Found 87 hits Enz. Inhib. hit(s) with all data for entry = 50033120 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339871
((S)-3-(1-(4-(5-chlorothiophen-2-yl)pyrimidin-2-yl)...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2ccc(Cl)s2)c1=O |r| Show InChI InChI=1S/C21H21ClN6OS/c1-2-27-16-6-3-10-23-19(16)28(21(27)29)14-5-4-12-26(13-14)20-24-11-9-15(25-20)17-7-8-18(22)30-17/h3,6-11,14H,2,4-5,12-13H2,1H3/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50244890
(CHEMBL472535 | N-(2-fluorophenyl)-4-(3-phenyl-1,2,...)Show SMILES Fc1ccccc1NC(=O)N1CCN(CC1)c1nc(ns1)-c1ccccc1 Show InChI InChI=1S/C19H18FN5OS/c20-15-8-4-5-9-16(15)21-18(26)24-10-12-25(13-11-24)19-22-17(23-27-19)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339872
((S)-3-(1-(4-(5-chlorothiophen-2-yl)pyrimidin-2-yl)...)Show SMILES FC(F)(F)Cn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2ccc(Cl)s2)c1=O |r| Show InChI InChI=1S/C21H18ClF3N6OS/c22-17-6-5-16(33-17)14-7-9-27-19(28-14)29-10-2-3-13(11-29)31-18-15(4-1-8-26-18)30(20(31)32)12-21(23,24)25/h1,4-9,13H,2-3,10-12H2/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339873
((S)-3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c1=O |r| Show InChI InChI=1S/C25H24N6OS/c1-2-30-20-9-5-12-26-23(20)31(25(30)32)18-8-6-14-29(16-18)24-27-13-11-19(28-24)22-15-17-7-3-4-10-21(17)33-22/h3-5,7,9-13,15,18H,2,6,8,14,16H2,1H3/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339874
(2-(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)p...)Show SMILES Cc1c(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc2n1CC#N Show InChI InChI=1S/C27H24N6S/c1-18-25(21-8-4-12-29-26(21)33(18)15-11-28)20-7-5-14-32(17-20)27-30-13-10-22(31-27)24-16-19-6-2-3-9-23(19)34-24/h2-4,6,8-10,12-13,16,20H,5,7,14-15,17H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339875
((S)-2-(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-...)Show SMILES Cc1c([C@@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc2n1CCO |r| Show InChI InChI=1S/C27H27N5OS/c1-18-25(21-8-4-11-28-26(21)32(18)14-15-33)20-7-5-13-31(17-20)27-29-12-10-22(30-27)24-16-19-6-2-3-9-23(19)34-24/h2-4,6,8-12,16,20,33H,5,7,13-15,17H2,1H3/t20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50244890
(CHEMBL472535 | N-(2-fluorophenyl)-4-(3-phenyl-1,2,...)Show SMILES Fc1ccccc1NC(=O)N1CCN(CC1)c1nc(ns1)-c1ccccc1 Show InChI InChI=1S/C19H18FN5OS/c20-15-8-4-5-9-16(15)21-18(26)24-10-12-25(13-11-24)19-22-17(23-27-19)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM26739
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339875
((S)-2-(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-...)Show SMILES Cc1c([C@@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc2n1CCO |r| Show InChI InChI=1S/C27H27N5OS/c1-18-25(21-8-4-11-28-26(21)32(18)14-15-33)20-7-5-13-31(17-20)27-29-12-10-22(30-27)24-16-19-6-2-3-9-23(19)34-24/h2-4,6,8-12,16,20,33H,5,7,13-15,17H2,1H3/t20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339871
((S)-3-(1-(4-(5-chlorothiophen-2-yl)pyrimidin-2-yl)...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2ccc(Cl)s2)c1=O |r| Show InChI InChI=1S/C21H21ClN6OS/c1-2-27-16-6-3-10-23-19(16)28(21(27)29)14-5-4-12-26(13-14)20-24-11-9-15(25-20)17-7-8-18(22)30-17/h3,6-11,14H,2,4-5,12-13H2,1H3/t14-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM26739
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339876
(6-bromo-N-(2-fluorophenyl)-4H-spiro[benzo[d][1,3]d...)Show InChI InChI=1S/C19H18BrFN2O3/c20-14-5-6-17-13(11-14)12-25-19(26-17)7-9-23(10-8-19)18(24)22-16-4-2-1-3-15(16)21/h1-6,11H,7-10,12H2,(H,22,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339877
