Found 82 hits with Last Name = 'wade' and Initial = 'sm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-2A adrenergic receptor
(PIG) | BDBM30712
(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)Show InChI InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| PDB PubMed
| 35.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-2A adrenergic receptor
(PIG) | BDBM50262179
(Iodoclonidine-p | p-iodoclonidine)Show InChI InChI=1S/C9H8Cl2IN3/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2H2,(H2,13,14,15)/p+1 | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
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MCE PC cid PC sid UniChem
Similars
| PubMed
| 51.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(PIG) | BDBM81979
(CAS_5051-62-7 | CAS_65636 | Fluprofylline | Guanab...)Show SMILES [#7]\[#6](-[#7])=[#7]\[#7]=[#6]-c1c(Cl)cccc1Cl |w:5.5| Show InChI InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14) | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
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DrugBank PC cid PC sid UniChem
Patents
Similars
| PubMed
| 57.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(PIG) | BDBM50016897
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show SMILES Clc1cccc(Cl)c1\[#7]=[#6]-1\[#7]-[#6]-[#6]-[#7]-1 Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
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PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 85.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(PIG) | BDBM81926
(Aminoclonidine, p | CAS_66711-21-5 | NSC_51763 | p...)Show InChI InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15) | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
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DrugBank MCE KEGG PC cid PC sid UniChem
Similars
| PubMed
| 288 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(PIG) | BDBM34572
(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)Show InChI InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17) | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| 479 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-2A adrenergic receptor
(PIG) | BDBM84342
(4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol...)Show InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
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KEGG PC cid PC sid PDB UniChem
Similars
| PubMed
| 646 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(PIG) | BDBM50027069
((2,6-Dimethyl-phenyl)-[1,3]thiazinan-2-ylidene-ami...)Show InChI InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14) | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(PIG) | BDBM35234
(DL-[7-3H]norepinephrine | NOREPINEPHRINE | Noradre...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 5.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(PIG) | BDBM85676
(BHT-933 | CAS_128-37-0 | NSC_169743)Show InChI InChI=1S/C9H15N3O/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7/h2-6H2,1H3,(H2,10,11) | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
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MCE PC cid PC sid UniChem
| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(PIG) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 294: 539-47 (2000)
BindingDB Entry DOI: 10.7270/Q2TM78NR |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436224
(CHEMBL2398697)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(Oc2ccccc2)c1 Show InChI InChI=1S/C27H22F6N2O3/c28-26(29,30)19-12-18(13-20(14-19)27(31,32)33)25(37)35-11-5-6-17(16-35)24(36)34-21-7-4-10-23(15-21)38-22-8-2-1-3-9-22/h1-4,7-10,12-15,17H,5-6,11,16H2,(H,34,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481356
(CCG-1423 | CHEMBL595382)Show SMILES CC(ONC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C18H15ClF6N2O3/c1-9(15(28)26-14-4-2-13(19)3-5-14)30-27-16(29)10-6-11(17(20,21)22)8-12(7-10)18(23,24)25/h2-9,15,26,28H,1H3,(H,27,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436223
