Found 244 hits Enz. Inhib. hit(s) with Target = 'Calcium release-activated calcium channel protein 1' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM81818
(CAS_1794 | CHEMBL1909810 | HMA | NSC_1794)Show InChI InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21) | PDB
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| Article
PubMed
| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Center for Bio-Pharmaceutical Sciences
Curated by PDSP Ki Database
| |
J Recept Res 11: 891-907 (1991)
Article DOI: 10.3109/10799899109064686
BindingDB Entry DOI: 10.7270/Q2TH8K5J |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM22913
(CHEMBL1237146 | CHEMBL498770 | Iodophenpropit | {[...)Show SMILES NC(SCCCc1cnc[nH]1)=NCCc1ccc(I)cc1 |w:11.12| Show InChI InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by PDSP Ki Database
| |
Br J Pharmacol 116: 2315-21 (1995)
Article DOI: 10.1111/j.1476-5381.1995.tb15071.x
BindingDB Entry DOI: 10.7270/Q2ZK5F64 |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM22913
(CHEMBL1237146 | CHEMBL498770 | Iodophenpropit | {[...)Show SMILES NC(SCCCc1cnc[nH]1)=NCCc1ccc(I)cc1 |w:11.12| Show InChI InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20) | PDB
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UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by PDSP Ki Database
| |
Br J Pharmacol 116: 2315-21 (1995)
Article DOI: 10.1111/j.1476-5381.1995.tb15071.x
BindingDB Entry DOI: 10.7270/Q2ZK5F64 |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM81819
(Benzamil | CAS_1937-37-7 | CHEMBL212579 | NSC_1081...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCc1ccccc1 |w:14.15| Show InChI InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22) | PDB
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| Article
PubMed
| 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Center for Bio-Pharmaceutical Sciences
Curated by PDSP Ki Database
| |
J Recept Res 11: 891-907 (1991)
Article DOI: 10.3109/10799899109064686
BindingDB Entry DOI: 10.7270/Q2TH8K5J |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM16173
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) | PDB
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UniChem
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| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Center for Bio-Pharmaceutical Sciences
Curated by PDSP Ki Database
| |
J Recept Res 11: 891-907 (1991)
Article DOI: 10.3109/10799899109064686
BindingDB Entry DOI: 10.7270/Q2TH8K5J |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | PDB
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| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by PDSP Ki Database
| |
Br J Pharmacol 116: 2315-21 (1995)
Article DOI: 10.1111/j.1476-5381.1995.tb15071.x
BindingDB Entry DOI: 10.7270/Q2ZK5F64 |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | PDB
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UniChem
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| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by PDSP Ki Database
| |
Br J Pharmacol 116: 2315-21 (1995)
Article DOI: 10.1111/j.1476-5381.1995.tb15071.x
BindingDB Entry DOI: 10.7270/Q2ZK5F64 |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM50094703
(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)Show SMILES Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1 Show InChI InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28) | PDB
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| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1156-64 (2000)
BindingDB Entry DOI: 10.7270/Q2DF6PSP |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM50035057
((eltoprazine)1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)...)Show InChI InChI=1S/C12H16N2O2/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12/h1-3,13H,4-9H2 | PDB
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duphar B.V.
