Compile Data Set for Download or QSAR

Found 126 hits Enz. Inhib. hit(s) with all data for entry = 8804   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420157 ((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...) Show SMILES CN(C)[C@H]1CCN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21 |r| Show InChI InChI=1S/C24H26ClN7OS/c1-30(2)16-6-8-31(11-16)24(33)14-3-4-17-20(9-14)34-23-21(17)22(26-13-27-23)29-19-10-15-5-7-28-32(15)12-18(19)25/h5,7,10,12-14,16H,3-4,6,8-9,11H2,1-2H3,(H,26,27,29)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420246 ((7S)—N-Ethyl-4-[(6-methoxypyrazolo[1,5-a]pyridin-5...) Show SMILES CCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C22H24N6O2S/c1-4-27(2)22(29)13-5-6-15-18(9-13)31-21-19(15)20(23-12-24-21)26-16-10-14-7-8-25-28(14)11-17(16)30-3/h7-8,10-13H,4-6,9H2,1-3H3,(H,23,24,26)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420249 ((7S)—N-Butyl-4-[(6-methoxypyrazolo[1,5-a]pyridin-5...) Show SMILES CCCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C24H28N6O2S/c1-4-5-10-29(2)24(31)15-6-7-17-20(11-15)33-23-21(17)22(25-14-26-23)28-18-12-16-8-9-27-30(16)13-19(18)32-3/h8-9,12-15H,4-7,10-11H2,1-3H3,(H,25,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420250 (1-((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)a...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)C#N |r| Show InChI InChI=1S/C23H21N7O2S/c1-32-18-11-30-15(4-5-27-30)7-17(18)28-21-20-16-3-2-14(23(31)29-9-13(8-24)10-29)6-19(16)33-22(20)26-12-25-21/h4-5,7,11-14H,2-3,6,9-10H2,1H3,(H,25,26,28)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420251 ((7S)—N-[3-(Dimethylamino)propyl]-4-[(6-methoxypyra...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CCCN(C)C |r| Show InChI InChI=1S/C25H31N7O2S/c1-30(2)10-5-11-31(3)25(33)16-6-7-18-21(12-16)35-24-22(18)23(26-15-27-24)29-19-13-17-8-9-28-32(17)14-20(19)34-4/h8-9,13-16H,5-7,10-12H2,1-4H3,(H,26,27,29)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420252 ((3-Hydroxy-3-methylazetidin-1-yl)(7S)-4-[(6-methox...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C)(O)C1 |r| Show InChI InChI=1S/C23H24N6O3S/c1-23(31)10-28(11-23)22(30)13-3-4-15-18(7-13)33-21-19(15)20(24-12-25-21)27-16-8-14-5-6-26-29(14)9-17(16)32-2/h5-6,8-9,12-13,31H,3-4,7,10-11H2,1-2H3,(H,24,25,27)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420256 ((7S)—N-(2-Methoxyethyl)-4-[(6-methoxypyrazolo[1,5-...) Show SMILES COCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C23H26N6O3S/c1-28(8-9-31-2)23(30)14-4-5-16-19(10-14)33-22-20(16)21(24-13-25-22)27-17-11-15-6-7-26-29(15)12-18(17)32-3/h6-7,11-14H,4-5,8-10H2,1-3H3,(H,24,25,27)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420258 (US10487092, Example 106 | [(3R)-3-(Dimethylamino)p...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC[C@H](C1)N(C)C |r| Show InChI InChI=1S/C25H29N7O2S/c1-30(2)17-7-9-31(12-17)25(33)15-4-5-18-21(10-15)35-24-22(18)23(26-14-27-24)29-19-11-16-6-8-28-32(16)13-20(19)34-3/h6,8,11,13-15,17H,4-5,7,9-10,12H2,1-3H3,(H,26,27,29)/t15-,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420260 (US10487092, Example 108 | [(3S,4S)-3,4-Dihydroxypy...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H](O)[C@@H](O)C1 |r| Show InChI InChI=1S/C23H24N6O4S/c1-33-18-10-29-13(4-5-26-29)7-15(18)27-21-20-14-3-2-12(6-19(14)34-22(20)25-11-24-21)23(32)28-8-16(30)17(31)9-28/h4-5,7,10-12,16-17,30-31H,2-3,6,8-9H2,1H3,(H,24,25,27)/t12-,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420261 (US10487092, Example 109 | [4-(Dimethylamino)piperi...