Found 43 hits with Last Name = 'boyle' and Initial = 'nj' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353151
(CHEMBL1829323)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1CCSc2cc(Cl)ccc12 |r,wU:11.14,wD:8.7,(10.22,-17.24,;8.89,-16.47,;8.89,-14.93,;7.56,-17.23,;6.77,-18.56,;8.31,-18.56,;6.22,-16.46,;4.89,-17.23,;3.56,-16.46,;3.56,-14.92,;2.22,-14.14,;.89,-14.92,;.89,-16.46,;2.22,-17.22,;-.45,-14.14,;-1.77,-14.92,;-1.77,-16.46,;-3.11,-14.15,;-4.44,-14.92,;-4.44,-16.47,;-5.78,-17.23,;-7.11,-16.46,;-7.11,-14.93,;-8.45,-14.16,;-8.45,-12.62,;-9.78,-11.85,;-7.12,-11.85,;-5.78,-12.61,;-5.77,-14.16,)| Show InChI InChI=1S/C20H30ClN3O3S2/c1-14(2)29(26,27)22-12-15-3-6-17(7-4-15)23-20(25)13-24-9-10-28-19-11-16(21)5-8-18(19)24/h5,8,11,14-15,17,22H,3-4,6-7,9-10,12-13H2,1-2H3,(H,23,25)/t15-,17- | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353150
(CHEMBL1829322)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1C(=O)CSc2cc(Cl)ccc12 |r,wU:11.14,wD:8.7,(33.09,-9.17,;31.76,-8.4,;31.76,-6.86,;30.43,-9.16,;29.65,-10.49,;31.19,-10.49,;29.1,-8.39,;27.76,-9.16,;26.43,-8.39,;26.43,-6.84,;25.09,-6.06,;23.76,-6.84,;23.76,-8.38,;25.09,-9.15,;22.43,-6.07,;21.1,-6.85,;21.1,-8.39,;19.77,-6.08,;18.43,-6.85,;18.43,-8.39,;19.76,-9.16,;17.09,-9.16,;15.76,-8.39,;15.76,-6.86,;14.42,-6.09,;14.43,-4.54,;13.09,-3.78,;15.76,-3.78,;17.09,-4.54,;17.1,-6.09,)| Show InChI InChI=1S/C20H28ClN3O4S2/c1-13(2)30(27,28)22-10-14-3-6-16(7-4-14)23-19(25)11-24-17-8-5-15(21)9-18(17)29-12-20(24)26/h5,8-9,13-14,16,22H,3-4,6-7,10-12H2,1-2H3,(H,23,25)/t14-,16- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353154
(CHEMBL1829326)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1CCCc2cc(Cl)ccc12 |r,wU:11.14,wD:8.7,(32.58,-25.11,;31.25,-24.34,;31.25,-22.8,;29.92,-25.11,;29.13,-26.43,;30.67,-26.43,;28.59,-24.34,;27.25,-25.1,;25.92,-24.33,;25.92,-22.79,;24.58,-22.01,;23.25,-22.79,;23.25,-24.33,;24.58,-25.09,;21.92,-22.02,;20.59,-22.79,;20.59,-24.33,;19.25,-22.02,;17.92,-22.8,;17.92,-24.34,;16.58,-25.1,;15.25,-24.33,;15.25,-22.8,;13.91,-22.03,;13.91,-20.49,;12.58,-19.72,;15.24,-19.72,;16.58,-20.48,;16.59,-22.03,)| Show InChI InChI=1S/C21H32ClN3O3S/c1-15(2)29(27,28)23-13-16-5-8-19(9-6-16)24-21(26)14-25-11-3-4-17-12-18(22)7-10-20(17)25/h7,10,12,15-16,19,23H,3-6,8-9,11,13-14H2,1-2H3,(H,24,26)/t16-,19- | KEGG
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| CHEMBL
PC cid
PC sid
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| Article
PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353148
(CHEMBL1829320)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1C(=O)COc2cc(Cl)ccc12 |r,wU:11.14,wD:8.7,(10,-2.04,;8.67,-1.27,;8.67,.27,;7.34,-2.03,;6.55,-3.36,;8.09,-3.36,;6.01,-1.26,;4.67,-2.02,;3.34,-1.25,;3.34,.29,;2,1.07,;.67,.29,;.67,-1.25,;2,-2.02,;-.66,1.06,;-1.99,.28,;-1.99,-1.26,;-3.33,1.06,;-4.66,.28,;-4.66,-1.26,;-3.33,-2.03,;-6,-2.03,;-7.33,-1.26,;-7.33,.27,;-8.67,1.04,;-8.67,2.59,;-10,3.35,;-7.34,3.36,;-6,2.6,;-5.99,1.05,)| Show InChI InChI=1S/C20H28ClN3O5S/c1-13(2)30(27,28)22-10-14-3-6-16(7-4-14)23-19(25)11-24-17-8-5-15(21)9-18(17)29-12-20(24)26/h5,8-9,13-14,16,22H,3-4,6-7,10-12H2,1-2H3,(H,23,25)/t14-,16- | KEGG
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PC cid
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| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353152
(CHEMBL1829324)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1CCS(=O)(=O)c2cc(Cl)ccc12 |r,wU:11.14,wD:8.7,(34.58,-17.57,;33.25,-16.8,;33.25,-15.26,;31.92,-17.56,;31.13,-18.89,;32.67,-18.89,;30.58,-16.79,;29.25,-17.56,;27.91,-16.79,;27.92,-15.25,;26.58,-14.47,;25.25,-15.25,;25.25,-16.79,;26.58,-17.55,;23.92,-14.47,;22.59,-15.25,;22.59,-16.79,;21.25,-14.48,;19.92,-15.25,;19.92,-16.8,;18.58,-17.56,;17.25,-16.79,;15.76,-16.38,;16.48,-18.12,;17.25,-15.26,;15.91,-14.49,;15.92,-12.95,;14.58,-12.18,;17.25,-12.18,;18.58,-12.94,;18.59,-14.49,)| Show InChI InChI=1S/C20H30ClN3O5S2/c1-14(2)31(28,29)22-12-15-3-6-17(7-4-15)23-20(25)13-24-9-10-30(26,27)19-11-16(21)5-8-18(19)24/h5,8,11,14-15,17,22H,3-4,6-7,9-10,12-13H2,1-2H3,(H,23,25)/t15-,17- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449332
