Compile Data Set for Download or QSAR

Found 102 hits with Last Name = 'molineaux' and Initial = 's'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255524 (N4-[(2,2-Difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]...) Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)=C1 |c:6,36| Show InChI InChI=1S/C22H21F3N6O4/c1-11-3-4-13(8-17(11)34-10-18(32)26-2)29-21-27-9-14(23)19(31-21)28-12-5-6-16-15(7-12)30-20(33)22(24,25)35-16/h5-9H,3-4,10H2,1-2H3,(H,26,32)(H,30,33)(H2,27,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50396071 (CHEMBL2170582 | US10828301, Compound R921303) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255515 (US10828301, Compound R950368 | US9499493, R950368) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCC(N)c4c3)n2)c1 Show InChI InChI=1S/C22H23FN6O3/c1-25-20(30)12-32-15-4-2-3-13(9-15)28-22-26-11-17(23)21(29-22)27-14-5-6-19-16(10-14)18(24)7-8-31-19/h2-6,9-11,18H,7-8,12,24H2,1H3,(H,25,30)(H2,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255515 (US10828301, Compound R950368 | US9499493, R950368) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCC(N)c4c3)n2)c1 Show InChI InChI=1S/C22H23FN6O3/c1-25-20(30)12-32-15-4-2-3-13(9-15)28-22-26-11-17(23)21(29-22)27-14-5-6-19-16(10-14)18(24)7-8-31-19/h2-6,9-11,18H,7-8,12,24H2,1H3,(H,25,30)(H2,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255514 (US10828301, Compound R921304 | US9499493, R921304) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4n3)n2)c1 Show InChI InChI=1S/C20H18FN7O4/c1-22-16(29)9-31-12-4-2-3-11(7-12)24-20-23-8-13(21)18(28-20)25-15-6-5-14-19(26-15)27-17(30)10-32-14/h2-8H,9-10H2,1H3,(H,22,29)(H3,23,24,25,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255514 (US10828301, Compound R921304 | US9499493, R921304) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4n3)n2)c1 Show InChI InChI=1S/C20H18FN7O4/c1-22-16(29)9-31-12-4-2-3-11(7-12)24-20-23-8-13(21)18(28-20)25-15-6-5-14-19(26-15)27-17(30)10-32-14/h2-8H,9-10H2,1H3,(H,22,29)(H3,23,24,25,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255518 ((+/-)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-phenox...) Show SMILES COC1=CCCC(Nc2ncc(F)c(Nc3ccc4OC(C)CNc4c3)n2)=C1NC(C)=O |c:29,t:2| Show InChI InChI=1S/C22H25FN6O3/c1-12-10-24-17-9-14(7-8-18(17)32-12)27-21-15(23)11-25-22(29-21)28-16-5-4-6-19(31-3)20(16)26-13(2)30/h6-9,11-12,24H,4-5,10H2,1-3H3,(H,26,30)(H2,25,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM471742 ((+/−)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-...) Show SMILES CNC(=O)Oc1cccc(Nc2ncc(F)c(Nc3ccc4OC(C)C=Nc4c3)n2)c1 |c:25| Show InChI InChI=1S/C21H19FN6O3/c1-12-10-24-17-9-14(6-7-18(17)30-12)26-19-16(22)11-25-20(28-19)27-13-4-3-5-15(8-13)31-21(29)23-2/h3-12H,1-2H3,(H,23,29)(H2,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255508 (US10828301, Compound R935302 | US9499493, R935302) Show SMILES OCCCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12 Show InChI InChI=1S/C22H21FN6O3/c23-17-13-24-22(27-15-2-4-18-14(10-15)12-25-29(18)6-1-7-30)28-21(17)26-16-3-5-19-20(11-16)32-9-8-31-19/h2-5,10-13,30H,1,6-9H2,(H2,24,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255508 (US10828301, Compound R935302 | US9499493, R935302) Show SMILES OCCCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12 Show InChI InChI=1S/C22H21FN6O3/c23-17-13-24-22(27-15-2-4-18-14(10-15)12-25-29(18)6-1-7-30)28-21(17)26-16-3-5-19-20(11-16)32-9-8-31-19/h2-5,10-13,30H,1,6-9H2,(H2,24,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255513 (US10828301, Compound R940338 | US9499493, R940338) Show