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCC(CC1)N(C)C |r| Show InChI InChI=1S/C26H31N7O2S/c1-31(2)17-7-10-32(11-8-17)26(34)16-4-5-19-22(12-16)36-25-23(19)24(27-15-28-25)30-20-13-18-6-9-29-33(18)14-21(20)35-3/h6,9,13-17H,4-5,7-8,10-12H2,1-3H3,(H,27,28,30)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420262 ((4-[2-Dimethylamino)ethyl]methyl)aminopiperidin-1-...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCC(CC1)N(C)CCN(C)C |r| Show InChI InChI=1S/C29H38N8O2S/c1-34(2)13-14-35(3)20-8-11-36(12-9-20)29(38)19-5-6-22-25(15-19)40-28-26(22)27(30-18-31-28)33-23-16-21-7-10-32-37(21)17-24(23)39-4/h7,10,16-20H,5-6,8-9,11-15H2,1-4H3,(H,30,31,33)/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420265 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCN(C)CC1 |r| Show InChI InChI=1S/C24H27N7O2S/c1-29-7-9-30(10-8-29)24(32)15-3-4-17-20(11-15)34-23-21(17)22(25-14-26-23)28-18-12-16-5-6-27-31(16)13-19(18)33-2/h5-6,12-15H,3-4,7-11H2,1-2H3,(H,25,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420266 (4-[2-(Dimethylamino)ethyl]piperazin-1-yl(7S)-4-[(6...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCN(CCN(C)C)CC1 |r| Show InChI InChI=1S/C27H34N8O2S/c1-32(2)8-9-33-10-12-34(13-11-33)27(36)18-4-5-20-23(14-18)38-26-24(20)25(28-17-29-26)31-21-15-19-6-7-30-35(19)16-22(21)37-3/h6-7,15-18H,4-5,8-14H2,1-3H3,(H,28,29,31)/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420267 ((7S)—N-[2-(Dimethylamino)ethyl]-N-ethyl-4-[(6-meth...) Show SMILES CCN(CCN(C)C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C25H31N7O2S/c1-5-31(11-10-30(2)3)25(33)16-6-7-18-21(12-16)35-24-22(18)23(26-15-27-24)29-19-13-17-8-9-28-32(17)14-20(19)34-4/h8-9,13-16H,5-7,10-12H2,1-4H3,(H,26,27,29)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420268 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H24N6O3S/c1-31-18-12-29-15(4-5-26-29)11-17(18)27-21-20-16-3-2-14(23(30)28-6-8-32-9-7-28)10-19(16)33-22(20)25-13-24-21/h4-5,11-14H,2-3,6-10H2,1H3,(H,24,25,27)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420269 ((7S)—N-Ethyl-N-(2-hydroxyethyl)-4-[(6-methoxypyraz...) Show SMILES CCN(CCO)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C23H26N6O3S/c1-3-28(8-9-30)23(31)14-4-5-16-19(10-14)33-22-20(16)21(24-13-25-22)27-17-11-15-6-7-26-29(15)12-18(17)32-2/h6-7,11-14,30H,3-5,8-10H2,1-2H3,(H,24,25,27)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420270 ((7S)—N-Ethyl-N-(2-methoxyethyl)-4-[(6-methoxypyraz...) Show SMILES CCN(CCOC)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C24H28N6O3S/c1-4-29(9-10-32-2)24(31)15-5-6-17-20(11-15)34-23-21(17)22(25-14-26-23)28-18-12-16-7-8-27-30(16)13-19(18)33-3/h7-8,12-15H,4-6,9-11H2,1-3H3,(H,25,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420273 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@@H]2C[C@H]1CN2C |r,TLB:34:33:28.27:30,25:27:33.32:30| Show InChI InChI=1S/C25H27N7O2S/c1-30-10-17-8-16(30)11-31(17)25(33)14-3-4-18-21(7-14)35-24-22(18)23(26-13-27-24)29-19-9-15-5-6-28-32(15)12-20(19)34-2/h5-6,9,12-14,16-17H,3-4,7-8,10-11H2,1-2H3,(H,26,27,29)/t14-,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420274 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CN2C |r,THB:34:33:27.28:30,25:27:32.33:30| Show InChI InChI=1S/C25H27N7O2S/c1-30-10-17-8-16(30)11-31(17)25(33)14-3-4-18-21(7-14)35-24-22(18)23(26-13-27-24)29-19-9-15-5-6-28-32(15)12-20(19)34-2/h5-6,9,12-14,16-17H,3-4,7-8,10-11H2,1-2H3,(H,26,27,29)/t14-,16+,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420276 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CO2 |r,THB:25:27:32.33:30| Show InChI