(CHEMBL3126041)Show SMILES Fc1cc(F)cc(c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)N2CCCCC2=O)nc1 |r,wU:15.15,18.22,(18.54,-26.36,;19.31,-25.02,;18.54,-23.7,;19.31,-22.36,;18.54,-21.02,;20.85,-22.36,;21.62,-23.7,;20.85,-25.02,;23.16,-23.7,;23.93,-22.36,;25.47,-22.36,;26.24,-23.7,;27.78,-23.7,;28.55,-25.02,;27.78,-26.36,;30.1,-25.02,;30.87,-26.36,;32.41,-26.36,;33.18,-25.02,;32.41,-23.7,;30.87,-23.7,;34.72,-25.02,;35.49,-23.7,;37.03,-23.7,;37.8,-25.02,;37.03,-26.36,;35.49,-26.36,;34.72,-27.7,;25.47,-25.02,;23.93,-25.02,)| Show InChI InChI=1S/C23H25F2N3O2/c24-18-11-17(12-19(25)13-18)16-6-9-21(26-14-16)27-23(30)15-4-7-20(8-5-15)28-10-2-1-3-22(28)29/h6,9,11-15,20H,1-5,7-8,10H2,(H,26,27,30)/t15-,20+ | KEGG
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PC cid
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UniChem
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| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449331
(CHEMBL3126043)Show SMILES C[C@@H]1CN([C@H]2CC[C@H](CC2)C(=O)Nc2ccc(cn2)-c2cc(F)cc(F)c2)C(=O)O1 |r,wU:7.10,1.0,4.3,(23.3,-26.17,;22.05,-27.08,;20.58,-26.6,;19.68,-27.85,;18.14,-27.85,;17.37,-29.19,;15.83,-29.19,;15.06,-27.85,;15.83,-26.51,;17.37,-26.51,;13.52,-27.85,;12.75,-26.51,;12.75,-29.19,;11.21,-29.19,;10.44,-27.85,;8.9,-27.85,;8.13,-29.19,;8.9,-30.51,;10.44,-30.51,;6.59,-29.19,;5.82,-27.85,;4.28,-27.85,;3.51,-26.51,;3.51,-29.19,;4.28,-30.51,;3.51,-31.85,;5.82,-30.51,;20.58,-29.09,;20.11,-30.57,;22.05,-28.62,)| Show InChI InChI=1S/C22H23F2N3O3/c1-13-12-27(22(29)30-13)19-5-2-14(3-6-19)21(28)26-20-7-4-15(11-25-20)16-8-17(23)10-18(24)9-16/h4,7-11,13-14,19H,2-3,5-6,12H2,1H3,(H,25,26,28)/t13-,14-,19+/m1/s1 | KEGG
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PC cid
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PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353153
(CHEMBL1829325)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1C(=O)CCc2cc(Cl)ccc12 |r,wU:11.14,wD:8.7,(10.7,-24.94,;9.37,-24.17,;9.37,-22.63,;8.04,-24.94,;7.25,-26.26,;8.79,-26.26,;6.71,-24.17,;5.37,-24.93,;4.04,-24.16,;4.04,-22.62,;2.7,-21.84,;1.37,-22.62,;1.37,-24.16,;2.7,-24.92,;.03,-21.85,;-1.29,-22.62,;-1.29,-24.16,;-2.63,-21.85,;-3.96,-22.63,;-3.96,-24.17,;-2.63,-24.94,;-5.3,-24.93,;-6.63,-24.17,;-6.63,-22.64,;-7.97,-21.86,;-7.97,-20.32,;-9.3,-19.55,;-6.64,-19.55,;-5.3,-20.31,;-5.3,-21.86,)| Show InChI InChI=1S/C21H30ClN3O4S/c1-14(2)30(28,29)23-12-15-3-7-18(8-4-15)24-20(26)13-25-19-9-6-17(22)11-16(19)5-10-21(25)27/h6,9,11,14-15,18,23H,3-5,7-8,10,12-13H2,1-2H3,(H,24,26)/t15-,18- | KEGG
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PC cid
PC sid
UniChem
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| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353149
(CHEMBL1829321)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1CCOc2cc(Cl)ccc12 |r,wU:11.14,wD:8.7,(10.92,-9.69,;9.59,-8.92,;9.6,-7.38,;8.26,-9.68,;7.48,-11.01,;9.02,-11.01,;6.93,-8.91,;5.59,-9.67,;4.26,-8.9,;4.26,-7.36,;2.92,-6.58,;1.6,-7.36,;1.59,-8.9,;2.92,-9.67,;.26,-6.59,;-1.07,-7.37,;-1.06,-8.91,;-2.4,-6.59,;-3.74,-7.37,;-3.74,-8.91,;-5.07,-9.68,;-6.4,-8.91,;-6.4,-7.38,;-7.74,-6.61,;-7.74,-5.06,;-9.08,-4.3,;-6.41,-4.3,;-5.08,-5.05,;-5.07,-6.61,)| Show InChI InChI=1S/C20H30ClN3O4S/c1-14(2)29(26,27)22-12-15-3-6-17(7-4-15)23-20(25)13-24-9-10-28-19-11-16(21)5-8-18(19)24/h5,8,11,14-15,17,22H,3-4,6-7,9-10,12-13H2,1-2H3,(H,23,25)/t15-,17- | KEGG
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PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449330
(CHEMBL3126045)Show SMILES CC(C)(C)C1CN([C@H]2CC[C@H](CC2)C(=O)Nc2ccc(cn2)-c2cc(F)cc(F)c2)C(=O)O1 |r,wU:10.13,7.6,(33.32,-25.01,;31.91,-24.38,;31.75,-22.85,;33.24,-23.6,;30.67,-25.29,;29.2,-24.81,;28.29,-26.06,;26.75,-26.06,;25.98,-27.38,;24.44,-27.38,;23.67,-26.06,;24.44,-24.72,;25.98,-24.72,;22.13,-26.06,;21.36,-24.72,;21.36,-27.38,;19.82,-27.38,;19.05,-28.72,;17.51,-28.72,;16.74,-27.38,;17.51,-26.06,;19.05,-26.06,;15.2,-27.38,;14.43,-26.06,;12.89,-26.06,;12.12,-24.72,;12.12,-27.38,;12.89,-28.72,;12.12,-30.06,;14.43,-28.72,;29.2,-27.3,;28.72,-28.76,;30.67,-26.83,)| Show InChI InChI=1S/C25H29F2N3O3/c1-25(2,3)21-14-30(24(32)33-21)20-7-4-15(5-8-20)23(31)29-22-9-6-16(13-28-22)17-10-18(26)12-19(27)11-17/h6,9-13,15,20-21H,4-5,7-8,14H2,1-3H3,(H,28,29,31)/t15-,20+,21? | KEGG
UniProtKB/SwissProt
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PC cid
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PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353162
