Compile Data Set for Download or QSAR

Found 409 hits of ic50 for UniProtKB: P42338   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM188124 (US9670194, Ex. 3 (S)-2-(1-((6-amino-5-(3-methyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189846 (US9670194, Ex. 65 (S)-2-(1-((6-amino-5-(3-methyl-1...) Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM188116 (US9670194, Ex. 1 (S)-2-(1-((6-amino-5-(5-methyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(29-21-19(20(26)27-12-28-21)23-32-31-13(2)35-23)22-30-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,29)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189408 (US9670194, Ex. 41 (S)-2-(1-((6-amino-5-(3-methyl-1...) Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C20H19ClN8O2/c1-9(25-17-15(16(22)23-8-24-17)19-26-10(2)28-31-19)18-27-13-5-3-4-12(21)14(13)20(30)29(18)11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H3,22,23,24,25)/t9-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189838 (US9670194, Ex. 57 (S)-2-(1-((6-amino-5-(3-isopropy...) Show SMILES CC(C)c1noc(n1)-c1c(N)ncnc1N[C@@H](C)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C22H23ClN8O2/c1-10(2)18-29-21(33-30-18)16-17(24)25-9-26-19(16)27-11(3)20-28-14-6-4-5-13(23)15(14)22(32)31(20)12-7-8-12/h4-6,9-12H,7-8H2,1-3H3,(H3,24,25,26,27)/t11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189403 (US9670194, Ex. 37 (S)-2-(1-((6-amino-5-(3-methyl-1...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H24N8O2/c1-4-17(30-22-20(21(26)27-13-28-22)24-29-15(3)32-35-24)23-31-18-12-8-9-14(2)19(18)25(34)33(23)16-10-6-5-7-11-16/h5-13,17H,4H2,1-3H3,(H3,26,27,28,30)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM188145 (US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189845 (US9670194, Ex. 64 (S)-2-(1-((6-amino-5-(5-methyl-1...) Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-31-30-13(2)34-22)21-29-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189837 (US9670194, Ex. 56 (S)-2-(1-((6-amino-5-(3-ethyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(CC)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C22H23ClN8O2/c1-3-13(27-19-17(18(24)25-10-26-19)21-29-15(4-2)30-33-21)20-28-14-7-5-6-12(23)16(14)22(32)31(20)11-8-9-11/h5-7,10-11,13H,3-4,8-9H2,1-2H3,(H3,24,25,26,27)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261151 (5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C1CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C26H28ClN7O2/c1-13-20(27)9-19(15(3)34-25-22(14(2)32-34)24(28)30-12-31-25)23(36-5)21(13)16-8-17(11-29-10-16)26(35)33(4)18-6-7-18/h8-12,15,18H,6-7H2,1-5H3,(H2,28,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261152 (5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H28ClN7O3/c1-13-19(26)9-18(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-8-17(11-28-10-16)25(35)32(4)6-7-34/h8-12,15,34H,6-7H2,1-5H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261153 (1-[(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]p...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N1CCC(O)CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C27H30ClN7O3/c1-14-21(28)10-20(16(3)35-26-23(15(2)33-35)25(29)31-13-32-26)24(38-4)22(14)17-9-18(12-30-11-17)27(37)34-7-5-19(36)6-8-34/h9-13,16,19,36H,5-8H2,1-4H3,(H2,29,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261154 (1-[(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]p...