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Compile Data Set for Download or QSAR

Found 156 hits with Last Name = 'campbell' and Initial = 'hf'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291847
PNG
(7-[3-(Quinolin-2-ylmethoxy)-benzyloxy]-2-(1H-tetra...)
Show SMILES O=C1CC(Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc12)c1nnn[nH]1
Show InChI InChI=1S/C27H21N5O4/c33-24-14-26(27-29-31-32-30-27)36-25-13-21(10-11-22(24)25)34-15-17-4-3-6-20(12-17)35-16-19-9-8-18-5-1-2-7-23(18)28-19/h1-13,26H,14-16H2,(H,29,30,31,32)
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 0.100n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291855
PNG
(7-[3-(Quinolin-2-ylmethoxy)-phenoxymethyl]-2-(1H-t...)
Show SMILES O=C1CC(Oc2cc(COc3cccc(OCc4ccc5ccccc5n4)c3)ccc12)c1nnn[nH]1
Show InChI InChI=1S/C27H21N5O4/c33-24-14-26(27-29-31-32-30-27)36-25-12-17(8-11-22(24)25)15-34-20-5-3-6-21(13-20)35-16-19-10-9-18-4-1-2-7-23(18)28-19/h1-13,26H,14-16H2,(H,29,30,31,32)
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 0.120n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000485
PNG
((S)-2-(5-chlorospiro[2,3-dihydrobenzo[b]furan-2,1'...)
Show SMILES Clc1cc2CC3(CCCCC3)Oc2c(c1)C(=O)N[C@@H]1CN2CCC1CC2 |wU:18.20,(5.27,-4.79,;6.6,-5.56,;6.6,-7.11,;7.93,-7.88,;8.26,-9.38,;9.8,-9.54,;9.03,-10.87,;9.8,-12.21,;11.35,-12.21,;12.12,-10.87,;11.35,-9.52,;10.41,-8.14,;9.27,-7.11,;9.27,-5.55,;7.93,-4.79,;10.6,-4.77,;10.04,-3.34,;12.12,-5,;13.08,-3.79,;14.6,-4.1,;15.63,-2.95,;15.14,-1.5,;13.64,-1.18,;12.61,-2.34,;13.71,-3.05,;14.57,-2.32,)|
Show InChI InChI=1S/C21H27ClN2O2/c22-16-10-15-12-21(6-2-1-3-7-21)26-19(15)17(11-16)20(25)23-18-13-24-8-4-14(18)5-9-24/h10-11,14,18H,1-9,12-13H2,(H,23,25)/t18-/m1/s1
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 0.190n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2


(Homo sapiens (Human))		BDBM50009075
PNG
(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Show SMILES COc1cc(ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H28N4O6S/c1-37-26-15-19(27(33)31-39(35,36)24-9-3-2-4-10-24)11-12-21(26)18-32-25-16-22(14-13-20(25)17-29-32)30-28(34)38-23-7-5-6-8-23/h2-4,9-17,23H,5-8,18H2,1H3,(H,30,34)(H,31,33)
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 0.200n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane

J Med Chem 33: 2828-41 (1990)


