The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28244748 |
119 |
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The"Phenylalkylaminome" with a Focus on Selected Drugs of Abuse. |
Virginia Commonwealth University |
| 28041833 |
52 |
X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT. |
3D-2Drug |
| 27933960 |
122 |
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors. |
National Institute On Drug Abuse |
| 27080180 |
39 |
Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. |
University of Arkansas For Medical Sciences |
| 26935940 |
23 |
Emerging targets and new small molecule therapies in Parkinson's disease treatment. |
School of Medicine of University of Electronic Science and Technology of China |
| 26748694 |
44 |
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands. |
Gedeon Richter |
| 26233799 |
15 |
Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine. |
Virginia Commonwealth University |
| 25593099 |
57 |
Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template. |
Wayne State University |
| 25461308 |
64 |
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 4. |
Medical University of Warsaw |
| 25193229 |
102 |
Alpha-ethyltryptamines as dual dopamine-serotonin releasers. |
Research Triangle Institute |
| 24944732 |
37 |
Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics. |
Rti International |
| 24942641 |
7 |
Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies. |
University of Barcelona |
| 24717153 |
46 |
Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors. |
Gedeon Richter |
| 722762 |
2 |
Effects of thiophene analogues of chloroamphetamines on central serotonergic mechanisms. |
TBA |
| 23394318 |
1 |
Antidepressant abietane diterpenoids from Chinese eaglewood. |
Chinese Academy of Medical Sciences and Peking Union Medical College |
| 23279866 |
69 |
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors. |
Jagiellonian University Medical College |
| 12372532 |
45 |
Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives. |
Ucb Pharma |
| 18829312 |
64 |
Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity. |
Glaxosmithkline |
| 18433113 |
124 |
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. |
Glaxosmithkline |
| 15261283 |
4 |
Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. |
Institute For Biological Research |
| 11755367 |
38 |
First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants. |
Ucb Pharma |
| 21486038 |
177 |
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. |
H. Lundbeck |
| 23022052 |
6 |
A novel spirocyclic tropanyl-¿²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake. |
Universit£ |
| 22749190 |
23 |
Wake-promoting agents: search for next generation modafinil: part IV. |
Cephalon (France) |
| 21344069 |
43 |
Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues. |
National Institute On Drug Abuse-Intramural Research Program |
| 20724153 |
31 |
Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
Korea Institute of Science and Technology |
| 20036131 |
68 |
Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. |
University of Kentucky |
| 19896846 |
44 |
Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. |
University of New Orleans |
| 18954038 |
62 |
Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. |
Neurocrine Biosciences |
| 18774292 |
72 |
Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol. |
National Institute On Drug Abuse-Intramural Research Program |
| 19038547 |
62 |
1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. |
The State University of New York |
| 18834188 |
232 |
Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. |
Wyeth Research |
| 18539031 |
126 |
Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
Neurocrine Biosciences |
| 18249549 |
54 |
Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. |
Wayne State University |
| 18278854 |
20 |
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. |
The University of Mississippi |
| 18060777 |
158 |
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. |
Johnson & Johnson Pharmaceutical Research & Development |
| 17228858 |
236 |
Advances in development of dopaminergic aporphinoids. |
Chinese Academy of Sciences |
| 17489581 |
95 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. |
Georgia Institute of Technology |
| 17267226 |
46 |
Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity. |
Taisho Pharmaceutical |
| 17034144 |
72 |
Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. |
National Institute On Drug Abuse-Intramural Research Program |
| 16854086 |
96 |
Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. |
Wyeth Research |
| 16821765 |
29 |
Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. |
Chinese Academy of Sciences |
| 16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
| 15857139 |
31 |
Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter. |
Universit£ |
| 15743177 |
43 |
Synthesis and biological evaluation of meperidine analogues at monoamine transporters. |
University of New Orleans |
| 15916437 |
90 |
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds. |
Research Triangle Institute |
| 15537337 |
95 |
Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. |
Acenta Discovery |
| 15456254 |
60 |
Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. |
Wayne State University |
| 15686927 |
39 |
Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. |
Yale University |
| 15163183 |
92 |
Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring. |
University of Illinois At Chicago |
| 15027858 |
35 |
Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. |
University of New Orleans |
| 14711303 |
115 |
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. |
Research Triangle Institute |
| 15189035 |
67 |
Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. |
National Institute On Drug Abuse-Intramural Research Program |
| 12672245 |
54 |
Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. |
Georgia Institute of Technology |
| 12646032 |
30 |
High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo. |
