Found 105 hits with Last Name = 'tute' and Initial = 'm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to Alpha-1 adrenergic receptor by displacement of [3H]prazosin |
J Med Chem 31: 1036-9 (1988)
BindingDB Entry DOI: 10.7270/Q2639RZK |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM96939
((4-amino-6,7-dimethoxy-quinazolin-2-yl)-dimethyl-a...)Show InChI InChI=1S/C12H16N4O2/c1-16(2)12-14-8-6-10(18-4)9(17-3)5-7(8)11(13)15-12/h5-6H,1-4H3,(H2,13,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| PubMed
| 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to Alpha-1 adrenergic receptor by displacement of [3H]prazosin |
J Med Chem 31: 1036-9 (1988)
BindingDB Entry DOI: 10.7270/Q2639RZK |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50227377
(CHEMBL414822)Show InChI InChI=1S/C13H17N3O2/c1-16(2)13-6-9(14)8-5-11(17-3)12(18-4)7-10(8)15-13/h5-7H,1-4H3,(H2,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to Alpha-1 adrenergic receptor by displacement of [3H]prazosin |
J Med Chem 31: 1036-9 (1988)
BindingDB Entry DOI: 10.7270/Q2639RZK |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50227382
(CHEMBL8588)Show SMILES COc1cc2cc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C20H22N4O4/c1-26-16-10-13-11-18(22-19(21)14(13)12-17(16)27-2)23-5-7-24(8-6-23)20(25)15-4-3-9-28-15/h3-4,9-12H,5-8H2,1-2H3,(H2,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to Alpha-1 adrenergic receptor by displacement of [3H]prazosin |
J Med Chem 31: 1036-9 (1988)
BindingDB Entry DOI: 10.7270/Q2639RZK |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM29568
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 4.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to alpha-2 adrenergic receptor by displacement of [3H]clonidine |
J Med Chem 31: 1036-9 (1988)
BindingDB Entry DOI: 10.7270/Q2639RZK |
More data for this Ligand-Target Pair | |
Neprilysin
(Oryctolagus cuniculus (rabbit)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of rabbit NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190771
((R)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)NC1(CO)Cc2ccccc2C1)C(O)=O Show InChI InChI=1S/C22H31NO4/c1-2-7-18(19(25)26)12-21(10-5-6-11-21)20(27)23-22(15-24)13-16-8-3-4-9-17(16)14-22/h3-4,8-9,18,24H,2,5-7,10-15H2,1H3,(H,23,27)(H,25,26)/t18-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Rattus norvegicus (Rat)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of rat NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50287481
(3-[5-(4-Fluoro-benzenesulfonylamino)-3-imidazol-1-...)Show SMILES Cc1c(Cn2ccnc2)c2cc(NS(=O)(=O)c3ccc(F)cc3)ccc2n1CCC(O)=O Show InChI InChI=1S/C22H21FN4O4S/c1-15-20(13-26-11-9-24-14-26)19-12-17(4-7-21(19)27(15)10-8-22(28)29)25-32(30,31)18-5-2-16(23)3-6-18/h2-7,9,11-12,14,25H,8,10,13H2,1H3,(H,28,29) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human platelet microsomal TXA2 synthase |
Bioorg Med Chem Lett 6: 1691-1696 (1996)
Article DOI: 10.1016/0960-894X(96)00299-5 BindingDB Entry DOI: 10.7270/Q27P8ZBS |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50000317
(3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-prop...)Show InChI InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human platelet microsomal TXA2 synthase |
Bioorg Med Chem Lett 6: 1691-1696 (1996)
Article DOI: 10.1016/0960-894X(96)00299-5 BindingDB Entry DOI: 10.7270/Q27P8ZBS |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190753
(2-((1-((5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl)c...)Show SMILES CCCC(CC1(CCCC1)C(=O)Nc1nnc(Cc2ccccc2)s1)C(O)=O Show InChI InChI=1S/C21H27N3O3S/c1-2-8-16(18(25)26)14-21(11-6-7-12-21)19(27)22-20-24-23-17(28-20)13-15-9-4-3-5-10-15/h3-5,9-10,16H,2,6-8,11-14H2,1H3,(H,25,26)(H,22,24,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50060378