(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)pipe...)Show SMILES Cc1[nH]c2ncccc2c1C1CCCN(C1)c1nccc(n1)-c1cc2ccccc2s1 Show InChI InChI=1S/C25H23N5S/c1-16-23(19-8-4-11-26-24(19)28-16)18-7-5-13-30(15-18)25-27-12-10-20(29-25)22-14-17-6-2-3-9-21(17)31-22/h2-4,6,8-12,14,18H,5,7,13,15H2,1H3,(H,26,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339878
((S)-3-(1-(4-(benzofuran-2-yl)pyrimidin-2-yl)piperi...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3o2)c1=O |r| Show InChI InChI=1S/C25H24N6O2/c1-2-30-20-9-5-12-26-23(20)31(25(30)32)18-8-6-14-29(16-18)24-27-13-11-19(28-24)22-15-17-7-3-4-10-21(17)33-22/h3-5,7,9-13,15,18H,2,6,8,14,16H2,1H3/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339872
((S)-3-(1-(4-(5-chlorothiophen-2-yl)pyrimidin-2-yl)...)Show SMILES FC(F)(F)Cn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2ccc(Cl)s2)c1=O |r| Show InChI InChI=1S/C21H18ClF3N6OS/c22-17-6-5-16(33-17)14-7-9-27-19(28-14)29-10-2-3-13(11-29)31-18-15(4-1-8-26-18)30(20(31)32)12-21(23,24)25/h1,4-9,13H,2-3,10-12H2/t13-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339879
((R)-3-(1-(4-(benzofuran-2-yl)pyrimidin-2-yl)piperi...)Show SMILES CCn1c2cccnc2n([C@@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3o2)c1=O |r| Show InChI InChI=1S/C25H24N6O2/c1-2-30-20-9-5-12-26-23(20)31(25(30)32)18-8-6-14-29(16-18)24-27-13-11-19(28-24)22-15-17-7-3-4-10-21(17)33-22/h3-5,7,9-13,15,18H,2,6,8,14,16H2,1H3/t18-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339880
(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)pipe...)Show SMILES Cn1cc(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc12 Show InChI InChI=1S/C25H23N5S/c1-29-16-20(19-8-4-11-26-24(19)29)18-7-5-13-30(15-18)25-27-12-10-21(28-25)23-14-17-6-2-3-9-22(17)31-23/h2-4,6,8-12,14,16,18H,5,7,13,15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339881
(2-(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)p...)Show SMILES N#CCn1cc(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc12 Show InChI InChI=1S/C26H22N6S/c27-10-14-31-17-21(20-7-3-11-28-25(20)31)19-6-4-13-32(16-19)26-29-12-9-22(30-26)24-15-18-5-1-2-8-23(18)33-24/h1-3,5,7-9,11-12,15,17,19H,4,6,13-14,16H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339882
((S)-3-(1-(2-amino-6-(benzofuran-2-yl)pyrimidin-4-y...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2cc(nc(N)n2)-c2cc3ccccc3o2)c1=O |r| Show InChI InChI=1S/C25H25N7O2/c1-2-31-19-9-5-11-27-23(19)32(25(31)33)17-8-6-12-30(15-17)22-14-18(28-24(26)29-22)21-13-16-7-3-4-10-20(16)34-21/h3-5,7,9-11,13-14,17H,2,6,8,12,15H2,1H3,(H2,26,28,29)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339879
((R)-3-(1-(4-(benzofuran-2-yl)pyrimidin-2-yl)piperi...)Show SMILES CCn1c2cccnc2n([C@@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3o2)c1=O |r| Show InChI InChI=1S/C25H24N6O2/c1-2-30-20-9-5-12-26-23(20)31(25(30)32)18-8-6-14-29(16-18)24-27-13-11-19(28-24)22-15-17-7-3-4-10-21(17)33-22/h3-5,7,9-13,15,18H,2,6,8,14,16H2,1H3/t18-/m1/s1 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50244718
(CHEMBL460273 | JNJ-1661010 | N-phenyl-4-(3-phenyl-...)Show InChI InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25) | PDB MMDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339883
