The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28319392 |
216 |
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. |
National Institute of Diabetes and Digestive and Kidney Diseases |
28274674 |
93 |
Design, synthesis and in vitro activity of 1,4-disubstituted piperazines and piperidines as triple reuptake inhibitors. |
Chonnam National University |
28089699 |
63 |
Investigation of piperazine benzamides as humanß |
Merck |
27997171 |
48 |
Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. |
The University of Newcastle |
27876250 |
60 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH |
Jagiellonian University Medical College |
27839919 |
192 |
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples. |
University of Kansas |
27280968 |
6 |
Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum. |
Chinese Academy of Medical Sciences and Peking Union Medical College |
27325446 |
42 |
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3. |
Takeda Pharmaceutical |
27041397 |
24 |
Design, synthesis, and biological evaluation of arylpiperazine-benzylpiperidines with dual serotonin and norepinephrine reuptake inhibitory activities. |
Chonnam National University |
26988801 |
55 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. |
Jagiellonian University Medical College |
26935940 |
23 |
Emerging targets and new small molecule therapies in Parkinson's disease treatment. |
School of Medicine of University of Electronic Science and Technology of China |
26739781 |
237 |
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines. |
The Alexander Shulgin Research Institute |
26421921 |
43 |
Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists. |
Glenmark Research Centre |
26337019 |
22 |
Design and synthesis of 4-benzylpiperidine carboxamides as dual serotonin and norepinephrine reuptake inhibitors. |
Chonnam National University |
26233799 |
15 |
Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine. |
Virginia Commonwealth University |
25164761 |
41 |
Synthesis and pharmacological investigation of aralkyl diamine derivatives as potential triple reuptake inhibitors. |
Shanghai Institute of Pharmaceutical Industry |
26051602 |
51 |
Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor. |
Takeda Pharmaceutical |
25695425 |
62 |
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. |
City University of New York |
25070422 |
126 |
Further evaluation of the tropane analogs of haloperidol. |
Florida A&M University |
25050161 |
112 |
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. |
Amri |
25017029 |
39 |
Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors. |
Takeda Pharmaceutical |
24974340 |
90 |
Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
Korea University |
24881566 |
140 |
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). |
Glaxosmithkline |
24944746 |
13 |
Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. |
National Institute On Drug Abuse-Intramural Research Program |
24800940 |
146 |
Identification of a new selective dopamine D4 receptor ligand. |
Florida A&M University |
24690494 |
92 |
Antagonists of the kappa opioid receptor. |
The Scripps Research Institute |
24187998 |
96 |
Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. |
University of Copenhagen |
23477943 |
51 |
Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression. |
Bristol-Myers Squibb |
23168018 |
10 |
A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter. |
National Institute On Drug Abuse-Intramural Research Program |
24900562 |
126 |
Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. |
Astrazeneca |
23061607 |
10 |
Organosilicon molecules with medicinal applications. |
University of California Davis |
19860431 |
1 |
chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. |
Xenome |
19592243 |
66 |
Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors. |
Roche Palo Alto |
12657274 |
109 |
Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists. |
Abbott Laboratories |
23084899 |
102 |
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors. |
Amri |
22959245 |
175 |
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs). |
The University of Sydney |
22082561 |
9 |
Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter. |
Johannes Gutenberg University |
21413808 |
170 |
Synopsis of some recent tactical application of bioisosteres in drug design. |
Bristol-Myers Squibb Pharmaceutical Research and Development |
23641311 |
38 |
From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design. |
TBA |
23006002 |
35 |
Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists. |
Suven Life Sciences |
22938049 |
29 |
Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors. |
Korea Institute of Science and Technology |
22608762 |
25 |
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors. |
Shanghai Institute of Pharmaceutical Industry |
22520153 |
135 |
Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. |
Florida A&M University |
22420844 |
86 |
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. |
Neuraxon |
22542010 |
31 |
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition. |
Amgen |
22313227 |
78 |
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype. |
National Institute of Mental Health |
21726069 |
98 |
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. |
University of Namur |
21634396 |
55 |
Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. |
Cephalon |
21058665 |
52 |
Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2ß-substituted Tropanes. |
Research Triangle Institute |
21207959 |
69 |
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging. |
National Institute of Mental Health |
20875743 |
90 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela |
Pfizer |
20931963 |
112 |
Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome. |
Aska Pharmaceutical |
20684563 |
176 |
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. |
H. Lundbeck |
20724153 |
31 |
Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
Korea Institute of Science and Technology |
