297 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28248104	385	Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.	Friedrich-Alexander University Erlangen-N£Rnberg
28214075	30	Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors.	Harvard Medical School
11392544	11	Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?	Ucb Pharma
27839919	192	Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.	University of Kansas
27933960	122	Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.	National Institute On Drug Abuse
27564135	499	1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists.	Aptuit
27364609	230	Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.	Florida A&M University
27132867	154	Structure-guided development of dualß2 adrenergic/dopamine D2 receptor agonists.	Friedrich-Alexander University
27080176	117	Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.	Vanderbilt University
26988801	55	Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.	Jagiellonian University Medical College
26951894	376	1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists.	Aptuit
26704965	229	Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.	University of Illinois At Chicago
26786693	153	Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists.	Aptuit
26288260	34	Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library.	Universit Degli Studi Di Milano
25826710	21	Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.	National Institute On Drug Abuse-Intramural Research Program
25650314	95	Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.	National Institute On Drug Abuse-Intramural Research Program
25557493	109	Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.	Jagiellonian University Collegium Medicum
25047579	130	Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D(2)-like receptors.	Friedrich-Alexander University
25556097	70	Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.	Washington University
25221667	66	Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity.	Vanderbilt University
24944737	20	Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.	National Institute On Drug Abuse-Intramural Research Program
24805037	380	Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.	Adamed
24559051	141	Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.	Intra-Cellular Therapies
23734634	33	Thes2 receptor: a novel protein for the imaging and treatment of cancer.	Washington University
23353740	21	Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.	Universidade Federal De Goi£S
18162395	89	Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.	Novartis Institutes For Biomedical Research
17507221	58	Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists.	Novartis Institutes For Biomedical Research
12443779	44	2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.	Janssen-Cilag
20005096	112	The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.	Glaxosmithkline
19635669	106	Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.	Imperial College
19560918	101	Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification.	Cancer Therapeutics
15808487	137	The role of QSAR in dopamine interactions.	Pomona College
12657274	109	Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.	Abbott Laboratories
11755365	113	Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2.	Janssen-Cilag
11755364	104	Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.	Janssen-Cilag
22959245	175	As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).	The University of Sydney
21413808	170	Synopsis of some recent tactical application of bioisosteres in drug design.	Bristol-Myers Squibb Pharmaceutical Research and Development
22738628	38	Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.	University of Li£Ge
22313227	78	Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.	National Institute of Mental Health
22268448	34	New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.	University of Li£Ge
21207959	69	Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.	National Institute of Mental Health
20542439	115	Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.	Washington University
20408551	13	Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).	Westfalische Wilhelms-Universitat
20153652	49	Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.	Universidade Federal Do Rio Grande Do Sul
19963380	38	Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.	Hunter College and The Graduate Center of The City University of New York
19744859	90	Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?	Friedrich-Schiller-Universit£T Jena
19331412	122	N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.	National Institute On Drug Abuse-Intramural Research Program
18181565	71	Multi-target-directed ligands to combat neurodegenerative diseases.	University of Bologna
17154515	40	trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.	Purdue University
16789750	155	2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.	Laboratoire De Chimie Th�Rapeutique
16420061	161	Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist.	University of Bonn
16168646	39	N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor.	Nps Pharmaceuticals
16198561	99	Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.	Novartis Institutes For Biomedical Research
16250647	71	2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.	Universit£
16220969	219	Designed multiple ligands. An emerging drug discovery paradigm.	Organon Laboratories
16134944	85	Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.	Friedrich-Alexander University
15801855	52	Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists.	Universit£
15658848	103	Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.	Wyeth Research
15916420	68	Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles.	Friedrich-Alexander University
15916415	150	Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.	National Institute On Drug Abuse-Intramural Research Program
15501032	14	Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors.	Florida A&M University
15084133	31	Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.	Abbott Laboratories
14998318	112	Selective optimization of side activities: another way for drug discovery.	Prestwick Chemical
15239663	60	Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.	Abbott Laboratories