Wayne State University |
| 14640559 |
405 |
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. |
Faes Farma |
| 12825932 |
61 |
Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. |
National Institute On Drug Abuse |
| 12801223 |
71 |
Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. |
Nida-Irp |
| 12747792 |
12 |
Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. |
Wayne State University |
| 12723962 |
69 |
Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. |
Georgetown University Medical Center |
| 12723940 |
145 |
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy. |
Research Triangle Institute |
| 11960503 |
140 |
Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors. |
Georgetown University Medical Center |
| 11806716 |
44 |
Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules. |
Wayne State University |
| 12190324 |
15 |
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter. |
Research Triangle Institute |
| 12109901 |
45 |
SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement. |
Georgetown University Medical Center |
| 11300876 |
47 |
Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. |
Wayne State University |
| 11170654 |
72 |
Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. |
National Institute On Drug Abuse-Intramural Research Program |
| 11689080 |
43 |
Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 11334571 |
79 |
Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors. |
Georgetown University Medical Center |
| 10737754 |
30 |
Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors. |
Georgetown University Medical Center |
| 11123996 |
21 |
Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 11123994 |
72 |
Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909). |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 10821718 |
69 |
Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. |
Georgetown University Medical Center |
| 10229626 |
66 |
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors. |
Universit£ |
| 10579846 |
68 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes. |
Georgia Institute of Technology |
| 10543888 |
60 |
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. |
National Institute On Drug Abuse-Intramural Research Program |
| 9513601 |
53 |
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives. |
Universit£ |
| 9836615 |
106 |
Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters. |
Georgetown University Medical Center |
| 9804688 |
51 |
Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes. |
University of Minnesota |
| 9457247 |
39 |
Synthesis and ligand binding of tropane ring analogues of paroxetine. |
Research Triangle Institute |
| 9632371 |
28 |
2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies. |
University of Oklahoma Health Sciences Center |
| 9135033 |
36 |
Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective compounds for the dopamine transporter. |
University of Tours |
| 9111298 |
18 |
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters. |
Research Triangle Institute |
| 9397165 |
27 |
3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter. |
Research Triangle Institute |
| 8941383 |
146 |
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909). |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 8863789 |
31 |
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter. |
Research Triangle Institute |
| 8831768 |
65 |
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs. |
Research Triangle Institute |
| 8558525 |
60 |
N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. |
Research Biochemicals International |
| 8709106 |
89 |
Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position. |
Research Triangle Institute |
| 7830281 |
237 |
Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter. |
Research Triangle Institute |
| 7658431 |
18 |
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes. |
Research Triangle Institute |
| 7629808 |
64 |
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies. |
Universit£ |
| 8176704 |
40 |
Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex. |
Wake Forest University |
| 8164265 |
42 |
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters. |
National Institute On Drug Abuse |
| 8411004 |
48 |
3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters. |
Research Triangle Institute |
| 1619622 |
51 |
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter. |
Research Triangle Institute |
| 1920365 |
8 |
[123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain. |
Research Biochemicals |
| 1976813 |
83 |
2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity. |
Wyeth-Ayerst Research |
| 2903929 |
143 |
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. |
H. Lundbeck |
| 3039136 |
328 |
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. |
TBA |
| 4032430 |
4 |
Molecular mechanism of action of 5,6-dihydroxytryptamine. Synthesis and biological evaluation of 4-methyl-, 7-methyl-, and 4,7-dimethyl-5,6-dihydroxytryptamines. |
TBA |
| 2999402 |
207 |
3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. |
TBA |
| 6747993 |
69 |
Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin. |
TBA |
| 6492080 |
195 |
Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins. |
TBA |
| 6134833 |
91 |
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans. |
TBA |
| 7452682 |
76 |
3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake. |
TBA |
| 15115403 |
48 |
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 15149693 |
56 |
The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. |
National Institute On Drug Abuse-Intramural Research Program |
| 15109634 |
129 |
SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis. |
Eli Lilly |
| 12699762 |
27 |
Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter. |
Wayne State University |
| 14505672 |
78 |
Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors. |
Georgetown University Medical Center |
| 11909701 |
35 |
Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors. |
Georgetown University Medical Center |