InChI=1S/C24H24N6O3S/c1-32-19-10-30-14(4-5-27-30)8-18(19)28-22-21-17-3-2-13(6-20(17)34-23(21)26-12-25-22)24(31)29-9-16-7-15(29)11-33-16/h4-5,8,10,12-13,15-16H,2-3,6-7,9,11H2,1H3,(H,25,26,28)/t13-,15+,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420277 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C24H26N6O3S/c1-14-12-33-8-7-29(14)24(31)15-3-4-17-20(9-15)34-23-21(17)22(25-13-26-23)28-18-10-16-5-6-27-30(16)11-19(18)32-2/h5-6,10-11,13-15H,3-4,7-9,12H2,1-2H3,(H,25,26,28)/t14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420278 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOC[C@H]1C |r| Show InChI InChI=1S/C24H26N6O3S/c1-14-12-33-8-7-29(14)24(31)15-3-4-17-20(9-15)34-23-21(17)22(25-13-26-23)28-18-10-16-5-6-27-30(16)11-19(18)32-2/h5-6,10-11,13-15H,3-4,7-9,12H2,1-2H3,(H,25,26,28)/t14-,15+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420259 (US10487092, Example 107 | [(3S)-3-(Dimethylamino)p...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C25H29N7O2S/c1-30(2)17-7-9-31(12-17)25(33)15-4-5-18-21(10-15)35-24-22(18)23(26-14-27-24)29-19-11-16-6-8-28-32(16)13-20(19)34-3/h6,8,11,13-15,17H,4-5,7,9-10,12H2,1-3H3,(H,26,27,29)/t15-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420271 ((7S)—N,N-Bis(2-methoxyethyl)-4-[(6-methoxypyrazolo...) Show SMILES COCCN(CCOC)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C25H30N6O4S/c1-33-10-8-30(9-11-34-2)25(32)16-4-5-18-21(12-16)36-24-22(18)23(26-15-27-24)29-19-13-17-6-7-28-31(17)14-20(19)35-3/h6-7,13-16H,4-5,8-12H2,1-3H3,(H,26,27,29)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420155 ((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...) Show SMILES CN(C)[C@@H]1CCN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21 |r| Show InChI InChI=1S/C24H26ClN7OS/c1-30(2)16-6-8-31(11-16)24(33)14-3-4-17-20(9-14)34-23-21(17)22(26-13-27-23)29-19-10-15-5-7-28-32(15)12-18(19)25/h5,7,10,12-14,16H,3-4,6,8-9,11H2,1-2H3,(H,26,27,29)/t14-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420195 ((7S)—N-(2-Hydroxy-2-methylpropyl)-4-[(6-methoxypyr...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCC(C)(C)O |r| Show InChI InChI=1S/C22H25N7O3S/c1-22(2,31)10-23-20(30)12-4-5-13-15(8-12)33-21-17(13)19(24-11-25-21)28-18-14(32-3)9-29-16(27-18)6-7-26-29/h6-7,9,11-12,31H,4-5,8,10H2,1-3H3,(H,23,30)(H,24,25,27,28)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420247 ((7S)—N-(2,2-Difluoroethyl)-4-[(6-methoxypyrazolo[1...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CC(F)F |r| Show InChI InChI=1S/C22H22F2N6O2S/c1-29(10-18(23)24)22(31)12-3-4-14-17(7-12)33-21-19(14)20(25-11-26-21)28-15-8-13-5-6-27-30(13)9-16(15)32-2/h5-6,8-9,11-12,18H,3-4,7,10H2,1-2H3,(H,25,26,28)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420253 ((7S)—N-[2-(Dimethylamino)ethyl]-4-[(6-methoxypyraz...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CCN(C)C |r| Show InChI InChI=1S/C24H29N7O2S/c1-29(2)9-10-30(3)24(32)15-5-6-17-20(11-15)34-23-21(17)22(25-14-26-23)28-18-12-16-7-8-27-31(16)13-19(18)33-4/h7-8,12-15H,5-6,9-11H2,1-4H3,(H,25,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420254 (US10487092, Example 102 | [3-(Dimethylamino)azetid...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)N(C)C |r| Show InChI InChI=1S/C24H27N7O2S/c1-29(2)16-10-30(11-16)24(32)14-4-5-17-20(8-14)34-23-21(17)22(25-13-26-23)28-18-9-15-6-7-27-31(15)12-19(18)33-3/h6-7,9,12-14,16H,4-5,8,10-11H2,1-3H3,(H,25,26,28)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420257 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)C(C)C |r| Show InChI InChI=1S/C23H26N6O2S/c1-13(2)28(3)23(30)14-5-6-16-19(9-14)32-22-20(16)21(24-12-25-22)27-17-10-15-7-8-26-29(15)11-18(17)31-4/h7-8,10-14H,5-6,9H2,1-4H3,(H,24,25,27)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420264 (US10487092, Example 112 | [(2R,6S)-2,6-Dimethylmor...