(CHEMBL1829334)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCCc2cc(Cl)ccc12 |r,wU:8.7,wD:11.14,(32.86,-9.09,;31.53,-8.32,;31.54,-6.78,;30.2,-9.08,;29.42,-10.41,;30.96,-10.41,;28.87,-8.31,;27.53,-9.08,;26.2,-8.3,;24.86,-9.07,;23.53,-8.3,;23.54,-6.76,;24.86,-5.98,;26.2,-6.76,;22.2,-5.99,;20.87,-6.76,;19.53,-6,;18.2,-6.77,;18.2,-8.31,;16.87,-9.08,;15.54,-8.31,;15.54,-6.78,;14.2,-6.01,;14.2,-4.46,;12.87,-3.69,;15.53,-3.69,;16.86,-4.46,;16.87,-6.01,)| Show InChI InChI=1S/C21H34ClN3O2S/c1-16(2)28(26,27)24-15-17-5-8-20(9-6-17)23-11-13-25-12-3-4-18-14-19(22)7-10-21(18)25/h7,10,14,16-17,20,23-24H,3-6,8-9,11-13,15H2,1-2H3/t17-,20- | KEGG
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PC cid
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UniChem
Similars
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PubMed
| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449327
(CHEMBL3126039)Show SMILES Fc1cc(F)cc(c1)-c1cnc(NC(=O)[C@@H]2CC[C@@H](CC2)N2CCCC2=O)nc1 |r,wU:15.15,18.22,(18.08,-29.04,;18.85,-27.7,;18.08,-26.37,;18.85,-25.03,;18.08,-23.7,;20.39,-25.03,;21.16,-26.37,;20.39,-27.7,;22.7,-26.37,;23.47,-25.03,;25.01,-25.03,;25.78,-26.37,;27.32,-26.37,;28.09,-27.7,;27.39,-29.08,;29.63,-27.62,;30.46,-28.91,;32,-28.84,;32.7,-27.46,;31.87,-26.17,;30.32,-26.25,;34.24,-27.38,;35.09,-26.08,;36.57,-26.49,;36.65,-28.02,;35.21,-28.58,;34.81,-30.07,;25.01,-27.7,;23.47,-27.7,)| Show InChI InChI=1S/C21H22F2N4O2/c22-16-8-14(9-17(23)10-16)15-11-24-21(25-12-15)26-20(29)13-3-5-18(6-4-13)27-7-1-2-19(27)28/h8-13,18H,1-7H2,(H,24,25,26,29)/t13-,18+ | KEGG
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449329
(CHEMBL3126046)Show SMILES Fc1cc(F)cc(c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)N2CCNC2=O)nc1 |r,wU:15.15,18.22,(13.81,-25.74,;14.58,-27.07,;13.81,-28.41,;14.58,-29.74,;13.81,-31.07,;16.12,-29.74,;16.89,-28.41,;16.12,-27.07,;18.43,-28.41,;19.2,-29.74,;20.74,-29.74,;21.51,-28.41,;23.05,-28.41,;23.82,-27.07,;23.05,-25.74,;25.36,-27.07,;26.13,-28.41,;27.67,-28.41,;28.44,-27.07,;27.67,-25.74,;26.13,-25.74,;29.98,-27.07,;30.88,-28.32,;32.35,-27.84,;32.35,-26.3,;30.88,-25.82,;30.41,-24.37,;20.74,-27.07,;19.2,-27.07,)| Show InChI InChI=1S/C21H22F2N4O2/c22-16-9-15(10-17(23)11-16)14-3-6-19(25-12-14)26-20(28)13-1-4-18(5-2-13)27-8-7-24-21(27)29/h3,6,9-13,18H,1-2,4-5,7-8H2,(H,24,29)(H,25,26,28)/t13-,18+ | KEGG
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449328
(CHEMBL3126047)Show SMILES CN1CCN([C@H]2CC[C@H](CC2)C(=O)Nc2ccc(cn2)-c2cc(F)cc(F)c2)C1=O |r,wU:8.11,5.4,(36.9,-26.87,;35.62,-27.72,;35.55,-29.25,;34.07,-29.66,;33.22,-28.38,;31.68,-28.31,;30.86,-29.61,;29.32,-29.55,;28.61,-28.18,;29.44,-26.88,;30.97,-26.95,;27.07,-28.11,;26.36,-26.74,;26.25,-29.41,;24.71,-29.34,;23.88,-30.64,;22.35,-30.57,;21.64,-29.21,;22.47,-27.91,;24,-27.97,;20.1,-29.14,;19.39,-27.77,;17.86,-27.7,;17.15,-26.34,;17.03,-29,;17.74,-30.37,;16.91,-31.66,;19.27,-30.44,;34.18,-27.18,;33.76,-25.7,)| Show InChI InChI=1S/C22H24F2N4O2/c1-27-8-9-28(22(27)30)19-5-2-14(3-6-19)21(29)26-20-7-4-15(13-25-20)16-10-17(23)12-18(24)11-16/h4,7,10-14,19H,2-3,5-6,8-9H2,1H3,(H,25,26,29)/t14-,19+ | KEGG
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449326
(CHEMBL3126040)Show SMILES Fc1cc(F)cc(c1)-c1cnc(NC(=O)[C@@H]2CC[C@@H](CC2)N2CCCC2=O)cn1 |r,wU:15.15,18.22,(14.68,-24.91,;15.45,-23.57,;14.68,-22.24,;15.45,-20.91,;14.68,-19.58,;16.99,-20.91,;17.76,-22.24,;16.99,-23.57,;19.3,-22.24,;20.08,-23.57,;21.62,-23.57,;22.39,-22.24,;23.93,-22.24,;24.7,-23.57,;24,-24.95,;26.24,-23.5,;27.07,-24.79,;28.61,-24.71,;29.31,-23.33,;28.48,-22.04,;26.93,-22.13,;30.85,-23.26,;31.69,-21.96,;33.18,-22.36,;33.26,-23.9,;31.82,-24.46,;31.42,-25.94,;21.62,-20.91,;20.08,-20.91,)| Show InChI InChI=1S/C21H22F2N4O2/c22-15-8-14(9-16(23)10-15)18-11-25-19(12-24-18)26-21(29)13-3-5-17(6-4-13)27-7-1-2-20(27)28/h8-13,17H,1-7H2,(H,25,26,29)/t13-,17+ | KEGG
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| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353143
(CHEMBL1829315)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1CCC(C)(C)Sc2ccccc12 |r,wU:11.14,wD:8.7,(11.55,-30.79,;10.2,-30.05,;10.17,-28.51,;8.88,-30.85,;8.1,-32.17,;9.64,-32.17,;7.53,-30.11,;6.22,-30.91,;4.87,-30.17,;4.83,-28.63,;3.48,-27.88,;2.17,-28.69,;2.2,-30.23,;3.55,-30.96,;.82,-27.95,;-.49,-28.76,;-.45,-30.29,;-1.84,-28.02,;-3.16,-28.82,;-3.2,-30.38,;-4.45,-31.31,;-5.96,-30.92,;-5.97,-32.45,;-7.3,-31.67,;-6.59,-29.49,;-5.87,-28.11,;-6.87,-26.93,;-6.36,-25.48,;-4.84,-25.2,;-3.84,-26.36,;-4.35,-27.81,)| Show InChI InChI=1S/C23H37N3O3S2/c1-17(2)31(28,29)24-15-18-9-11-19(12-10-18)25-22(27)16-26-14-13-23(3,4)30-21-8-6-5-7-20(21)26/h5-8,17-19,24H,9-16H2,1-4H3,(H,25,27)/t18-,19- | KEGG
