Found 441 hits with Last Name = 'pezzetta' and Initial = 'd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27359
(7-ethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)Show InChI InChI=1S/C14H15N3O/c1-2-9-8-16-14(18)11-7-12(17-13(9)11)10-3-5-15-6-4-10/h3-7,9,17H,2,8H2,1H3,(H,16,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27362
(7-(2-fluoroethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-...)Show InChI InChI=1S/C14H14FN3O/c15-4-1-10-8-17-14(19)11-7-12(18-13(10)11)9-2-5-16-6-3-9/h2-3,5-7,10,18H,1,4,8H2,(H,17,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27380
((7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)Show SMILES Nc1nccc(n1)-c1cc2c([nH]1)[C@@H](CCF)CNC2=O |r| Show InChI InChI=1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| DrugBank PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50343559
(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting |
Bioorg Med Chem Lett 21: 2969-74 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.054 BindingDB Entry DOI: 10.7270/Q27M088W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329915
(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)Show SMILES Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCNCC4)nc3-c12 Show InChI InChI=1S/C22H23F3N8O2/c1-32-19-14(18(31-32)20(26)34)4-2-12-11-28-21(30-17(12)19)29-15-10-13(33-8-6-27-7-9-33)3-5-16(15)35-22(23,24)25/h3,5,10-11,27H,2,4,6-9H2,1H3,(H2,26,34)(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27371
(2-(2-aminopyrimidin-4-yl)-7,7-dimethyl-1H,4H,5H,6H...)Show InChI InChI=1S/C13H15N5O/c1-13(2)6-16-11(19)7-5-9(17-10(7)13)8-3-4-15-12(14)18-8/h3-5,17H,6H2,1-2H3,(H,16,19)(H2,14,15,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329914
(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C23H25F3N8O2/c1-32-7-9-34(10-8-32)14-4-6-17(36-23(24,25)26)16(11-14)29-22-28-12-13-3-5-15-19(21(27)35)31-33(2)20(15)18(13)30-22/h4,6,11-12H,3,5,7-10H2,1-2H3,(H2,27,35)(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50343568
(1-methyl-8-(5-(1-methyl-1,2,3,6-tetrahydropyridin-...)Show SMILES CN1CCC(=CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 |c:4| Show InChI InChI=1S/C24H24F3N7O2/c1-33-9-7-13(8-10-33)14-4-6-18(36-24(25,26)27)17(11-14)30-23-29-12-15-3-5-16-20(22(28)35)32-34(2)21(16)19(15)31-23/h4,6-7,11-12H,3,5,8-10H2,1-2H3,(H2,28,35)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting |
Bioorg Med Chem Lett 21: 2969-74 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.054 BindingDB Entry DOI: 10.7270/Q27M088W |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27363
(7,7-dimethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)Show InChI InChI=1S/C14H15N3O/c1-14(2)8-16-13(18)10-7-11(17-12(10)14)9-3-5-15-6-4-9/h3-7,17H,8H2,1-2H3,(H,16,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27348
(6-(2-methylpropyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)Show InChI InChI=1S/C16H19N3O/c1-10(2)7-12-8-15-13(16(20)18-12)9-14(19-15)11-3-5-17-6-4-11/h3-6,9-10,12,19H,7-8H2,1-2H3,(H,18,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27370
(2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1H,4H,...)Show InChI InChI=1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329914
(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C23H25F3N8O2/c1-32-7-9-34(10-8-32)14-4-6-17(36-23(24,25)26)16(11-14)29-22-28-12-13-3-5-15-19(21(27)35)31-33(2)20(15)18(13)30-22/h4,6,11-12H,3,5,7-10H2,1-2H3,(H2,27,35)(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting |
Bioorg Med Chem Lett 21: 2969-74 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.054 BindingDB Entry DOI: 10.7270/Q27M088W |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27361