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H](C)O[C@H](C)C1 |r| Show InChI InChI=1S/C25H28N6O3S/c1-14-10-30(11-15(2)34-14)25(32)16-4-5-18-21(8-16)35-24-22(18)23(26-13-27-24)29-19-9-17-6-7-28-31(17)12-20(19)33-3/h6-7,9,12-16H,4-5,8,10-11H2,1-3H3,(H,26,27,29)/t14-,15+,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420275 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@@H]2C[C@H]1CO2 |r| Show InChI InChI=1S/C24H24N6O3S/c1-32-19-10-30-14(4-5-27-30)8-18(19)28-22-21-17-3-2-13(6-20(17)34-23(21)26-12-25-22)24(31)29-9-16-7-15(29)11-33-16/h4-5,8,10,12-13,15-16H,2-3,6-7,9,11H2,1H3,(H,25,26,28)/t13-,15-,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420193 ((7S)—N-(2,2-Difluoroethyl)-4-[(6-methoxypyrazolo[1...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCC(F)F |r| Show InChI InChI=1S/C20H19F2N7O2S/c1-31-12-8-29-15(4-5-26-29)27-17(12)28-18-16-11-3-2-10(19(30)23-7-14(21)22)6-13(11)32-20(16)25-9-24-18/h4-5,8-10,14H,2-3,6-7H2,1H3,(H,23,30)(H,24,25,27,28)/t10-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420194 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCC(F)(F)F |r| Show InChI InChI=1S/C21H20F3N7O2S/c1-33-13-9-31-15(4-6-28-31)29-17(13)30-18-16-12-3-2-11(19(32)25-7-5-21(22,23)24)8-14(12)34-20(16)27-10-26-18/h4,6,9-11H,2-3,5,7-8H2,1H3,(H,25,32)(H,26,27,29,30)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420196 ((7S)—N-[2-(Dimethylamino)ethyl]-4-[(6-methoxypyraz...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCN(C)C |r| Show InChI InChI=1S/C22H26N8O2S/c1-29(2)9-8-23-21(31)13-4-5-14-16(10-13)33-22-18(14)20(24-12-25-22)28-19-15(32-3)11-30-17(27-19)6-7-26-30/h6-7,11-13H,4-5,8-10H2,1-3H3,(H,23,31)(H,24,25,27,28)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420197 ((7S)—N-(2-Hydroxyethyl)-4-[(6-methoxypyrazolo[1,5-...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCO |r| Show InChI InChI=1S/C20H21N7O3S/c1-30-13-9-27-15(4-5-24-27)25-17(13)26-18-16-12-3-2-11(19(29)21-6-7-28)8-14(12)31-20(16)23-10-22-18/h4-5,9-11,28H,2-3,6-8H2,1H3,(H,21,29)(H,22,23,25,26)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420198 ((7S)—N-(2-Methoxyethyl)-4-[(6-methoxypyrazolo[1,5-...) Show SMILES COCCNC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3nc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C21H23N7O3S/c1-30-8-7-22-20(29)12-3-4-13-15(9-12)32-21-17(13)19(23-11-24-21)27-18-14(31-2)10-28-16(26-18)5-6-25-28/h5-6,10-12H,3-4,7-9H2,1-2H3,(H,22,29)(H,23,24,26,27)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420222 ((7S)—N-(1H-Indol-5-yl)-4-[(6-methoxypyrazolo[1,5-a...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)Nc1ccc2[nH]ccc2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420255 ((7S)—N-(2-Hydroxyethyl)-4-[(6-methoxypyrazolo [1,5...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CCO |r| Show InChI InChI=1S/C22H24N6O3S/c1-27(7-8-29)22(30)13-3-4-15-18(9-13)32-21-19(15)20(23-12-24-21)26-16-10-14-5-6-25-28(14)11-17(16)31-2/h5-6,10-13,29H,3-4,7-9H2,1-2H3,(H,23,24,26)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420263 ((7S)—N-[3-(Dimethylamino)propyl]-N-(2-hydroxyethyl...