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| 6.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449325
(CHEMBL3126044)Show SMILES C[C@H]1CN([C@H]2CC[C@H](CC2)C(=O)Nc2ccc(cn2)-c2cc(F)cc(F)c2)C(=O)O1 |r,wU:7.10,4.3,wD:1.0,(24.06,-26.45,;22.81,-27.35,;21.34,-26.87,;20.44,-28.12,;18.9,-28.12,;18.13,-29.45,;16.59,-29.45,;15.82,-28.12,;16.59,-26.79,;18.13,-26.79,;14.28,-28.12,;13.51,-26.79,;13.51,-29.45,;11.97,-29.45,;11.2,-28.12,;9.66,-28.12,;8.89,-29.45,;9.66,-30.79,;11.2,-30.79,;7.35,-29.45,;6.58,-28.12,;5.04,-28.12,;4.27,-26.79,;4.27,-29.45,;5.04,-30.79,;4.27,-32.12,;6.58,-30.79,;21.34,-29.37,;20.87,-30.83,;22.81,-28.89,)| Show InChI InChI=1S/C22H23F2N3O3/c1-13-12-27(22(29)30-13)19-5-2-14(3-6-19)21(28)26-20-7-4-15(11-25-20)16-8-17(23)10-18(24)9-16/h4,7-11,13-14,19H,2-3,5-6,12H2,1H3,(H,25,26,28)/t13-,14-,19+/m0/s1 | KEGG
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449323
(CHEMBL3126053)Show SMILES Fc1cc(F)cc(c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)N2CCCC2=O)nc1 |r,wU:18.22,15.15,(5.33,-14.93,;6.16,-13.64,;5.46,-12.27,;6.29,-10.97,;5.58,-9.6,;7.83,-11.04,;8.53,-12.41,;7.7,-13.71,;10.07,-12.49,;10.78,-13.86,;12.32,-13.93,;13.15,-12.63,;14.69,-12.71,;15.52,-11.41,;14.88,-10,;17.05,-11.56,;17.68,-12.97,;19.22,-13.12,;20.12,-11.88,;19.48,-10.46,;17.95,-10.32,;21.65,-12.02,;22.42,-13.36,;23.92,-13.03,;24.08,-11.5,;22.67,-10.88,;22.34,-9.37,;12.45,-11.26,;10.91,-11.19,)| Show InChI InChI=1S/C22H23F2N3O2/c23-17-10-16(11-18(24)12-17)15-5-8-20(25-13-15)26-22(29)14-3-6-19(7-4-14)27-9-1-2-21(27)28/h5,8,10-14,19H,1-4,6-7,9H2,(H,25,26,29)/t14-,19+ | KEGG
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449324
(CHEMBL3126042)Show SMILES Fc1cc(F)cc(c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)N2CCOC2=O)nc1 |r,wU:15.15,18.22,(16.56,-26.33,;17.33,-24.99,;16.56,-23.66,;17.33,-22.33,;16.56,-21,;18.87,-22.33,;19.64,-23.66,;18.87,-24.99,;21.18,-23.66,;21.95,-22.33,;23.49,-22.33,;24.26,-23.66,;25.8,-23.66,;26.57,-24.99,;25.8,-26.33,;28.11,-24.99,;28.88,-26.33,;30.42,-26.33,;31.19,-24.99,;30.42,-23.66,;28.88,-23.66,;32.73,-24.99,;33.63,-26.24,;35.1,-25.76,;35.1,-24.22,;33.63,-23.75,;33.15,-22.29,;23.49,-24.99,;21.95,-24.99,)| Show InChI InChI=1S/C21H21F2N3O3/c22-16-9-15(10-17(23)11-16)14-3-6-19(24-12-14)25-20(27)13-1-4-18(5-2-13)26-7-8-29-21(26)28/h3,6,9-13,18H,1-2,4-5,7-8H2,(H,24,25,27)/t13-,18+ | KEGG
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353147
(CHEMBL1829319)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1C(=O)COc2cc(F)ccc12 |r,wU:11.14,wD:8.7,(10.22,-.38,;8.88,.4,;8.89,1.94,;7.55,-.37,;6.77,-1.7,;8.31,-1.7,;6.22,.4,;4.88,-.36,;3.55,.41,;3.55,1.95,;2.22,2.73,;.89,1.95,;.89,.41,;2.21,-.36,;-.45,2.72,;-1.78,1.95,;-1.78,.41,;-3.11,2.71,;-4.45,1.94,;-4.45,.4,;-3.12,-.37,;-5.78,-.37,;-7.11,.4,;-7.11,1.93,;-8.45,2.7,;-8.45,4.25,;-9.78,5.02,;-7.12,5.02,;-5.79,4.25,;-5.78,2.7,)| Show InChI InChI=1S/C20H28FN3O5S/c1-13(2)30(27,28)22-10-14-3-6-16(7-4-14)23-19(25)11-24-17-8-5-15(21)9-18(17)29-12-20(24)26/h5,8-9,13-14,16,22H,3-4,6-7,10-12H2,1-2H3,(H,23,25)/t14-,16- | KEGG
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| 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449321
(CHEMBL3126052)Show SMILES Fc1cc(F)cc(c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)N2CCN(C3CC3)C2=O)nc1 |r,wU:15.15,18.22,(10.52,-42.21,;11.28,-43.54,;10.49,-44.87,;11.25,-46.21,;10.46,-47.53,;12.79,-46.23,;13.57,-44.9,;12.82,-43.56,;15.11,-44.92,;15.87,-46.27,;17.41,-46.28,;18.19,-44.96,;19.73,-44.98,;20.52,-43.65,;19.76,-42.31,;22.06,-43.67,;22.81,-45.01,;24.35,-45.03,;25.14,-43.7,;24.38,-42.36,;22.84,-42.35,;26.68,-43.72,;27.57,-44.98,;29.04,-44.52,;29.05,-42.98,;30.31,-42.08,;30.95,-40.69,;31.84,-41.94,;27.59,-42.49,;27.14,-41.02,;17.44,-43.61,;15.9,-43.6,)| Show InChI InChI=1S/C24H26F2N4O2/c25-18-11-17(12-19(26)13-18)16-3-8-22(27-14-16)28-23(31)15-1-4-20(5-2-15)29-9-10-30(24(29)32)21-6-7-21/h3,8,11-15,20-21H,1-2,4-7,9-10H2,(H,27,28,31)/t15-,20+ | KEGG
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449322