Curated by PDSP Ki Database
| |
Drug Metabol Drug Interact 8: 85-114 (1990)
Article DOI: 10.1515/dmdi.1990.8.1-2.85
BindingDB Entry DOI: 10.7270/Q27M06DV |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652093
(US11905244, Compound 112) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652068
(US11905244, Compound 87) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652092
(US11905244, Compound 111) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652087
(US11905244, Compound 106) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652094
(US11905244, Compound 113) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 5.83 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652096
(US11905244, Compound 115) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 5.84 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652067
(US11905244, Compound 86) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 6.34 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652083
(US11905244, Compound 102) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652047
(US11905244, Compound 66) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652077
(US11905244, Compound 96) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 10.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652082
(US11905244, Compound 101) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 11.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652043
(US11905244, Compound 62) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652060
(US11905244, Compound 79) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652034
(US11905244, Compound 53) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652081
(US11905244, Compound 100) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 14.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652084
(US11905244, Compound 103) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 15.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652080
(US11905244, Compound 99) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 18.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141416
(US10668051, Compound Example 67 | US8921364, 67)Show SMILES Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-15-10-24-8-7-14(15)18(28)25-12-3-5-13(6-4-12)27-16(11-1-2-11)9-17(26-27)19(21,22)23/h3-11H,1-2H2,(H,25,28) | PDB
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UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20.4 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141426
(US10668051, Compound Example 84 | US8921364, 84)Show SMILES Cc1oncc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4O2/c1-9-12(8-23-28-9)17(27)24-11-4-5-14(13(19)6-11)26-15(10-2-3-10)7-16(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27) | PDB
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UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20.8 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652079
(US11905244, Compound 98) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 21.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652063
(US11905244, Compound 82) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 22.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141438
(US10668051, Compound Example 104 | US8921364, 104)Show SMILES Cc1ccccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C20H17F3N4O/c1-12-4-2-3-5-15(12)19(28)25-14-8-9-18(24-11-14)27-16(13-6-7-13)10-17(26-27)20(21,22)23/h2-5,8-11,13H,6-7H2,1H3,(H,25,28) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652045
(US11905244, Compound 64) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 24.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM50204536
(CHEMBL3984105)Show SMILES COc1ccc(OC)c(c1)-c1ccc(cc1)N(C)C(=O)c1ccncc1F Show InChI InChI=1S/C21H19FN2O3/c1-24(21(25)17-10-11-23-13-19(17)22)15-6-4-14(5-7-15)18-12-16(26-2)8-9-20(18)27-3/h4-13H,1-3H3 | PDB
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| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Inhibition of Orai1 (unknown origin) by patch clamp assay |
Bioorg Med Chem 25: 440-449 (2017)
Article DOI: 10.1016/j.bmc.2016.11.007
BindingDB Entry DOI: 10.7270/Q2HT2R9F |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM652046
(US11905244, Compound 65) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 30.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141428
(US10668051, Compound Example 87 | US8921364, 87)Show SMILES Fc1cccc(C(=O)Nc2ccc(c(F)c2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C20H13F6N3O/c21-13-3-1-2-12(18(13)23)19(30)27-11-6-7-15(14(22)8-11)29-16(10-4-5-10)9-17(28-29)20(24,25)26/h1-3,6-10H,4-5H2,(H,27,30) | PDB
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| n/a | n/a | 32.6 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141421
(US10668051, Compound Example 78 | US8921364, 78)Show SMILES Cc1ncsc1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4OS/c1-10-17(27-9-22-10)23-16(26)12-4-6-13(7-5-12)25-14(11-2-3-11)8-15(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26) | PDB
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| US Patent
| n/a | n/a | 34.1 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141424
(US10668051, Compound Example 82 | US8921364, 82)Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C17H13F4N5OS/c1-8-15(28-25-23-8)16(27)22-10-4-5-12(11(18)6-10)26-13(9-2-3-9)7-14(24-26)17(19,20)21/h4-7,9H,2-3H2,1H3,(H,22,27) | PDB
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| n/a | n/a | 35.7 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141396
