyl-4-(carboxymethyl-carbamoyl)-5-phenyl-pent...) Show SMILES OC(=O)CNC(=O)[C@@H](C[C@@H](Cc1ccccc1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C21H23NO5/c23-19(24)14-22-20(25)17(11-15-7-3-1-4-8-15)13-18(21(26)27)12-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2,(H,22,25)(H,23,24)(H,26,27)/t17-,18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatum				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50056259 ((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[11.3....) Show SMILES OC(=O)[C@@H]1CCCCCCc2cccc(C[C@H](CS)C(=O)N1)c2 Show InChI InChI=1S/C18H25NO3S/c20-17-15(12-23)11-14-8-5-7-13(10-14)6-3-1-2-4-9-16(19-17)18(21)22/h5,7-8,10,15-16,23H,1-4,6,9,11-12H2,(H,19,20)(H,21,22)/t15-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit neutral endopeptidase (NEP)				J Med Chem 40: 506-14 (1997) Article DOI: 10.1021/jm960583g BindingDB Entry DOI: 10.7270/Q2TM797S
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50056251 ((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...) Show SMILES OC(=O)[C@@H]1CCCCCc2ccccc2C[C@@H](CS)C(=O)N1 Show InChI InChI=1S/C17H23NO3S/c19-16-14(11-22)10-13-8-5-4-7-12(13)6-2-1-3-9-15(18-16)17(20)21/h4-5,7-8,14-15,22H,1-3,6,9-11H2,(H,18,19)(H,20,21)/t14-,15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit neutral endopeptidase (NEP)				J Med Chem 40: 506-14 (1997) Article DOI: 10.1021/jm960583g BindingDB Entry DOI: 10.7270/Q2TM797S
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50283637 (2-{(S)-3-Biphenyl-4-yl-2-[(S)-3-methyl-1-oxo-2-(ph...) Show SMILES CC(C)[C@H](NCP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C30H36N3O8P/c1-19(2)27(31-18-42(39,40)41)29(36)32-25(16-20-8-12-23(13-9-20)22-6-4-3-5-7-22)28(35)33-26(30(37)38)17-21-10-14-24(34)15-11-21/h3-15,19,25-27,31,34H,16-18H2,1-2H3,(H,32,36)(H,33,35)(H,37,38)(H2,39,40,41)/t25-,26-,27-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory concentration against neutral endopeptidase				Bioorg Med Chem Lett 4: 2715-2720 (1994) Article DOI: 10.1016/S0960-894X(01)80703-4 BindingDB Entry DOI: 10.7270/Q2SB467B
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50017734 (2-Benzyl-4-(2-benzylsulfanyl-1-carboxy-ethylcarbam...) Show SMILES OC(=O)[C@@H](C[C@@H](Cc1ccccc1)C(=O)NC(CSCc1ccccc1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C29H31NO5S/c31-27(30-26(29(34)35)20-36-19-23-14-8-3-9-15-23)24(16-21-10-4-1-5-11-21)18-25(28(32)33)17-22-12-6-2-7-13-22/h1-15,24-26H,16-20H2,(H,30,31)(H,32,33)(H,34,35)/t24-,25-,26?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatum				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM21641 (2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...) Show SMILES OC(=O)CNC(=O)C(CS)Cc1ccccc1 Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharmaceuticals Corporation Curated by ChEMBL					Assay Description Inhibition of neutral endopeptidase				J Med Chem 40: 495-505 (1997) Article DOI: 10.1021/jm960582o BindingDB Entry DOI: 10.7270/Q2ZC81Z3
					More data for this Ligand-Target Pair				3D Structure (crystal)

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