(CHEMBL3126048)Show SMILES Fc1cc(F)cc(c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)N2CCCNC2=O)nc1 |r,wU:15.15,18.22,(20.67,-38.97,;21.44,-40.29,;20.68,-41.63,;21.45,-42.96,;20.69,-44.3,;22.99,-42.96,;23.75,-41.62,;22.98,-40.29,;25.29,-41.61,;26.07,-42.95,;27.6,-42.94,;28.37,-41.6,;29.91,-41.6,;30.67,-40.26,;29.9,-38.94,;32.22,-40.25,;32.99,-41.59,;34.53,-41.58,;35.29,-40.24,;34.52,-38.92,;32.98,-38.92,;36.83,-40.24,;37.6,-41.57,;39.14,-41.56,;39.91,-40.23,;39.13,-38.9,;37.6,-38.91,;36.82,-37.58,;27.6,-40.27,;26.06,-40.28,)| Show InChI InChI=1S/C22H24F2N4O2/c23-17-10-16(11-18(24)12-17)15-4-7-20(26-13-15)27-21(29)14-2-5-19(6-3-14)28-9-1-8-25-22(28)30/h4,7,10-14,19H,1-3,5-6,8-9H2,(H,25,30)(H,26,27,29)/t14-,19+ | KEGG
UniProtKB/SwissProt
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UniChem
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PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353160
(CHEMBL1829332)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2cc(ccc12)C(F)(F)F |r,wU:8.7,wD:11.14,(32.37,-.82,;31.04,-.05,;31.04,1.49,;29.7,-.81,;28.92,-2.14,;30.46,-2.14,;28.37,-.04,;27.03,-.81,;25.7,-.04,;24.36,-.8,;23.04,-.03,;23.04,1.51,;24.37,2.28,;25.7,1.51,;21.7,2.28,;20.37,1.5,;19.04,2.27,;17.7,1.5,;17.7,-.04,;16.37,-.81,;15.04,-.04,;15.04,1.49,;13.7,2.26,;13.7,3.8,;15.03,4.57,;16.37,3.81,;16.37,2.26,;12.37,4.57,;12.37,6.11,;11.03,3.8,;11.03,5.34,)| Show InChI InChI=1S/C21H32F3N3O3S/c1-15(2)31(28,29)26-14-16-3-6-18(7-4-16)25-9-10-27-11-12-30-20-13-17(21(22,23)24)5-8-19(20)27/h5,8,13,15-16,18,25-26H,3-4,6-7,9-12,14H2,1-2H3/t16-,18- | KEGG
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| 9.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449320
(CHEMBL3126050)Show SMILES CCN1CCN([C@H]2CC[C@H](CC2)C(=O)Nc2ccc(cn2)-c2cc(F)cc(F)c2)C1=O |r,wU:9.12,6.5,(35.65,-39.74,;34.26,-39.09,;33,-39.97,;32.97,-41.51,;31.5,-41.95,;30.61,-40.69,;29.07,-40.67,;28.27,-41.99,;26.73,-41.96,;25.99,-40.61,;26.78,-39.29,;28.32,-39.31,;24.45,-40.58,;23.7,-39.23,;23.65,-41.9,;22.11,-41.87,;21.32,-43.18,;19.78,-43.15,;19.03,-41.81,;19.83,-40.49,;21.37,-40.52,;17.49,-41.78,;16.75,-40.43,;15.21,-40.4,;14.47,-39.05,;14.41,-41.72,;15.16,-43.07,;14.36,-44.39,;16.7,-43.1,;31.54,-39.46,;31.09,-38,)| Show InChI InChI=1S/C23H26F2N4O2/c1-2-28-9-10-29(23(28)31)20-6-3-15(4-7-20)22(30)27-21-8-5-16(14-26-21)17-11-18(24)13-19(25)12-17/h5,8,11-15,20H,2-4,6-7,9-10H2,1H3,(H,26,27,30)/t15-,20+ | KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449319
(CHEMBL3126049)Show SMILES CN1CCCN([C@H]2CC[C@H](CC2)C(=O)Nc2ccc(cn2)-c2cc(F)cc(F)c2)C1=O |r,wU:9.12,6.5,(29.98,-38.65,;29.2,-39.98,;29.96,-41.32,;29.19,-42.65,;27.65,-42.65,;26.88,-41.31,;25.34,-41.3,;24.57,-42.63,;23.03,-42.62,;22.26,-41.28,;23.04,-39.95,;24.58,-39.96,;20.72,-41.28,;19.96,-39.94,;19.95,-42.61,;18.41,-42.6,;17.63,-43.93,;16.09,-43.92,;15.33,-42.59,;16.1,-41.25,;17.64,-41.26,;13.79,-42.58,;13.02,-41.24,;11.48,-41.23,;10.72,-39.89,;10.71,-42.56,;11.47,-43.9,;10.7,-45.23,;13.01,-43.9,;27.66,-39.97,;26.9,-38.63,)| Show InChI InChI=1S/C23H26F2N4O2/c1-28-9-2-10-29(23(28)31)20-6-3-15(4-7-20)22(30)27-21-8-5-16(14-26-21)17-11-18(24)13-19(25)12-17/h5,8,11-15,20H,2-4,6-7,9-10H2,1H3,(H,26,27,30)/t15-,20+ | KEGG
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353159
(CHEMBL1829331)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2cc(Cl)ccc12 |r,wU:8.7,wD:11.14,(10.45,-.43,;9.12,.34,;9.12,1.88,;7.78,-.43,;7,-1.75,;8.54,-1.75,;6.45,.35,;5.11,-.42,;3.78,.35,;2.45,-.41,;1.12,.36,;1.12,1.9,;2.45,2.67,;3.78,1.9,;-.21,2.66,;-1.55,1.89,;-2.88,2.66,;-4.21,1.89,;-4.22,.35,;-5.55,-.42,;-6.88,.35,;-6.88,1.88,;-8.22,2.65,;-8.22,4.19,;-9.55,4.96,;-6.89,4.96,;-5.55,4.2,;-5.55,2.65,)| Show InChI InChI=1S/C20H32ClN3O3S/c1-15(2)28(25,26)23-14-16-3-6-18(7-4-16)22-9-10-24-11-12-27-20-13-17(21)5-8-19(20)24/h5,8,13,15-16,18,22-23H,3-4,6-7,9-12,14H2,1-2H3/t16-,18- | KEGG
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353142
(CHEMBL1829314)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1c2ccccc2SC(C)(C)CC1=O |r,wU:11.14,wD:8.7,(30.6,-20.93,;29.25,-20.19,;29.21,-18.65,;27.93,-20.99,;27.15,-22.31,;28.69,-22.31,;26.58,-20.25,;25.26,-21.05,;23.91,-20.31,;23.88,-18.77,;22.53,-18.02,;21.22,-18.83,;21.25,-20.37,;22.6,-21.1,;19.87,-18.09,;18.56,-18.9,;18.6,-20.44,;17.2,-18.16,;15.89,-18.96,;14.7,-17.95,;15.21,-16.5,;14.21,-15.34,;12.69,-15.62,;12.17,-17.07,;13.18,-18.25,;12.45,-19.63,;13.09,-21.06,;13.08,-22.59,;11.75,-21.82,;14.6,-21.45,;15.85,-20.52,;17.22,-21.23,)| Show InChI InChI=1S/C23H35N3O4S2/c1-16(2)32(29,30)24-14-17-9-11-18(12-10-17)25-21(27)15-26-19-7-5-6-8-20(19)31-23(3,4)13-22(26)28/h5-8,16-18,24H,9-15H2,1-4H3,(H,25,27)/t17-,18- | KEGG
