The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28590753 |
162 |
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A |
Universit£ |
| 28380296 |
64 |
N |
Seoul National University |
| 28055204 |
74 |
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A |
Advinus Therapeutics |
| 27842891 |
75 |
A |
Advinus Therapeutics |
| 28238512 |
54 |
Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A |
Advinus Therapeutics |
| 27933962 |
89 |
Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A |
Universit£ |
| 27718474 |
40 |
Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A |
Leiden University |
| 27876250 |
60 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH |
Jagiellonian University Medical College |
| 27933955 |
123 |
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships. |
RhôNe-Poulenc Rorer |
| 27933810 |
166 |
Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 27227326 |
156 |
Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling. |
Julius-Maximilians-Universit£T W£Rzburg |
| 27485602 |
183 |
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors. |
Jagiellonian University Medical College |
| 27161878 |
83 |
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors. |
Universit£ |
| 26890707 |
27 |
Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 26824742 |
43 |
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. |
Uppsala University |
| 26988801 |
55 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. |
Jagiellonian University Medical College |
| 26819673 |
55 |
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. |
Astrazeneca |
| 26756468 |
44 |
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. |
University of Warwick |
| 26356532 |
39 |
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. |
Georgia Institute of Technology |
| 26781932 |
109 |
Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists. |
Merck Research Laboratories |
| 26638043 |
66 |
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor. |
Universit£ |
| 26717203 |
129 |
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors. |
Universit£ |
| 26210506 |
26 |
Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists. |
Leiden University |
| 26191370 |
34 |
Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 26048804 |
57 |
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists. |
Merck Research Laboratories |
| 26046697 |
46 |
One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists. |
Universit£ |
| 25969169 |
54 |
A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors. |
University of Barcelona |
| 25780876 |
205 |
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor. |
Universit£ |
| 25699637 |
91 |
5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists. |
University of Camerino |
| 25633494 |
128 |
A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists. |
National University of Singapore |
| 25701253 |
23 |
Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility. |
H. Lundbeck |
| 25686851 |
54 |
Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies. |
B. V. Patel Pharmaceutical Education and Research Development (Perd) Centre |
| 25063944 |
56 |
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A1 and A(2A) adenosine receptors. Molecular modeling and pharmacological studies. |
Universit£ |
| 24972108 |
256 |
Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study. |
Universit£ |
| 24969016 |
16 |
Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 24863744 |
15 |
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain. |
University of Missouri |
| 25497490 |
30 |
1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies. |
Universit£ |
| 25462223 |
27 |
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists. |
Universit£ |
| 25221664 |
21 |
Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 25181013 |
4 |
Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene. |
Universit£ |
| 24871036 |
13 |
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity. |
Astrazeneca |
| 24164628 |
186 |
Adenosine A2A receptor as a drug discovery target. |
Merck Research Laboratories |
| 24669958 |
39 |
Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines. |
Leiden University |
| 23597047 |
5 |
Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 23516963 |
99 |
Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1). |
Astrazeneca |
| 23427825 |
45 |
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation. |
Universit£ |
| 23245803 |
87 |
Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands. |
University of Bonn |
| 23231967 |
23 |
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold. |
University of Santiago De Compostela |
| 23171656 |
23 |
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies. |
Universita' Di Firenze |
| 22277057 |
11 |
Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold. |
University of Nottingham |
| 17249651 |
4 |
New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells. |
University of Nottingham |
| 23145215 |
23 |
Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions. |
TBA |
| 20371139 |
16 |
Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists. |
Universidade De A Coru£A |
| 20382540 |
9 |
In silico directed chemical probing of the adenosine receptor family. |
Universidade Do Minho |
| 20137957 |
35 |
Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists. |
Universidade De Porto |
| 16392813 |
329 |
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor. |
Universit£ |
| 23098605 |
248 |
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists. |
Universit£ |
| 22468757 |
171 |
Medicinal chemistry of A3 adenosine receptor modulators: pharmacological activities and therapeutic implications. |
Universit£ |
| 22921089 |
62 |
Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 22889387 |
2 |
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor. |
Universit£ |
| 22827545 |
11 |
Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data. |
Leiden/Amsterdam Center For Drug Research |
| 22738238 |
29 |
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. |
University of North Carolina At Chapel Hill |
| 22239465 |
26 |
Design and characterization of optimized adenosine A2A/A1 receptor antagonists for the treatment of Parkinson's disease. |
Janssen Research and Development |
| 21664729 |
142 |
Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones. |
Jagiellonian University Medical College |
| 23342198 |
77 |
Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists. |
TBA |
| 22568637 |
158 |
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. |
Universit£ |
| 22486652 |
44 |
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 22559880 |
52 |
Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 22677030 |
29 |
New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships. |
Universidade Do Minho |
| 22432713 |
64 |
Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists. |
Monash University |
| 24900277 |
36 |
Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B Antagonists. |
TBA |
| 22236250 |
16 |
Exploring activity cliffs in medicinal chemistry. |
Rheinische Friedrich-Wilhelms-Universit£T |
| 22257095 |
65 |