(CHEMBL2398698)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(Cc2ccccc2)c1 Show InChI InChI=1S/C28H24F6N2O2/c29-27(30,31)22-14-21(15-23(16-22)28(32,33)34)26(38)36-11-5-9-20(17-36)25(37)35-24-10-4-8-19(13-24)12-18-6-2-1-3-7-18/h1-4,6-8,10,13-16,20H,5,9,11-12,17H2,(H,35,37) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481362
(CHEMBL591786)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C22H13ClF6N2O2/c23-16-4-6-17(7-5-16)30-19(32)12-2-1-3-18(10-12)31-20(33)13-8-14(21(24,25)26)11-15(9-13)22(27,28)29/h1-11H,(H,30,32)(H,31,33) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436222
(CHEMBL2398699)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(OCCc2ccccn2)c1 Show InChI InChI=1S/C28H25F6N3O3/c29-27(30,31)20-13-19(14-21(15-20)28(32,33)34)26(39)37-11-4-5-18(17-37)25(38)36-23-7-3-8-24(16-23)40-12-9-22-6-1-2-10-35-22/h1-3,6-8,10,13-16,18H,4-5,9,11-12,17H2,(H,36,38) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481364
(CHEMBL606913)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCc1csc(n1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H11ClF6N2OS/c20-14-3-1-10(2-4-14)17-28-15(9-30-17)8-27-16(29)11-5-12(18(21,22)23)7-13(6-11)19(24,25)26/h1-7,9H,8H2,(H,27,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481352
(CHEMBL589372)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C1=NOC(CC(=O)Nc2ccc(Cl)cc2)C1 |t:15| Show InChI InChI=1S/C19H13ClF6N2O2/c20-13-1-3-14(4-2-13)27-17(29)9-15-8-16(28-30-15)10-5-11(18(21,22)23)7-12(6-10)19(24,25)26/h1-7,15H,8-9H2,(H,27,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436244
(CHEMBL2398669)Show SMILES Clc1ccc(NC(=O)C2CCCN(C2)C(=O)c2cccc(c2)-c2cccs2)cc1 Show InChI InChI=1S/C23H21ClN2O2S/c24-19-8-10-20(11-9-19)25-22(27)18-6-2-12-26(15-18)23(28)17-5-1-4-16(14-17)21-7-3-13-29-21/h1,3-5,7-11,13-14,18H,2,6,12,15H2,(H,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC/Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50481337
(CHEMBL594911)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NOCC(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C17H11ClF6N2O3/c18-12-1-3-13(4-2-12)25-14(27)8-29-26-15(28)9-5-10(16(19,20)21)7-11(6-9)17(22,23)24/h1-7H,8H2,(H,25,27)(H,26,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481343
(CHEMBL590596)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCCNc1ccc(Cl)cc1 Show InChI InChI=1S/C18H15ClF6N2O/c19-14-2-4-15(5-3-14)26-6-1-7-27-16(28)11-8-12(17(20,21)22)10-13(9-11)18(23,24)25/h2-5,8-10,26H,1,6-7H2,(H,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436236
(CHEMBL2398678)Show SMILES Clc1ccc(NC(=O)C2CCCN(C2)C(=O)c2cccc(c2)-c2ccco2)cc1 Show InChI InChI=1S/C23H21ClN2O3/c24-19-8-10-20(11-9-19)25-22(27)18-6-2-12-26(15-18)23(28)17-5-1-4-16(14-17)21-7-3-13-29-21/h1,3-5,7-11,13-14,18H,2,6,12,15H2,(H,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human SK-Mel-147 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene ... |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436221
(CHEMBL2398700)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(c1)S(=O)(=O)N1CCCC1 Show InChI InChI=1S/C25H25F6N3O4S/c26-24(27,28)18-11-17(12-19(13-18)25(29,30)31)23(36)33-8-4-5-16(15-33)22(35)32-20-6-3-7-21(14-20)39(37,38)34-9-1-2-10-34/h3,6-7,11-14,16H,1-2,4-5,8-10,15H2,(H,32,35) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481340
(CHEMBL591077)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NOCC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C17H11ClF6N2O3/c18-12-2-1-3-13(7-12)25-14(27)8-29-26-15(28)9-4-10(16(19,20)21)6-11(5-9)17(22,23)24/h1-7H,8H2,(H,25,27)(H,26,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436255
(CHEMBL2398701)Show SMILES Cc1nc(cs1)-c1cccc(NC(=O)C2CCCN(C2)C(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C25H21F6N3O2S/c1-14-32-21(13-37-14)15-4-2-6-20(10-15)33-22(35)16-5-3-7-34(12-16)23(36)17-8-18(24(26,27)28)11-19(9-17)25(29,30)31/h2,4,6,8-11,13,16H,3,5,7,12H2,1H3,(H,33,35) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436236