((S)-1-ethyl-3-(1-(2-(4-fluorophenyl)pyrimidin-4-yl...)Show SMILES CCn1c2ccccc2n([C@H]2CCCN(C2)c2ccnc(n2)-c2ccc(F)cc2)c1=O |r| Show InChI InChI=1S/C24H24FN5O/c1-2-29-20-7-3-4-8-21(20)30(24(29)31)19-6-5-15-28(16-19)22-13-14-26-23(27-22)17-9-11-18(25)12-10-17/h3-4,7-14,19H,2,5-6,15-16H2,1H3/t19-/m0/s1 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339884
((S)-1-ethyl-3-(1-(4-(4-fluorophenyl)pyrimidin-2-yl...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2ccc(F)cc2)c1=O |r| Show InChI InChI=1S/C23H23FN6O/c1-2-29-20-6-3-12-25-21(20)30(23(29)31)18-5-4-14-28(15-18)22-26-13-11-19(27-22)16-7-9-17(24)10-8-16/h3,6-13,18H,2,4-5,14-15H2,1H3/t18-/m0/s1 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339885
(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)pipe...)Show SMILES CCn1c(C)c(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc12 Show InChI InChI=1S/C27H27N5S/c1-3-32-18(2)25(21-10-6-13-28-26(21)32)20-9-7-15-31(17-20)27-29-14-12-22(30-27)24-16-19-8-4-5-11-23(19)33-24/h4-6,8,10-14,16,20H,3,7,9,15,17H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339886
((S)-3-(1-(2-amino-6-(4-fluorophenyl)pyrimidin-4-yl...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2cc(nc(N)n2)-c2ccc(F)cc2)c1=O |r| Show InChI InChI=1S/C23H24FN7O/c1-2-30-19-6-3-11-26-21(19)31(23(30)32)17-5-4-12-29(14-17)20-13-18(27-22(25)28-20)15-7-9-16(24)10-8-15/h3,6-11,13,17H,2,4-5,12,14H2,1H3,(H2,25,27,28)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
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Similars
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50161517
(6-Phenyl-1-(5-pyridin-2-yl-oxazol-2-yl)-hexan-1-on...)Show InChI InChI=1S/C20H20N2O2/c23-18(13-6-2-5-11-16-9-3-1-4-10-16)20-22-15-19(24-20)17-12-7-8-14-21-17/h1,3-4,7-10,12,14-15H,2,5-6,11,13H2 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339874
(2-(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)p...)Show SMILES Cc1c(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc2n1CC#N Show InChI InChI=1S/C27H24N6S/c1-18-25(21-8-4-12-29-26(21)33(18)15-11-28)20-7-5-14-32(17-20)27-30-13-10-22(31-27)24-16-19-6-2-3-9-23(19)34-24/h2-4,6,8-10,12-13,16,20H,5,7,14-15,17H2,1H3 | PDB MMDB
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339878
((S)-3-(1-(4-(benzofuran-2-yl)pyrimidin-2-yl)piperi...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3o2)c1=O |r| Show InChI InChI=1S/C25H24N6O2/c1-2-30-20-9-5-12-26-23(20)31(25(30)32)18-8-6-14-29(16-18)24-27-13-11-19(28-24)22-15-17-7-3-4-10-21(17)33-22/h3-5,7,9-13,15,18H,2,6,8,14,16H2,1H3/t18-/m0/s1 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50161517
(6-Phenyl-1-(5-pyridin-2-yl-oxazol-2-yl)-hexan-1-on...)Show InChI InChI=1S/C20H20N2O2/c23-18(13-6-2-5-11-16-9-3-1-4-10-16)20-22-15-19(24-20)17-12-7-8-14-21-17/h1,3-4,7-10,12,14-15H,2,5-6,11,13H2 | PDB MMDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339873
((S)-3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c1=O |r| Show InChI InChI=1S/C25H24N6OS/c1-2-30-20-9-5-12-26-23(20)31(25(30)32)18-8-6-14-29(16-18)24-27-13-11-19(28-24)22-15-17-7-3-4-10-21(17)33-22/h3-5,7,9-13,15,18H,2,6,8,14,16H2,1H3/t18-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339887
(1-(1-(4-(benzofuran-2-yl)pyrimidin-2-yl)piperidin-...)Show SMILES Cn1c2ccccc2n(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3o2)c1=O Show InChI InChI=1S/C25H23N5O2/c1-28-20-9-3-4-10-21(20)30(25(28)31)18-8-6-14-29(16-18)24-26-13-12-19(27-24)23-15-17-7-2-5-11-22(17)32-23/h2-5,7,9-13,15,18H,6,8,14,16H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339884