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists. |
Universit£ |
| 22220592 |
27 |
Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design. |
Heptares Therapeutics |
| 21858244 |
62 |
Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element. |
TBA |
| 21210664 |
74 |
Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist. |
H. Lundbeck |
| 20875743 |
90 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela |
Pfizer |
| 20931963 |
112 |
Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome. |
Aska Pharmaceutical |
| 20684563 |
176 |
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. |
H. Lundbeck |
| 20541935 |
131 |
4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists. |
Roche Research Center |
| 20408530 |
98 |
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation. |
Universit£ |
| 20303771 |
24 |
Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists. |
University of Delhi |
| 20188574 |
141 |
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. |
University of Bonn |
| 19569717 |
251 |
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. |
Institute |
| 19463000 |
50 |
High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. |
University of Bonn |
| 19282184 |
195 |
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |
University of Camerino |
| 18637670 |
80 |
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. |
Leiden/Amsterdam Center For Drug Research |
| 10757709 |
8 |
Luteolin, a compound with adenosine A(1) receptor-binding activity, and chromone and dihydronaphthalenone constituents from Senna siamea. |
Leiden University |
| 16562853 |
22 |
Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. |
Tom'S of Maine |
| 18262425 |
27 |
Synthesis of eudistomin D analogues and its effects on adenosine receptors. |
Hokkaido University |
| 18424135 |
131 |
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 18411049 |
134 |
Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. |
Vernalis (R&D) |
| 18407496 |
127 |
Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. |
Vernalis (R&D) |
| 18406614 |
56 |
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. |
Vernalis (R&D) |
| 18321039 |
144 |
Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases. |
Cv Therapeutics |
| 18321038 |
85 |
Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 18077171 |
108 |
1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists. |
Universit£ |
| 18042389 |
42 |
N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists. |
Monash University (Parkville Campus) |
| 18258439 |
69 |
A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. |
Leiden/Amsterdam Center For Drug Research |
| 18226909 |
162 |
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor. |
Universit£ |
| 17483457 |
58 |
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. |
Abbott Laboratories |
| 18255292 |
35 |
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists. |
Ewha Womans University |
| 17933541 |
145 |
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species. |
Universit£ |
| 17337182 |
23 |
Potent and selective xanthine-based inhibitors of phosphodiesterase 5. |
Novartis Institutes of Biomedical Research |
| 17967536 |
34 |
Structure-activity relationships of adenosines with heterocyclic N6-substituents. |
Monash University (Parkville Campus) |
| 17927167 |
107 |
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists. |
Universit£ |
| 17306548 |
84 |
N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor. |
Universit£ |
| 17378544 |
121 |
Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 17309246 |
108 |
N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. |
Universit£ |
| 17228880 |
76 |
Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists. |
Universit£ |
| 17228876 |
36 |
SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase. |
Pfizer |
| 17201410 |
4 |
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics. |
University of California San Francisco |
| 16487705 |
107 |
N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists. |
University of Virginia |
| 16509587 |
72 |
Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations. |
Universit£ |
| 16366607 |
81 |
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching. |
Universit£ |
| 16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
| 15771447 |
24 |
A series of ligands displaying a remarkable agonistic-antagonistic profile at the adenosine A1 receptor. |
Leiden/Amsterdam Center For Drug Research |
| 15771445 |
22 |
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors. |
University of Ferrara |
| 15743197 |
37 |
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. |
Universit£ |
| 16078833 |
37 |
6-aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency. |
University of Virginia |
| 15481989 |
70 |
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists. |
Universit£ |
| 15341491 |
62 |
2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists. |
Cv Therapeutics |
| 15267242 |
54 |
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor. |
Iiqab (Csic) |
| 15876531 |
28 |
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential. |
Novartis Institutes For Biomedical Research |
| 15341938 |
6 |
Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor. |
Ewha Womans University |
| 14998332 |
328 |
Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. |
Universit£ |
| 15239649 |
24 |
New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. |
University of Leiden |
| 15214785 |
58 |
1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies. |
Universit£ |
| 15139758 |
50 |
Incorporating molecular shape into the alignment-free Grid-Independent Descriptors. |
Universitat Pompeu Fabra |
| 12672250 |
10 |
N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor. |
Leiden University |
| 12646033 |
124 |
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists. |
Universit£ |
| 12109910 |
8 |
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. |
Universit£ |
| 11585444 |
295 |
From hit to lead. Analyzing structure-profile relationships. |
Universities of Lille |
| 10841798 |
64 |
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. |
National Institute of Diabetes |
| 10212124 |
26 |
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
Leiden University |
| 9191951 |
8 |
9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. |
Upr 421 Du Cnrs |
| 8355252 |
54 |
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
Kyowa Hakko Kogyo |
| 15203136 |
39 |
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents. |
Virginia Commonwealth University |
| 11714602 |
18 |
7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors. |
Universit£ |
| 11459663 |
19 |
Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. |
Universit£ |
| 11392549 |
45 |
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Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold. |
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Roche Research Center |
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Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection. |
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Johnson & Johnson Pharmaceutical Research and Development |