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N1CC(C1)C#N)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C26H25ClN8O2/c1-13-20(27)6-19(15(3)35-25-22(14(2)33-35)24(29)31-12-32-25)23(37-4)21(13)17-5-18(9-30-8-17)26(36)34-10-16(7-28)11-34/h5-6,8-9,12,15-16H,10-11H2,1-4H3,(H2,29,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261155 (5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)CCN)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H29ClN8O2/c1-13-19(26)9-18(15(3)34-24-21(14(2)32-34)23(28)30-12-31-24)22(36-5)20(13)16-8-17(11-29-10-16)25(35)33(4)7-6-27/h8-12,15H,6-7,27H2,1-5H3,(H2,28,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261156 (3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CNC(=O)CCc1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C20H25ClN6O2/c1-10-13(6-7-16(28)23-4)18(29-5)14(8-15(10)21)12(3)27-20-17(11(2)26-27)19(22)24-9-25-20/h8-9,12H,6-7H2,1-5H3,(H,23,28)(H2,22,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261157 (3-(3-(1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...) Show SMILES COc1c(cc(Cl)c(C)c1CCC(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C21H27ClN6O2/c1-11-14(7-8-17(29)27(4)5)19(30-6)15(9-16(11)22)13(3)28-21-18(12(2)26-28)20(23)24-10-25-21/h9-10,13H,7-8H2,1-6H3,(H2,23,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261158 (1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H31ClN8O/c1-14-20(26)10-19(16(3)34-25-22(15(2)31-34)24(27)28-13-29-25)23(35-5)21(14)17-11-30-33(12-17)18-6-8-32(4)9-7-18/h10-13,16,18H,6-9H2,1-5H3,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261159 (1-(1-{3-[1-(1-Acetylpiperidin-4-yl)-1H-pyrazol-4-y...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(CC1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C26H31ClN8O2/c1-14-21(27)10-20(16(3)35-26-23(15(2)32-35)25(28)29-13-30-26)24(37-5)22(14)18-11-31-34(12-18)19-6-8-33(9-7-19)17(4)36/h10-13,16,19H,6-9H2,1-5H3,(H2,28,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261160 (1-[1-(5-Chloro-3-{1-[2-(dimethylamino)ethyl]-1H-py...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(CCN(C)C)c1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H29ClN8O/c1-13-18(24)9-17(15(3)32-23-20(14(2)29-32)22(25)26-12-27-23)21(33-6)19(13)16-10-28-31(11-16)8-7-30(4)5/h9-12,15H,7-8H2,1-6H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261161 (2-[(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(NCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C23H28ClN7O2/c1-12-17(24)9-16(14(3)31-23-20(13(2)25)22(26)29-11-30-23)21(33-4)19(12)15-5-6-18(28-10-15)27-7-8-32/h5-6,9-11,14,25,32H,7-8H2,1-4H3,(H,27,28)(H3,26,29,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261162 (1-(1-(5-chloro-3-(6- (dimethylamino)pyridin-3-yl)-...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H26ClN7O/c1-12-17(24)9-16(14(3)31-23-20(13(2)29-31)22(25)27-11-28-23)21(32-6)19(12)15-7-8-18(26-10-15)30(4)5/h7-11,14H,1-6H3,(H2,25,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261163 (1-(1-(5-chloro-3-(2- (dimethylamino)pyridin-4-yl)-...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)N(C)C)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C23H28ClN7O/c1-12-18(24)8-17(14(3)30-23-20(13(2)25)22(26)28-11-29-23)21(32-6)19(12)15-7-16(31(4)5)10-27-9-15/h7-11,14,25H,1-6H3,(H3,26,28,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261164 (1-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)N1CC(O)C1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C24H28ClN7O2/c1-12-19(25)6-18(14(3)31-24-21(13(2)26)23(27)29-11-30-24)22(34-4)20(12)15-5-16(8-28-7-15)32-9-17(33)10-32/h5-8,11,14,17,26,33H,9-10H2,1-4H3,(H3,27,29,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261165 (2-(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(OCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C23H27ClN6O3/c1-12-17(24)9-16(14(3)30-23-20(13(2)25)22(26)28-11-29-23)21(32-4)19(12)15-5-6-18(27-10-15)33-8-7-31/h5-6,9-11,14,25,31H,7-8H2,1-4H3,(H3,26,28,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261166 (5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CC(Nc1ncnc(N)c1C(C)=N)c1cc(Cl)c(C)c(-c2ccc(nc2)C(=O)N(C)C)c1OCC(F)F Show InChI