BindingDB Entry DOI: 10.7270/Q29C6WDM
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291848
PNG
(7-{2-[3-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-2-(1...)
Show SMILES O=C1CC(Oc2cc(CCc3cccc(OCc4ccc5ccccc5n4)c3)ccc12)c1nnn[nH]1
Show InChI InChI=1S/C28H23N5O3/c34-25-16-27(28-30-32-33-31-28)36-26-15-19(10-13-23(25)26)9-8-18-4-3-6-22(14-18)35-17-21-12-11-20-5-1-2-7-24(20)29-21/h1-7,10-15,27H,8-9,16-17H2,(H,30,31,32,33)
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 0.300n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50009075
PNG
(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Show SMILES COc1cc(ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H28N4O6S/c1-37-26-15-19(27(33)31-39(35,36)24-9-3-2-4-10-24)11-12-21(26)18-32-25-16-22(14-13-20(25)17-29-32)30-28(34)38-23-7-5-6-8-23/h2-4,9-17,23H,5-8,18H2,1H3,(H,30,34)(H,31,33)
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 0.300n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000482
PNG
((R)-2-(5-chlorospiro[2,3-dihydrobenzo[b]furan-2,1'...)
Show SMILES Clc1cc2CC3(CCCCC3)Oc2c(c1)C(=O)N[C@H]1CN2CCC1CC2 |wD:18.20,(5.27,-4.79,;6.6,-5.56,;6.6,-7.11,;7.93,-7.88,;8.26,-9.38,;9.8,-9.54,;9.03,-10.87,;9.8,-12.21,;11.35,-12.21,;12.12,-10.87,;11.35,-9.52,;10.41,-8.14,;9.27,-7.11,;9.27,-5.55,;7.93,-4.79,;10.6,-4.77,;10.04,-3.34,;12.12,-5,;13.08,-3.79,;14.6,-4.1,;15.63,-2.95,;15.14,-1.5,;13.64,-1.18,;12.61,-2.34,;13.71,-3.05,;14.57,-2.32,)|
Show InChI InChI=1S/C21H27ClN2O2/c22-16-10-15-12-21(6-2-1-3-7-21)26-19(15)17(11-16)20(25)23-18-13-24-8-4-14(18)5-9-24/h10-11,14,18H,1-9,12-13H2,(H,23,25)/t18-/m0/s1
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 0.890n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000480
PNG
(2-(5-chlorospiro[2,3-dihydrobenzo[b]furan-2,1'-cyc...)
Show SMILES Clc1cc2CC3(CCCCC3)Oc2c(c1)C(=O)NC1CN2CCC1CC2 |(5.27,-4.79,;6.6,-5.56,;6.6,-7.11,;7.93,-7.88,;8.26,-9.38,;9.8,-9.54,;9.03,-10.87,;9.8,-12.21,;11.35,-12.21,;12.12,-10.87,;11.35,-9.52,;10.41,-8.14,;9.27,-7.11,;9.27,-5.55,;7.93,-4.79,;10.6,-4.77,;10.04,-3.34,;12.12,-5,;13.08,-3.79,;14.6,-4.1,;15.63,-2.95,;15.14,-1.5,;13.64,-1.18,;12.61,-2.34,;13.71,-3.05,;14.57,-2.32,)|
Show InChI InChI=1S/C21H27ClN2O2/c22-16-10-15-12-21(6-2-1-3-7-21)26-19(15)17(11-16)20(25)23-18-13-24-8-4-14(18)5-9-24/h10-11,14,18H,1-9,12-13H2,(H,23,25)
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 1.10n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291849
PNG
(CHEMBL47662 | N-[4-Oxo-2-(1H-tetrazol-5-yl)-chroma...)
Show SMILES O=C(Nc1cccc2C(=O)CC(Oc12)c1nnn[nH]1)c1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C27H20N6O4/c34-23-14-24(26-30-32-33-31-26)37-25-20(23)5-3-7-22(25)29-27(35)17-9-12-19(13-10-17)36-15-18-11-8-16-4-1-2-6-21(16)28-18/h1-13,24H,14-15H2,(H,29,35)(H,30,31,32,33)
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 1.10n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000479
PNG
(7-Chloro-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carb...)
Show SMILES Clc1cc2CCCCOc2c(c1)C(=O)NC1CN2CCC1CC2 |(3.81,-7.51,;5.15,-6.74,;6.48,-7.51,;7.82,-6.74,;9.03,-7.7,;10.52,-7.35,;11.18,-5.96,;10.52,-4.59,;9.03,-4.24,;7.82,-5.2,;6.48,-4.43,;5.15,-5.2,;6.48,-2.88,;5.15,-2.11,;7.82,-2.11,;7.82,-.57,;9.21,.13,;9.29,1.65,;8,2.52,;6.62,1.82,;6.53,.27,;7.84,.39,;8.07,1.5,)|