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Molecular modeling study on potent and selective adenosine A(3) receptor agonists. |
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Dipartimento Di Scienze Farmaceutiche |
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Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists. |
Bayer Schering Pharma |
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Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors. |
Ewha Womans University |
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Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists. |
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A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. |
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East China University of Science and Technology |
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Monash University |
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Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. |
Johnson & Johnson Pharmaceutical Research and Development |
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Hybrid ortho/allosteric ligands for the adenosine A(1) receptor. |
Leiden University |
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Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists. |
Novartis Institutes For Biomedical Research |
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Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors. |
Universidad De M£Laga |
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Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. |
Ewha Womans University |
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3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists. |
Monash University (Parkville Campus) |
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Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system. |
National Institute of Diabetes and Digestive and Kidney Diseases |
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Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor. |
University of Camerino |
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Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist. |
Aix-Marseille Universit£ |
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Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites. |
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Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors. |
Hokkaido University |
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Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. |
Ewha Womans University |
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Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides. |
Vernalis (R+D) |
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The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists. |
TBA |
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1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships. |
Universidade De Santiago De Compostela |
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N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice. |
University of Camerino |
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Universita Di Firenze |
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Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists. |
Pharmacopeia |
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Neurocrine Biosciences |
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Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists. |
Pharmacopeia |
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Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors. |
University Institute of Pharmaceutical Sciences |
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Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists. |
Università |
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Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies. |
Università |
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2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability. |
Neurocrine Biosciences |
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Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. |
Ewha Womans University |
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2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists. |
Monash University |
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Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system. |
National Institute of Diabetes and Digestive and Kidney Diseases |
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Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor. |
Dipartimento Di Scienze Farmaceutiche |
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Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. |
Universita' Di Firenze |
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Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. |
University of Bonn |
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Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists. |
Neurocrine Biosciences |
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Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines. |
Cv Therapeutics |
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Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy. |
Neurocrine Biosciences |
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Jagiellonian University Medical College |
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Dual acting antioxidant A1 adenosine receptor agonists. |
Monash University (Parkville Campus) |
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New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. |
Università |
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Design, synthesis, and biological evaluation of LNA nucleosides as adenosine A3 receptor ligands. |
Santaris Pharma |
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Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists. |
Ewha Womans University |
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Novel ergopeptides as dual ligands for adenosine and dopamine receptors. |
Institut D'Investigacions BiomèDiques August Pi I |
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Jagiellonian University |
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Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist. |
Almirall |
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2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. |
Leiden/Amsterdam Center For Drug Research |
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Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines. |
Schering-Plough Research Institute |
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2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists. |
Ghent University |
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Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists. |
Biogen Idec |
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Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. |
