The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28248104 |
385 |
Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure. |
Friedrich-Alexander University Erlangen-N£Rnberg |
28214075 |
30 |
Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
Harvard Medical School |
6306238 |
4 |
4-(Aminoalkyl)-7-hydroxy-2(3H)-indolones, a novel class of potent presynaptic dopamine receptor agonists. |
TBA |
11392544 |
11 |
Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic? |
Ucb Pharma |
27839919 |
192 |
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples. |
University of Kansas |
27933960 |
122 |
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors. |
National Institute On Drug Abuse |
27564135 |
499 |
1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists. |
Aptuit |
27364609 |
230 |
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores. |
Florida A&M University |
27132867 |
154 |
Structure-guided development of dualß2 adrenergic/dopamine D2 receptor agonists. |
Friedrich-Alexander University |
26876931 |
36 |
Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket. |
Abbott Healthcare Products |
27080176 |
117 |
Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists. |
Vanderbilt University |
26988801 |
55 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. |
Jagiellonian University Medical College |
26951894 |
376 |
1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists. |
Aptuit |
26704965 |
229 |
Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. |
University of Illinois At Chicago |
26786693 |
153 |
Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists. |
Aptuit |
26421921 |
43 |
Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists. |
Glenmark Research Centre |
26288260 |
34 |
Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library. |
Universit Degli Studi Di Milano |
25826710 |
21 |
Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis. |
National Institute On Drug Abuse-Intramural Research Program |
25650314 |
95 |
Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands. |
National Institute On Drug Abuse-Intramural Research Program |
25557493 |
109 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia. |
Jagiellonian University Collegium Medicum |
25047579 |
130 |
Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D(2)-like receptors. |
Friedrich-Alexander University |
25556097 |
70 |
Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands. |
Washington University |
25221667 |
66 |
Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity. |
Vanderbilt University |
24944737 |
20 |
Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66. |
National Institute On Drug Abuse-Intramural Research Program |
24805037 |
380 |
Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia. |
Adamed |
24559051 |
141 |
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders. |
Intra-Cellular Therapies |
23734634 |
33 |
Thes2 receptor: a novel protein for the imaging and treatment of cancer. |
Washington University |
23353740 |
21 |
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
Universidade Federal De Goi£S |
18162395 |
89 |
Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor. |
Novartis Institutes For Biomedical Research |
17507221 |
58 |
Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists. |
Novartis Institutes For Biomedical Research |
12443779 |
44 |
2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties. |
Janssen-Cilag |
20005096 |
112 |
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2. |
Glaxosmithkline |
19635669 |
106 |
Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. |
Imperial College |
19560918 |
101 |
Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification. |
Cancer Therapeutics |
15808487 |
137 |
The role of QSAR in dopamine interactions. |
Pomona College |
6737423 |
6 |
Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application. |
TBA |
12657274 |
109 |
Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists. |
Abbott Laboratories |
11755365 |
113 |
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2. |
Janssen-Cilag |
11755364 |
104 |
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1. |
Janssen-Cilag |
22959245 |
175 |
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs). |
The University of Sydney |
21413808 |
170 |
Synopsis of some recent tactical application of bioisosteres in drug design. |
Bristol-Myers Squibb Pharmaceutical Research and Development |
22738628 |
38 |
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors. |
University of Li£Ge |
22313227 |
78 |
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype. |
National Institute of Mental Health |
22268448 |
34 |
New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation. |
University of Li£Ge |
21207959 |
69 |
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging. |
National Institute of Mental Health |
20542439 |
115 |
Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. |
Washington University |
20408551 |
13 |
Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular). |
Westfalische Wilhelms-Universitat |
20153652 |
49 |
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
Universidade Federal Do Rio Grande Do Sul |
19963380 |
38 |
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. |
Hunter College and The Graduate Center of The City University of New York |
19744859 |
90 |
Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
Friedrich-Schiller-Universit£T Jena |
19331412 |
122 |
N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. |
National Institute On Drug Abuse-Intramural Research Program |
18181565 |
71 |
Multi-target-directed ligands to combat neurodegenerative diseases. |
University of Bologna |
17154515 |
40 |
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
Purdue University |
16789750 |
155 |
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist. |
Laboratoire De Chimie Th�Rapeutique |
16420061 |
161 |
Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist. |
University of Bonn |
16168646 |
39 |
N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor. |
Nps Pharmaceuticals |
16198561 |
99 |
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. |
Novartis Institutes For Biomedical Research |
16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
16134944 |
85 |
Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists. |
Friedrich-Alexander University |
15801855 |
52 |
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists. |
Universit£ |
15658848 |
103 |
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. |
Wyeth Research |
15916420 |
68 |
Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles. |
Friedrich-Alexander University |
15916415 |
150 |
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents. |
National Institute On Drug Abuse-Intramural Research Program |
15501032 |
14 |
Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors. |
Florida A&M University |
15084133 |
31 |
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. |
Abbott Laboratories |
14998318 |
112 |
Selective optimization of side activities: another way for drug discovery. |
Prestwick Chemical |
15239663 |
60 |
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. |
Abbott Laboratories |
12519065 |
243 |
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists. |
H. Lundbeck |
12477356 |
137 |
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands. |
Universit£ |
12361386 |
113 |
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists. |
Friedrich-Alexander University |
12213075 |
70 |
Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD). |
Purdue University |
11170639 |
73 |
Current and novel approaches to the drug treatment of schizophrenia. |
Merck Sharp and Dohme Research Laboratories |
11585444 |
295 |
From hit to lead. Analyzing structure-profile relationships. |
Universities of Lille |
11543687 |
92 |
Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype. |
National Institute On Drug Abuse-Intramural Research Program |
10691700 |
112 |
Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype. |
Friedrich-Alexander University |
11087581 |
72 |
Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments. |
Friedrich-Alexander University |
11052797 |
68 |
trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents. |
Neurogen |
11000009 |
23 |
Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists. |
University of Maastricht |
10956195 |
38 |
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
University Centre For Pharmacy |
10602703 |
73 |
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent. |
Warner-Lambert |
9435894 |
206 |
New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans. |
Wyeth-Ayerst Research Laboratories |
8863800 |
115 |
Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
University of Groningen |
8831770 |
136 |
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate. |
Hoechst Marion Roussel |
7861418 |
61 |
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors. |
Vanderbilt University |
8523409 |
37 |
1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding. |
Neurogen |
2903247 |
9 |
Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
State University of Groningen |
15203136 |
39 |
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents. |
Virginia Commonwealth University |
12617906 |
46 |
Cyclic amidines as benzamide bioisosteres: EPC synthesis and SAR studies leading to the selective dopamine D4 receptor agonist FAUC 312. |
Friedrich-Alexander University |
11844688 |
102 |
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy. |
Friedrich-Alexander University |
11814775 |
35 |
New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template. |
Wyeth-Ayerst Research Laboratories |
12113813 |
53 |
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356. |
Friedrich-Alexander University |
11992769 |
93 |
Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands. |
Institute of Science and Technology |
11206464 |
6 |
Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand. |
Universit£ |
11549463 |
72 |
Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179). |
Friedrich-Alexander University |
10987445 |
140 |
Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles. |
Friedrich-Alexander University |
10206547 |
95 |
Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid. |
Universit£T Erlangen-N£Rnberg |
9990464 |
64 |
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps. |
Universit£T Erlangen-N£Rnberg |
9873481 |
80 |
SAR of novel biarylmethylamine dopamine D4 receptor ligands. |
Darmstadt |
| 24 |
D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis |
TBA |
22100258 |
124 |
Bivalent molecular probes for dopamine D2-like receptors. |
Friedrich-Alexander University |
22000209 |
54 |
Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
Vu University Medical Center |
21823597 |
373 |
Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter. |
Green Cross |
21536445 |
63 |
Synthesis and characterization of selective dopamine D2 receptor ligands using aripiprazole as the lead compound. |
Washington University |
21555222 |
25 |
Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity. |
The University of Sydney |
21520940 |
40 |
Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor. |
Vu University Medical Center |
21495689 |
134 |
N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity. |
National Institute On Drug Abuse-Intramural Research Program |
21348515 |
75 |
Synthesis and pharmacological evaluation of fluorine-containing D3 dopamine receptor ligands. |
Washington University |
21190848 |
61 |
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands. |
Korea Research Institute of Chemical Technology |
20709559 |
16 |
Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. |
Purdue University |
20655748 |
92 |
Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: a novel series of atypical antipsychotic agents. |
Korea Research Institute of Chemical Technology |
20620058 |
41 |
Smoothened antagonists for hair inhibition. |
Pfizer |
20223662 |
174 |
Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists. |
Yangji Chemicals |
20149649 |
133 |
Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant. |
Green Cross |
20064718 |
88 |
Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists. |
Merck Research Laboratories |
20061148 |
73 |
Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists. |
Merck Research Laboratories |
19523834 |
79 |
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. |
Wyeth Research |
19719241 |
55 |
Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. |
Wyeth Research |
19606869 |
41 |
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
Friedrich-Alexander University |
| 40 |
(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists |
TBA |
| 32 |
A new series of selective dopamine D4 ligands: 3-([4-arylpiperazin-1-yl]alkylamino)-2H-1,4-benzoxazines |
TBA |
| 39 |
4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D4 receptor |
TBA |
| 25 |
Discovery of selective dopamine D4 receptor antagonists: 1-Aryloxy-3-(4-aryloxypiperidinyl)-2-propanols |
TBA |
| 33 |
1-(2-METHOXYPHENYL)-4-ALKYLPIPERAZINES: EFFECT OF THE N-4 SUBSTITUENT ON THE AFFINITY AND SELECTIVITY FOR DOPAMINE D4 RECEPTOR |
TBA |
| 25 |
Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic properties |
TBA |
19329329 |
183 |
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. |
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz |
19155177 |
52 |
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups. |
Florida A&M University |
18834111 |
68 |
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. |
Friedrich-Alexander University |
18783208 |
11 |
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
National Institute of Mental Health |
18774793 |
85 |
Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol. |
National Institute On Drug Abuses |
18602261 |
65 |
Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists. |
Korea Research Institute of Chemical Technology |
18595716 |
142 |
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one. |
Florida A&M University |
18053713 |
78 |
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. |
Korea Research Institute of Chemical Technology |
17676831 |
67 |
Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors. |
Friedrich-Schiller-UniversitäT Jena |
17672446 |
149 |
Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. |
National Institute On Drug Abuse-Intramural Research Program |
17571866 |
49 |
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography. |
National Institute of Mental Health |
17316913 |
15 |
Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors. |
Sungshin Women'S University |
17266201 |
13 |
Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. |
Friedrich-Alexander University |
17254782 |
28 |
Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors. |
Faculté |
17251022 |
48 |
Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors. |
Université |
17149874 |
110 |
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. |
Abbott Laboratories |
17095222 |
134 |
Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. |
National Institute On Drug Abuse-Intramural Research Program |
17034146 |
24 |
Dopamine/serotonin receptor ligands. 13: Homologization of a benzindoloazecine-type dopamine receptor antagonist modulates the affinities for dopamine D(1)-D(5) receptors. |
Friedrich-Schiller-UniversitäT Jena |
16913699 |
372 |
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
Abbott Laboratories |
16809034 |
142 |
Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists. |
Schering-Plough Research Institute |
16759104 |
46 |
Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists. |
Friedrich-Alexander University |
16722655 |
28 |
Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist. |
Pfizer |
16722631 |
87 |
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. |
Predix Pharmaceuticals |
16621538 |
35 |
Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol. |
Florida A&M University |
16563764 |
100 |
Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype. |
Friedrich-Alexander University |
16539400 |
97 |
Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist. |
Friedrich-Schiller-UniversitäT Jena |
16458504 |
37 |
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand. |
Columbia University College of Physicians and Surgeons |
16392798 |
46 |
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand. |
Columbia University College of Physicians and Surgeons |
16361098 |
70 |
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists. |
F. Hoffmann-La Roche |
16143528 |
213 |
Synthesis of potent and selective serotonin 5-HT1B receptor ligands. |
Columbia University College of Physicians and Surgeons |
16139501 |
54 |
Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents. |
University of Erlangen-Nuremberg |
15801839 |
51 |
CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists. |
Friedrich-Alexander University |
15771448 |
187 |
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. |
Janssen-Cilag |
15689168 |
89 |
Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. |
National Institute On Drug Abuse-Intramural Research Program |
15689154 |
27 |
Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. |
Friedrich-Alexander University |
15603958 |
77 |
N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists. |
Wyeth Research |
15380206 |
37 |
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand. |
Abbott Laboratories |
15341937 |
39 |
N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists. |
Nps Pharmaceuticals |
15341483 |
110 |
Indolebutylamines as selective 5-HT(1A) agonists. |
Merck |
15293986 |
65 |
Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity. |
Friedrich-Schiller-UniversitäT Jena |
15225707 |
42 |
Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. |
University of Erlangen-Nuremberg |
15163190 |
40 |
New series of morpholine and 1,4-oxazepane derivatives as dopamine D4 receptor ligands: synthesis and 3D-QSAR model. |
Neurosearch |
14684327 |
60 |
Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands. |
Wake Forest University School of Medicine |
14643338 |
124 |
Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
Virginia Commonwealth University |
14611858 |
65 |
1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands. |
Neurogen |
14552786 |
88 |
Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor. |
Merck Frosst Centre For Therapeutic Research |
14552778 |
18 |
The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+. |
Florida A&M University |
12951112 |
150 |
Stereocontrolled dopamine receptor binding and subtype selectivity of clebopride analogues synthesized from aspartic acid. |
Friedrich-Alexander University |
12930150 |
155 |
N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands. |
Johann Wolfgang Goethe-UniversitäT |
12643910 |
55 |
Identification of a novel series of selective 5-HT7 receptor antagonists. |
Glaxosmithkline |
12639562 |
41 |
Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist. |
Neurogen |
12570387 |
60 |
Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands. |
Università |
12408724 |
79 |
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors. |
University of LièGe |
12372513 |
102 |
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation. |
Neurogen |
12372512 |
239 |
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships. |
Neurogen |
12161137 |
39 |
Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725. |
Friedrich-Alexander University |
12109911 |
47 |
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine. |
University Center For Pharmacy |
11689074 |
112 |
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands. |
Merck Sharp & Dohme Research Laboratories |
11495580 |
35 |
Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). |
Friedrich-Alexander University |
32631561 |
110 |
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT |
City University of New York |
11378358 |
254 |
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. |
Columbia University College of Physicians and Surgeons |
11354362 |
18 |
Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands. |
Sumitomo Pharmaceuticals |
11327592 |
9 |
1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors. |
Wyeth-Ayerst Research |
32227883 |
40 |
Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge |
University of Mississippi |
10999484 |
38 |
Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists. |
Neurogen |
31098001 |
35 |
Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. |
University of Texas Medical Branch |
27508895 |
141 |
Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. |
National Institute On Drug Abuse-Intramural Research Program |
30597325 |
17 |
Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (? |
Memorial Sloan Kettering Cancer Center |
31404862 |
138 |
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases. |
Palack£ |
10649982 |
54 |
A structure-affinity relationship study on derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D(4) receptor ligand. |
Universitá |
32342685 |
325 |
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D |
National Institute of Neurological Disorders and Stroke |
32282200 |
320 |
Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands. |
Shanghaitech University |
10560741 |
60 |
Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. |
Friedrich-Alexander University |
10498215 |
60 |
New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. |
Wyeth-Ayerst Research Laboratories |
10479303 |
36 |
Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists. |
Warner-Lambert |
10464021 |
59 |
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents. |
Knoll Pharmaceuticals |
31021617 |
136 |
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D |
University of Pennsylvania |
10450964 |
35 |
2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands. |
UniversitäT Erlangen - NüRnberg |
10411491 |
96 |
1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels. |
Merck Sharp and Dohme Research Laboratories |
30883109 |
206 |
Dopamine D |
Rowan University |
30875219 |
254 |
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D |
University of North Carolina At Chapel Hill |
30844609 |
101 |
Chemical manipulations on the 1,4-dioxane ring of 5-HT |
Universit£ |
10377229 |
107 |
New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
University of GöTeborg |
10340615 |
51 |
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors. |
Merck Sharp and Dohme Research Laboratories |
10098669 |
33 |
Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands. |
Merck Sharp & Dohme Research Laboratories |
31846328 |
8 |
Docking Finds GPCR Ligands in Dark Chemical Matter. |
Uppsala University |
9876110 |
58 |
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). |
Centro De InvestigacióN Grupo Ferrer |