Show InChI InChI=1S/C18H23ClN2O2/c19-14-9-13-3-1-2-8-23-17(13)15(10-14)18(22)20-16-11-21-6-4-12(16)5-7-21/h9-10,12,16H,1-8,11H2,(H,20,22)
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 1.20n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291850
PNG
(3-{2-Methyl-4-oxo-7-[3-(quinolin-2-ylmethoxy)-benz...)
Show SMILES CC1(CCC(O)=O)CC(=O)c2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1
Show InChI InChI=1S/C30H27NO6/c1-30(14-13-29(33)34)17-27(32)25-12-11-24(16-28(25)37-30)35-18-20-5-4-7-23(15-20)36-19-22-10-9-21-6-2-3-8-26(21)31-22/h2-12,15-16H,13-14,17-19H2,1H3,(H,33,34)
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 1.20n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291854
PNG
(4-Oxo-6-[3-(quinolin-2-ylmethoxy)-benzyloxy]-chrom...)
Show SMILES OC(=O)C1CC(=O)c2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc2O1
Show InChI InChI=1S/C27H21NO6/c29-24-14-26(27(30)31)34-25-11-10-21(13-22(24)25)32-15-17-4-3-6-20(12-17)33-16-19-9-8-18-5-1-2-7-23(18)28-19/h1-13,26H,14-16H2,(H,30,31)
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 1.30n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000492
PNG
((zacopride)4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CN2CCC1CC2 |(27.19,-33.96,;28.52,-34.73,;28.53,-36.27,;27.2,-37.04,;27.2,-38.58,;25.86,-39.35,;28.53,-39.36,;28.53,-40.89,;29.87,-38.58,;29.86,-37.03,;31.19,-36.26,;31.19,-34.72,;32.53,-37.02,;33.86,-36.25,;35.2,-37.02,;36.52,-36.25,;36.52,-34.71,;35.19,-33.94,;33.85,-34.71,;34.61,-36.04,;35.74,-34.91,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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 1.5n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000495
PNG
((ICS 205-930)1H-Indole-3-carboxylic acid 6-methyl-...)
Show SMILES CN1CC2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |THB:0:1:8.7.9:5.4,10:8:1.2:5.4|
Show InChI InChI=1S/C18H22N2O2/c1-20-11-12-6-7-13(20)9-14(8-12)22-18(21)16-10-19-17-5-3-2-4-15(16)17/h2-5,10,12-14,19H,6-9,11H2,1H3
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 1.70n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000483
PNG
((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)
Show SMILES CN1C2CCCC1CC(C2)NC(=O)c1nn(C)c2ccccc12 |THB:10:8:1:3.5.4|
Show InChI InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)
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 1.70n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291856
PNG
(4-Oxo-7-[3-(quinolin-2-ylmethoxy)-benzyloxy]-chrom...)
Show SMILES OC(=O)C1CC(=O)c2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1
Show InChI InChI=1S/C27H21NO6/c29-24-14-26(27(30)31)34-25-13-21(10-11-22(24)25)32-15-17-4-3-6-20(12-17)33-16-19-9-8-18-5-1-2-7-23(18)28-19/h1-13,26H,14-16H2,(H,30,31)
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 2.10n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013556
PNG
(2-{4-[2-(1H-Tetrazol-5-ylmethoxy)-benzyloxy]-pheno...)
Show SMILES C(Oc1ccccc1COc1ccc(OCc2ccc3ccccc3n2)cc1)c1nnn[nH]1
Show InChI InChI=1S/C25H21N5O3/c1-3-7-23-18(5-1)9-10-20(26-23)16-32-22-13-11-21(12-14-22)31-15-19-6-2-4-8-24(19)33-17-25-27-29-30-28-25/h1-14H,15-17H2,(H,27,28,29,30)
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 2.10n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000494
PNG
(7-Bromo-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carbo...)