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353145
(CHEMBL1829317)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1C(=O)COc2ccccc12 |r,wU:11.14,wD:8.7,(9.85,-41.33,;8.52,-40.55,;8.52,-39.01,;7.18,-41.32,;6.4,-42.65,;7.94,-42.65,;5.85,-40.55,;4.52,-41.31,;3.18,-40.54,;3.19,-39,;1.85,-38.22,;.52,-39,;.52,-40.54,;1.85,-41.31,;-.81,-38.23,;-2.15,-39,;-2.14,-40.54,;-3.48,-38.24,;-4.81,-39.01,;-4.82,-40.55,;-3.48,-41.32,;-6.15,-41.32,;-7.48,-40.55,;-7.48,-39.02,;-8.82,-38.25,;-8.81,-36.7,;-7.49,-35.93,;-6.15,-36.7,;-6.15,-38.25,)| Show InChI InChI=1S/C20H29N3O5S/c1-14(2)29(26,27)21-11-15-7-9-16(10-8-15)22-19(24)12-23-17-5-3-4-6-18(17)28-13-20(23)25/h3-6,14-16,21H,7-13H2,1-2H3,(H,22,24)/t15-,16- | KEGG
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353144
(CHEMBL1829316)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1CCC(C)(C)S(=O)(=O)c2ccccc12 |r,wU:11.14,wD:8.7,(34.12,-30.75,;32.77,-30.01,;32.73,-28.47,;31.45,-30.81,;30.67,-32.13,;32.21,-32.13,;30.1,-30.07,;28.79,-30.87,;27.44,-30.13,;27.4,-28.59,;26.05,-27.84,;24.74,-28.65,;24.77,-30.19,;26.12,-30.92,;23.39,-27.91,;22.08,-28.72,;22.12,-30.25,;20.73,-27.98,;19.41,-28.78,;19.37,-30.34,;18.12,-31.27,;16.61,-30.88,;16.6,-32.41,;15.27,-31.63,;15.98,-29.45,;14.87,-30.54,;14.63,-28.68,;16.7,-28.07,;15.7,-26.89,;16.21,-25.44,;17.73,-25.16,;18.73,-26.32,;18.22,-27.77,)| Show InChI InChI=1S/C23H37N3O5S2/c1-17(2)33(30,31)24-15-18-9-11-19(12-10-18)25-22(27)16-26-14-13-23(3,4)32(28,29)21-8-6-5-7-20(21)26/h5-8,17-19,24H,9-16H2,1-4H3,(H,25,27)/t18-,19- | KEGG
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353137
(CHEMBL1829309)Show SMILES CN(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1c2ccccc2SC(C)(C)CC1=O |r,wU:11.14,wD:8.7,(10.2,.26,;8.85,1,;8.82,2.54,;7.54,.2,;6.76,-1.12,;8.3,-1.12,;6.19,.94,;4.87,.15,;3.52,.89,;3.49,2.43,;2.13,3.17,;.83,2.36,;.86,.82,;2.2,.09,;-.52,3.1,;-1.84,2.3,;-1.8,.76,;-3.19,3.03,;-4.5,2.23,;-5.69,3.24,;-5.19,4.69,;-6.19,5.86,;-7.71,5.58,;-8.22,4.12,;-7.22,2.94,;-7.94,1.56,;-7.3,.13,;-7.32,-1.4,;-8.65,-.62,;-5.79,-.26,;-4.54,.67,;-3.18,-.04,)| Show InChI InChI=1S/C22H34N4O4S2/c1-22(2)13-21(28)26(18-7-5-6-8-19(18)31-22)15-20(27)24-17-11-9-16(10-12-17)14-23-32(29,30)25(3)4/h5-8,16-17,23H,9-15H2,1-4H3,(H,24,27)/t16-,17- | KEGG
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449318
(CHEMBL3126051)Show SMILES CC(C)N1CCN([C@H]2CC[C@H](CC2)C(=O)Nc2ccc(cn2)-c2cc(F)cc(F)c2)C1=O |r,wU:10.13,7.6,(31.81,-39.8,;32.04,-41.33,;33.45,-41.95,;30.8,-42.22,;30.79,-43.76,;29.33,-44.23,;28.42,-42.98,;26.88,-42.97,;26.11,-44.31,;24.57,-44.3,;23.8,-42.96,;24.58,-41.64,;26.12,-41.64,;22.27,-42.96,;21.5,-41.63,;21.49,-44.29,;19.95,-44.28,;19.18,-45.62,;17.64,-45.61,;16.88,-44.27,;17.65,-42.94,;19.19,-42.95,;15.34,-44.27,;14.57,-42.93,;13.03,-42.93,;12.27,-41.6,;12.26,-44.26,;13.02,-45.6,;12.25,-46.93,;14.56,-45.6,;29.34,-41.74,;28.86,-40.28,)| Show InChI InChI=1S/C24H28F2N4O2/c1-15(2)29-9-10-30(24(29)32)21-6-3-16(4-7-21)23(31)28-22-8-5-17(14-27-22)18-11-19(25)13-20(26)12-18/h5,8,11-16,21H,3-4,6-7,9-10H2,1-2H3,(H,27,28,31)/t16-,21+ | KEGG
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353158
(CHEMBL1829330)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2ccc(Cl)cc12 |r,wU:8.7,wD:11.14,(32.62,-44.4,;31.29,-43.63,;31.29,-42.08,;29.95,-44.4,;29.17,-45.72,;30.71,-45.72,;28.62,-43.62,;27.28,-44.39,;25.95,-43.61,;24.62,-44.38,;23.29,-43.61,;23.29,-42.07,;24.62,-41.3,;25.95,-42.07,;21.95,-41.31,;20.62,-42.07,;19.28,-41.31,;17.95,-42.08,;17.95,-43.62,;16.61,-44.39,;15.28,-43.62,;15.28,-42.09,;13.95,-41.32,;13.95,-39.78,;15.28,-39,;15.27,-37.46,;16.61,-39.77,;16.62,-41.32,)| Show InChI InChI=1S/C20H32ClN3O3S/c1-15(2)28(25,26)23-14-16-3-6-18(7-4-16)22-9-10-24-11-12-27-20-8-5-17(21)13-19(20)24/h5,8,13,15-16,18,22-23H,3-4,6-7,9-12,14H2,1-2H3/t16-,18- | KEGG
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| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353157
(CHEMBL1829329)Show SMILES COc1ccc2N(CCN[C@H]3CC[C@H](CNS(=O)(=O)C(C)C)CC3)CCOc2c1 |r,wU:13.13,wD:10.9,(-9.34,-36.38,;-9.34,-37.92,;-8.01,-38.7,;-6.68,-37.92,;-5.34,-38.69,;-5.34,-40.24,;-4,-41,;-2.67,-40.23,;-1.34,-40.99,;-.01,-40.22,;1.32,-40.99,;1.32,-42.53,;2.65,-43.3,;3.99,-42.53,;5.32,-43.31,;6.65,-42.53,;7.98,-43.31,;7.2,-44.64,;8.74,-44.64,;9.31,-42.54,;10.64,-43.32,;9.32,-41,;3.99,-40.99,;2.65,-40.22,;-4.01,-42.54,;-5.34,-43.31,;-6.67,-42.53,;-6.67,-41,;-8.01,-40.24,)| Show InChI InChI=1S/C21H35N3O4S/c1-16(2)29(25,26)23-15-17-4-6-18(7-5-17)22-10-11-24-12-13-28-21-14-19(27-3)8-9-20(21)24/h8-9,14,16-18,22-23H,4-7,10-13,15H2,1-3H3/t17-,18- | KEGG