30035545 |
3 |
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds. |
Goethe University Frankfurt |
9873609 |
15 |
NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. |
Neurogen |
9873601 |
45 |
New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. |
Wyeth-Ayerst Research Laboratory |
9873377 |
54 |
Isoindolinone enantiomers having affinity for the dopamine D4 receptor. |
Parke-Davis Pharmaceutical Research |
31257877 |
94 |
The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D |
National Institute On Drug Abuse-Intramural Research Program |
9871673 |
79 |
New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates. |
Wyeth-Ayerst Research Laboratories |
9871530 |
41 |
Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
Pfizer |
9822559 |
47 |
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand. |
Universitá |
31387791 |
60 |
Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D |
Temple University |
9632349 |
38 |
Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects. |
Pharmacia & Upjohn |
9406594 |
82 |
(Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: potential antipsychotic agents. |
Warner-Lambert |
9276014 |
62 |
Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents. |
Warner-Lambert |
9240352 |
111 |
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor. |
Merck Sharp and Dohme Research Laboratories |
9191952 |
63 |
Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
Warner-Lambert |
31613617 |
195 |
Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D |
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg |
30715878 |
68 |
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. |
Genentech |
9016321 |
30 |
2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors. |
Neurogen |
9003524 |
23 |
3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists. |
Division of Warner Lambert |
31620230 |
283 |
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT |
University of Minnesota Twin Cities |
8759640 |
61 |
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships. |
Warner-Lambert |
8709107 |
99 |
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds. |
Yamanouchi Pharmaceutical |
8642551 |
27 |
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. |
Merck Sharp and Dohme Research Laboratories |
8642550 |
30 |
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. |
Merck Sharp and Dohme Research Laboratories |
8544176 |
16 |
Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
Warner-Lambert |
24156012 |
42 |
Synthesis and |
Washington University School of Medicine |
8230107 |
61 |
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists. |
University of GöTeborg |
8064797 |
118 |
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
Vanderbilt University |
23792350 |
53 |
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
Universidade Federal Do Rio De Janeiro |
7932581 |
32 |
The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
Parke-Davis Pharmaceutical Research |
21075638 |
105 |
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. |
Drug Discovery Laboratory |
17880057 |
131 |
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs. |
Solvay Pharma |
15887956 |
77 |
Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. |
Glaxosmithkline |
16002289 |
65 |
Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. |
Glaxosmithkline |
14736232 |
39 |
Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species. |
Florida A and M University |
11312915 |
29 |
Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. |
Friedrich-Alexander University |
8642552 |
20 |
Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists. |
Smithkline Beecham Pharmaceuticals |
8057272 |
33 |
Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. |
Glaxo Research and Development |
30344905 |
40 |
New Dopamine D3-Selective Receptor Ligands Containing a 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol Motif. |
City University of New York |
30389290 |
146 |
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity. |
Texas Tech University Health Sciences Center |
29631959 |
86 |
Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D |
Southern Illinois University Edwardsville |
29656199 |
148 |
Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties. |
University of Texas At Austin |
2391685 |
10 |
N-fluoroalkylated and N-alkylated analogues of the dopaminergic D-2 receptor antagonist raclopride. |
Washington University |
28495386 |
43 |
Development of molecular tools based on the dopamine D |
Friedrich-Alexander University |
29589445 |
154 |
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D |
Universit£ |
28870802 |
175 |
?-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation. |
Friedrich-Alexander University Erlangen-N£Rnberg |
27662034 |
69 |
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT |
Universit£ |
28489950 |
119 |
Return of D |
University of Nebraska Medical Center |
29125762 |
37 |
Highly Selective Dopamine D |
University of Pennsylvania |
28489379 |
165 |
Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for?-Arrestin-Biased D |
Friedrich-Alexander University Erlangen-Nuernberg |
26833890 |
18 |
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease. |
Yogi Vemana University |
26851737 |
36 |
One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies. |
University of Karachi |
26469307 |
7 |
Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b. |
University of Leipzig |
26218629 |
26 |
Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). |
Oregon Health & Science University |
25746740 |
23 |
The adenosine receptor affinities and monoamine oxidase B inhibitory properties of sulfanylphthalimide analogues. |
North-West University |