Show SMILES Brc1cc2CCCCOc2c(c1)C(=O)NC1CN2CCC1CC2 |(3.81,-7.51,;5.15,-6.74,;6.48,-7.51,;7.82,-6.74,;9.03,-7.7,;10.52,-7.35,;11.18,-5.96,;10.52,-4.59,;9.03,-4.24,;7.82,-5.2,;6.48,-4.43,;5.15,-5.2,;6.48,-2.88,;5.15,-2.11,;7.82,-2.11,;7.82,-.57,;9.21,.13,;9.29,1.65,;8,2.52,;6.62,1.82,;6.53,.27,;7.84,.39,;8.07,1.5,)|
Show InChI InChI=1S/C18H23BrN2O2/c19-14-9-13-3-1-2-8-23-17(13)15(10-14)18(22)20-16-11-21-6-4-12(16)5-7-21/h9-10,12,16H,1-8,11H2,(H,20,22)
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 2.20n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013548
PNG
(2-{4-[3-(1H-Tetrazol-5-yl)-benzyloxy]-phenoxymethy...)
Show SMILES C(Oc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C24H19N5O2/c1-2-7-23-18(5-1)8-9-20(25-23)16-31-22-12-10-21(11-13-22)30-15-17-4-3-6-19(14-17)24-26-28-29-27-24/h1-14H,15-16H2,(H,26,27,28,29)
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 2.20n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013559
PNG
(2-{3-[4-(1H-Tetrazol-5-ylmethoxy)-benzyloxy]-pheno...)
Show SMILES C(Oc1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc1)c1nnn[nH]1
Show InChI InChI=1S/C25H21N5O3/c1-2-7-24-19(4-1)10-11-20(26-24)16-32-23-6-3-5-22(14-23)31-15-18-8-12-21(13-9-18)33-17-25-27-29-30-28-25/h1-14H,15-17H2,(H,27,28,29,30)
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 2.20n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291858
PNG
(7-{2-[3-(Quinolin-2-ylmethoxy)-phenyl]-vinyl}-2-(1...)
Show SMILES O=C1CC(Oc2cc(\C=C\c3cccc(OCc4ccc5ccccc5n4)c3)ccc12)c1nnn[nH]1
Show InChI InChI=1S/C28H21N5O3/c34-25-16-27(28-30-32-33-31-28)36-26-15-19(10-13-23(25)26)9-8-18-4-3-6-22(14-18)35-17-21-12-11-20-5-1-2-7-24(20)29-21/h1-15,27H,16-17H2,(H,30,31,32,33)/b9-8+
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 2.5n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013570
PNG
(7-Chloro-2-(2-{4-[2-(1H-tetrazol-5-ylmethyl)-benzy...)
Show SMILES Clc1ccc2ccc(C=Cc3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 |w:8.7|
Show InChI InChI=1S/C26H20ClN5O/c27-22-10-8-19-9-12-23(28-25(19)16-22)11-5-18-6-13-24(14-7-18)33-17-21-4-2-1-3-20(21)15-26-29-31-32-30-26/h1-14,16H,15,17H2,(H,29,30,31,32)
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 2.5n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013562
PNG
(7-Chloro-2-{4-[2-(1H-tetrazol-5-ylmethyl)-benzylox...)
Show SMILES Clc1ccc2ccc(COc3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1
Show InChI InChI=1S/C25H20ClN5O2/c26-20-7-5-17-6-8-21(27-24(17)14-20)16-33-23-11-9-22(10-12-23)32-15-19-4-2-1-3-18(19)13-25-28-30-31-29-25/h1-12,14H,13,15-16H2,(H,28,29,30,31)
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 2.5n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013550
PNG
(2-{3-[4-(1H-Tetrazol-5-yl)-phenoxymethyl]-phenoxym...)
Show SMILES C(Oc1ccc(cc1)-c1nnn[nH]1)c1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C24H19N5O2/c1-2-7-23-18(5-1)8-11-20(25-23)16-31-22-6-3-4-17(14-22)15-30-21-12-9-19(10-13-21)24-26-28-29-27-24/h1-14H,15-16H2,(H,26,27,28,29)
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 2.90n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50006799
PNG
(2-{4-[2-(1H-Tetrazol-5-ylmethyl)-benzyloxy]-phenox...)
Show SMILES C(Oc1ccc(OCc2ccccc2Cc2nnn[nH]2)cc1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H21N5O2/c1-2-7-20(19(6-1)15-25-27-29-30-28-25)16-31-22-11-13-23(14-12-22)32-17-21-10-9-18-5-3-4-8-24(18)26-21/h1-14H,15-17H2,(H,27,28,29,30)