(CHEMBL2398678)Show SMILES Clc1ccc(NC(=O)C2CCCN(C2)C(=O)c2cccc(c2)-c2ccco2)cc1 Show InChI InChI=1S/C23H21ClN2O3/c24-19-8-10-20(11-9-19)25-22(27)18-6-2-12-26(15-18)23(28)17-5-1-4-16(14-17)21-7-3-13-29-21/h1,3-5,7-11,13-14,18H,2,6,12,15H2,(H,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436241
(CHEMBL2398672)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(OCc2ccccn2)c1 Show InChI InChI=1S/C27H23F6N3O3/c28-26(29,30)19-11-18(12-20(13-19)27(31,32)33)25(38)36-10-4-5-17(15-36)24(37)35-21-7-3-8-23(14-21)39-16-22-6-1-2-9-34-22/h1-3,6-9,11-14,17H,4-5,10,15-16H2,(H,35,37) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481344
(CHEMBL591549)Show SMILES FC(F)(F)c1cc(CNCCC(=O)Nc2ccc(Cl)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C18H15ClF6N2O/c19-14-1-3-15(4-2-14)27-16(28)5-6-26-10-11-7-12(17(20,21)22)9-13(8-11)18(23,24)25/h1-4,7-9,26H,5-6,10H2,(H,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436254
(CHEMBL2398702)Show SMILES CCc1cccc(NC(=O)C2CCCN(C2)C(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C23H22F6N2O2/c1-2-14-5-3-7-19(9-14)30-20(32)15-6-4-8-31(13-15)21(33)16-10-17(22(24,25)26)12-18(11-16)23(27,28)29/h3,5,7,9-12,15H,2,4,6,8,13H2,1H3,(H,30,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481359
(CHEMBL591080)Show SMILES FC(F)(F)c1cc(NC(=O)CONC(=O)c2ccc(Cl)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C17H11ClF6N2O3/c18-12-3-1-9(2-4-12)15(28)26-29-8-14(27)25-13-6-10(16(19,20)21)5-11(7-13)17(22,23)24/h1-7H,8H2,(H,25,27)(H,26,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481369
(CHEMBL592022)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCCOc1ccc(Cl)cc1 Show InChI InChI=1S/C18H14ClF6NO2/c19-14-2-4-15(5-3-14)28-7-1-6-26-16(27)11-8-12(17(20,21)22)10-13(9-11)18(23,24)25/h2-5,8-10H,1,6-7H2,(H,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481360
(CHEMBL591550)Show SMILES FC(F)(F)c1cc(CNCCCNc2ccc(Cl)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C18H17ClF6N2/c19-15-2-4-16(5-3-15)27-7-1-6-26-11-12-8-13(17(20,21)22)10-14(9-12)18(23,24)25/h2-5,8-10,26-27H,1,6-7,11H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436243
(CHEMBL2398670)Show SMILES Clc1ccc(NC(=O)C2CCCN(C2)C(=O)c2ccc(cc2)-c2ccco2)cc1 Show InChI InChI=1S/C23H21ClN2O3/c24-19-9-11-20(12-10-19)25-22(27)18-3-1-13-26(15-18)23(28)17-7-5-16(6-8-17)21-4-2-14-29-21/h2,4-12,14,18H,1,3,13,15H2,(H,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481347
(CHEMBL591081)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCCC1CC(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C22H19ClF6N2O2/c23-16-4-6-17(7-5-16)30-19(32)12-18-3-1-2-8-31(18)20(33)13-9-14(21(24,25)26)11-15(10-13)22(27,28)29/h4-7,9-11,18H,1-3,8,12H2,(H,30,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50436237
(CHEMBL603141)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C21H17ClF6N2O2/c22-16-3-5-17(6-4-16)29-18(31)12-2-1-7-30(11-12)19(32)13-8-14(20(23,24)25)10-15(9-13)21(26,27)28/h3-6,8-10,12H,1-2,7,11H2,(H,29,31) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436237
(CHEMBL603141)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C21H17ClF6N2O2/c22-16-3-5-17(6-4-16)29-18(31)12-2-1-7-30(11-12)19(32)13-8-14(20(23,24)25)10-15(9-13)21(26,27)28/h3-6,8-10,12H,1-2,7,11H2,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436235
(CHEMBL2398679)Show SMILES Clc1ccc(NC(=O)C2CCCN(C2)C(=O)c2cccc(c2)C(=O)c2ccccc2)cc1 Show InChI InChI=1S/C26H23ClN2O3/c27-22-11-13-23(14-12-22)28-25(31)21-10-5-15-29(17-21)26(32)20-9-4-8-19(16-20)24(30)18-6-2-1-3-7-18/h1-4,6-9,11-14,16,21H,5,10,15,17H2,(H,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481363
(CHEMBL589131)Show SMILES FC(F)(F)c1cc(NC(=O)C2CCN(CC2)C(=O)c2ccc(Cl)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C21H17ClF6N2O2/c22-16-3-1-13(2-4-16)19(32)30-7-5-12(6-8-30)18(31)29-17-10-14(20(23,24)25)9-15(11-17)21(26,27)28/h1-4,9-12H,5-8H2,(H,29,31) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436239
(CHEMBL2398674)Show SMILES CSc1cccc(NC(=O)C2CCCN(C2)C(=O)c2cccc(c2)-c2ccco2)c1 Show InChI InChI=1S/C24H24N2O3S/c1-30-21-10-3-9-20(15-21)25-23(27)19-8-4-12-26(16-19)24(28)18-7-2-6-17(14-18)22-11-5-13-29-22/h2-3,5-7,9-11,13-15,19H,4,8,12,16H2,1H3,(H,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436240