SMILES Cn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OC(C)(C)C(=O)Nc5c4)n3)ccc12 Show InChI InChI=1S/C22H20FN7O2/c1-22(2)20(31)28-16-9-14(5-7-18(16)32-22)26-19-15(23)11-24-21(29-19)27-13-4-6-17-12(8-13)10-25-30(17)3/h4-11H,1-3H3,(H,28,31)(H2,24,26,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255513 (US10828301, Compound R940338 | US9499493, R940338) Show SMILES Cn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OC(C)(C)C(=O)Nc5c4)n3)ccc12 Show InChI InChI=1S/C22H20FN7O2/c1-22(2)20(31)28-16-9-14(5-7-18(16)32-22)26-19-15(23)11-24-21(29-19)27-13-4-6-17-12(8-13)10-25-30(17)3/h4-11H,1-3H3,(H,28,31)(H2,24,26,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM471768 (N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)c1 Show InChI InChI=1S/C22H22FN7O4/c1-22(2)20(32)29-19-15(34-22)7-8-16(28-19)27-18-14(23)10-25-21(30-18)26-12-5-4-6-13(9-12)33-11-17(31)24-3/h4-10H,11H2,1-3H3,(H,24,31)(H3,25,26,27,28,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255525 (N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...) Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)=C1 |c:6,36| Show InChI InChI=1S/C23H26FN7O4/c1-12-5-6-13(9-16(12)34-11-18(32)25-4)27-22-26-10-14(24)19(31-22)28-17-8-7-15-20(29-17)30-21(33)23(2,3)35-15/h7-10H,5-6,11H2,1-4H3,(H,25,32)(H3,26,27,28,29,30,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM471741 (N4-(1,4-Benzoxazine-3-on-6-yl)-5-fluoro-N2-(3-hydr...) Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3ccc4OCC=Nc4c3)n2)c1 |c:20| Show InChI InChI=1S/C18H14FN5O2/c19-14-10-21-18(23-11-2-1-3-13(25)8-11)24-17(14)22-12-4-5-16-15(9-12)20-6-7-26-16/h1-6,8-10,25H,7H2,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37.8	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255501 (US9499493, R908702) Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C18H14FN5O3/c19-13-8-20-18(22-10-2-1-3-12(25)6-10)24-17(13)21-11-4-5-15-14(7-11)23-16(26)9-27-15/h1-8,25H,9H2,(H,23,26)(H2,20,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37.8	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255509 (US10828301, Compound R935304 | US9499493, R935304) Show SMILES OCCCn1ncc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc12 Show InChI InChI=1S/C20H19FN6O2/c21-17-12-22-20(26-19(17)24-14-3-1-4-16(29)10-14)25-15-5-6-18-13(9-15)11-23-27(18)7-2-8-28/h1,3-6,9-12,28-29H,2,7-8H2,(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255509 (US10828301, Compound R935304 | US9499493, R935304) Show SMILES OCCCn1ncc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc12 Show InChI InChI=1S/C20H19FN6O2/c21-17-12-22-20(26-19(17)24-14-3-1-4-16(29)10-14)25-15-5-6-18-13(9-15)11-23-27(18)7-2-8-28/h1,3-6,9-12,28-29H,2,7-8H2,(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255488 (US10828301, Compound R935191 | US9499493, R935191) Show SMILES Oc1cccc(Nc2nc(Nc3ccc4cn[nH]c4c3)ncc2F)c1 Show InChI InChI=1S/C17H13FN6O/c18-14-9-19-17(22-12-5-4-10-8-20-24-15(10)7-12)23-16(14)21-11-2-1-3-13(25)6-11/h1-9,25H,(H,20,24)(H2,19,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255488 (US10828301, Compound R935191 | US9499493, R935191) Show SMILES Oc1cccc(Nc2nc(Nc3ccc4cn[nH]c4c3)ncc2F)c1 Show InChI InChI=1S/C17H13FN6O/c18-14-9-19-17(22-12-5-4-10-8-20-24-15(10)7-12)23-16(14)21-11-2-1-3-13(25)6-11/h1-9,25H,(H,20,24)(H2,19,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255506 (US9499493, R935237) Show SMILES COC(=O)Cn1ncc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc12 Show InChI