The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28279847 |
40 |
Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. |
Carna Biosciences |
28291344 |
56 |
First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-¿B Activity As Novel Anticancer Agents. |
Saarland University |
27789138 |
355 |
Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. |
Abbvie Bioresearch Center |
28523101 |
24 |
Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket. |
The University of Tokyo |
28001064 |
16 |
Recent Advances in Scaffold Hopping. |
Rheinische Friedrich-Wilhelms-Universit£T |
27816515 |
143 |
Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. |
Merck |
27769621 |
109 |
Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors. |
Amgen |
27255178 |
3 |
Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c. |
Universit£ |
27173800 |
13 |
Identification of quinones as novel PIM1 kinase inhibitors. |
Xavier University of Louisiana |
27096050 |
36 |
Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors. |
Amgen |
27003761 |
120 |
Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor. |
Nerviano Medical Sciences |
26995528 |
60 |
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. |
Novartis Institutes For Biomedical Research |
26979485 |
5 |
Synthesis and biological evaluation of quinoline derivatives as potential anti-prostate cancer agents and Pim-1 kinase inhibitors. |
Shenyang Pharmaceutical University |
26896709 |
113 |
Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2. |
Saarland University |
26890118 |
8 |
Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties. |
Mendeleyev University of Chemical Technology |
26804231 |
20 |
Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors. |
Shenyang Pharmaceutical University |
26762835 |
342 |
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). |
Icahn School of Medicine At Mount Sinai |
26459208 |
115 |
Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors. |
Genentech |
26526744 |
14 |
Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. |
Universit£ |
26342867 |
52 |
Discovery of 6-phenylimidazo[2,1-b]thiazole derivatives as a new type of FLT3 inhibitors. |
Sichuan University |
26222319 |
192 |
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. |
Nerviano Medical Sciences |
26275107 |
1 |
Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1. |
Taiwan Academia Sinica |
25835317 |
63 |
Design, Synthesis, and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer. |
Sichuan University |
25616902 |
112 |
Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. |
Amgen |
25597005 |
86 |
The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. |
Amgen |
25087047 |
7 |
Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition. |
Clermont Universit£ |
25050155 |
4 |
Pim kinase inhibitors for the treatment of cancer and possibly more. |
Therachem Research Medilab (India) |
25022204 |
78 |
Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells. |
Universit£ |
25589932 |
60 |
Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors. |
Astex Pharmaceuticals |
25575657 |
48 |
Structure-based design of low-nanomolar PIM kinase inhibitors. |
Biogen Idec |
24139169 |
175 |
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases. |
Nerviano Medical Sciences |
24793884 |
151 |
Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. |
Amgen |
24775304 |
36 |
Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives. |
Keimyung University |
16302800 |
12 |
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. |
Oxford University |
24479418 |
39 |
Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia. |
Heinrich Heine Universit£T |
24328302 |
94 |
Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum. |
Heinrich-Heine-Universit£T D£Sseldorf |
24900629 |
102 |
Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. |
Novartis Institutes For Biomedical Research |
24100158 |
148 |
Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90). |
Nerviano Medical Sciences |
24091081 |
49 |
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach. |
Merck Research Laboratories |
23981088 |
10 |
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition. |
Nagasaki University |
23937569 |
22 |
Selectivity data: assessment, predictions, concordance, and implications. |
Eli Lilly |
23735828 |
15 |
Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors. |
Clermont Universit£ |
23623490 |
54 |
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. |
Genentech |
23499503 |
9 |
Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors. |
Clermont Universit£ |
23434140 |
35 |
Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis. |
East China University of Science and Technology |
23394126 |
170 |
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). |
Exelixis |
23362959 |
72 |
Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo. |
Sichuan University |
23442188 |
4 |
A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. |
Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences |
23410005 |
147 |
Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors. |
The University of Arizona |
22982527 |
6 |
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors. |
TBA |
23103095 |
125 |
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors. |
Abbott Laboratories |
22998443 |
69 |
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
Cnrs |
22924342 |
15 |
Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy. |
Cylene Pharmaceuticals |
21413800 |
56 |
A one-pot synthesis and biological activity of ageladine A and analogues. |
Macquarie University |
22540945 |
19 |
Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound. |
The University of Tokyo |
22727640 |
68 |
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. |
Astrazeneca |
22452518 |
22 |
Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo. |
Sichuan University |
22543026 |
6 |
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives. |
Clermont Universit£ |
22542012 |
155 |
The design, synthesis, and biological evaluation of PIM kinase inhibitors. |