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 3n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50006799
PNG
(2-{4-[2-(1H-Tetrazol-5-ylmethyl)-benzyloxy]-phenox...)
Show SMILES C(Oc1ccc(OCc2ccccc2Cc2nnn[nH]2)cc1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H21N5O2/c1-2-7-20(19(6-1)15-25-27-29-30-28-25)16-31-22-11-13-23(14-12-22)32-17-21-10-9-18-5-3-4-8-24(18)26-21/h1-14H,15-17H2,(H,27,28,29,30)
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 3n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013553
PNG
(2-(2-{4-[2-(1H-Tetrazol-5-ylmethyl)-benzyloxy]-phe...)
Show SMILES C(Oc1ccc(C=Cc2ccc3ccccc3n2)cc1)c1ccccc1Cc1nnn[nH]1 |w:7.7|
Show InChI InChI=1S/C26H21N5O/c1-2-7-22(21(6-1)17-26-28-30-31-29-26)18-32-24-15-10-19(11-16-24)9-13-23-14-12-20-5-3-4-8-25(20)27-23/h1-16H,17-18H2,(H,28,29,30,31)
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 3.40n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013544
PNG
(2-{3-[2-Methoxy-4-(1H-tetrazol-5-yl)-benzyloxy]-ph...)
Show SMILES COc1cc(ccc1COc1cccc(OCc2ccc3ccccc3n2)c1)-c1nnn[nH]1
Show InChI InChI=1S/C25H21N5O3/c1-31-24-13-18(25-27-29-30-28-25)9-10-19(24)15-32-21-6-4-7-22(14-21)33-16-20-12-11-17-5-2-3-8-23(17)26-20/h2-14H,15-16H2,1H3,(H,27,28,29,30)
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 4.30n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000487
PNG
(8-Chloro-3,4,5,6-tetrahydro-2H-benzo[b]oxocine-10-...)
Show SMILES Clc1cc2CCCCCOc2c(c1)C(=O)NC1CN2CCC1CC2 |(3.8,-7.5,;5.14,-6.73,;6.47,-7.5,;7.8,-6.73,;8.9,-7.82,;10.45,-7.82,;11.55,-6.73,;11.55,-5.19,;10.46,-4.09,;8.91,-4.08,;7.8,-5.18,;6.47,-4.42,;5.14,-5.19,;6.47,-2.88,;5.14,-2.11,;7.8,-2.11,;7.8,-.57,;9.19,.13,;9.27,1.65,;7.99,2.51,;6.61,1.81,;6.52,.27,;7.82,.39,;8.06,1.49,)|
Show InChI InChI=1S/C19H25ClN2O2/c20-15-10-14-4-2-1-3-9-24-18(14)16(11-15)19(23)21-17-12-22-7-5-13(17)6-8-22/h10-11,13,17H,1-9,12H2,(H,21,23)
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 4.70n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013547
PNG
(2-{3-[3-(1H-Tetrazol-5-yl)-phenoxymethyl]-phenoxym...)
Show SMILES C(Oc1cccc(c1)-c1nnn[nH]1)c1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C24H19N5O2/c1-2-10-23-18(6-1)11-12-20(25-23)16-31-21-8-3-5-17(13-21)15-30-22-9-4-7-19(14-22)24-26-28-29-27-24/h1-14H,15-16H2,(H,26,27,28,29)
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 5.30n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50000489
PNG
(CHEMBL353993 | N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-5-...)
Show SMILES COc1c(cc(Cl)cc1C(=O)NC1CN2CCC1CC2)C1CCCCC1 |(13.13,-7.36,;11.79,-8.15,;10.46,-7.38,;9.14,-8.16,;7.78,-7.38,;7.78,-5.84,;6.45,-5.07,;9.13,-5.07,;10.46,-5.82,;11.79,-5.05,;11.19,-3.63,;13.32,-5.24,;14.25,-4.02,;15.77,-4.3,;16.77,-3.14,;16.26,-1.68,;14.74,-1.39,;13.74,-2.57,;14.85,-3.27,;15.7,-2.53,;9.14,-9.7,;10.49,-10.45,;10.49,-12,;9.14,-12.77,;7.81,-12,;7.81,-10.47,)|
Show InChI InChI=1S/C21H29ClN2O2/c1-26-20-17(14-5-3-2-4-6-14)11-16(22)12-18(20)21(25)23-19-13-24-9-7-15(19)8-10-24/h11-12,14-15,19H,2-10,13H2,1H3,(H,23,25)
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 6.10n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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 6.20n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.