InChI=1S/C20H17FN6O3/c1-30-18(29)11-27-17-6-5-14(7-12(17)9-23-27)25-20-22-10-16(21)19(26-20)24-13-3-2-4-15(28)8-13/h2-10,28H,11H2,1H3,(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM471755 (5-Fluoro-N4-(3-hydroxyphenyl)-N2-[1-(methoxycarbon...) Show SMILES COC(=O)n1ncc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc12 Show InChI InChI=1S/C19H15FN6O3/c1-29-19(28)26-16-6-5-13(7-11(16)9-22-26)24-18-21-10-15(20)17(25-18)23-12-3-2-4-14(27)8-12/h2-10,27H,1H3,(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255487 (US10828301, Compound R935190 | US9499493, R935190) Show SMILES Fc1cnc(Nc2ccc3cn[nH]c3c2)nc1Nc1ccc2OCCOc2c1 Show InChI InChI=1S/C19H15FN6O2/c20-14-10-21-19(24-12-2-1-11-9-22-26-15(11)7-12)25-18(14)23-13-3-4-16-17(8-13)28-6-5-27-16/h1-4,7-10H,5-6H2,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255507 (US10828301, Compound R935293 | US9499493, R935293) Show SMILES OCCCn1ncc2ccc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)cc12 Show InChI InChI=1S/C20H19FN6O2/c21-17-12-22-20(26-19(17)24-14-3-1-4-16(29)9-14)25-15-6-5-13-11-23-27(7-2-8-28)18(13)10-15/h1,3-6,9-12,28-29H,2,7-8H2,(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255487 (US10828301, Compound R935190 | US9499493, R935190) Show SMILES Fc1cnc(Nc2ccc3cn[nH]c3c2)nc1Nc1ccc2OCCOc2c1 Show InChI InChI=1S/C19H15FN6O2/c20-14-10-21-19(24-12-2-1-11-9-22-26-15(11)7-12)25-18(14)23-13-3-4-16-17(8-13)28-6-5-27-16/h1-4,7-10H,5-6H2,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255507 (US10828301, Compound R935293 | US9499493, R935293) Show SMILES OCCCn1ncc2ccc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)cc12 Show InChI InChI=1S/C20H19FN6O2/c21-17-12-22-20(26-19(17)24-14-3-1-4-16(29)9-14)25-15-6-5-13-11-23-27(7-2-8-28)18(13)10-15/h1,3-6,9-12,28-29H,2,7-8H2,(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255505 (US10828301, Compound R926839 | US9499493, R926839) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(C)c(Cl)c3)n2)c1 Show InChI InChI=1S/C20H19ClFN5O2/c1-12-6-7-14(9-16(12)21)25-19-17(22)10-24-20(27-19)26-13-4-3-5-15(8-13)29-11-18(28)23-2/h3-10H,11H2,1-2H3,(H,23,28)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255505 (US10828301, Compound R926839 | US9499493, R926839) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(C)c(Cl)c3)n2)c1 Show InChI InChI=1S/C20H19ClFN5O2/c1-12-6-7-14(9-16(12)21)25-19-17(22)10-24-20(27-19)26-13-4-3-5-15(8-13)29-11-18(28)23-2/h3-10H,11H2,1-2H3,(H,23,28)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255510 (US10828301, Compound R935307 | US9499493, R935307) Show SMILES CC(C)Oc1ccc(Nc2nc(Nc3ccc4n(CCCO)ncc4c3)ncc2F)cc1 Show InChI InChI=1S/C23H25FN6O2/c1-15(2)32-19-7-4-17(5-8-19)27-22-20(24)14-25-23(29-22)28-18-6-9-21-16(12-18)13-26-30(21)10-3-11-31/h4-9,12-15,31H,3,10-11H2,1-2H3,(H2,25,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255510 (US10828301, Compound R935307 | US9499493, R935307) Show SMILES CC(C)Oc1ccc(Nc2nc(Nc3ccc4n(CCCO)ncc4c3)ncc2F)cc1 Show InChI InChI=1S/C23H25FN6O2/c1-15(2)32-19-7-4-17(5-8-19)27-22-20(24)14-25-23(29-22)28-18-6-9-21-16(12-18)13-26-30(21)10-3-11-31/h4-9,12-15,31H,3,10-11H2,1-2H3,(H2,25,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255485 (US10828301, Compound R926816 | US9499493, R926816) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1 Show InChI InChI=1S/C21H20FN5O4/c1-23-19(28)12-31-15-4-2-3-13(9-15)26-21-24-11-16(22)20(27-21)25-14-5-6-17-18(10-14)30-8-7-29-17/h2-6,9-11H,7-8,12H2,1H3,(H,23,28)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	61.