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Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches. |
Vernalis (R&D) |
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A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists. |
University of Bonn |
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Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. |
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Cv Therapeutics |
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Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. |
Leiden University |
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New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists. |
RhôNe-Poulenc Rorer |
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2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. |
Leiden/Amsterdam Center For Drug Research |
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Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand. |
Columbia University College of Physicians and Surgeons |
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Ewha Womans University |
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Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection. |
National Institute of Diabetes and Digestive and Kidney Diseases |
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Università |
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Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer. |
Università |
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Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety. |
National Institute of Diabetes and Digestive and Kidney Diseases |
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Università |
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New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. |
Università |
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"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. |
National Institute of Diabetes and Digestive and Kidney Diseases |
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New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists. |
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(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. |
National Institute of Diabetes and Digestive and Kidney Diseases |
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Leiden/Amsterdam Center For Drug Research |
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Biogen Idec |
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Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma. |
Otsuka Pharmaceutical Factory |
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A mild, efficient and alpha-selective glycosidation by using potassium dodecatungstocobaltate trihydrate as catalyst. |
University of Isfahan |
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Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives. |
Università |
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Comparison of inhibitory activity of isomeric triazolopyridine derivatives towards adenosine receptor subtypes or do similar structures reveal similar bioactivities? |
F. Hoffmann-La Roche |
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2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors. |
Inotek Pharmaceuticals |
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F. Hoffmann-La Roche |
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Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors. |
Leiden University |
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Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF). |
Cv Therapeutics |
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Università |
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2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications. |
Deakin University |
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3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor. |
Pfizer |
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New irreversible adenosine A(1) antagonists based on FSCPX. |
Monash University (Parkville Campus) |
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Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor. |
Cv Therapeutics |
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Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist. |
TBA |
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Instituto De QuíMica MéDica (Csic) |
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2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors. |
University of Virginia |
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5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists. |
Ghent University |
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1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. |
University of Bonn |
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Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
Università |
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Università |
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New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A |
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Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A |
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Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
Università |
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C2-substituted quinazolinone derivatives exhibit A |
North-West University |
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Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A |
Uppsala University |
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2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
Eisai |
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Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor. |
Deakin University |
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Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
Università |
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Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography. |
University of Milano-Bicocca |
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Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies. |
Jagiellonian University Medical College |
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8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors. |
University of Bonn |
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Novel non-xanthine antagonist of the A |
Bayer Pharmaceuticals |
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Identification of new potent A |
Nankai University |
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Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. |
National Institute of Diabetes |
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Trifluorinated Pyrimidine-Based A |
Uppsala University |
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Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases. |
Palack£ |
| 10698437 |
7 |
Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors. |