((S)-1-ethyl-3-(1-(4-(4-fluorophenyl)pyrimidin-2-yl...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2ccc(F)cc2)c1=O |r| Show InChI InChI=1S/C23H23FN6O/c1-2-29-20-6-3-12-25-21(20)30(23(29)31)18-5-4-14-28(15-18)22-26-13-11-19(27-22)16-7-9-17(24)10-8-16/h3,6-13,18H,2,4-5,14-15H2,1H3/t18-/m0/s1 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Similars
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339888
(1-(1-(4-(benzofuran-2-yl)pyrimidin-2-yl)piperidin-...)Show SMILES CCn1c2ccccc2n(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3o2)c1=O Show InChI InChI=1S/C26H25N5O2/c1-2-30-21-10-4-5-11-22(21)31(26(30)32)19-9-7-15-29(17-19)25-27-14-13-20(28-25)24-16-18-8-3-6-12-23(18)33-24/h3-6,8,10-14,16,19H,2,7,9,15,17H2,1H3 | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339891
((S)-1-ethyl-3-(1-(4-(thiophen-2-yl)pyrimidin-2-yl)...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2cccs2)c1=O |r| Show InChI InChI=1S/C21H22N6OS/c1-2-26-17-7-3-10-22-19(17)27(21(26)28)15-6-4-12-25(14-15)20-23-11-9-16(24-20)18-8-5-13-29-18/h3,5,7-11,13,15H,2,4,6,12,14H2,1H3/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339890
((S)-1-(1-(2-(4-chlorophenyl)pyrimidin-4-yl)piperid...)Show SMILES CCn1c2ccccc2n([C@H]2CCCN(C2)c2ccnc(n2)-c2ccc(Cl)cc2)c1=O |r| Show InChI InChI=1S/C24H24ClN5O/c1-2-29-20-7-3-4-8-21(20)30(24(29)31)19-6-5-15-28(16-19)22-13-14-26-23(27-22)17-9-11-18(25)12-10-17/h3-4,7-14,19H,2,5-6,15-16H2,1H3/t19-/m0/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339889
((S)-1-(1-(2-(benzofuran-2-yl)pyrimidin-4-yl)piperi...)Show SMILES CCn1c2ccccc2n([C@H]2CCCN(C2)c2ccnc(n2)-c2cc3ccccc3o2)c1=O |r| Show InChI InChI=1S/C26H25N5O2/c1-2-30-20-10-4-5-11-21(20)31(26(30)32)19-9-7-15-29(17-19)24-13-14-27-25(28-24)23-16-18-8-3-6-12-22(18)33-23/h3-6,8,10-14,16,19H,2,7,9,15,17H2,1H3/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339876
(6-bromo-N-(2-fluorophenyl)-4H-spiro[benzo[d][1,3]d...)Show InChI InChI=1S/C19H18BrFN2O3/c20-14-5-6-17-13(11-14)12-25-19(26-17)7-9-23(10-8-19)18(24)22-16-4-2-1-3-15(16)21/h1-6,11H,7-10,12H2,(H,22,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339875
((S)-2-(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-...)Show SMILES Cc1c([C@@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc2n1CCO |r| Show InChI InChI=1S/C27H27N5OS/c1-18-25(21-8-4-11-28-26(21)32(18)14-15-33)20-7-5-13-31(17-20)27-29-12-10-22(30-27)24-16-19-6-2-3-9-23(19)34-24/h2-4,6,8-12,16,20,33H,5,7,13-15,17H2,1H3/t20-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339892
((S)-1-ethyl-3-(1-(2-p-tolylpyrimidin-4-yl)piperidi...)Show SMILES CCn1c2ccccc2n([C@H]2CCCN(C2)c2ccnc(n2)-c2ccc(C)cc2)c1=O |r| Show InChI InChI=1S/C25H27N5O/c1-3-29-21-8-4-5-9-22(21)30(25(29)31)20-7-6-16-28(17-20)23-14-15-26-24(27-23)19-12-10-18(2)11-13-19/h4-5,8-15,20H,3,6-7,16-17H2,1-2H3/t20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339886
((S)-3-(1-(2-amino-6-(4-fluorophenyl)pyrimidin-4-yl...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2cc(nc(N)n2)-c2ccc(F)cc2)c1=O |r| Show InChI InChI=1S/C23H24FN7O/c1-2-30-19-6-3-11-26-21(19)31(23(30)32)17-5-4-12-29(14-17)20-13-18(27-22(25)28-20)15-7-9-16(24)10-8-15/h3,6-11,13,17H,2,4-5,12,14H2,1H3,(H2,25,27,28)/t17-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339894
((S)-1-ethyl-3-(1-(2-(3-fluorophenyl)pyrimidin-4-yl...)Show SMILES CCn1c2ccccc2n([C@H]2CCCN(C2)c2ccnc(n2)-c2cccc(F)c2)c1=O |r| Show InChI InChI=1S/C24H24FN5O/c1-2-29-20-10-3-4-11-21(20)30(24(29)31)19-9-6-14-28(16-19)22-12-13-26-23(27-22)17-7-5-8-18(25)15-17/h3-5,7-8,10-13,15,19H,2,6,9,14,16H2,1H3/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339893