J Med Chem 35: 895-903 (1992)


BindingDB Entry DOI: 10.7270/Q2SJ1M77
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50291853
PNG
(4-Oxo-7-[4-(quinolin-2-ylmethoxy)-phenoxymethyl]-c...)
Show SMILES OC(=O)C1CC(=O)c2ccc(COc3ccc(OCc4ccc5ccccc5n4)cc3)cc2O1
Show InChI InChI=1S/C27H21NO6/c29-24-14-26(27(30)31)34-25-13-17(5-12-22(24)25)15-32-20-8-10-21(11-9-20)33-16-19-7-6-18-3-1-2-4-23(18)28-19/h1-13,26H,14-16H2,(H,30,31)
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 6.30n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against LTD4 receptor in guinea pig lung membranes.

J Med Chem 34: 1704-7 (1991)


BindingDB Entry DOI: 10.7270/Q2FJ2FR5
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013554
PNG
(2-{3-[3-Methoxy-5-(1H-tetrazol-5-yl)-benzyloxy]-ph...)
Show SMILES COc1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C25H21N5O3/c1-31-23-12-17(11-19(13-23)25-27-29-30-28-25)15-32-21-6-4-7-22(14-21)33-16-20-10-9-18-5-2-3-8-24(18)26-20/h2-14H,15-16H2,1H3,(H,27,28,29,30)
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 7n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013561
PNG
(2-{3-[4-(1H-Tetrazol-5-ylmethyl)-benzyloxy]-phenox...)
Show SMILES C(Oc1cccc(OCc2ccc3ccccc3n2)c1)c1ccc(Cc2nnn[nH]2)cc1
Show InChI InChI=1S/C25H21N5O2/c1-2-7-24-20(4-1)12-13-21(26-24)17-32-23-6-3-5-22(15-23)31-16-19-10-8-18(9-11-19)14-25-27-29-30-28-25/h1-13,15H,14,16-17H2,(H,27,28,29,30)
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 7.30n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013541
PNG
(2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl...)
Show SMILES COc1cc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C25H21N5O3/c1-31-22-12-19(25-27-29-30-28-25)13-23(14-22)32-15-17-6-10-21(11-7-17)33-16-20-9-8-18-4-2-3-5-24(18)26-20/h2-14H,15-16H2,1H3,(H,27,28,29,30)
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 7.5n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2