20597489 |
17 |
Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography. |
Emory University |
20471260 |
146 |
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity. |
Pfizer |
20153188 |
44 |
Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores. |
Pfizer |
19963380 |
38 |
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. |
Hunter College and The Graduate Center of The City University of New York |
19740668 |
48 |
Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. |
Human Biomolecular Research Institute |
19821575 |
47 |
Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
Glaxosmithkline |
19523837 |
54 |
Synthesis and structure-activity relationship of 3beta-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3beta-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters. |
Research Triangle Institute |
19821577 |
178 |
Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. |
Research Triangle Institute |
19722525 |
31 |
1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors. |
Wyeth Research |
19329313 |
50 |
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors. |
Wyeth Research |
17846138 |
26 |
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. |
Veterans Affairs Medical Center |
19201198 |
210 |
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. |
Human Biomolecular Research Institute |
18954038 |
62 |
Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. |
Neurocrine Biosciences |
18800760 |
96 |
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. |
Emory University |
19067522 |
18 |
Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter. |
Emory University |
19014888 |
52 |
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. |
Human Biomolecular Research Institute |
18951020 |
34 |
Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors. |
Wyeth Research |
18847250 |
37 |
Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. |
Virginia Commonwealth University |
18771916 |
37 |
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors. |
Wyeth Research |
18550369 |
82 |
Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). |
Neurocrine Biosciences |
18539031 |
126 |
Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
Neurocrine Biosciences |
18672364 |
119 |
Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability. |
Neurocrine Biosciences |
18556210 |
75 |
Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes. |
Research Triangle Institute |
17428804 |
1 |
chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. |
The University of Queensland |
18434164 |
42 |
Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives. |
Research Triangle Institute |
18417343 |
62 |
Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity. |
Pfizer |
18313294 |
68 |
[4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors. |
Pfizer |
18207394 |
126 |
Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors. |
Neurocrine Bioscience |
18468895 |
102 |
Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors. |
Neurocrine Bioscience |
18445525 |
141 |
Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors. |
Neurocrine Bioscience |
17983754 |
21 |
Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter. |
Emory University |
18242987 |
75 |
In vitro and in vivo evaluation of O-alkyl derivatives of tramadol. |
Sepracor |
18240382 |
104 |
1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity. |
Pfizer |
18060777 |
158 |
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. |
Johnson & Johnson Pharmaceutical Research & Development |
17766113 |
51 |
Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
17446076 |
187 |
Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters. |
University of Aarhus |
16279803 |
59 |
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes. |
Research Triangle Institute |
15566309 |
69 |
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers. |
Research Triangle Institute |
17228864 |
328 |
Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. |
Massachusetts College of Pharmacy and Health Sciences |
16750359 |
58 |
N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. |
Pfizer |
16750363 |
101 |
Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. |
Pfizer |
16821765 |
29 |
Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. |
Chinese Academy of Sciences |
16854064 |
65 |
Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol. |
Research Triangle Institute |
16413778 |
12 |
Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter. |
Eli Lilly |
16480278 |
279 |
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. |
Organix |
16257206 |
18 |
Derivatives of tramadol for increased duration of effect. |
Sepracor |
16213721 |
60 |
N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. |
National Institute On Drug Abuse-Intramural Research Program |
16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
16162005 |
30 |
Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
15828826 |
17 |
Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol. |
Medical University of South Carolina |
12954071 |
109 |
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
Alcon Research |
12723940 |
145 |
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy. |
Research Triangle Institute |
12213053 |
117 |
Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. |
Drew University |
11585444 |
295 |
From hit to lead. Analyzing structure-profile relationships. |
Universities of Lille |
11150168 |
165 |
Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse. |
Pharm-Eco Laboratories |
10649976 |
72 |
Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands. |
Massachusetts General Hospital |
10821718 |
69 |
Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. |
Georgetown University Medical Center |
10479296 |
66 |
Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors. |
Massachusetts General Hospital |
9804682 |
12 |
TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter. |
Institut F£R Bioanorganische Und Radiopharmazeutische Chemie |