((S)-1-ethyl-3-(1-(4-phenylpyrimidin-2-yl)piperidin...)Show SMILES CCn1c2cccnc2n([C@H]2CCCN(C2)c2nccc(n2)-c2ccccc2)c1=O |r| Show InChI InChI=1S/C23H24N6O/c1-2-28-20-11-6-13-24-21(20)29(23(28)30)18-10-7-15-27(16-18)22-25-14-12-19(26-22)17-8-4-3-5-9-17/h3-6,8-9,11-14,18H,2,7,10,15-16H2,1H3/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339875
((S)-2-(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-...)Show SMILES Cc1c([C@@H]2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc2n1CCO |r| Show InChI InChI=1S/C27H27N5OS/c1-18-25(21-8-4-11-28-26(21)32(18)14-15-33)20-7-5-13-31(17-20)27-29-12-10-22(30-27)24-16-19-6-2-3-9-23(19)34-24/h2-4,6,8-12,16,20,33H,5,7,13-15,17H2,1H3/t20-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339888
(1-(1-(4-(benzofuran-2-yl)pyrimidin-2-yl)piperidin-...)Show SMILES CCn1c2ccccc2n(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3o2)c1=O Show InChI InChI=1S/C26H25N5O2/c1-2-30-21-10-4-5-11-22(21)31(26(30)32)19-9-7-15-29(17-19)25-27-14-13-20(28-25)24-16-18-8-3-6-12-23(18)33-24/h3-6,8,10-14,16,19H,2,7,9,15,17H2,1H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50339895
((S)-1-(1-(2-(5-chlorothiophen-2-yl)pyrimidin-4-yl)...)Show SMILES CCn1c2ccccc2n([C@H]2CCCN(C2)c2ccnc(n2)-c2ccc(Cl)s2)c1=O |r| Show InChI InChI=1S/C22H22ClN5OS/c1-2-27-16-7-3-4-8-17(16)28(22(27)29)15-6-5-13-26(14-15)20-11-12-24-21(25-20)18-9-10-19(23)30-18/h3-4,7-12,15H,2,5-6,13-14H2,1H3/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339877
(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)pipe...)Show SMILES Cc1[nH]c2ncccc2c1C1CCCN(C1)c1nccc(n1)-c1cc2ccccc2s1 Show InChI InChI=1S/C25H23N5S/c1-16-23(19-8-4-11-26-24(19)28-16)18-7-5-13-30(15-18)25-27-12-10-20(29-25)22-14-17-6-2-3-9-21(17)31-22/h2-4,6,8-12,14,18H,5,7,13,15H2,1H3,(H,26,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339885
(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)pipe...)Show SMILES CCn1c(C)c(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc12 Show InChI InChI=1S/C27H27N5S/c1-3-32-18(2)25(21-10-6-13-28-26(21)32)20-9-7-15-31(17-20)27-29-14-12-22(30-27)24-16-19-8-4-5-11-23(19)33-24/h4-6,8,10-14,16,20H,3,7,9,15,17H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339881
(2-(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)p...)Show SMILES N#CCn1cc(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc12 Show InChI InChI=1S/C26H22N6S/c27-10-14-31-17-21(20-7-3-11-28-25(20)31)19-6-4-13-32(16-19)26-29-12-9-22(30-26)24-15-18-5-1-2-8-23(18)33-24/h1-3,5,7-9,11-12,15,17,19H,4,6,13-14,16H2 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339883
((S)-1-ethyl-3-(1-(2-(4-fluorophenyl)pyrimidin-4-yl...)Show SMILES CCn1c2ccccc2n([C@H]2CCCN(C2)c2ccnc(n2)-c2ccc(F)cc2)c1=O |r| Show InChI InChI=1S/C24H24FN5O/c1-2-29-20-7-3-4-8-21(20)30(24(29)31)19-6-5-15-28(16-19)22-13-14-26-23(27-22)17-9-11-18(25)12-10-17/h3-4,7-14,19H,2,5-6,15-16H2,1H3/t19-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50339880
(3-(1-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)pipe...)Show SMILES Cn1cc(C2CCCN(C2)c2nccc(n2)-c2cc3ccccc3s2)c2cccnc12 Show InChI InChI=1S/C25H23N5S/c1-29-16-20(19-8-4-11-26-24(19)29)18-7-5-13-30(15-18)25-27-12-10-21(28-25)23-14-17-6-2-3-9-22(17)31-23/h2-4,6,8-12,14,16,18H,5,7,13,15H2,1H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin |
Bioorg Med Chem Lett 21: 2492-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.052 BindingDB Entry DOI: 10.7270/Q2BG2P9M |
More data for this Ligand-Target Pair | |