InChI=1S/C25H28ClF2N7O2/c1-12-17(26)8-16(14(3)34-24-21(13(2)29)23(30)32-11-33-24)22(37-10-19(27)28)20(12)15-6-7-18(31-9-15)25(36)35(4)5/h6-9,11,14,19,29H,10H2,1-5H3,(H3,30,32,33,34)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261167 (5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CC(Nc1ncnc(N)c1C(C)=N)c1cc(Cl)c(C)c(-c2ccc(nc2)C(=O)N(C)C)c1OCC1CC1 Show InChI InChI=1S/C27H32ClN7O2/c1-14-20(28)10-19(16(3)34-26-23(15(2)29)25(30)32-13-33-26)24(37-12-17-6-7-17)22(14)18-8-9-21(31-11-18)27(36)35(4)5/h8-11,13,16-17,29H,6-7,12H2,1-5H3,(H3,30,32,33,34)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261168 (5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(=N)C(F)F Show InChI InChI=1S/C24H26ClF2N7O2/c1-11-15(25)8-14(12(2)33-23-18(19(28)21(26)27)22(29)31-10-32-23)20(36-5)17(11)13-6-7-16(30-9-13)24(35)34(3)4/h6-10,12,21,28H,1-5H3,(H3,29,31,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261171 (US10092570, Example 194 | US11433071, Example 194 ...) Show SMILES COc1c(CC#N)c(C)c(Cl)cc1C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C18H21ClN6O/c1-9-12(5-6-20)16(26-4)13(7-14(9)19)11(3)25-18-15(10(2)21)17(22)23-8-24-18/h7-8,11,21H,5H2,1-4H3,(H3,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255803 (5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261173 (5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-18(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)9-19(26)13(2)20(22)16-8-17(11-28-10-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261174 (1-(1-(5-chloro-2-ethoxy-4-methyl- 3-(1-methyl-1H-p...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C21H24ClN7O/c1-6-30-19-15(7-16(22)11(2)17(19)14-8-26-28(5)9-14)13(4)29-21-18(12(3)27-29)20(23)24-10-25-21/h7-10,13H,6H2,1-5H3,(H2,23,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261175 (1-(1-(5-chloro-2-ethoxy-4-methyl- 3-(5-(methylsulf...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H25ClN6O3S/c1-6-33-21-17(14(4)30-23-20(13(3)29-30)22(25)27-11-28-23)8-18(24)12(2)19(21)15-7-16(10-26-9-15)34(5,31)32/h7-11,14H,6H2,1-5H3,(H2,25,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261176 (5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)NC)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C24H26ClN7O2/c1-6-34-21-16(14(4)32-23-20(13(3)31-32)22(26)29-11-30-23)9-17(25)12(2)19(21)15-7-8-18(28-10-15)24(33)27-5/h7-11,14H,6H2,1-5H3,(H,27,33)(H2,26,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261177 (4-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C24H28ClN7O2/c1-12-17(25)10-16(14(3)31-23-20(13(2)26)22(27)29-11-30-23)21(34-6)19(12)15-7-8-28-18(9-15)24(33)32(4)5/h7-11,14,26H,1-6H3,(H3,27,29,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261178 (4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)10-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-27-18(9-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255808 (4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)11-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-28-19(10-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261180 (2-(4-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(N)=O)c1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C22H27ClN8O2/c1-5-33-20-15(13(4)30-22-19(12(3)24)21(26)27-10-28-22)6-16(23)11(2)18(20)14-7-29-31(8-14)9-17(25)32/h6-8,10,13,24H,5,9H2,1-4H3,(H2,25,32)(H3,26,27,28,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261181 (2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(=O)NC)c1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H27ClN8O2/c1-6-34-21-16(14(4)32-23-20(13(3)30-32)22(25)27-11-28-23)7-17(24)12(2)19(21)15-8-29-31(9-15)10-18(33)26-5/h7-9,11,14H,6,10H2,1-5H3,(H,26,33)(H2,25,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261182 (2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(=O)N(C)C)c1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C24H31ClN8O2/c1-7-35-22-17(15(4)31-24-21(14(3)26)23(27)28-12-29-24)8-18(25)13(2)20(22)16-9-30-33(10-16)11-19(34)32(5)6/h8-10,12,15,26H,7,11H2,1-6H3,(H3,27,28,29,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261183 (2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(=O)N(C)C)c1)C(C)C1N=C(C)c2c1ncnc2N |t:27| Show InChI InChI=1S/C25H30ClN7O2/c1-7-35-24-17(13(2)22-23-21(15(4)31-22)25(27)29-12-28-23)8-18(26)14(3)20(24)16-9-30-33(10-16)11-19(34)32(5)6/h8-10,12-13,22H,7,11H2,1-6H3,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261184 (2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(c1)C(C)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H31ClN8O2/c1-8-36-22-18(15(4)34-24-21(14(3)31-34)23(27)28-12-29-24)9-19(26)13(2)20(22)17-10-30-33(11-17)16(5)25(35)32(6)7/h9-12,15-16H,8H2,1-7H3,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261185 (6-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(cn1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C25H30ClN7O2/c1-7-35-22-17(15(4)32-24-21(14(3)27)23(28)30-12-31-24)10-18(26)13(2)20(22)19-9-8-16(11-29-19)25(34)33(5)6/h8-12,15,27H,7H2,1-6H3,(H3,28,30,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261187 (5-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...) Show SMILES CCOc1c(cc(C#N)c(C)c1-c1cnn(C)c1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C22H26N8O/c1-6-31-20-17(14(4)29-22-19(13(3)24)21(25)26-11-27-22)7-15(8-23)12(2)18(20)16-9-28-30(5)10-16/h7,9-11,14,24H,6H2,1-5H3,(H3,25,26,27,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261188 (3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...) Show SMILES CCOc1c(cc(Cl)c(C)c1C#N)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C18H21ClN6O/c1-5-26-16-12(6-14(19)9(2)13(16)7-20)11(4)25-18-15(10(3)21)17(22)23-8-24-18/h6,8,11,21H,5H2,1-4H3,(H3,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261189 (4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...) Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C20H22ClN7O/c1-4-29-18-13(5-15(21)14(6-22)17(18)12-7-24-8-12)11(3)28-20-16(10(2)27-28)19(23)25-9-26-20/h5,9,11-12,24H,4,7-8H2,1-3H3,(H2,23,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261190 (4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...) Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C21H24ClN7O/c1-5-30-19-14(6-16(22)15(7-23)18(19)13-8-28(4)9-13)12(3)29-21-17(11(2)27-29)20(24)25-10-26-21/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261191 (US10092570, Example 214 | US10376513, Example 214 ...) Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC)C1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C22H26ClN7O/c1-5-29-9-14(10-29)19-16(8-24)17(23)7-15(20(19)31-6-2)13(4)30-22-18(12(3)28-30)21(25)26-11-27-22/h7,11,13-14H,5-6,9-10H2,1-4H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261192 (US10092570, Example 215 | US10376513, Example 215 ...) Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H28ClN7O/c1-6-32-21-16(14(5)31-23-19(13(4)29-31)22(26)27-11-28-23)7-18(24)17(8-25)20(21)15-9-30(10-15)12(2)3/h7,11-12,14-15H,6,9-10H2,1-5H3,(H2,26,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261193 (US10092570, Example 216 | US10376513, Example 216 ...) Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC(C)C)C1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C24H30ClN7O/c1-6-33-22-17(15(5)32-24-20(14(4)30-32)23(27)28-12-29-24)7-19(25)18(8-26)21(22)16-10-31(11-16)9-13(2)3/h7,12-13,15-16H,6,9-11H2,1-5H3,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261194 (US10092570, Example 217 | US10376513, Example 217 ...) Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C24H28ClN7O/c1-4-33-22-17(14(3)32-24-20(13(2)30-32)23(27)28-12-29-24)7-19(25)18(8-26)21(22)16-10-31(11-16)9-15-5-6-15/h7,12,14-16H,4-6,9-11H2,1-3H3,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair

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