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Compile Data Set for Download or QSAR

Found 42 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 50007199   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059631
PNG
(6-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)CCCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C21H23NO5/c1-22(27)17(24)9-4-2-3-6-13-10-11-15-12-14-7-5-8-16(23)18(14)21(26)19(15)20(13)25/h5,7-8,10-11,23,25,27H,2-4,6,9,12H2,1H3
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n/an/a 400n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059608
PNG
(5-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)CCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C20H21NO5/c1-21(26)16(23)8-3-2-5-12-9-10-14-11-13-6-4-7-15(22)17(13)20(25)18(14)19(12)24/h4,6-7,9-10,22,24,26H,2-3,5,8,11H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059616
PNG
(3-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)CCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C18H17NO5/c1-19(24)14(21)8-7-10-5-6-12-9-11-3-2-4-13(20)15(11)18(23)16(12)17(10)22/h2-6,20,22,24H,7-9H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059604
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)CCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C19H19NO5/c1-20(25)15(22)7-3-4-11-8-9-13-10-12-5-2-6-14(21)16(12)19(24)17(13)18(11)23/h2,5-6,8-9,21,23,25H,3-4,7,10H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059599
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)c1ccc(Cc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc1
Show InChI InChI=1S/C23H19NO5/c1-24(29)23(28)14-7-5-13(6-8-14)11-17-10-9-16-12-15-3-2-4-18(25)19(15)22(27)20(16)21(17)26/h2-10,25-26,29H,11-12H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059634
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)C(Cc1ccccc1)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C23H18O5/c24-18-8-4-7-14-12-15-9-10-16(21(25)20(15)22(26)19(14)18)17(23(27)28)11-13-5-2-1-3-6-13/h1-10,17,24-25H,11-12H2,(H,27,28)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059627
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)Cc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C17H15NO5/c1-18(23)13(20)8-11-6-5-10-7-9-3-2-4-12(19)14(9)17(22)15(10)16(11)21/h2-6,19,21,23H,7-8H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041803
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)c1ccc(Cc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc1
Show InChI InChI=1S/C22H16O5/c23-17-3-1-2-14-11-15-8-9-16(20(24)19(15)21(25)18(14)17)10-12-4-6-13(7-5-12)22(26)27/h1-9,23-24H,10-11H2,(H,26,27)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059623
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracene-2-c...)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C22H14O6/c23-16-3-1-2-13-10-14-8-9-15(20(25)18(14)21(26)17(13)16)19(24)11-4-6-12(7-5-11)22(27)28/h1-9,23,25H,10H2,(H,27,28)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059621
PNG
(5-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES ONC(=O)CCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C19H19NO5/c21-14-6-3-5-12-10-13-9-8-11(4-1-2-7-15(22)20-25)18(23)17(13)19(24)16(12)14/h3,5-6,8-9,21,23,25H,1-2,4,7,10H2,(H,20,22)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059619
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CC(C)C(C(O)=O)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C19H18O5/c1-9(2)14(19(23)24)12-7-6-11-8-10-4-3-5-13(20)15(10)18(22)16(11)17(12)21/h3-7,9,14,20-21H,8H2,1-2H3,(H,23,24)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059606
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)C(CCc1ccccc1)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C24H20O5/c25-19-8-4-7-15-13-16-10-12-17(22(26)21(16)23(27)20(15)19)18(24(28)29)11-9-14-5-2-1-3-6-14/h1-8,10,12,18,25-26H,9,11,13H2,(H,28,29)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059612
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES ONC(=O)CCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C18H17NO5/c20-13-5-1-4-11-9-12-8-7-10(3-2-6-14(21)19-24)17(22)16(12)18(23)15(11)13/h1,4-5,7-8,20,22,24H,2-3,6,9H2,(H,19,21)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059626
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracene-2-c...)