Exelixis |
22372864 |
25 |
Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases. |
Hanmi Research Center |
24900437 |
32 |
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. |
TBA |
22560567 |
82 |
Discovery of XL413, a potent and selective CDC7 inhibitor. |
Exelixis |
22339127 |
14 |
Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. |
Genzyme |
22320327 |
250 |
Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series. |
Amgen |
24900264 |
106 |
The Discovery of VX-745: A Novel and Selective p38a Kinase Inhibitor. |
TBA |
22460033 |
85 |
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells. |
Cylene Pharmaceuticals |
18183025 |
12060 |
A quantitative analysis of kinase inhibitor selectivity. |
Ambit Biosciences |
17850214 |
99 |
The selectivity of protein kinase inhibitors: a further update. |
University of Dundee |
19397322 |
58 |
Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. |
National Cancer Institute-Bethesda |
19179076 |
9 |
Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. |
Universit£ |
18502121 |
31 |
Novel aryl and heteroaryl substituted N-[3-(4-phenylpiperazin-1-yl)propyl]-1,2,4-oxadiazole-5-carboxamides as selective GSK-3 inhibitors. |
Chemical Diversity Research Institute |
18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University of Oxford |
17935989 |
146 |
Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. |
Abbott Laboratories |
22386260 |
9 |
Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors. |
Clermont Universit£ |
22266039 |
119 |
Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors. |
Spanish National Cancer Research Centre (Cnio) |
22136433 |
67 |
7,8-dichloro-1-oxo-ß-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. |
Ludwig-Maximilians University of Munich |
22014550 |
337 |
Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD). |
Ansaris |
21982797 |
128 |
9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
Peking University |
21999461 |
90 |
1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. |
RhôNe-Poulenc Rorer |
21982499 |
180 |
7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. |
Cylene Pharmaceuticals |
21945284 |
73 |
Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. |
Novartis Institutes of Biomedical Research |
22037378 |
31824 |
Comprehensive analysis of kinase inhibitor selectivity. |
Ambit Biosciences |
21856155 |
45 |
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. |
University of Siena |
21741249 |
32 |
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
Heinrich Heine Universit£T |
21615147 |
230 |
Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
Universite£? De Rennes 1 |
21507633 |
77 |
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. |
Genzyme |
21470862 |
110 |
NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. |
Nerviano Medical Sciences |
21391610 |
139 |
Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors. |
Vertex Pharmaceuticals |
21288717 |
131 |
Scaffold oriented synthesis. Part 4: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions. |
Abbott Laboratories |
21282054 |
178 |
Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions. |
Abbott Laboratories |
21174434 |
13 |
Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. |
Cylene Pharmaceuticals |
20873740 |
111 |
Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. |
Nerviano Medical Sciences |
20728368 |
16 |
Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. |
Clermont Université |
19654408 |
2521 |
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). |
Ambit Biosciences |
20655209 |
18 |
Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities. |
Université |
20363627 |
56 |
Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase. |
Universit£ |
20346655 |
117 |
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases. |
Abbott Laboratories |
20141146 |
234 |
Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors. |
Nerviano Medical Sciences |
19926477 |
100 |
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization. |
Abbott Laboratories |
19837585 |
46 |
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). |
National Human Genome Research Institute |
19836860 |
5 |
Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach. |
German University In Cairo |
19788246 |
11 |
Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors. |
Clermont Universit£ |
19414255 |
58 |
Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase. |
Vertex Pharmaceuticals |
19285393 |
90 |
Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors. |
Glaxosmithkline |
19035792 |
85 |
Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
Glaxosmithkline |
18799313 |
20 |
Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening. |
Università |
17637507 |
21 |
Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase. |
Loma Linda University School of Medicine |
15711537 |
653 |
A small molecule-kinase interaction map for clinical kinase inhibitors. |
Ambit Biosciences |
32433887 |
62 |
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity |
University of Nottingham |
31757666 |
314 |
Discovery and optimization of heteroaryl piperazines as potent and selective PI3K? inhibitors. |
Merck |
27491711 |
422 |
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. |
Merck And |
27285051 |
86 |
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors. |
Amgen |
30986571 |
66 |
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. |
Zhejiang University |
31693351 |
473 |
Discovery of 4 |
TBA |
30553737 |
90 |
Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III. |
Sanofi |
30733087 |
53 |
A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs. |
China Pharmaceutical University |
30624936 |
55 |
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies. |
TBA |
31207462 |
42 |
Dual FLT3 inhibitors: Against the drug resistance of acute myeloid leukemia in recent decade. |
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital |
30978559 |
38 |
Third-generation CDK inhibitors: A review on the synthesis and binding modes of Palbociclib, Ribociclib and Abemaciclib. |
University of Padova |
30954777 |
9 |
PIM kinase inhibitors: Structural and pharmacological perspectives. |
Nri Institute of Pharmacy |
30802730 |
163 |
Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors. |
Spanish National Cancer Research Centre (Cnio) |
31647655 |
114 |
Kinase Chemodiversity from the Arctic: The Breitfussins. |
Uit - The Arctic University of Norway |
30530193 |
64 |
Targeting the immunity protein kinases for immuno-oncology. |
China Pharmaceutical University |
30508668 |
62 |
Discovery of a highly selective FLT3 inhibitor with specific proliferation inhibition against AML cells harboring FLT3-ITD mutation. |
China Pharmaceutical University |
30384048 |
365 |
ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. |
University of Florida |
31526603 |
379 |
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application. |
Takeda Pharmaceutical |
30807144 |
23 |
Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein-Ligand Complexes. |
Cresset |
30715878 |
68 |
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. |
Genentech |
26505898 |
123 |
Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. |
Novartis Institutes For Biomedical Research |
26509640 |
234 |
Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders. |
Abbvie Bioresearch Center |
26547690 |
17 |
Design and synthesis of an in vivo-efficacious PIM3 kinase inhibitor as a candidate anti-pancreatic cancer agent. |
The University of Tokyo |
29578342 |
35 |
Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
Yunnan University |
30082069 |
359 |
ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors. |
Vertex Pharmaceuticals |
30026041 |
139 |
Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. |
University College Cork |
29945794 |
193 |
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups. |
Vertex Pharmaceuticals |
29559278 |
99 |
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases. |
Astrazeneca |
29505935 |
13 |
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms. |
Mazandaran University of Medical Sciences |
29778892 |
48 |
Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors. |
University of Tours |
29107425 |
90 |
Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders. |
Korea Institute of Science & Technology (Kist) |
29057057 |
54 |
From PIM1 to PI3K? via GSK3?: Target Hopping through the Kinome. |
Glaxosmithkline |
29871845 |
125 |
Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors. |
Keimyung University |
29853332 |
50 |
Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration. |
Universit£ |
28445037 |
51 |
Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. |
Genentech |
28947155 |
34 |
Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. |
Sanofi Genzyme |
28927793 |
97 |
Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. |
Sanofi Genzyme |
28760531 |
31 |
Structure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of quinolone-based inhibitors. |
Zarqa University |
28337328 |
6 |
Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. |
Dana-Farber Cancer Institute |
28431341 |
12 |
Eco-friendly synthesis of novel cyanopyridine derivatives and their anticancer and PIM-1 kinase inhibitory activities. |
Ain Shams University |
28341403 |
57 |
Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family. |
University of Oxford |
22545939 |
5 |
Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors. |
East China University of Science and Technology |
21827363 |
20 |
Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-a converting enzyme (TACE/ADAM-17). |
China Pharmaceutical University |
20235688 |
7 |
Design, synthesis, and urease inhibition studies of some 1,3,4-oxadiazoles and 1,2,4-triazoles derived from mandelic acid. |
Quaid-I-Azam University |
24443569 |
4 |
The different inhibition mechanisms of OXA-1 and OXA-24 ß-lactamases are determined by the stability of active site carboxylated lysine. |
Case Western Reserve University |
23935105 |
20 |
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. |
National Institutes of Health, National Institutes of Health Biomedical Research Center |
27346364 |
28 |
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently. |
Korea Institute of Science and Technology |
2925675 |
15 |
A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. |
Nagoya University School of Medicine |
11404457 |
5 |
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. |
Merck Research Laboratories |
11306677 |
6 |
BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. |
Upr 9023 |
11303056 |
2 |
Pharmacological characterization of KUR-1246, a selective uterine relaxant. |
Kissei Pharmaceutical |
8558445 |
17 |
Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor. |
Abbott Laboratories |
8102785 |
91 |
Characterization of cloned somatostatin receptors SSTR4 and SSTR5. |
University of Pennsylvania |
7582508 |
13 |
The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist. |
Zeneca Pharmaceuticals |
7582507 |
14 |
RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. |
Syntex Discovery Research |
7582481 |
62 |
The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. |
Syntex Discovery Research |
7568007 |
15 |
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. |
Massachusetts General Hospital |
7562491 |
10 |
Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity. |
Zeneca Pharmaceuticals |
1310135 |
23 |
Pharmacological characterization of a novel muscarinic partial agonist, YM796, in transfected cells expressing the m1 or m2 muscarinic receptor gene. |
University of Arizona |
19896847 |
36 |
Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. |
Bristol-Myers Squibb |
16406782 |
9 |
Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. |
Cornell University |
9629473 |
34 |
Structure-activity relationship of HIV-1 protease inhibitors containing AHPBA. Part III: Modification of P2 site. |
Sankyo |
16316253 |
5 |
Strong solute-solute dispersive interactions in a protein-ligand complex. |
University of Leeds |