12565962 |
41 |
Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. |
University of Michigan |
14592523 |
42 |
Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes. |
Organix |
12798324 |
36 |
Bivalent biogenic amine reuptake inhibitors. |
Human Biomolecular Research Institute |
10698458 |
26 |
Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine. |
Georgetown University Medical Center |
9871604 |
114 |
Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group. |
Hong Kong University of Science and Technology |
22175825 |
19 |
Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
Pfizer |
22175766 |
45 |
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities. |
Neuraxon |
22226656 |
75 |
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test. |
Cephalon |
22300887 |
8 |
QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT). |
University of Tours |
22037049 |
62 |
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. |
Research Triangle Institute |
21458259 |
29 |
Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter. |
Key Laboratory of Radiopharmaceuticals (Beijing Normal University) |
21863888 |
9 |
Efficient conversion of a nonselective norepinephrin reuptake inhibitor into a dual muscarinic antagonist-ß2-agonist for the treatment of chronic obstructive pulmonary disease. |
Pfizer |
21916421 |
68 |
Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152). |
Pfizer |
21899931 |
27 |
Synthesis and pharmacological evaluation of indole-based sigma receptor ligands. |
The University of Mississippi |
21788137 |
33 |
N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (s) receptor ligands. |
The University of Sydney |
21319801 |
54 |
Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine. |
Research Triangle Institute |
21398123 |
56 |
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS). |
Astrazeneca Charnwood |
21310612 |
99 |
Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor. |
Sunovion Pharmaceuticals |
21310609 |
108 |
Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. |
Sunovion Pharmaceuticals |
21095126 |
60 |
Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor. |
Sunovion Pharmaceuticals |
21093273 |
154 |
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. |
Sepracor |
21146989 |
46 |
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands. |
The University of Sydney |
21112782 |
80 |
The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain. |
Msd |
21185183 |
111 |
Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists. |
Pfizer |
20949929 |
63 |
Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors. |
Bristol-Myers Squibb |
20945906 |
33 |
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain. |
Abbott Laboratories |
20812727 |
157 |
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. |
National Institute of Mental Health |
20813948 |
63 |
Spiroindolones, a potent compound class for the treatment of malaria. |
Swiss Tropical and Public Health Institute |
20692833 |
41 |
N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B. |
Csiro Molecular and Health Technologies |
20509659 |
182 |
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. |
Barrow Neurological Institute |
20466553 |
6 |
Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines. |
Trinity College |
20462211 |
92 |
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231). |
Pfizer |
20378347 |
27 |
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors. |
Wyeth Research |
20137933 |
218 |
Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity. |
Amgen |
19717215 |
56 |
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. |
Trinity College |
19647430 |
104 |
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration. |
Pfizer |
20034793 |
31 |
Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles. |
Bristol-Myers Squibb |
20031410 |
84 |
Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists. |
Pfizer |
19926484 |
26 |
Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands. |
University of Tours |
20158204 |
136 |
Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. |
Research Triangle Institute |
20131864 |
59 |
1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors. |
Wyeth Research |
19954972 |
14 |
Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling. |
University of Sydney |
19646882 |
72 |
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways. |
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj |
19560930 |
69 |
An extended study of dimeric phenyl tropanes. |
Aarhus University |
19740658 |
73 |
Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. |
Pfizer |
19632110 |
29 |
Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols. |
Wyeth Research |
19713106 |
66 |
Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors. |
Wyeth Research |
19854053 |
152 |
Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. |
Pfizer |
19791802 |
21 |
Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters. |
Oregon State University |
19616432 |
176 |
Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template. |
Pfizer |
19560923 |
20 |
Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
19359175 |
132 |
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships. |
Pfizer |
19199480 |
6 |
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. |
Sirtris Pharmaceuticals |
8496700 |
16 |
The Role of Receptor Binding in Drug Discovery |
TBA |
19492813 |
56 |
Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues. |
Glaxosmithkline |
19445453 |
87 |
Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists. |
National Institute On Drug Abuse-Intramural Research Program |
19284718 |
191 |
Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action. |
University of Illinois At Chicago |
19282174 |
85 |
Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. |
Pfizer |
19053782 |
18 |
Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. |
Emory University |
19053748 |
57 |
Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter. |
Research Triangle Institute |