(7-cyclobutyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)Show InChI InChI=1S/C16H17N3O/c20-16-12-8-14(11-4-6-17-7-5-11)19-15(12)13(9-18-16)10-2-1-3-10/h4-8,10,13,19H,1-3,9H2,(H,18,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329913
(1-(2-fluoroethyl)-8-(5-(piperazin-1-yl)-2-(trifluo...)Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCF)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C24H26F4N8O2/c1-34-8-10-35(11-9-34)15-3-5-18(38-24(26,27)28)17(12-15)31-23-30-13-14-2-4-16-20(22(29)37)33-36(7-6-25)21(16)19(14)32-23/h3,5,12-13H,2,4,6-11H2,1H3,(H2,29,37)(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27368
(2-(2-aminopyrimidin-4-yl)-7-(propan-2-yl)-1H,4H,5H...)Show InChI InChI=1S/C14H17N5O/c1-7(2)9-6-17-13(20)8-5-11(18-12(8)9)10-3-4-16-14(15)19-10/h3-5,7,9,18H,6H2,1-2H3,(H,17,20)(H2,15,16,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27377
(2-(2-aminopyrimidin-4-yl)-7-(2-hydroxyethyl)-1H,4H...)Show InChI InChI=1S/C13H15N5O2/c14-13-15-3-1-9(18-13)10-5-8-11(17-10)7(2-4-19)6-16-12(8)20/h1,3,5,7,17,19H,2,4,6H2,(H,16,20)(H2,14,15,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329926
(8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylam...)Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(n[nH]c4C(N)=O)-c3n2)c1 Show InChI InChI=1S/C22H23F3N8O2/c1-32-6-8-33(9-7-32)13-3-5-16(35-22(23,24)25)15(10-13)28-21-27-11-12-2-4-14-18(17(12)29-21)30-31-19(14)20(26)34/h3,5,10-11H,2,4,6-9H2,1H3,(H2,26,34)(H,30,31)(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27372
(2-(2-aminopyrimidin-4-yl)-7,7-diethyl-1H,4H,5H,6H,...)Show InChI InChI=1S/C15H19N5O/c1-3-15(4-2)8-18-13(21)9-7-11(19-12(9)15)10-5-6-17-14(16)20-10/h5-7,19H,3-4,8H2,1-2H3,(H,18,21)(H2,16,17,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27347
(6-cyclopropyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrr...)Show InChI InChI=1S/C15H15N3O/c19-15-11-7-12(10-3-5-16-6-4-10)17-14(11)8-13(18-15)9-1-2-9/h3-7,9,13,17H,1-2,8H2,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27379
((7R)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)Show SMILES Nc1nccc(n1)-c1cc2c([nH]1)[C@H](CCF)CNC2=O |r| Show InChI InChI=1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27367
(2-(2-aminopyrimidin-4-yl)-7-ethyl-1H,4H,5H,6H,7H-p...)Show InChI InChI=1S/C13H15N5O/c1-2-7-6-16-12(19)8-5-10(17-11(7)8)9-3-4-15-13(14)18-9/h3-5,7,17H,2,6H2,1H3,(H,16,19)(H2,14,15,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27369
(2-(2-aminopyrimidin-4-yl)-7-cyclobutyl-1H,4H,5H,6H...)Show InChI InChI=1S/C15H17N5O/c16-15-17-5-4-11(20-15)12-6-9-13(19-12)10(7-18-14(9)21)8-2-1-3-8/h4-6,8,10,19H,1-3,7H2,(H,18,21)(H2,16,17,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27366
(2-(2-aminopyrimidin-4-yl)-7-methyl-1H,4H,5H,6H,7H-...)Show InChI InChI=1S/C12H13N5O/c1-6-5-15-11(18)7-4-9(16-10(6)7)8-2-3-14-12(13)17-8/h2-4,6,16H,5H2,1H3,(H,15,18)(H2,13,14,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329927
(1-ethyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)...)Show SMILES CCn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12 Show InChI InChI=1S/C24H27F3N8O2/c1-3-35-21-16(20(32-35)22(28)36)6-4-14-13-29-23(31-19(14)21)30-17-12-15(34-10-8-33(2)9-11-34)5-7-18(17)37-24(25,26)27/h5,7,12-13H,3-4,6,8-11H2,1-2H3,(H2,28,36)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50343569
(9-methyl-2-(5-(1-methylpiperidin-4-yl)-2-(trifluor...)Show SMILES CN1CCC(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(cn(C)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C25H27F3N6O2/c1-33-9-7-14(8-10-33)15-4-6-20(36-25(26,27)28)19(11-15)31-24-30-12-16-3-5-17-18(23(29)35)13-34(2)22(17)21(16)32-24/h4,6,11-14H,3,5,7-10H2,1-2H3,(H2,29,35)(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting |
Bioorg Med Chem Lett 21: 2969-74 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.054 BindingDB Entry DOI: 10.7270/Q27M088W |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27364
(7,7-diethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrol...)Show InChI InChI=1S/C16H19N3O/c1-3-16(4-2)10-18-15(20)12-9-13(19-14(12)16)11-5-7-17-8-6-11/h5-9,19H,3-4,10H2,1-2H3,(H,18,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329929
(8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylam...)Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C=C)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C24H25F3N8O2/c1-3-35-21-16(20(32-35)22(28)36)6-4-14-13-29-23(31-19(14)21)30-17-12-15(34-10-8-33(2)9-11-34)5-7-18(17)37-24(25,26)27/h3,5,7,12-13H,1,4,6,8-11H2,2H3,(H2,28,36)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27346
(6-(propan-2-yl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-py...)Show InChI InChI=1S/C15H17N3O/c1-9(2)12-8-14-11(15(19)18-12)7-13(17-14)10-3-5-16-6-4-10/h3-7,9,12,17H,8H2,1-2H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27375
(2-(2-aminopyrimidin-4-yl)-7-[2-(benzyloxy)ethyl]-1...)Show SMILES Nc1nccc(n1)-c1cc2c([nH]1)C(CCOCc1ccccc1)CNC2=O Show InChI InChI=1S/C20H21N5O2/c21-20-22-8-6-16(25-20)17-10-15-18(24-17)14(11-23-19(15)26)7-9-27-12-13-4-2-1-3-5-13/h1-6,8,10,14,24H,7,9,11-12H2,(H,23,26)(H2,21,22,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329916
(1-(2-chloroethyl)-8-(5-(piperazin-1-yl)-2-(trifluo...)Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCCl)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C24H26ClF3N8O2/c1-34-8-10-35(11-9-34)15-3-5-18(38-24(26,27)28)17(12-15)31-23-30-13-14-2-4-16-20(22(29)37)33-36(7-6-25)21(16)19(14)32-23/h3,5,12-13H,2,4,6-11H2,1H3,(H2,29,37)(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27351
(2-(2-aminopyrimidin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)Show InChI InChI=1S/C11H11N5O/c12-11-14-4-2-8(16-11)9-5-6-7(15-9)1-3-13-10(6)17/h2,4-5,15H,1,3H2,(H,13,17)(H2,12,14,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329921
(8-(5-(4-ethylpiperazin-1-yl)-2-(trifluoromethoxy)p...)Show SMILES CCN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C24H27F3N8O2/c1-3-34-8-10-35(11-9-34)15-5-7-18(37-24(25,26)27)17(12-15)30-23-29-13-14-4-6-16-20(22(28)36)32-33(2)21(16)19(14)31-23/h5,7,12-13H,3-4,6,8-11H2,1-2H3,(H2,28,36)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27355
(2-(2-aminopyrimidin-4-yl)-6-(2-methylpropyl)-1H,4H...)Show InChI InChI=1S/C15H19N5O/c1-8(2)5-9-6-12-10(14(21)18-9)7-13(19-12)11-3-4-17-15(16)20-11/h3-4,7-9,19H,5-6H2,1-2H3,(H,18,21)(H2,16,17,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27374
(2-(2-aminopyrimidin-4-yl)-7-(3,3,3-trifluoropropyl...)Show SMILES Nc1nccc(n1)-c1cc2c([nH]1)C(CCC(F)(F)F)CNC2=O Show InChI InChI=1S/C14H14F3N5O/c15-14(16,17)3-1-7-6-20-12(23)8-5-10(21-11(7)8)9-2-4-19-13(18)22-9/h2,4-5,7,21H,1,3,6H2,(H,20,23)(H2,18,19,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27360
(7-(propan-2-yl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-py...)Show InChI InChI=1S/C15H17N3O/c1-9(2)12-8-17-15(19)11-7-13(18-14(11)12)10-3-5-16-6-4-10/h3-7,9,12,18H,8H2,1-2H3,(H,17,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27358
(7-methyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)Show InChI InChI=1S/C13H13N3O/c1-8-7-15-13(17)10-6-11(16-12(8)10)9-2-4-14-5-3-9/h2-6,8,16H,7H2,1H3,(H,15,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27354
(2-(2-aminopyrimidin-4-yl)-6-cyclopropyl-1H,4H,5H,6...)Show InChI InChI=1S/C14H15N5O/c15-14-16-4-3-9(19-14)12-5-8-11(17-12)6-10(7-1-2-7)18-13(8)20/h3-5,7,10,17H,1-2,6H2,(H,18,20)(H2,15,16,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27378
(2-(2-aminopyrimidin-4-yl)-7-(3-hydroxypropyl)-1H,4...)Show InChI InChI=1S/C14H17N5O2/c15-14-16-4-3-10(19-14)11-6-9-12(18-11)8(2-1-5-20)7-17-13(9)21/h3-4,6,8,18,20H,1-2,5,7H2,(H,17,21)(H2,15,16,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27353