(Homo sapiens (Human))		BDBM50228527
PNG
(CHEMBL93991)
Show SMILES C(Cc1nnn[nH]1)C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)c1ccccc1
Show InChI InChI=1S/C27H25N5O/c1-2-6-21(7-3-1)23(13-17-27-29-31-32-30-27)18-20-10-15-25(16-11-20)33-19-24-14-12-22-8-4-5-9-26(22)28-24/h1-12,14-16,23H,13,17-19H2,(H,29,30,31,32)
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 8n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane

J Med Chem 33: 2828-41 (1990)


BindingDB Entry DOI: 10.7270/Q29C6WDM
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013560
PNG
(2-{4-[3-(1H-Tetrazol-5-ylmethoxy)-benzyloxy]-pheno...)
Show SMILES C(Oc1cccc(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1)c1nnn[nH]1
Show InChI InChI=1S/C25H21N5O3/c1-2-7-24-19(5-1)8-9-20(26-24)16-32-22-12-10-21(11-13-22)31-15-18-4-3-6-23(14-18)33-17-25-27-29-30-28-25/h1-14H,15-17H2,(H,27,28,29,30)
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 8n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013546
PNG
(2-{4-[3-(1H-Tetrazol-5-ylmethyl)-benzyloxy]-phenox...)
Show SMILES C(Oc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc(Cc2nnn[nH]2)c1
Show InChI InChI=1S/C25H21N5O2/c1-2-7-24-20(6-1)8-9-21(26-24)17-32-23-12-10-22(11-13-23)31-16-19-5-3-4-18(14-19)15-25-27-29-30-28-25/h1-14H,15-17H2,(H,27,28,29,30)
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 8n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013549
PNG
(4-[3-(Quinolin-2-ylmethoxy)-phenoxymethyl]-3-(1H-t...)
Show SMILES COC(=O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c(OCc2nnn[nH]2)c1
Show InChI InChI=1S/C27H23N5O5/c1-34-27(33)19-9-10-20(25(13-19)37-17-26-29-31-32-30-26)15-35-22-6-4-7-23(14-22)36-16-21-12-11-18-5-2-3-8-24(18)28-21/h2-14H,15-17H2,1H3,(H,29,30,31,32)
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 8n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013558
PNG
(2-{4-[4-(1H-Tetrazol-5-ylmethyl)-benzyloxy]-phenox...)
Show SMILES C(Oc1ccc(OCc2ccc3ccccc3n2)cc1)c1ccc(Cc2nnn[nH]2)cc1
Show InChI InChI=1S/C25H21N5O2/c1-2-4-24-20(3-1)9-10-21(26-24)17-32-23-13-11-22(12-14-23)31-16-19-7-5-18(6-8-19)15-25-27-29-30-28-25/h1-14H,15-17H2,(H,27,28,29,30)
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 8.5n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013564
PNG
(2-(3-{2-[3-(1H-Tetrazol-5-yl)-phenyl]-vinyl}-pheno...)
Show SMILES C(Oc1cccc(\C=C\c2cccc(c2)-c2nnn[nH]2)c1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H19N5O/c1-2-10-24-20(7-1)13-14-22(26-24)17-31-23-9-4-6-19(16-23)12-11-18-5-3-8-21(15-18)25-27-29-30-28-25/h1-16H,17H2,(H,27,28,29,30)/b12-11+
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 8.5n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013555
PNG
(2-{3-[4-(1H-Tetrazol-5-yl)-benzyloxy]-phenoxymethy...)
Show SMILES C(Oc1cccc(OCc2ccc3ccccc3n2)c1)c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C24H19N5O2/c1-2-7-23-18(4-1)12-13-20(25-23)16-31-22-6-3-5-21(14-22)30-15-17-8-10-19(11-9-17)24-26-28-29-27-24/h1-14H,15-16H2,(H,26,27,28,29)
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 10n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013569
PNG
(2-{3-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl...)
Show SMILES COc1cc(OCc2cccc(OCc3ccc4ccccc4n3)c2)cc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C25H21N5O3/c1-31-22-12-19(25-27-29-30-28-25)13-23(14-22)32-15-17-5-4-7-21(11-17)33-16-20-10-9-18-6-2-3-8-24(18)26-20/h2-14H,15-16H2,1H3,(H,27,28,29,30)
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 10n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013540
PNG
(2-{3-[3-(1H-Tetrazol-5-ylmethyl)-benzyloxy]-phenox...)
Show SMILES C(Oc1cccc(OCc2ccc3ccccc3n2)c1)c1cccc(Cc2nnn[nH]2)c1
Show InChI InChI=1S/C25H21N5O2/c1-2-10-24-20(7-1)11-12-21(26-24)17-32-23-9-4-8-22(15-23)31-16-19-6-3-5-18(13-19)14-25-27-29-30-28-25/h1-13,15H,14,16-17H2,(H,27,28,29,30)
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 10n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2