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| 88 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353146
(CHEMBL1829318)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1C(=O)COc2ccc(F)cc12 |r,wU:11.14,wD:8.7,(33.95,-41.42,;32.61,-40.65,;32.62,-39.11,;31.28,-41.41,;30.5,-42.74,;32.04,-42.74,;29.95,-40.64,;28.61,-41.41,;27.28,-40.64,;27.28,-39.09,;25.95,-38.32,;24.62,-39.09,;24.62,-40.63,;25.94,-41.4,;23.28,-38.32,;21.95,-39.1,;21.95,-40.64,;20.62,-38.33,;19.28,-39.1,;19.28,-40.64,;20.61,-41.41,;17.95,-41.41,;16.62,-40.64,;16.62,-39.11,;15.28,-38.34,;15.28,-36.8,;16.61,-36.03,;16.6,-34.49,;17.94,-36.79,;17.95,-38.34,)| Show InChI InChI=1S/C20H28FN3O5S/c1-13(2)30(27,28)22-10-14-3-6-16(7-4-14)23-19(25)11-24-17-9-15(21)5-8-18(17)29-12-20(24)26/h5,8-9,13-14,16,22H,3-4,6-7,10-12H2,1-2H3,(H,23,25)/t14-,16- | KEGG
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| 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353156
(CHEMBL1829328)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2cc(F)c(F)cc12 |r,wU:8.7,wD:11.14,(32.07,-34.92,;30.74,-34.14,;30.74,-32.6,;29.4,-34.91,;28.62,-36.23,;30.16,-36.23,;28.08,-34.13,;26.74,-34.9,;25.41,-34.13,;24.07,-34.89,;22.74,-34.12,;22.75,-32.59,;24.07,-31.81,;25.41,-32.59,;21.41,-31.82,;20.08,-32.59,;18.74,-31.83,;17.42,-32.59,;17.42,-34.13,;16.08,-34.91,;14.75,-34.13,;14.75,-32.6,;13.41,-31.84,;13.42,-30.29,;12.08,-29.52,;14.74,-29.52,;14.74,-27.98,;16.08,-30.29,;16.09,-31.84,)| Show InChI InChI=1S/C20H31F2N3O3S/c1-14(2)29(26,27)24-13-15-3-5-16(6-4-15)23-7-8-25-9-10-28-20-12-18(22)17(21)11-19(20)25/h11-12,14-16,23-24H,3-10,13H2,1-2H3/t15-,16- | KEGG
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PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353155
(CHEMBL1829327)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2ccc(F)cc12 |r,wU:8.7,wD:11.14,(9.66,-34.35,;8.32,-33.57,;8.33,-32.03,;6.99,-34.34,;6.21,-35.67,;7.75,-35.67,;5.65,-33.56,;4.32,-34.34,;2.98,-33.56,;1.65,-34.33,;.32,-33.56,;.33,-32.02,;1.65,-31.24,;2.98,-32.02,;-1.01,-31.25,;-2.34,-32.02,;-3.68,-31.26,;-5.01,-32.02,;-5.02,-33.57,;-6.35,-34.34,;-7.68,-33.56,;-7.68,-32.03,;-9.01,-31.27,;-9.01,-29.72,;-7.69,-28.95,;-7.69,-27.41,;-6.35,-29.72,;-6.35,-31.27,)| Show InChI InChI=1S/C20H32FN3O3S/c1-15(2)28(25,26)23-14-16-3-6-18(7-4-16)22-9-10-24-11-12-27-20-8-5-17(21)13-19(20)24/h5,8,13,15-16,18,22-23H,3-4,6-7,9-12,14H2,1-2H3/t16-,18- | KEGG
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PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353140
(CHEMBL1829312)Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1c2ccccc2SC(C)(C)CC1=O |r,wU:10.13,wD:7.6,(34.12,-10.51,;32.78,-9.77,;31.46,-10.57,;30.68,-11.89,;32.22,-11.89,;30.11,-9.82,;28.79,-10.62,;27.44,-9.88,;27.41,-8.34,;26.06,-7.6,;24.75,-8.4,;24.78,-9.94,;26.13,-10.68,;23.4,-7.67,;22.09,-8.47,;22.13,-10.01,;20.73,-7.74,;19.42,-8.54,;18.23,-7.53,;18.74,-6.08,;17.74,-4.91,;16.22,-5.19,;15.7,-6.64,;16.71,-7.82,;15.98,-9.21,;16.62,-10.64,;16.61,-12.17,;15.28,-11.39,;18.13,-11.02,;19.38,-10.09,;20.75,-10.8,)| Show InChI InChI=1S/C22H33N3O4S2/c1-4-31(28,29)23-14-16-9-11-17(12-10-16)24-20(26)15-25-18-7-5-6-8-19(18)30-22(2,3)13-21(25)27/h5-8,16-17,23H,4,9-15H2,1-3H3,(H,24,26)/t16-,17- | KEGG
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PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353141
(CHEMBL1829313)Show SMILES CC1(C)CC(=O)N(CC(=O)N[C@H]2CC[C@H](CNS(=O)(=O)C3CC3)CC2)c2ccccc2S1 |r,wU:11.10,wD:14.14,(-7.58,-23.09,;-7.57,-21.56,;-8.91,-22.31,;-6.06,-21.95,;-4.81,-21.02,;-3.44,-21.73,;-4.77,-19.46,;-3.45,-18.66,;-2.1,-19.39,;-2.06,-20.93,;-.79,-18.59,;.57,-19.32,;1.87,-18.52,;3.22,-19.26,;3.26,-20.8,;4.61,-21.54,;5.93,-20.75,;7.27,-21.49,;6.49,-22.81,;8.03,-22.81,;8.59,-20.69,;10.12,-20.65,;9.33,-19.34,;1.94,-21.6,;.6,-20.86,;-5.96,-18.45,;-5.45,-17,;-6.45,-15.83,;-7.97,-16.11,;-8.49,-17.56,;-7.48,-18.74,;-8.2,-20.13,)| Show InChI InChI=1S/C23H33N3O4S2/c1-23(2)13-22(28)26(19-5-3-4-6-20(19)31-23)15-21(27)25-17-9-7-16(8-10-17)14-24-32(29,30)18-11-12-18/h3-6,16-18,24H,7-15H2,1-2H3,(H,25,27)/t16-,17- | KEGG