18954985 |
111 |
Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
Roche Palo Alto |
18954981 |
108 |
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics. |
Neurocrine Biosciences |
18793858 |
27 |
Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging. |
University of Tours |
18782666 |
34 |
Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines. |
Pfizer |
18701276 |
97 |
Highly functionalized 7-azaindoles as selective PPAR gamma modulators. |
Merck Research Laboratories |
18667309 |
123 |
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint. |
Neurocrine Biosciences |
18644726 |
36 |
3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination. |
Institut FüR InterdisziplinäRe Isotopenforschung |
18625557 |
60 |
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors. |
Pfizer |
18621528 |
133 |
Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity. |
Pfizer |
18571404 |
132 |
Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines. |
Pfizer |
18557608 |
108 |
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. |
Wyeth Research |
18487050 |
36 |
Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter. |
Hadassah Hebrew University Hospital |
18461921 |
65 |
Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions. |
University of Maryland |
16989524 |
3 |
Antidepressant principles of the roots of Polygala tenuifolia. |
Medical and Pharmaceutical Industry Technology and Development Center |
18085744 |
12 |
Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands. |
Emory University |
18052090 |
39 |
2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents. |
University of Pennsylvania |
17869101 |
60 |
High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors. |
University of Aarhus |
17705359 |
3 |
Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent. |
Emory University |
17616397 |
107 |
Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors. |
Johnson & Johnson Pharmaceutical Research & Development |
17583504 |
51 |
Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors. |
Johnson & Johnson Pharmaceutical Research & Development |
17571866 |
49 |
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography. |
National Institute of Mental Health |
17446069 |
15 |
Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents. |
Emory University |
17418570 |
141 |
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
17412583 |
81 |
Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity. |
Johnson & Johnson Pharmaceutical Research & Development |
17391962 |
27 |
Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
17267217 |
76 |
N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors. |
Pfizer |
17154506 |
6 |
Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. |
Emory University |
17127059 |
96 |
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors. |
Johnson & Johnson Pharmaceutical Research and Development |
17123820 |
4 |
Synthesis of 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET. |
Institutet |
16931001 |
93 |
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
16784855 |
22 |
Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position. |
Emory University |
16722655 |
28 |
Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist. |
Pfizer |
16722631 |
87 |
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. |
Predix Pharmaceuticals |
16513343 |
3 |
(R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis. |
Paradigm Therapeutics |
16509591 |
75 |
Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity. |
Niddk |
16497500 |
128 |
N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake. |
Eli Lilly |
16458504 |
37 |
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand. |
Columbia University College of Physicians and Surgeons |
16451060 |
3 |
Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET. |
Emory University |
16392816 |
113 |
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
Alcon Research |
16392798 |
46 |
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand. |
Columbia University College of Physicians and Surgeons |
16361098 |
70 |
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists. |
F. Hoffmann-La Roche |
16337793 |
39 |
Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands. |
University of Tours |
16314097 |
113 |
Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine. |
Pfizer |
16302792 |
19 |
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter. |
National Institute On Drug Abuse-Intramural Research Program |
16202585 |
30 |
Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes. |
University of Illinois At Chicago |
16137883 |
84 |
1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors. |
Eli Lilly |
15974579 |
36 |
Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands. |
Emory University |
15801845 |
45 |
Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents. |
Columbia University College of Physicians and Surgeons |
15456270 |
24 |
2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent. |
University of Pennsylvania |
15177457 |
39 |
Synthesis and biological activity of some known and putative duloxetine metabolites. |
Eli Lilly |
15081025 |
23 |
Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA). |
Virginia Commonwealth University |
15080991 |
38 |
Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). |
Yale School of Medicine |
14971892 |
32 |
Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter. |
Emory University |
14643350 |
38 |
Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake. |
Eli Lilly |
14643338 |
124 |
Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
Virginia Commonwealth University |
12951108 |
63 |
Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression. |
Eli Lilly |
12620070 |
24 |
Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. |
Emory University |
12213078 |
31 |
Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter. |
Niddk |
12213054 |
38 |
Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. |
Drew University |
32567857 |
1 |
Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT |
University of Texas Medical Branch |
32227883 |
40 |
Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge |
University of Mississippi |
10956218 |
12 |
Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines. |
Centre For Addiction and Mental Health |
27647372 |
86 |
Exploration of substituted arylpiperazine-tetrazoles as promising dual norepinephrine and dopamine reuptake inhibitors. |
Chonnam National University |
27309376 |
224 |
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. |
East China Normal University |
10715164 |
57 |
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. |
Virginia Commonwealth University |
32342685 |
325 |
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D |
National Institute of Neurological Disorders and Stroke |
10576690 |
13 |
Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine. |
Georgetown University Medical Center |
31268317 |
6 |
Norepinephrine-Transporter-Targeted and DNA-Co-Targeted Theranostic Guanidines. |
University of Nebraska Medical Center |
31021617 |
136 |
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D |
University of Pennsylvania |
31841637 |
112 |
Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters. |
University of Vienna |
9986702 |
11 |
A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol. |
University of Pennsylvania |
30605331 |
236 |
Design and in Vivo Characterization of A |
Medical College of Wisconsin |
31185168 |
144 |
Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor. |
Rti International |
31199640 |
50 |
Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. |
Astrazeneca |
9871666 |
4 |
Design and synthesis of a biotinylated dopamine transporter ligand for the purification and labeling of dopaminergic neurons. |
Novartis Pharma |
9435902 |
60 |
Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. |
National Institute On Drug Abuse |
31620230 |
283 |
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT |
University of Minnesota Twin Cities |
8558529 |
195 |
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
24262882 |
15 |
Synthesis, radiosynthesis and first in vitro evaluation of novel PET-tracers for the dopamine transporter: [(11)C]IPCIT and [(18)F]FE@IPCIT. |
Medical University of Vienna |
24012181 |
46 |
Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors. |
Sogang University |
23880542 |
4 |
Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. |
University of Utah |
23769168 |
57 |
Novel triple reuptake inhibitors with low risk of CAD associated liabilities: design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds. |
Takeda Pharmaceutical |
23578689 |
20 |
Conformationally restricted homotryptamines. Part 6: indole-5-cycloalkyl methylamines as selective serotonin reuptake inhibitors. |
Bristol-Myers Squibb Research and Development |
23347683 |
166 |
A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships. |
Theravance |
17618015 |
13 |
Bioactive peroxides as potential therapeutic agents. |
The Hebrew University of Jerusalem |
17064074 |
2 |
Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter. |
University of Queensland |
30293797 |
45 |
Design, synthesis, and systematic evaluation of 4-arylpiperazine- and 4-benzylpiperidine napthyl ethers as inhibitors of monoamine neurotransmitters reuptake. |
Chonnam National University |
30389290 |
146 |
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity. |
Texas Tech University Health Sciences Center |
30007567 |
70 |
Design, synthesis and docking study of 4-arylpiperazine carboxamides as monoamine neurotransmitters reuptake inhibitors. |
Chonnam National University |
29039662 |
62 |
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds. |
Csir-National Chemical Laboratory |
28731336 |
151 |
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
Biocon Bristol-Myers Squibb R&D Centre |
30240563 |
136 |
Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. |
Organix |
29767967 |
74 |
Structure-Guided Modification of Heterocyclic Antagonists of the P2Y |
National Institute of Diabetes and Digestive and Kidney Diseases |
29029933 |
45 |
Highly potent and selective Na |
Pfizer |
29656199 |
148 |
Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties. |
University of Texas At Austin |
29631962 |
252 |
Identification and biological evaluation of thiazole-based inverse agonists of ROR?t. |
Phenex Pharmaceuticals |
28807575 |
58 |
Triple reuptake inhibitors: Design, synthesis and structure-activity relationship of benzylpiperidine-tetrazoles. |
Chonnam National University |
28636348 |
9 |
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle. |
National Institute of Diabetes and Digestive and Kidney Diseases |
29091428 |
52 |
Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors. |
University of Vienna |
34213885 |
38 |
Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease. |
Wichita State University |
26864917 |
3 |
Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening. |
Southern Research Institute |
26943478 |
16 |
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives. |
Chulabhorn Research Institute |
26214585 |
23 |
Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. |
University of Wisconsin-Madison |
11579444 |
23 |
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA. |
The Royal Danish School of Pharmacy |
9349523 |
22 |
Cloning and expression of a human serotonin 5-HT4 receptor cDNA. |
Janssen Research Foundation |
7774670 |
11 |
Pharmacological properties of two recombinant splice variants of the PACAP type I receptor, transfected and stably expressed in CHO cells. |
UniversitÉ |
19326941 |
104 |
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. |
Washington University |
16731764 |
10 |
CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. |
Celera Genomics |
18434145 |
56 |
Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases. |
Methylgene |
15771455 |
110 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties. |
Universita Degli Studi Di Firenze |