| 11859009 |
16 |
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. |
Inha University |
| 12127543 |
26 |
Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. |
Southern Research Institute |
| 12067559 |
34 |
Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol. |
University of Michigan |
| 11354356 |
42 |
Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors. |
Georgetown University Medical Center |
| 11277529 |
14 |
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter. |
Universit£ |
| 11720867 |
24 |
[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter. |
National Institute On Drug Abuse-Intramural Research Program |
| 11527726 |
15 |
Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter. |
Wayne State University |
| 11514143 |
71 |
Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles. |
Georgetown University Medical Center |
| 11078197 |
65 |
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. |
Research Triangle Institute |
| 10937724 |
56 |
Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors. |
Georgetown University Medical Center |
| 10915050 |
14 |
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. |
Inha University |
| 10888328 |
17 |
An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes. |
Georgetown University Medical Center |
| 10612593 |
33 |
N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter. |
Georgetown University Medical Center |
| 10576696 |
32 |
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands. |
Merck |
| 9871604 |
114 |
Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group. |
Hong Kong University of Science and Technology |
| 9934496 |
27 |
Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes. |
Research Triangle Institute |
| | 28 |
Synthesis and evaluation of novel-N-[2-(bis-aryl-methoxy)ethyl-N-aralkyl-,-alkanediamines as potent and selective dopamine reuptake inhibitors: Seco analogs of GBR12935 and GBR12909 |
TBA |
| 22341942 |
18 |
Wake-promoting agents: search for next generation modafinil: part II. |
Cephalon |
| 22264475 |
10 |
Wake-promoting agents: search for next generation modafinil: part I. |
Cephalon |
| 22309909 |
37 |
Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors. |
National Medicines Institute |
| 22055716 |
45 |
Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters. |
University of New Orleans |
| 21469694 |
4 |
Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. |
University of Navarra |
| 21446715 |
43 |
Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. |
Wayne State University |
| 21093118 |
32 |
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. part 3. |
Medical University of Warsaw |
| 21093273 |
154 |
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. |
Sepracor |
| 20980153 |
83 |
Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands. |
University of New Orleans |
| 20672825 |
67 |
Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. |
National Institute On Drug Abuse-Intramural Research Program |
| 19717215 |
56 |
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. |
Trinity College |
| 20022503 |
15 |
Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056). |
Institute of Pharmaceutical Industry |
| 20064720 |
44 |
Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity. |
Wyeth Research |
| 19665823 |
38 |
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. |
Medical University of Warsaw |
| 19640707 |
12 |
Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. |
University of Glasgow |
| 19719241 |
55 |
Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. |
Wyeth Research |
| 15801844 |
54 |
Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors. |
TBA |
| | 18 |
N-Phthalimidoalkyl derivatives of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT): Brain monoamine transporter affinity |
TBA |
| | 34 |
Bivalent indoles exhibiting serotonergic binding affinity |
TBA |
| 18995929 |
24 |
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1. |
Medical University of Warsaw |
| 18793858 |
27 |
Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging. |
University of Tours |
| 18762424 |
4 |
New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. |
University of Glasgow |
| 18571421 |
78 |
Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. |
Wyeth Research |
| 18557608 |
108 |
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. |
Wyeth Research |
| 17698848 |
4 |
Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter. |
Yale University |
| 17765543 |
56 |
Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores. |
Johnson & Johnson Pharmaceutical Research and Development |
| 17658253 |
23 |
New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET. |
University of Tours |
| 17616397 |
107 |
Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors. |
Johnson & Johnson Pharmaceutical Research & Development |
| 17583504 |
51 |
Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors. |
Johnson & Johnson Pharmaceutical Research & Development |
| 17412583 |
81 |
Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity. |
Johnson & Johnson Pharmaceutical Research & Development |
| 17407811 |
34 |
Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor. |
Wyeth Research |
| 17376695 |
7 |
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines. |
Inha University |
| 17350257 |
54 |
Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters. |
University of Oslo |
| 17328523 |
36 |
Novel sigma receptor ligands: synthesis and biological profile. |
University of Catania |
| 17317177 |
69 |
Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors. |
Johnson & Johnson Pharmaceutical Research and Development |
| 17307358 |
81 |
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors. |
Johnson & Johnson Pharmaceutical Research & Development |
| 17234422 |
118 |
Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor. |
Taisho Pharmaceutical |
| 17127069 |
96 |
DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. |
University Heights |
| 17127059 |
96 |
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors. |