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| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353161
(CHEMBL1829333)Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCSc2cc(Cl)ccc12 |r,wU:8.7,wD:11.14,(10.64,-8.81,;9.31,-8.04,;9.32,-6.5,;7.98,-8.8,;7.19,-10.13,;8.73,-10.13,;6.64,-8.03,;5.31,-8.8,;3.98,-8.02,;2.64,-8.79,;1.31,-8.02,;1.32,-6.48,;2.64,-5.7,;3.98,-6.48,;-.02,-5.71,;-1.35,-6.48,;-2.69,-5.72,;-4.02,-6.49,;-4.02,-8.03,;-5.35,-8.8,;-6.68,-8.03,;-6.68,-6.5,;-8.02,-5.73,;-8.02,-4.18,;-9.36,-3.41,;-6.69,-3.41,;-5.36,-4.18,;-5.35,-5.73,)| Show InChI InChI=1S/C20H32ClN3O2S2/c1-15(2)28(25,26)23-14-16-3-6-18(7-4-16)22-9-10-24-11-12-27-20-13-17(21)5-8-19(20)24/h5,8,13,15-16,18,22-23H,3-4,6-7,9-12,14H2,1-2H3/t16-,18- | KEGG
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| 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353138
(CHEMBL1829310)Show SMILES CN(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1c2ccccc2SCCC1=O |r,wU:11.14,wD:8.7,(32.54,-1.69,;31.19,-.95,;31.16,.59,;29.87,-1.75,;29.09,-3.07,;30.63,-3.07,;28.52,-1.01,;27.21,-1.81,;25.86,-1.07,;25.82,.48,;24.47,1.22,;23.17,.41,;23.2,-1.13,;24.54,-1.86,;21.81,1.15,;20.5,.35,;20.54,-1.19,;19.15,1.08,;17.83,.28,;16.64,1.29,;17.15,2.74,;16.15,3.91,;14.63,3.62,;14.12,2.17,;15.12,.99,;14.4,-.39,;15.03,-1.82,;16.55,-2.21,;17.79,-1.28,;19.16,-1.99,)| Show InChI InChI=1S/C20H30N4O4S2/c1-23(2)30(27,28)21-13-15-7-9-16(10-8-15)22-19(25)14-24-17-5-3-4-6-18(17)29-12-11-20(24)26/h3-6,15-16,21H,7-14H2,1-2H3,(H,22,25)/t15-,16- | KEGG
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| 420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449317
(CHEMBL3126054)Show SMILES Fc1cc(F)cc(c1)-c1ccc(NC(=O)[C@H]2CC[C@@H](CC2)N2CCCC2=O)nc1 |r,wU:18.22,wD:15.15,(19.4,-21.94,;20.17,-20.6,;19.4,-19.27,;20.17,-17.93,;19.4,-16.6,;21.71,-17.93,;22.48,-19.27,;21.71,-20.6,;24.02,-19.27,;24.79,-17.93,;26.33,-17.93,;27.1,-19.27,;28.64,-19.27,;29.41,-20.6,;28.71,-21.98,;30.94,-20.52,;31.78,-21.81,;33.32,-21.74,;34.02,-20.36,;33.18,-19.07,;31.64,-19.15,;35.56,-20.28,;36.4,-18.99,;37.88,-19.39,;37.97,-20.92,;36.53,-21.48,;36.12,-22.96,;26.33,-20.6,;24.79,-20.6,)| Show InChI InChI=1S/C22H23F2N3O2/c23-17-10-16(11-18(24)12-17)15-5-8-20(25-13-15)26-22(29)14-3-6-19(7-4-14)27-9-1-2-21(27)28/h5,8,10-14,19H,1-4,6-7,9H2,(H,25,26,29)/t14-,19- | KEGG
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| 720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50353139
(CHEMBL1829311)Show SMILES CC1(C)CC(=O)N(CC(=O)N[C@H]2CC[C@H](CNS(C)(=O)=O)CC2)c2ccccc2S1 |r,wU:11.10,wD:14.14,(-6.39,-11.75,;-6.38,-10.22,;-7.72,-10.98,;-4.87,-10.61,;-3.62,-9.68,;-2.25,-10.39,;-3.58,-8.13,;-2.26,-7.32,;-.91,-8.06,;-.87,-9.6,;.4,-7.25,;1.75,-7.99,;3.06,-7.18,;4.41,-7.93,;4.45,-9.47,;5.8,-10.21,;7.11,-9.41,;8.46,-10.15,;9.78,-9.35,;7.68,-11.47,;9.22,-11.47,;3.13,-10.27,;1.78,-9.53,;-4.77,-7.12,;-4.26,-5.66,;-5.26,-4.5,;-6.78,-4.78,;-7.29,-6.23,;-6.29,-7.41,;-7.01,-8.8,)| Show InChI InChI=1S/C21H31N3O4S2/c1-21(2)12-20(26)24(17-6-4-5-7-18(17)29-21)14-19(25)23-16-10-8-15(9-11-16)13-22-30(3,27)28/h4-7,15-16,22H,8-14H2,1-3H3,(H,23,25)/t15-,16- | KEGG
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| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation counting |
Bioorg Med Chem Lett 21: 5573-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.078
BindingDB Entry DOI: 10.7270/Q2TQ61X3 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50449316
(CHEMBL3126038)Show SMILES CN(C(=O)[C@@H]1CC[C@@H](CC1)N1CCCC1=O)c1ccc(cn1)-c1cc(F)cc(F)c1 |r,wU:4.3,7.10,(22.11,-20.01,;21.36,-21.35,;22.17,-22.67,;21.43,-24.02,;23.71,-22.63,;24.51,-23.94,;26.05,-23.9,;26.78,-22.55,;25.99,-21.23,;24.44,-21.28,;28.33,-22.51,;29.2,-21.24,;30.67,-21.68,;30.71,-23.22,;29.27,-23.73,;28.83,-25.21,;19.83,-21.36,;19.04,-20.03,;17.5,-20.04,;16.74,-21.38,;17.52,-22.7,;19.06,-22.69,;15.2,-21.39,;14.44,-22.73,;12.9,-22.74,;12.14,-24.08,;12.12,-21.42,;12.88,-20.08,;12.1,-18.75,;14.42,-20.06,)| Show InChI InChI=1S/C23H25F2N3O2/c1-27(21-9-6-16(14-26-21)17-11-18(24)13-19(25)12-17)23(30)15-4-7-20(8-5-15)28-10-2-3-22(28)29/h6,9,11-15,20H,2-5,7-8,10H2,1H3/t15-,20+ | KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation counting |
Bioorg Med Chem Lett 24: 1458-61 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.023
BindingDB Entry DOI: 10.7270/Q2S75HT1 |
More data for this
Ligand-Target Pair | |
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