Show SMILES CN(O)C(=O)c1ccc(cc1)C(=O)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C23H17NO6/c1-24(30)23(29)13-7-5-12(6-8-13)20(26)16-10-9-15-11-14-3-2-4-17(25)18(14)22(28)19(15)21(16)27/h2-10,25,27,30H,11H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059630
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES ONC(=O)C(Cc1ccccc1)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C23H19NO5/c25-18-8-4-7-14-12-15-9-10-16(21(26)20(15)22(27)19(14)18)17(23(28)24-29)11-13-5-2-1-3-6-13/h1-10,17,25-26,29H,11-12H2,(H,24,28)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059622
PNG
(3-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES ONC(=O)CCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C17H15NO5/c19-12-3-1-2-10-8-11-5-4-9(6-7-13(20)18-23)16(21)15(11)17(22)14(10)12/h1-5,19,21,23H,6-8H2,(H,18,20)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059605
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES ONC(=O)c1ccc(Cc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc1
Show InChI InChI=1S/C22H17NO5/c24-17-3-1-2-14-11-15-8-9-16(20(25)19(15)21(26)18(14)17)10-12-4-6-13(7-5-12)22(27)23-28/h1-9,24-25,28H,10-11H2,(H,23,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059607
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CC(C)C(C(=O)N(C)O)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C20H21NO5/c1-10(2)15(20(25)21(3)26)13-8-7-12-9-11-5-4-6-14(22)16(11)19(24)17(12)18(13)23/h4-8,10,15,22-23,26H,9H2,1-3H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059629
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)C(Cc1ccccc1)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C24H21NO5/c1-25(30)24(29)18(12-14-6-3-2-4-7-14)17-11-10-16-13-15-8-5-9-19(26)20(15)23(28)21(16)22(17)27/h2-11,18,26-27,30H,12-13H2,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059600
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES ONC(=O)Cc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C16H13NO5/c18-11-3-1-2-8-6-9-4-5-10(7-12(19)17-22)15(20)14(9)16(21)13(8)11/h1-5,18,20,22H,6-7H2,(H,17,19)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059598
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CC(C(=O)N(C)O)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C18H17NO5/c1-9(18(23)19(2)24)12-7-6-11-8-10-4-3-5-13(20)14(10)17(22)15(11)16(12)21/h3-7,9,20-21,24H,8H2,1-2H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059628
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CC(C(=O)NO)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C17H15NO5/c1-8(17(22)18-23)11-6-5-10-7-9-3-2-4-12(19)13(9)16(21)14(10)15(11)20/h2-6,8,19-20,23H,7H2,1H3,(H,18,22)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059613
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CC(C)C(C(=O)NO)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C19H19NO5/c1-9(2)14(19(24)20-25)12-7-6-11-8-10-4-3-5-13(21)15(10)18(23)16(11)17(12)22/h3-7,9,14,21-22,25H,8H2,1-2H3,(H,20,24)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059614
PNG
(6-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)CCCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C20H20O5/c21-15-7-4-6-13-11-14-10-9-12(5-2-1-3-8-16(22)23)19(24)18(14)20(25)17(13)15/h4,6-7,9-10,21,24H,1-3,5,8,11H2,(H,22,23)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059632
PNG
(5-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)CCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C19H18O5/c20-14-6-3-5-12-10-13-9-8-11(4-1-2-7-15(21)22)18(23)17(13)19(24)16(12)14/h3,5-6,8-9,20,23H,1-2,4,7,10H2,(H,21,22)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059610
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CC(C(O)=O)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C17H14O5/c1-8(17(21)22)11-6-5-10-7-9-3-2-4-12(18)13(9)16(20)14(10)15(11)19/h2-6,8,18-19H,7H2,1H3,(H,21,22)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059602
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)CCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C18H16O5/c19-13-5-1-4-11-9-12-8-7-10(3-2-6-14(20)21)17(22)16(12)18(23)15(11)13/h1,4-5,7-8,19,22H,2-3,6,9H2,(H,20,21)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059617
PNG
(3-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)CCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C17H14O5/c18-12-3-1-2-10-8-11-5-4-9(6-7-13(19)20)16(21)15(11)17(22)14(10)12/h1-5,18,21H,6-8H2,(H,19,20)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059618
PNG
((1,8-DIHYDROXY-9-OXO-9,10-DIHYDRO-ANTHRACEN-2-YL)-...)
Show SMILES OC(=O)Cc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C16H12O5/c17-11-3-1-2-8-6-9-4-5-10(7-12(18)19)15(20)14(9)16(21)13(8)11/h1-5,17,20H,6-7H2,(H,18,19)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059615
PNG
(6-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES COC(=O)CCCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C21H22O5/c1-26-17(23)9-4-2-3-6-13-10-11-15-12-14-7-5-8-16(22)18(14)21(25)19(15)20(13)24/h5,7-8,10-11,22,24H,2-4,6,9,12H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059625
PNG
(3-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES COC(=O)CCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C18H16O5/c1-23-14(20)8-7-10-5-6-12-9-11-3-2-4-13(19)15(11)18(22)16(12)17(10)21/h2-6,19,21H,7-9H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041807
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES COC(=O)c1ccc(Cc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc1
Show InChI InChI=1S/C23H18O5/c1-28-23(27)14-7-5-13(6-8-14)11-17-10-9-16-12-15-3-2-4-18(24)19(15)22(26)20(16)21(17)25/h2-10,24-25H,11-12H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059633
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES COC(=O)C(C(C)C)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C20H20O5/c1-10(2)15(20(24)25-3)13-8-7-12-9-11-5-4-6-14(21)16(11)19(23)17(12)18(13)22/h4-8,10,15,21-22H,9H2,1-3H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059609
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES COC(=O)C(Cc1ccccc1)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C24H20O5/c1-29-24(28)18(12-14-6-3-2-4-7-14)17-11-10-16-13-15-8-5-9-19(25)20(15)23(27)21(16)22(17)26/h2-11,18,25-26H,12-13H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059624
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES COC(=O)CCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C19H18O5/c1-24-15(21)7-3-4-11-8-9-13-10-12-5-2-6-14(20)16(12)19(23)17(13)18(11)22/h2,5-6,8-9,20,22H,3-4,7,10H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059620
PNG
(5-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES COC(=O)CCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C20H20O5/c1-25-16(22)8-3-2-5-12-9-10-14-11-13-6-4-7-15(21)17(13)20(24)18(14)19(12)23/h4,6-7,9-10,21,23H,2-3,5,8,11H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50408249
PNG
(CHEMBL2114282)
Show SMILES COC(=O)C(CCc1ccccc1)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C25H22O5/c1-30-25(29)19(12-10-15-6-3-2-4-7-15)18-13-11-17-14-16-8-5-9-20(26)21(16)24(28)22(17)23(18)27/h2-9,11,13,19,26-27H,10,12,14H2,1H3
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059611
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracene-2-c...)
Show SMILES COC(=O)c1ccc(cc1)C(=O)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C23H16O6/c1-29-23(28)13-7-5-12(6-8-13)20(25)16-10-9-15-11-14-3-2-4-17(24)18(14)22(27)19(15)21(16)26/h2-10,24,26H,11H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059603
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES COC(=O)C(C)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C18H16O5/c1-9(18(22)23-2)12-7-6-11-8-10-4-3-5-13(19)14(10)17(21)15(11)16(12)20/h3-7,9,19-20H,8H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059601
PNG
((1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl)-...)
Show SMILES COC(=O)Cc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C17H14O5/c1-22-13(19)8-11-6-5-10-7-9-3-2-4-12(18)14(9)17(21)15(10)16(11)20/h2-6,18,20H,7-8H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50015144
PNG
(2-(4-Butoxy-phenyl)-N-hydroxy-acetamide | Bufexama...)
Show SMILES CCCCOc1ccc(CC(=O)NO)cc1
Show InChI InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041802
PNG
(1,8-dihydroxy-9(10H)-anthracenone | 1,8-dihydroxy-...)
Show SMILES Oc1cccc2Cc3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2
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n/an/a 3.70E+4n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


J Med Chem 40: 2780-7 (1997)


Article DOI: 10.1021/jm9701785
BindingDB Entry DOI: 10.7270/Q28C9VB4
More data for this
Ligand-Target Pair