Johnson & Johnson Pharmaceutical Research and Development |
| 17107798 |
90 |
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore. |
Johnson & Johnson Pharmaceutical Research and Development |
| 17095215 |
25 |
Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER. |
Institute For Degenerative Diseases |
| 17064081 |
10 |
Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane. |
National Institute On Drug Abuse-Intramural Research Program |
| 16908151 |
24 |
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine. |
Yale University |
| 16905316 |
42 |
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. |
University of Kentucky |
| 16821783 |
60 |
Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and no |
Wayne State University |
| 16753296 |
25 |
Discovery of potent CRTh2 (DP2) receptor antagonists. |
Astrazeneca R&D Charnwood |
| 16335921 |
99 |
Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors. |
University of Illinois At Chicago |
| 16332439 |
58 |
Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity. |
Wyeth Research |
| 16250644 |
66 |
Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition. |
Solvay Pharma |
| 16236497 |
48 |
Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes. |
Yale University |
| 16033275 |
7 |
Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. |
Wayne State University |
| 16033253 |
27 |
Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity. |
Schering-Plough Research Institute |
| 15863297 |
57 |
Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. |
Acenta Discovery |
| 15686885 |
28 |
Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor. |
Wyeth Research |
| 15482938 |
45 |
Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. |
Harvard Medical School |
| 15454211 |
19 |
Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HT transporter and 5-HT1A affinity. |
Wyeth Research |
| 15341484 |
159 |
Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors. |
Merck |
| 15239661 |
120 |
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines. |
Wyeth Research |
| 15080991 |
38 |
Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). |
Yale School of Medicine |
| 15026075 |
51 |
Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites. |
State University of New York |
| 14592479 |
60 |
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3. |
Eli Lilly |
| 12873501 |
110 |
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants. |
Johnson & Johnson Pharmaceutical Research & Development |
| 12824042 |
64 |
Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2. |
Eli Lilly |
| 12749894 |
48 |
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1. |
Eli Lilly |
| 12672246 |
68 |
Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. |
Niddk |
| 12668005 |
21 |
Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist. |
Universidad Complutense |
| 12657288 |
102 |
Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter. |
Niddk |
| 12639545 |
37 |
Synthesis of dopamine transporter selective 3-[2-(diarylmethoxyethylidene)]-8-alkylaryl-8-azabicyclo[3.2.1]octanes. |
University of New Orleans |
| 12565970 |
44 |
Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 12565939 |
38 |
SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition. |
Solvay Pharma |
| 12482441 |
45 |
Development of a presynaptic 5-HT1A antagonist. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 12443787 |
2 |
Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter. |
Institutet |
| 12361398 |
19 |
New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine). |
University of Pennsylvania |
| 12213056 |
42 |
Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors. |
Universidad De Navarra |
| 12109911 |
47 |
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine. |
University Center For Pharmacy |
| 11965364 |
36 |
Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter. |
National Institute On Drug Abuse-Intramural Research Program |
| 11958976 |
30 |
Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters. |
State University of New York |
| 11882001 |
34 |
Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 11881994 |
42 |
Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. |
University of Tours |
| 11814784 |
53 |
Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors. |
Wyeth-Ayerst Research Laboratories |
| 11714608 |
30 |
Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. |
Alcohol and Drug Abuse Research Center |
| 11462981 |
184 |
New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
Universidad De Navarra |
| 11459653 |
31 |
Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors. |
Wyeth-Ayerst Research Laboratories |
| 11334561 |
63 |
Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites. |
State University of New York |
| 11229754 |
28 |
Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl. |
State University of New York |
| 31661268 |
99 |
Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability. |
National Institute On Drug Abuse-Intramural Research Program |
| 11133081 |
33 |
A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents. |
Georgetown University Medical Center |
| 11128642 |
5 |
Serotonin transporter inhibitors: synthesis and binding potency of 2'-methyl- and 3'-methyl-6-nitroquipazine. |
Central Washington University |
| 30685525 |
34 |
Benzimidazolone-based selective ? |
University of Florida |
| 10969967 |
34 |
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted) biphenyltropanes. |
Yale University |
| 27524311 |
34 |
Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. |
University of Kentucky |
| 10782691 |
1 |
Novel 3-(4-piperidinylthio)-1H-indoles as potent nonopioid orally active central analgesics. |
Laboratoires Upsa |
| 10669562 |
29 |
Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. |
Georgetown University Medical Center |
| 31699607 |
9 |
Synthesis and antidepressant-like activity of novel alkoxy-piperidine derivatives targeting SSRI/5-HT |
China Pharmaceutical University |
| 31627993 |
33 |
Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT |
China State Institute of Pharmaceutical Industry |
| 10612583 |
27 |
Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine. |
University of New Orleans |
| 10585212 |
138 |
Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 30703658 |
79 |
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT |
Medical University of Warsaw |
| 29400967 |
136 |
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. |
Bristol-Myers Squibb |
| 31325785 |
92 |
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT |
Medical University of Warsaw |
| 9719604 |
11 |
Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker. |
Hokkaido University |
| 9703474 |
21 |
Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter. |
Organix |
| 30744931 |
170 |
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
Csir-Central Drug Research Institute |
| 9526575 |
14 |
Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA). |
Purdue University |
| 9513598 |
20 |
Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues. |
Organix |
| 9435902 |
60 |
Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. |
National Institute On Drug Abuse |
| 9397171 |
81 |
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. |
University of Minnesota |
| 9357518 |
74 |
Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. |
University of Strathclyde |
| 9089327 |
58 |
Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT uptake inhibiting and alpha2-antagonistic activities. |
Abbott Laboratories |
| 31082225 |
26 |
Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms. |
China Pharmaceutical University |
| 9057857 |
169 |
Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 9016326 |
38 |
Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity. |
Organix |
| 9016323 |
2 |
Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents. |
University of Pennsylvania |
| 8960553 |
60 |
Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter. |
Drew University |
| 8941398 |
17 |
Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist. |
Hokkaido University |
| 8691453 |
42 |
Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site. |
State University of New York |
| 8576918 |
38 |
Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites. |
Organix |
| 8515426 |
12 |
Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs. |
University of Toledo |
| 8487257 |
57 |
New indole derivatives as potent and selective serotonin uptake inhibitors. |
Centre De Recherches De Vitry-Alfortville |
| 24494745 |
92 |
Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues. |
National Institute On Drug Abuse-Intramural Research Program |
| 24262884 |
22 |
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor. |
Universidad De Chile |
| 24237160 |
52 |
Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites. |
National Institute On Drug Abuse-Intramural Research Program |
| 24211020 |
35 |
Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands. |
University of Maryland |
| 23806554 |
36 |
3-Aryl-3-arylmethoxyazetidines. A new class of high affinity ligands for monoamine transporters. |
University of New Orleans |
| 23049232 |
21 |
Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid-base properties. |
Jagiellonian University Medical College |
| 6716399 |
2 |
Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines. |
TBA |
| 17129726 |
121 |
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors. |
Glaxosmithkline |
| 6458703 |
72 |
Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake. |
TBA |
| 15887956 |
77 |
Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. |
Glaxosmithkline |
| 15664848 |
43 |
3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity. |
Glaxosmithkline |
| 11262089 |
213 |
Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. |
Institut De Recherches Servier |
| 30383372 |
190 |
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics. |
Huazhong University of Science and Technology |
| 3735309 |
50 |
Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles. |
TBA |
| 29291438 |
46 |
Synthesis and antidepressant-like activity of novel aralkyl piperazine derivatives targeting SSRI/5-HT |
Shanghai Institute of Pharmaceutical Industry |
| 28731336 |
151 |
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
Biocon Bristol-Myers Squibb R&D Centre |
| 29153425 |
69 |
Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [ |
University of Kentucky |
| 29138029 |
21 |
Synthesis and antidepressant activity of a series of arylalkanol and aralkyl piperazine derivatives targeting SSRI/5-HT |
Shanghai Institute of Pharmaceutical Industry |
| 29589445 |
154 |
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D |
Universit£ |
| 1967651 |
2 |
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA). |
Purdue University |
| 28763213 |
193 |
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity. |
Jagiellonian University Medical College |
| 29227643 |
70 |
Structure-Activity Relationship Studies on a Series of 3?-[Bis(4-fluorophenyl)methoxy]tropanes and 3?-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders. |
National Institute On Drug Abuse-Intramural Research Program |
| 28345895 |
5 |
Asymmetric Anchoring Is Required for Efficient O-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. |
University of Waterloo |
| 26964016 |
18 |
Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as a-glucosidase inhibitors. |
Jishou University |
| 26744768 |
4 |
Mechanism of the Flavoprotein l-Hydroxynicotine Oxidase: Kinetic Mechanism, Substrate Specificity, Reaction Product, and Roles of Active-Site Residues. |
University of Texas At San Antonio |
| 26943478 |
16 |
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives. |
Chulabhorn Research Institute |
| 26214585 |
23 |
Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. |
University of Wisconsin-Madison |
| 2530094 |
94 |
The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. |
Novo Industri |
| 16242653 |
33 |
A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. |
Gpc Biotech |
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