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(CCO)CCCN(C)C |r| Show InChI InChI=1S/C26H33N7O3S/c1-31(2)9-4-10-32(11-12-34)26(35)17-5-6-19-22(13-17)37-25-23(19)24(27-16-28-25)30-20-14-18-7-8-29-33(18)15-21(20)36-3/h7-8,14-17,34H,4-6,9-13H2,1-3H3,(H,27,28,30)/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420101 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)C |r| Show InChI InChI=1S/C21H22N6O2S/c1-26(2)21(28)12-4-5-14-17(8-12)30-20-18(14)19(22-11-23-20)25-15-9-13-6-7-24-27(13)10-16(15)29-3/h6-7,9-12H,4-5,8H2,1-3H3,(H,22,23,25)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420169 ((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...) Show SMILES Clc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C22H21ClN6O2S/c23-16-11-29-14(3-4-26-29)10-17(16)27-20-19-15-2-1-13(22(30)28-5-7-31-8-6-28)9-18(15)32-21(19)25-12-24-20/h3-4,10-13H,1-2,5-9H2,(H,24,25,27)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420184 ((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...) Show SMILES CN1C[C@H]2C[C@@H]1CN2C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21 |r,TLB:0:1:7.6:4,8:7:2.1:4| Show InChI InChI=1S/C24H24ClN7OS/c1-30-9-16-7-15(30)10-31(16)24(33)13-2-3-17-20(6-13)34-23-21(17)22(26-12-27-23)29-19-8-14-4-5-28-32(14)11-18(19)25/h4-5,8,11-13,15-16H,2-3,6-7,9-10H2,1H3,(H,26,27,29)/t13-,15+,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420199 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NC(C)C |r| Show InChI InChI=1S/C21H23N7O2S/c1-11(2)25-20(29)12-4-5-13-15(8-12)31-21-17(13)19(22-10-23-21)27-18-14(30-3)9-28-16(26-18)6-7-24-28/h6-7,9-12H,4-5,8H2,1-3H3,(H,25,29)(H,22,23,26,27)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420200 ((7S)—N-tert-Butyl-4-[(6-methoxypyrazolo[1,5-a]pyri...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NC(C)(C)C |r| Show InChI InChI=1S/C22H25N7O2S/c1-22(2,3)28-20(30)12-5-6-13-15(9-12)32-21-17(13)19(23-11-24-21)27-18-14(31-4)10-29-16(26-18)7-8-25-29/h7-8,10-12H,5-6,9H2,1-4H3,(H,28,30)(H,23,24,26,27)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420201 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NC1(C)CCC1 |r| Show InChI InChI=1S/C23H25N7O2S/c1-23(7-3-8-23)29-21(31)13-4-5-14-16(10-13)33-22-18(14)20(24-12-25-22)28-19-15(32-2)11-30-17(27-19)6-9-26-30/h6,9,11-13H,3-5,7-8,10H2,1-2H3,(H,29,31)(H,24,25,27,28)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420144 ((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...) Show SMILES CN(C)CCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21 |r| Show InChI InChI=1S/C24H28ClN7OS/c1-30(2)9-4-10-31(3)24(33)15-5-6-17-20(11-15)34-23-21(17)22(26-14-27-23)29-19-12-16-7-8-28-32(16)13-18(19)25/h7-8,12-15H,4-6,9-11H2,1-3H3,(H,26,27,29)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420192 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES CNC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C20H20N6O2S/c1-21-19(27)11-3-4-13-16(7-11)29-20-17(13)18(22-10-23-20)25-14-8-12-5-6-24-26(12)9-15(14)28-2/h5-6,8-11H,3-4,7H2,1-2H3,(H,21,27)(H,22,23,25)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420272 ((7S)—N-tert-Butyl-4-[(6-methoxypyrazolo[1,5-a]pyri...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)C(C)(C)C |r| Show InChI InChI=1S/C24H28N6O2S/c1-24(2,3)29(4)23(31)14-6-7-16-19(10-14)33-22-20(16)21(25-13-26-22)28-17-11-15-8-9-27-30(15)12-18(17)32-5/h8-9,11-14H,6-7,10H2,1-5H3,(H,25,26,28)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420166 ((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...) Show SMILES CN1CCN(CC1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21 |r| Show InChI InChI=1S/C23H24ClN7OS/c1-29-6-8-30(9-7-29)23(32)14-2-3-16-19(10-14)33-22-20(16)21(25-13-26-22)28-18-11-15-4-5-27-31(15)12-17(18)24/h4-5,11-14H,2-3,6-10H2,1H3,(H,25,26,28)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 126 total )  |  Next  |  Last  >>

Jump to: