Found 41 hits with Last Name = 'derbin' and Initial = 'gm' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189609
(CHEMBL209555 | N-cyclopropyl-4-fluoro-3-(2-(2-(pyr...)Show InChI InChI=1S/C20H19FN4OS/c21-17-9-5-14(19(26)24-15-6-7-15)11-13(17)4-8-16-12-23-20(27-16)25-18-3-1-2-10-22-18/h1-3,5,9-12,15H,4,6-8H2,(H,24,26)(H,22,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189611
(CHEMBL384909 | N-benzyl-4-fluoro-3-((2-(pyridin-2-...)Show SMILES Fc1ccc(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NCc1ccccc1 Show InChI InChI=1S/C23H20FN5OS/c24-19-10-9-17(22(30)27-13-16-6-2-1-3-7-16)12-20(19)26-14-18-15-28-23(31-18)29-21-8-4-5-11-25-21/h1-12,15,26H,13-14H2,(H,27,30)(H,25,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168387
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189613
(CHEMBL379370 | N-cyclopropyl-4-fluoro-3-((2-(pyrid...)Show InChI InChI=1S/C19H18FN5OS/c20-15-7-4-12(18(26)24-13-5-6-13)9-16(15)22-10-14-11-23-19(27-14)25-17-3-1-2-8-21-17/h1-4,7-9,11,13,22H,5-6,10H2,(H,24,26)(H,21,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189606
(4-fluoro-N-methyl-3-((2-(pyridin-2-ylamino)thiazol...)Show InChI InChI=1S/C17H16FN5OS/c1-19-16(24)11-5-6-13(18)14(8-11)21-9-12-10-22-17(25-12)23-15-4-2-3-7-20-15/h2-8,10,21H,9H2,1H3,(H,19,24)(H,20,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50189605
(CHEMBL379495 | N-(5-((5-tert-butyloxazol-2-yl)meth...)Show SMILES COc1ccc(cc1OC)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 Show InChI InChI=1S/C20H23N3O4S2/c1-20(2,3)15-9-21-16(27-15)11-28-17-10-22-19(29-17)23-18(24)12-6-7-13(25-4)14(8-12)26-5/h6-10H,11H2,1-5H3,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189604
(4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmeth...)Show SMILES Fc1ccc(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NCc1ccccn1 Show InChI InChI=1S/C22H19FN6OS/c23-18-8-7-15(21(30)27-12-16-5-1-3-9-24-16)11-19(18)26-13-17-14-28-22(31-17)29-20-6-2-4-10-25-20/h1-11,14,26H,12-13H2,(H,27,30)(H,25,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189602
(2,4-difluoro-N-methyl-5-((2-(pyridin-2-ylamino)thi...)Show InChI InChI=1S/C17H15F2N5OS/c1-20-16(25)11-6-14(13(19)7-12(11)18)22-8-10-9-23-17(26-10)24-15-4-2-3-5-21-15/h2-7,9,22H,8H2,1H3,(H,20,25)(H,21,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189608
(CHEMBL379661 | N-methoxy-3-((2-(pyridin-2-ylamino)...)Show InChI InChI=1S/C17H16N4O2S2/c1-23-21-16(22)13-6-4-5-12(9-13)11-24-15-10-19-17(25-15)20-14-7-2-3-8-18-14/h2-10H,11H2,1H3,(H,21,22)(H,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189610
(4-fluoro-N-(2-morpholinoethyl)-3-((2-(pyridin-2-yl...)Show SMILES Fc1ccc(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C22H25FN6O2S/c23-18-5-4-16(21(30)25-7-8-29-9-11-31-12-10-29)13-19(18)26-14-17-15-27-22(32-17)28-20-3-1-2-6-24-20/h1-6,13,15,26H,7-12,14H2,(H,25,30)(H,24,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189607
(CHEMBL379320 | N-methyl-3-((2-(pyridin-2-ylamino)t...)Show InChI InChI=1S/C17H16N4OS2/c1-18-16(22)13-6-4-5-12(9-13)11-23-15-10-20-17(24-15)21-14-7-2-3-8-19-14/h2-10H,11H2,1H3,(H,18,22)(H,19,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189612
(CHEMBL208911 | N-cyclopentyl-4-fluoro-3-((2-(pyrid...)Show SMILES Fc1ccc(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CCCC1 Show InChI InChI=1S/C21H22FN5OS/c22-17-9-8-14(20(28)26-15-5-1-2-6-15)11-18(17)24-12-16-13-25-21(29-16)27-19-7-3-4-10-23-19/h3-4,7-11,13,15,24H,1-2,5-6,12H2,(H,26,28)(H,23,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR beta |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189614
(CHEMBL207520 | N-methyl-3-((2-(pyridin-2-ylamino)t...)Show InChI InChI=1S/C17H17N5OS/c1-18-16(23)12-5-4-6-13(9-12)20-10-14-11-21-17(24-14)22-15-7-2-3-8-19-15/h2-9,11,20H,10H2,1H3,(H,18,23)(H,19,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of c-kit |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189605
(CHEMBL379495 | N-(5-((5-tert-butyloxazol-2-yl)meth...)Show SMILES COc1ccc(cc1OC)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 Show InChI InChI=1S/C20H23N3O4S2/c1-20(2,3)15-9-21-16(27-15)11-28-17-10-22-19(29-17)23-18(24)12-6-7-13(25-4)14(8-12)26-5/h6-10H,11H2,1-5H3,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 11/12/13/14
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of p38 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase-3
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of GSK3 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
RAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of AKT |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of MEK |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
SRSF protein kinase 1
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of SRPK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Src |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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| n/a | n/a | 1.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human ERG expressed in HEK293 cells |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PKCzeta |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PKCalpha |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Protein kinase C eta type
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PKCeta |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PKCdelta |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ITK/TSK
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Itk |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Her1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of MAPKAPK2 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
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PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Lck |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase type II subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of CaMK2 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Syk |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of JAK3 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50189603
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1 Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Her2 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this
Ligand-Target Pair | |
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