(CHEMBL2398673)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(Oc2ccccn2)c1 Show InChI InChI=1S/C26H21F6N3O3/c27-25(28,29)18-11-17(12-19(13-18)26(30,31)32)24(37)35-10-4-5-16(15-35)23(36)34-20-6-3-7-21(14-20)38-22-8-1-2-9-33-22/h1-3,6-9,11-14,16H,4-5,10,15H2,(H,34,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481351
(CHEMBL602642)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCC(CC1)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C20H17ClF6N2O/c21-15-1-3-16(4-2-15)28-17-5-7-29(8-6-17)18(30)12-9-13(19(22,23)24)11-14(10-12)20(25,26)27/h1-4,9-11,17,28H,5-8H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436253
(CHEMBL2398703)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(C=C)c1 Show InChI InChI=1S/C23H20F6N2O2/c1-2-14-5-3-7-19(9-14)30-20(32)15-6-4-8-31(13-15)21(33)16-10-17(22(24,25)26)12-18(11-16)23(27,28)29/h2-3,5,7,9-12,15H,1,4,6,8,13H2,(H,30,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436251
(CHEMBL2398705)Show SMILES CSc1cccc(NC(=O)C2CCCN(C2)C(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C22H20F6N2O2S/c1-33-18-6-2-5-17(11-18)29-19(31)13-4-3-7-30(12-13)20(32)14-8-15(21(23,24)25)10-16(9-14)22(26,27)28/h2,5-6,8-11,13H,3-4,7,12H2,1H3,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436252
(CHEMBL2398704)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(c1)-c1cnco1 Show InChI InChI=1S/C24H19F6N3O3/c25-23(26,27)17-7-16(8-18(10-17)24(28,29)30)22(35)33-6-2-4-15(12-33)21(34)32-19-5-1-3-14(9-19)20-11-31-13-36-20/h1,3,5,7-11,13,15H,2,4,6,12H2,(H,32,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481349
(CHEMBL600670)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCC(=O)N1CCc2cc(Cl)ccc12 Show InChI InChI=1S/C20H15ClF6N2O2/c21-15-1-2-16-11(9-15)4-6-29(16)17(30)3-5-28-18(31)12-7-13(19(22,23)24)10-14(8-12)20(25,26)27/h1-2,7-10H,3-6H2,(H,28,31) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481345
(CHEMBL590838)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCC(CC1)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C21H17ClF6N2O2/c22-16-1-3-17(4-2-16)29-18(31)12-5-7-30(8-6-12)19(32)13-9-14(20(23,24)25)11-15(10-13)21(26,27)28/h1-4,9-12H,5-8H2,(H,29,31) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481346
(CHEMBL601501)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCC(C1)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C20H15ClF6N2O2/c21-15-1-3-16(4-2-15)28-17(30)11-5-6-29(10-11)18(31)12-7-13(19(22,23)24)9-14(8-12)20(25,26)27/h1-4,7-9,11H,5-6,10H2,(H,28,30) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Rho-related GTP-binding protein RhoC
(Homo sapiens) | BDBM50481339
(CHEMBL594913)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCCC(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C19H15ClF6N2O2/c20-14-3-5-15(6-4-14)28-16(29)2-1-7-27-17(30)11-8-12(18(21,22)23)10-13(9-11)19(24,25)26/h3-6,8-10H,1-2,7H2,(H,27,30)(H,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay |
Bioorg Med Chem Lett 20: 665-72 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.056 BindingDB Entry DOI: 10.7270/Q29S1TTD |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436242
(CHEMBL2398671)Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(c1)-c1ccco1 Show InChI InChI=1S/C25H20F6N2O3/c26-24(27,28)18-10-17(11-19(13-18)25(29,30)31)23(35)33-8-2-5-16(14-33)22(34)32-20-6-1-4-15(12-20)21-7-3-9-36-21/h1,3-4,6-7,9-13,16H,2,5,8,14H2,(H,32,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |
Transforming protein RhoA
(Homo sapiens (Human)) | BDBM50436233
(CHEMBL2398681)Show SMILES CC(C)(C)CC(=O)Nc1cccc(c1)C(=O)N1CCCC(C1)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C25H30ClN3O3/c1-25(2,3)15-22(30)27-21-8-4-6-17(14-21)24(32)29-13-5-7-18(16-29)23(31)28-20-11-9-19(26)10-12-20/h4,6,8-12,14,18H,5,7,13,15-16H2,1-3H3,(H,27,30)(H,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3826-32 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.080 BindingDB Entry DOI: 10.7270/Q28P61XS |
More data for this Ligand-Target Pair | |