Università |
| 10669571 |
24 |
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists. |
University of WüRzburg |
| 31306001 |
117 |
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity. |
Universit£ |
| 32271569 |
76 |
Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A |
Medical College of Wisconsin |
| 10579811 |
70 |
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
Università |
| 10476879 |
52 |
Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays. |
Cadus Pharmaceutical |
| 31129454 |
51 |
The chemical biology of apoptosis: Revisited after 17 years. |
Tsinghua University |
| 30869893 |
26 |
Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A |
Leiden University |
| 31280999 |
29 |
2-Aryladenine derivatives as a potent scaffold for A |
Universidade Do Minho |
| 31846328 |
8 |
Docking Finds GPCR Ligands in Dark Chemical Matter. |
Uppsala University |
| 31738058 |
154 |
Structure-Based Optimization of Coumarin hA |
University of Porto |
| 30605331 |
236 |
Design and in Vivo Characterization of A |
Medical College of Wisconsin |
| 31255928 |
82 |
Design, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as A |
National Engineering Research Center For The Emergency Drug |
| 30835463 |
202 |
A |
Rheinische Friedrich-Wilhelms-Universitat Bonn |
| 30826188 |
25 |
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
University of Science & Technology (Ust) |
| 9622554 |
59 |
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists. |
Università |
| 30638876 |
108 |
Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity. |
Universit£ |
| 9191953 |
11 |
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine. |
Cv Therapeutics |
| 31453698 |
97 |
Antioxidant-Conjugated 1,2,4-Triazolo[4,3- |
Universit£ |
| 8863790 |
55 |
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. |
National Institute of Diabetes |
| 26592528 |
37 |
Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. |
Stockholm University |
| 26236460 |
36 |
Structure-Based Design, Synthesis by Click Chemistry and |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 24456490 |
33 |
Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists. |
Seoul National University |
| 24556147 |
52 |
Novel 8-(p-substituted-phenyl/benzyl)xanthines with selectivity for the A2A adenosine receptor possess bronchospasmolytic activity. |
Panjab University |
| 24518296 |
119 |
Discovery of simplified Nē-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies. |
National University of Singapore |
| 24139167 |
419 |
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases. |
University of Bonn |
| 24900602 |
32 |
Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists. |
University of Santiago De Compostela |
| 24189496 |
67 |
8-(2-Furyl)adenine derivatives as A?A adenosine receptor ligands. |
University of Camerino |
| 24077183 |
32 |
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives. |
Universit£ |
| 8064798 |
44 |
Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors. |
University of South Florida |
| 23953686 |
28 |
Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists. |
University of Delhi |
| 23789814 |
22 |
Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease. |
Universit£ |
| 23685887 |
80 |
New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides. |
B.V. Patel Pharmaceutical Education and Research Development |
| 23631427 |
212 |
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones. |
University of Bonn |
| 23602401 |
50 |
Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space. |
Monash University (Parkville Campus) |
| 23522563 |
94 |
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists. |
Janssen Research & Development |
| 18249548 |
62 |
Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines. |
University of Santiago De Compostela |
| 15715480 |
4 |
Synthesis and biological evaluation of a new series of 2,3,5-substituted [1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action. |
Leiden/Amsterdam Center For Drug Research |
| 10072675 |
7 |
Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)- pyridazinebutanoic acid (FK 838): a novel non-xanthine adenosine A1 receptor antagonist with potent diuretic activity. |
Fujisawa Pharmaceutical |
| 30144700 |
176 |
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A |
Universit£ |
| 29268131 |
32 |
Antagonists of the adenosine A |
Umr-S1172 - Jparc - Centre De Recherche Jean-Pierre Aubert Neurosciences Et Cancer |
| 29525433 |
41 |
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A |
Universit£ |
| 28835798 |
68 |
Discovery of Potent and Selective A |
Advinus Therapeutics |
| 29681156 |
71 |
Fluorescent-Labeled Selective Adenosine A |
University of Bonn |
| 29029933 |
45 |
Highly potent and selective Na |
Pfizer |
| 29909340 |
90 |
Structure-activity relationship studies and pharmacological characterization of N |
Universit£ |
| 29614417 |
110 |
New potent and selective A |
University of Camerino |
| 29965759 |
26 |
2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus. |
Janssen Infectious Diseases-Diagnostics |
| 29880250 |
84 |
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A |
Universit£ |
| 29792714 |
32 |
Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson's Disease. |
Uppsala University |
| 29631962 |
252 |
Identification and biological evaluation of thiazole-based inverse agonists of ROR?t. |
Phenex Pharmaceuticals |
| 29627261 |
15 |
Development of novel pyridazinone-based adenosine receptor ligands. |
Universit£ |
| 28447789 |
134 |
Exploring the Role of N |
University of Camerino |
| 28368607 |
26 |
Enantiospecific Recognition at the A |
Uppsala University |
| 29446948 |
82 |
A Structure-Activity Relationship Study of Bitopic N |
Monash University |
| 27721147 |
30 |
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A |
Universita Degli Studi Di Firenze |
| 28792759 |
22 |
Effect of Nitrogen Atom Substitution in A |
Uppsala University |
| 1694546 |
64 |
Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors. |
Vanderbilt University |
| 29257884 |
75 |
Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A |
University of Camerino |
| 28799755 |
51 |
Polypharmacology of N |
Sahmyook University |
| 23839987 |
6 |
Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1. |
University of Iowa |
| 26833890 |
18 |
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease. |
Yogi Vemana University |
| 26440714 |
28 |
Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives. |
Quaid-I-Azam University |
| 26432614 |
18 |
Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of a-glucosidases. |
Universiti Teknologi Mara |
| 26469307 |
7 |
Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b. |
University of Leipzig |
| 12110997 |
380 |
In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs. |
WestfÄLische Wilhelms-UniversitÄ |
| 6087359 |
69 |
Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine. |
TBA |
| 1831904 |
27 |
Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. |
Duke University |
| 19880322 |
56 |
N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53. |
Nih |
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