12519065	243	Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.	H. Lundbeck
12477356	137	Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.	Universit£
12361386	113	Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.	Friedrich-Alexander University
12213075	70	Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).	Purdue University
11170639	73	Current and novel approaches to the drug treatment of schizophrenia.	Merck Sharp and Dohme Research Laboratories
11585444	295	From hit to lead. Analyzing structure-profile relationships.	Universities of Lille
11543687	92	Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.	National Institute On Drug Abuse-Intramural Research Program
10691700	112	Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype.	Friedrich-Alexander University
11087581	72	Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.	Friedrich-Alexander University
11052797	68	trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents.	Neurogen
11000009	23	Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists.	University of Maastricht
10956195	38	Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).	University Centre For Pharmacy
10602703	73	A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.	Warner-Lambert
9435894	206	New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.	Wyeth-Ayerst Research Laboratories
8863800	115	Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.	University of Groningen
8831770	136	Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.	Hoechst Marion Roussel
7861418	61	Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.	Vanderbilt University
8523409	37	1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding.	Neurogen
15203136	39	(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.	Virginia Commonwealth University
12617906	46	Cyclic amidines as benzamide bioisosteres: EPC synthesis and SAR studies leading to the selective dopamine D4 receptor agonist FAUC 312.	Friedrich-Alexander University
11844688	102	Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.	Friedrich-Alexander University
11814775	35	New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.	Wyeth-Ayerst Research Laboratories
12113813	53	2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.	Friedrich-Alexander University
11992769	93	Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands.	Institute of Science and Technology
11206464	6	Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand.	Universit£
11549463	72	Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).	Friedrich-Alexander University
10987445	140	Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.	Friedrich-Alexander University
10206547	95	Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid.	Universit£T Erlangen-N£Rnberg
9990464	64	Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.	Universit£T Erlangen-N£Rnberg
9873481	80	SAR of novel biarylmethylamine dopamine D4 receptor ligands.	Darmstadt
	24	D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis	TBA
22100258	124	Bivalent molecular probes for dopamine D2-like receptors.	Friedrich-Alexander University
22000209	54	Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor.	Vu University Medical Center
21823597	373	Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.	Green Cross
21536445	63	Synthesis and characterization of selective dopamine D2 receptor ligands using aripiprazole as the lead compound.	Washington University
21555222	25	Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity.	The University of Sydney
21520940	40	Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor.	Vu University Medical Center
21495689	134	N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.	National Institute On Drug Abuse-Intramural Research Program
21348515	75	Synthesis and pharmacological evaluation of fluorine-containing D3 dopamine receptor ligands.	Washington University
21190848	61	1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.	Korea Research Institute of Chemical Technology
20709559	16	Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists.	Purdue University
20655748	92	Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: a novel series of atypical antipsychotic agents.	Korea Research Institute of Chemical Technology
20620058	41	Smoothened antagonists for hair inhibition.	Pfizer
20223662	174	Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.	Yangji Chemicals
20149649	133	Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.	Green Cross
20064718	88	Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists.	Merck Research Laboratories
20061148	73	Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.	Merck Research Laboratories
19523834	79	Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.	Wyeth Research
19719241	55	Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.	Wyeth Research
19606869	41	Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.	Friedrich-Alexander University
	40	(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists	TBA
	32	A new series of selective dopamine D4 ligands: 3-([4-arylpiperazin-1-yl]alkylamino)-2H-1,4-benzoxazines	TBA
	39	4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D4 receptor	TBA
	25	Discovery of selective dopamine D4 receptor antagonists: 1-Aryloxy-3-(4-aryloxypiperidinyl)-2-propanols	TBA
	33	1-(2-METHOXYPHENYL)-4-ALKYLPIPERAZINES: EFFECT OF THE N-4 SUBSTITUENT ON THE AFFINITY AND SELECTIVITY FOR DOPAMINE D4 RECEPTOR	TBA
	25	Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic properties	TBA
19329329	183	Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.	Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
19155177	52	Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.	Florida A&M University
18834111	68	Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.	Friedrich-Alexander University
18783208	11	Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.	National Institute of Mental Health
18774793	85	Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.	National Institute On Drug Abuses
18602261	65	Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.	Korea Research Institute of Chemical Technology
18595716	142	Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.	Florida A&M University
18053713	78	Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.	Korea Research Institute of Chemical Technology
17676831	67	Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors.	Friedrich-Schiller-UniversitäT Jena
17672446	149	Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.	National Institute On Drug Abuse-Intramural Research Program
17571866	49	Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.	National Institute of Mental Health
17316913	15	Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors.	Sungshin Women'S University
17266201	13	Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands.	Friedrich-Alexander University
17254782	28	Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.	Faculté
17251022	48	Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors.	Université
17149874	110	Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.	Abbott Laboratories
17095222	134	Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.	National Institute On Drug Abuse-Intramural Research Program
17034146	24	Dopamine/serotonin receptor ligands. 13: Homologization of a benzindoloazecine-type dopamine receptor antagonist modulates the affinities for dopamine D(1)-D(5) receptors.	Friedrich-Schiller-UniversitäT Jena
16913699	372	1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.	Abbott Laboratories
16809034	142	Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists.	Schering-Plough Research Institute
16759104	46	Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists.	Friedrich-Alexander University
16722655	28	Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.	Pfizer
16621538	35	Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol.	Florida A&M University
16563764	100	Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype.	Friedrich-Alexander University
16539400	97	Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist.	Friedrich-Schiller-UniversitäT Jena
16458504	37	Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.	Columbia University College of Physicians and Surgeons
16392798	46	Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.	Columbia University College of Physicians and Surgeons
16361098	70	Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.	F. Hoffmann-La Roche
16143528	213	Synthesis of potent and selective serotonin 5-HT1B receptor ligands.	Columbia University College of Physicians and Surgeons
16139501	54	Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents.	University of Erlangen-Nuremberg
15801839	51	CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists.	Friedrich-Alexander University
15771448	187	Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.	Janssen-Cilag
15689168	89	Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.	National Institute On Drug Abuse-Intramural Research Program
15689154	27	Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes.	Friedrich-Alexander University
15603958	77	N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.	Wyeth Research
15380206	37	Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.	Abbott Laboratories
15341937	39	N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists.	Nps Pharmaceuticals
15341483	110	Indolebutylamines as selective 5-HT(1A) agonists.	Merck
15293986	65	Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.	Friedrich-Schiller-UniversitäT Jena
15225707	42	Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype.	University of Erlangen-Nuremberg
15163190	40	New series of morpholine and 1,4-oxazepane derivatives as dopamine D4 receptor ligands: synthesis and 3D-QSAR model.	Neurosearch
14684327	60	Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.	Wake Forest University School of Medicine
14611858	65	1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands.	Neurogen
14552778	18	The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+.	Florida A&M University
12951112	150	Stereocontrolled dopamine receptor binding and subtype selectivity of clebopride analogues synthesized from aspartic acid.	Friedrich-Alexander University
12930150	155	N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.	Johann Wolfgang Goethe-UniversitäT
12643910	55	Identification of a novel series of selective 5-HT7 receptor antagonists.	Glaxosmithkline
12639562	41	Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.	Neurogen
12570387	60	Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.	Università
12408724	79	New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.	University of LièGe
12372513	102	Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.	Neurogen
12372512	239	Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.	Neurogen
12161137	39	Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.	Friedrich-Alexander University
12109911	47	Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.	University Center For Pharmacy
11689074	112	N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.	Merck Sharp & Dohme Research Laboratories
11495580	35	Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).	Friedrich-Alexander University
32631561	110	Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT	City University of New York
11378358	254	Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.	Columbia University College of Physicians and Surgeons
11354362	18	Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands.	Sumitomo Pharmaceuticals
11327592	9	1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.	Wyeth-Ayerst Research
32227883	40	Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge	University of Mississippi
10999484	38	Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists.	Neurogen
31098001	35	Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists.	University of Texas Medical Branch
27508895	141	Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.	National Institute On Drug Abuse-Intramural Research Program
30597325	17	Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (?	Memorial Sloan Kettering Cancer Center
31404862	138	Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.	Palack£
10649982	54	A structure-affinity relationship study on derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D(4) receptor ligand.	Universitá
32342685	325	Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D	National Institute of Neurological Disorders and Stroke
32282200	320	Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.	Shanghaitech University
10560741	60	Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands.	Friedrich-Alexander University
10498215	60	New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.	Wyeth-Ayerst Research Laboratories
10479303	36	Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists.	Warner-Lambert
10464021	59	N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.	Knoll Pharmaceuticals
31021617	136	Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D	University of Pennsylvania
10450964	35	2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.	UniversitäT Erlangen - NüRnberg
10411491	96	1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.	Merck Sharp and Dohme Research Laboratories
30883109	206	Dopamine D	Rowan University
30875219	254	Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D	University of North Carolina At Chapel Hill
30844609	101	Chemical manipulations on the 1,4-dioxane ring of 5-HT	Universit£
10377229	107	New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.	University of GöTeborg
10340615	51	4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.	Merck Sharp and Dohme Research Laboratories
10098669	33	Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.	Merck Sharp & Dohme Research Laboratories
31846328	8	Docking Finds GPCR Ligands in Dark Chemical Matter.	Uppsala University
9876110	58	7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).	Centro De InvestigacióN Grupo Ferrer
30035545	3	Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds.	Goethe University Frankfurt
9873609	15	NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.	Neurogen
9873601	45	New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.	Wyeth-Ayerst Research Laboratory
9873377	54	Isoindolinone enantiomers having affinity for the dopamine D4 receptor.	Parke-Davis Pharmaceutical Research
31257877	94	The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D	National Institute On Drug Abuse-Intramural Research Program
9871673	79	New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.	Wyeth-Ayerst Research Laboratories
9871530	41	Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist.	Pfizer
9822559	47	N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.	Universitá
31387791	60	Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D	Temple University
9632349	38	Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.	Pharmacia & Upjohn
9406594	82	(Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: potential antipsychotic agents.	Warner-Lambert
9276014	62	Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.	Warner-Lambert
9240352	111	4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.	Merck Sharp and Dohme Research Laboratories
9191952	63	Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.	Warner-Lambert
31613617	195	Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D	Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
9016321	30	2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors.	Neurogen
9003524	23	3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists.	Division of Warner Lambert
31620230	283	3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT	University of Minnesota Twin Cities
8759640	61	Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.	Warner-Lambert
8709107	99	Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.	Yamanouchi Pharmaceutical
8642551	27	5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.	Merck Sharp and Dohme Research Laboratories
8642550	30	3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.	Merck Sharp and Dohme Research Laboratories
8544176	16	Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent.	Warner-Lambert
24156012	42	Synthesis and	Washington University School of Medicine
8230107	61	Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.	University of GöTeborg
8064797	118	Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.	Vanderbilt University
23792350	53	Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.	Universidade Federal Do Rio De Janeiro
7932581	32	The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents.	Parke-Davis Pharmaceutical Research
21075638	105	Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.	Drug Discovery Laboratory
17880057	131	Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.	Solvay Pharma
15887956	77	Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.	Glaxosmithkline
16002289	65	Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.	Glaxosmithkline
14736232	39	Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species.	Florida A and M University
11312915	29	Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine.	Friedrich-Alexander University
8642552	20	Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists.	Smithkline Beecham Pharmaceuticals
8057272	33	Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.	Glaxo Research and Development
30344905	40	New Dopamine D3-Selective Receptor Ligands Containing a 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol Motif.	City University of New York
30389290	146	Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.	Texas Tech University Health Sciences Center
29631959	86	Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D	Southern Illinois University Edwardsville
29656199	148	Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties.	University of Texas At Austin
28495386	43	Development of molecular tools based on the dopamine D	Friedrich-Alexander University
29589445	154	1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D	Universit£
28870802	175	?-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation.	Friedrich-Alexander University Erlangen-N£Rnberg
27662034	69	The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT	Universit£
28489950	119	Return of D	University of Nebraska Medical Center
29125762	37	Highly Selective Dopamine D	University of Pennsylvania
28489379	165	Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for?-Arrestin-Biased D	Friedrich-Alexander University Erlangen-Nuernberg
26833890	18	Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.	Yogi Vemana University
26851737	36	One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.	University of Karachi
26469307	7	Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.	University of Leipzig
26218629	26	Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).	Oregon Health & Science University
25746740	23	The adenosine receptor affinities and monoamine oxidase B inhibitory properties of sulfanylphthalimide analogues.	North-West University