(2-(2-aminopyrimidin-4-yl)-6-(propan-2-yl)-1H,4H,5H...)Show InChI InChI=1S/C14H17N5O/c1-7(2)10-6-11-8(13(20)18-10)5-12(17-11)9-3-4-16-14(15)19-9/h3-5,7,10,17H,6H2,1-2H3,(H,18,20)(H2,15,16,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27345
(6-methyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)Show InChI InChI=1S/C13H13N3O/c1-8-6-12-10(13(17)15-8)7-11(16-12)9-2-4-14-5-3-9/h2-5,7-8,16H,6H2,1H3,(H,15,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329928
(1-(2-methoxyethyl)-8-(5-(piperazin-1-yl)-2-(triflu...)Show SMILES COCCn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12 Show InChI InChI=1S/C25H29F3N8O3/c1-34-7-9-35(10-8-34)16-4-6-19(39-25(26,27)28)18(13-16)31-24-30-14-15-3-5-17-21(23(29)37)33-36(11-12-38-2)22(17)20(15)32-24/h4,6,13-14H,3,5,7-12H2,1-2H3,(H2,29,37)(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27373
(2-(2-aminopyrimidin-4-yl)-7-phenyl-1H,4H,5H,6H,7H-...)Show InChI InChI=1S/C17H15N5O/c18-17-19-7-6-13(22-17)14-8-11-15(21-14)12(9-20-16(11)23)10-4-2-1-3-5-10/h1-8,12,21H,9H2,(H,20,23)(H2,18,19,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27365
(7-phenyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)Show InChI InChI=1S/C18H15N3O/c22-18-14-10-16(13-6-8-19-9-7-13)21-17(14)15(11-20-18)12-4-2-1-3-5-12/h1-10,15,21H,11H2,(H,20,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27376
(2-(2-aminopyrimidin-4-yl)-7-[3-(benzyloxy)propyl]-...)Show SMILES Nc1nccc(n1)-c1cc2c([nH]1)C(CCCOCc1ccccc1)CNC2=O Show InChI InChI=1S/C21H23N5O2/c22-21-23-9-8-17(26-21)18-11-16-19(25-18)15(12-24-20(16)27)7-4-10-28-13-14-5-2-1-3-6-14/h1-3,5-6,8-9,11,15,25H,4,7,10,12-13H2,(H,24,27)(H2,22,23,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50329923
(1-methyl-8-(5-(4-methyl-1,4-diazepan-1-yl)-2-(trif...)Show SMILES CN1CCCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C24H27F3N8O2/c1-33-8-3-9-35(11-10-33)15-5-7-18(37-24(25,26)27)17(12-15)30-23-29-13-14-4-6-16-20(22(28)36)32-34(2)21(16)19(14)31-23/h5,7,12-13H,3-4,6,8-11H2,1-2H3,(H2,28,36)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27352
(2-(2-aminopyrimidin-4-yl)-6-methyl-1H,4H,5H,6H,7H-...)Show InChI InChI=1S/C12H13N5O/c1-6-4-9-7(11(18)15-6)5-10(16-9)8-2-3-14-12(13)17-8/h2-3,5-6,16H,4H2,1H3,(H,15,18)(H2,13,14,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM27380
((7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)Show SMILES Nc1nccc(n1)-c1cc2c([nH]1)[C@@H](CCF)CNC2=O |r| Show InChI InChI=1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| DrugBank PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27349
(6,6-dimethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)Show InChI InChI=1S/C14H15N3O/c1-14(2)8-12-10(13(18)17-14)7-11(16-12)9-3-5-15-6-4-9/h3-7,16H,8H2,1-2H3,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | 7.9 | 25 |
Nerviano Medical Sciences Srl
| Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ... |
J Med Chem 52: 293-307 (2009)
Article DOI: 10.1021/jm800977q BindingDB Entry DOI: 10.7270/Q27W69JX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK3
(Homo sapiens (Human)) | BDBM50329932
(1-methyl-8-(2-(trifluoromethoxy)phenylamino)-4,5-d...)Show SMILES Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4OC(F)(F)F)nc3-c12 Show InChI InChI=1S/C18H15F3N6O2/c1-27-15-10(14(26-27)16(22)28)7-6-9-8-23-17(25-13(9)15)24-11-4-2-3-5-12(11)29-18(19,20)21/h2-5,8H,6-7H2,1H3,(H2,22,28)(H,23,24,25) | PDB
NCI pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description Inhibition of PLK3 |
Bioorg Med Chem Lett 20: 6489-94 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.060 BindingDB Entry DOI: 10.7270/Q2VT1T39 |
More data for this Ligand-Target Pair | |