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255485 (US10828301, Compound R926816 | US9499493, R926816) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1 Show InChI InChI=1S/C21H20FN5O4/c1-23-19(28)12-31-15-4-2-3-13(9-15)26-21-24-11-16(22)20(27-21)25-14-5-6-17-18(10-14)30-8-7-29-17/h2-6,9-11H,7-8,12H2,1H3,(H,23,28)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	61.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM471765 (N4-[(2,2-Dimethyl-4H-benzo[1,4]oxazin-3-one)-6-yl]...) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C23H23FN6O4/c1-23(2)21(32)29-17-10-14(7-8-18(17)34-23)27-20-16(24)11-26-22(30-20)28-13-5-4-6-15(9-13)33-12-19(31)25-3/h4-11H,12H2,1-3H3,(H,25,31)(H,29,32)(H2,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255523 (N4-[(2,2-Dimethyl-4H-benzo[1,4]oxazin-3-one)-6-yl]...) Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4c3)n2)=C1 |c:6,36| Show InChI InChI=1S/C24H27FN6O4/c1-13-5-6-15(10-19(13)34-12-20(32)26-4)29-23-27-11-16(25)21(31-23)28-14-7-8-18-17(9-14)30-22(33)24(2,3)35-18/h7-11H,5-6,12H2,1-4H3,(H,26,32)(H,30,33)(H2,27,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255526 (N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N...) Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3cccc(c3)C(=O)NOC)n2)=C1 |c:6,33| Show InChI InChI=1S/C22H25FN6O4/c1-13-7-8-16(10-18(13)33-12-19(30)24-2)27-22-25-11-17(23)20(28-22)26-15-6-4-5-14(9-15)21(31)29-32-3/h4-6,9-11H,7-8,12H2,1-3H3,(H,24,30)(H,29,31)(H2,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM471772 (N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N...) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3cccc(c3)C(=O)NOC)n2)c1 Show InChI InChI=1S/C21H21FN6O4/c1-23-18(29)12-32-16-8-4-7-15(10-16)26-21-24-11-17(22)19(27-21)25-14-6-3-5-13(9-14)20(30)28-31-2/h3-11H,12H2,1-2H3,(H,23,29)(H,28,30)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255477 (US10828301, Compound R926505 | US9499493, R926505) Show SMILES OCCNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1 Show InChI InChI=1S/C22H22FN5O5/c23-17-12-25-22(27-14-2-1-3-16(10-14)33-13-20(30)24-6-7-29)28-21(17)26-15-4-5-18-19(11-15)32-9-8-31-18/h1-5,10-12,29H,6-9,13H2,(H,24,30)(H2,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	70.3	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255477 (US10828301, Compound R926505 | US9499493, R926505) Show SMILES OCCNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1 Show InChI InChI=1S/C22H22FN5O5/c23-17-12-25-22(27-14-2-1-3-16(10-14)33-13-20(30)24-6-7-29)28-21(17)26-15-4-5-18-19(11-15)32-9-8-31-18/h1-5,10-12,29H,6-9,13H2,(H,24,30)(H2,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	70.3	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255489 (US9499493, R935193) Show SMILES Cn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12 Show InChI InChI=1S/C20H17FN6O2/c1-27-16-4-2-13(8-12(16)10-23-27)25-20-22-11-15(21)19(26-20)24-14-3-5-17-18(9-14)29-7-6-28-17/h2-5,8-11H,6-7H2,1H3,(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM471724 (N4-(3,4-Ethylenedioxyphenyl)-5-fluoro-N2-(1-methyl...) Show SMILES Fc1cnc(Nc2ccc3[nH]ncc3c2)nc1Nc1ccc2OCCOc2c1 Show InChI InChI=1S/C19H15FN6O2/c20-14-10-21-19(24-12-1-3-15-11(7-12)9-22-26-15)25-18(14)23-13-2-4-16-17(8-13)28-6-5-27-16/h1-4,7-10H,5-6H2,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255481 (US10828301, Compound R926745 | US9499493, R926745) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4cc[nH]c4c3)n2)c1 Show InChI InChI=1S/C21H19FN6O2/c1-23-19(29)12-30-16-4-2-3-14(9-16)27-21-25-11-17(22)20(28-21)26-15-6-5-13-7-8-24-18(13)10-15/h2-11,24H,12H2,1H3,(H,23,29)(H2,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	92.