(US10668051, Compound Example 7 | US8921364, 7)Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C23H23N3O/c1-15-4-2-3-5-20(15)23(27)24-18-10-12-19(13-11-18)26-22(17-8-9-17)14-21(25-26)16-6-7-16/h2-5,10-14,16-17H,6-9H2,1H3,(H,24,27) | PDB
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| n/a | n/a | 36.4 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141444
(US10668051, Compound Example 114 | US8921364, 114)Show SMILES Fc1cnccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H13F4N5O/c19-13-9-23-6-5-12(13)17(28)25-11-3-4-16(24-8-11)27-14(10-1-2-10)7-15(26-27)18(20,21)22/h3-10H,1-2H2,(H,25,28) | PDB
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| n/a | n/a | 37.6 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM152937
(US8993612, 20)Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cn2nnc3ccccc23)cc1 Show InChI InChI=1S/C21H17F3N6O/c22-21(23,24)19-11-18(13-5-6-13)30(27-19)15-9-7-14(8-10-15)25-20(31)12-29-17-4-2-1-3-16(17)26-28-29/h1-4,7-11,13H,5-6,12H2,(H,25,31) | PDB
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| n/a | n/a | 39.2 | n/a | n/a | n/a | n/a | n/a | 37 |
Rhizen Pharmaceuticals SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu... |
US Patent US8993612 (2015)
BindingDB Entry DOI: 10.7270/Q2CN72NK |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141442
(US10668051, Compound Example 111 | US8921364, 111)Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2cccnc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-8-14(11-3-4-11)26(25-15)16-6-5-13(10-23-16)24-17(27)12-2-1-7-22-9-12/h1-2,5-11H,3-4H2,(H,24,27) | PDB
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| n/a | n/a | 47.2 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141419
(US10668051, Compound Example 74 | US8921364, 74)Show SMILES Cc1ncsc1CNc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H17F3N4S/c1-11-16(26-10-23-11)9-22-13-4-6-14(7-5-13)25-15(12-2-3-12)8-17(24-25)18(19,20)21/h4-8,10,12,22H,2-3,9H2,1H3 | PDB
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RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141418
(US10668051, Compound Example 72 | US8921364, 72)Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cc2cccnc2)cc1 Show InChI InChI=1S/C20H17F3N4O/c21-20(22,23)18-11-17(14-3-4-14)27(26-18)16-7-5-15(6-8-16)25-19(28)10-13-2-1-9-24-12-13/h1-2,5-9,11-12,14H,3-4,10H2,(H,25,28) | PDB
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| n/a | n/a | 48.2 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141425
(US10668051, Compound Example 83 | US8921364, 83)Show SMILES Cc1ncsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4OS/c1-9-16(28-8-23-9)17(27)24-11-4-5-13(12(19)6-11)26-14(10-2-3-10)7-15(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27) | PDB
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| n/a | n/a | 48.2 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141441
(US10668051, Compound Example 108 | US8921364, 108)Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H13F5N4O/c20-12-2-1-3-13(21)17(12)18(29)26-11-6-7-16(25-9-11)28-14(10-4-5-10)8-15(27-28)19(22,23)24/h1-3,6-10H,4-5H2,(H,26,29) | PDB
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| n/a | n/a | 50.6 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM152932
(US8993612, 6)Show SMILES O=C(Cn1nnc2ccccc12)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C23H22N6O/c30-23(14-28-21-4-2-1-3-19(21)25-27-28)24-17-9-11-18(12-10-17)29-22(16-7-8-16)13-20(26-29)15-5-6-15/h1-4,9-13,15-16H,5-8,14H2,(H,24,30) | PDB
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| n/a | n/a | 51.3 | n/a | n/a | n/a | n/a | n/a | 37 |
Rhizen Pharmaceuticals SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu... |
US Patent US8993612 (2015)
BindingDB Entry DOI: 10.7270/Q2CN72NK |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141448
(US10668051, Compound Example 126 | US8921364, 126)Show SMILES Cc1ncsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)F)C(F)(F)F Show InChI InChI=1S/C16H11F5N4OS/c1-8-13(27-7-22-8)15(26)23-9-2-4-10(5-3-9)25-11(14(17)18)6-12(24-25)16(19,20)21/h2-7,14H,1H3,(H,23,26) | PDB
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| n/a | n/a | 52.6 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM152936
(US8993612, 18)Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccc3nccnc3c2)cc1 Show InChI InChI=1S/C22H16F3N5O/c23-22(24,25)20-12-19(13-1-2-13)30(29-20)16-6-4-15(5-7-16)28-21(31)14-3-8-17-18(11-14)27-10-9-26-17/h3-13H,1-2H2,(H,28,31) | PDB
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| n/a | n/a | 53.4 | n/a | n/a | n/a | n/a | n/a | 37 |
Rhizen Pharmaceuticals SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu... |
US Patent US8993612 (2015)
BindingDB Entry DOI: 10.7270/Q2CN72NK |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141439
(US10668051, Compound Example 106 | US8921364, 106)Show SMILES Fc1ccccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-14-4-2-1-3-13(14)18(28)25-12-7-8-17(24-10-12)27-15(11-5-6-11)9-16(26-27)19(21,22)23/h1-4,7-11H,5-6H2,(H,25,28) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
Calcium release-activated calcium channel protein 1
(Homo sapiens (Human)) | BDBM141402
(US10668051, Compound Example 28 | US8921364, 28)Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C19H18FN5OS/c1-10-18(27-24-22-10)19(26)21-13-6-7-16(14(20)8-13)25-17(12-4-5-12)9-15(23-25)11-2-3-11/h6-9,11-12H,2-5H2,1H3,(H,21,26) | PDB
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RHIZEN PHARMACEUTICALS SA
US Patent
| Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... |
US Patent US10668051 (2020)
BindingDB Entry DOI: 10.7270/Q2V40Z7G |
More data for this
Ligand-Target Pair | |
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