(Homo sapiens (Human))		BDBM50228524
PNG
(CHEMBL317945)
Show SMILES CCCC(CCc1nnn[nH]1)Cc1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C24H27N5O/c1-2-6-18(11-14-24-26-28-29-27-24)15-19-7-5-9-22(16-19)30-17-21-13-12-20-8-3-4-10-23(20)25-21/h3-5,7-10,12-13,16,18H,2,6,11,14-15,17H2,1H3,(H,26,27,28,29)
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 11n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane

J Med Chem 33: 2828-41 (1990)


BindingDB Entry DOI: 10.7270/Q29C6WDM
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(Homo sapiens (Human))		BDBM50013901
PNG
(2-(4-{2-[2-(1H-Tetrazol-5-yl)-ethyl]-pentyl}-pheno...)
Show SMILES CCCC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C24H27N5O/c1-2-5-18(10-15-24-26-28-29-27-24)16-19-8-13-22(14-9-19)30-17-21-12-11-20-6-3-4-7-23(20)25-21/h3-4,6-9,11-14,18H,2,5,10,15-17H2,1H3,(H,26,27,28,29)
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 11n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung membrane

J Med Chem 33: 2828-41 (1990)


BindingDB Entry DOI: 10.7270/Q29C6WDM
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013565
PNG
(2-{3-[2-(1H-Tetrazol-5-ylmethyl)-benzyloxy]-phenox...)
Show SMILES C(Oc1cccc(OCc2ccccc2Cc2nnn[nH]2)c1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H21N5O2/c1-2-8-20(19(7-1)14-25-27-29-30-28-25)16-31-22-9-5-10-23(15-22)32-17-21-13-12-18-6-3-4-11-24(18)26-21/h1-13,15H,14,16-17H2,(H,27,28,29,30)
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 12n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2


(Homo sapiens (Human))		BDBM50228506
PNG
(CHEMBL97656)
Show SMILES CC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C22H23N5O/c1-16(6-13-22-24-26-27-25-22)14-17-7-11-20(12-8-17)28-15-19-10-9-18-4-2-3-5-21(18)23-19/h2-5,7-12,16H,6,13-15H2,1H3,(H,24,25,26,27)
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 12n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane

J Med Chem 33: 2828-41 (1990)


BindingDB Entry DOI: 10.7270/Q29C6WDM
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)		BDBM50013567
PNG
(2-{3-[3-(1H-Tetrazol-5-ylmethoxy)-benzyloxy]-pheno...)
Show SMILES C(Oc1cccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c1)c1nnn[nH]1
Show InChI InChI=1S/C25H21N5O3/c1-2-10-24-19(6-1)11-12-20(26-24)16-32-23-9-4-8-22(14-23)31-15-18-5-3-7-21(13-18)33-17-25-27-29-30-28-25/h1-14H,15-17H2,(H,27,28,29,30)
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 13n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)

J Med Chem 33: 1194-200 (1990)


BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair
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