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255481 (US10828301, Compound R926745 | US9499493, R926745) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4cc[nH]c4c3)n2)c1 Show InChI InChI=1S/C21H19FN6O2/c1-23-19(29)12-30-16-4-2-3-14(9-16)27-21-25-11-17(22)20(28-21)26-15-6-5-13-7-8-24-18(13)10-15/h2-11,24H,12H2,1H3,(H,23,29)(H2,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	92.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255511 (US10828301, Compound R935309 | US9499493, R935309) Show SMILES CNC(=O)CCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12 Show InChI InChI=1S/C23H22FN7O3/c1-25-21(32)6-7-31-18-4-2-15(10-14(18)12-27-31)29-23-26-13-17(24)22(30-23)28-16-3-5-19-20(11-16)34-9-8-33-19/h2-5,10-13H,6-9H2,1H3,(H,25,32)(H2,26,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255511 (US10828301, Compound R935309 | US9499493, R935309) Show SMILES CNC(=O)CCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12 Show InChI InChI=1S/C23H22FN7O3/c1-25-21(32)6-7-31-18-4-2-15(10-14(18)12-27-31)29-23-26-13-17(24)22(30-23)28-16-3-5-19-20(11-16)34-9-8-33-19/h2-5,10-13H,6-9H2,1H3,(H,25,32)(H2,26,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255519 (5-Fluoro-N4-(3-hydroxy-4-methylphenyl)-N2-[3-[(N-m...) Show SMILES CNC(=O)COC1=CCCC(Nc2ncc(F)c(Nc3ccc(C)c(O)c3)n2)=C1 |c:29,t:6| Show InChI InChI=1S/C20H22FN5O3/c1-12-6-7-14(9-17(12)27)24-19-16(21)10-23-20(26-19)25-13-4-3-5-15(8-13)29-11-18(28)22-2/h5-10,27H,3-4,11H2,1-2H3,(H,22,28)(H2,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	108	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM471746 (5-Fluoro-N4-(3-hydroxy-4-methylphenyl)-N2-[3-[(N-m...) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(C)c(O)c3)n2)c1 Show InChI InChI=1S/C20H20FN5O3/c1-12-6-7-14(9-17(12)27)24-19-16(21)10-23-20(26-19)25-13-4-3-5-15(8-13)29-11-18(28)22-2/h3-10,27H,11H2,1-2H3,(H,22,28)(H2,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255482 (US10828301, Compound R926782 | US9499493, R926782) Show SMILES OCC(O)CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1 Show InChI InChI=1S/C23H24FN5O6/c24-18-11-26-23(29-22(18)27-15-4-5-19-20(9-15)34-7-6-33-19)28-14-2-1-3-17(8-14)35-13-21(32)25-10-16(31)12-30/h1-5,8-9,11,16,30-31H,6-7,10,12-13H2,(H,25,32)(H2,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255482 (US10828301, Compound R926782 | US9499493, R926782) Show SMILES OCC(O)CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1 Show InChI InChI=1S/C23H24FN5O6/c24-18-11-26-23(29-22(18)27-15-4-5-19-20(9-15)34-7-6-33-19)28-14-2-1-3-17(8-14)35-13-21(32)25-10-16(31)12-30/h1-5,8-9,11,16,30-31H,6-7,10,12-13H2,(H,25,32)(H2,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	117	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255502 (US10828301, Compound R909268 | US9499493, R909268) Show SMILES Oc1cccc(Nc2nc(Nc3ccc4OCC(=O)Nc4c3)ncc2F)c1 Show InChI InChI=1S/C18H14FN5O3/c19-13-8-20-18(24-17(13)21-10-2-1-3-12(25)6-10)22-11-4-5-15-14(7-11)23-16(26)9-27-15/h1-8,25H,9H2,(H,23,26)(H2,20,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255502 (US10828301, Compound R909268 | US9499493, R909268) Show SMILES Oc1cccc(Nc2nc(Nc3ccc4OCC(=O)Nc4c3)ncc2F)c1 Show InChI InChI=1S/C18H14FN5O3/c19-13-8-20-18(24-17(13)21-10-2-1-3-12(25)6-10)22-11-4-5-15-14(7-11)23-16(26)9-27-15/h1-8,25H,9H2,(H,23,26)(H2,20,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	125	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair

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