(3-[5-(4-Fluoro-benzenesulfonylamino)-3-imidazol-1-...)Show SMILES OC(=O)CCn1cc(Cn2ccnc2)c2cc(NS(=O)(=O)c3ccc(F)cc3)ccc12 Show InChI InChI=1S/C21H19FN4O4S/c22-16-1-4-18(5-2-16)31(29,30)24-17-3-6-20-19(11-17)15(12-25-10-8-23-14-25)13-26(20)9-7-21(27)28/h1-6,8,10-11,13-14,24H,7,9,12H2,(H,27,28) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human platelet microsomal TXA2 synthase |
Bioorg Med Chem Lett 6: 1691-1696 (1996)
Article DOI: 10.1016/0960-894X(96)00299-5 BindingDB Entry DOI: 10.7270/Q27P8ZBS |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190762
(2-((1-((5-(cyclopropylmethyl)-1,3,4-thiadiazol-2-y...)Show SMILES CCCC(CC1(CCCC1)C(=O)Nc1nnc(CC2CC2)s1)C(O)=O Show InChI InChI=1S/C18H27N3O3S/c1-2-5-13(15(22)23)11-18(8-3-4-9-18)16(24)19-17-21-20-14(25-17)10-12-6-7-12/h12-13H,2-11H2,1H3,(H,22,23)(H,19,21,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190737
(2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cy...)Show SMILES CCc1nnc(NC(=O)C2(CC(CCc3ccccc3)C(O)=O)CCCC2)s1 Show InChI InChI=1S/C21H27N3O3S/c1-2-17-23-24-20(28-17)22-19(27)21(12-6-7-13-21)14-16(18(25)26)11-10-15-8-4-3-5-9-15/h3-5,8-9,16H,2,6-7,10-14H2,1H3,(H,25,26)(H,22,24,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50060380
(3-[5-(4-Fluoro-benzenesulfonylamino)-3-pyridin-3-y...)Show SMILES OC(=O)CCn1cc(Cc2cccnc2)c2cc(NS(=O)(=O)c3ccc(F)cc3)ccc12 Show InChI InChI=1S/C23H20FN3O4S/c24-18-3-6-20(7-4-18)32(30,31)26-19-5-8-22-21(13-19)17(12-16-2-1-10-25-14-16)15-27(22)11-9-23(28)29/h1-8,10,13-15,26H,9,11-12H2,(H,28,29) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human platelet microsomal TXA2 synthase |
Bioorg Med Chem Lett 6: 1691-1696 (1996)
Article DOI: 10.1016/0960-894X(96)00299-5 BindingDB Entry DOI: 10.7270/Q27P8ZBS |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190773
(2-[1-(5-ethyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-cyc...)Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190752
(2-((1-((1-ethyl-1H-1,2,3-triazol-4-yl)carbamoyl)cy...)Show InChI InChI=1S/C16H26N4O3/c1-3-7-12(14(21)22)10-16(8-5-6-9-16)15(23)17-13-11-20(4-2)19-18-13/h11-12H,3-10H2,1-2H3,(H,17,23)(H,21,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190764
(2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cy...)Show InChI InChI=1S/C17H27N3O3S/c1-3-5-8-12(14(21)22)11-17(9-6-7-10-17)15(23)18-16-20-19-13(4-2)24-16/h12H,3-11H2,1-2H3,(H,21,22)(H,18,20,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190750
(2-((1-((4-benzylpyridin-2-yl)carbamoyl)cyclopentyl...)Show SMILES CCCC(CC1(CCCC1)C(=O)Nc1cc(Cc2ccccc2)ccn1)C(O)=O Show InChI InChI=1S/C24H30N2O3/c1-2-8-20(22(27)28)17-24(12-6-7-13-24)23(29)26-21-16-19(11-14-25-21)15-18-9-4-3-5-10-18/h3-5,9-11,14,16,20H,2,6-8,12-13,15,17H2,1H3,(H,27,28)(H,25,26,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190769
(CHEMBL377037 | rac-2-((1-((2-(hydroxymethyl)-2,3-d...)Show SMILES CCCC(CC1(CCCC1)C(=O)NC1(CO)Cc2ccccc2C1)C(O)=O Show InChI InChI=1S/C22H31NO4/c1-2-7-18(19(25)26)12-21(10-5-6-11-21)20(27)23-22(15-24)13-16-8-3-4-9-17(16)14-22/h3-4,8-9,18,24H,2,5-7,10-15H2,1H3,(H,23,27)(H,25,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190739
((R)-2-((1-((5-methyl-1,3,4-thiadiazol-2-yl)carbamo...)Show InChI InChI=1S/C15H23N3O3S/c1-3-6-11(12(19)20)9-15(7-4-5-8-15)13(21)16-14-18-17-10(2)22-14/h11H,3-9H2,1-2H3,(H,19,20)(H,16,18,21)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 114 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190738
(2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cy...)Show SMILES CCc1nnc(NC(=O)C2(CC(CCC(C)C)C(O)=O)CCCC2)s1 Show InChI InChI=1S/C18H29N3O3S/c1-4-14-20-21-17(25-14)19-16(24)18(9-5-6-10-18)11-13(15(22)23)8-7-12(2)3/h12-13H,4-11H2,1-3H3,(H,22,23)(H,19,21,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190758
(2-((1-((5-isobutyl-1,3,4-thiadiazol-2-yl)carbamoyl...)Show SMILES CCCC(CC1(CCCC1)C(=O)Nc1nnc(CC(C)C)s1)C(O)=O Show InChI InChI=1S/C18H29N3O3S/c1-4-7-13(15(22)23)11-18(8-5-6-9-18)16(24)19-17-21-20-14(25-17)10-12(2)3/h12-13H,4-11H2,1-3H3,(H,22,23)(H,19,21,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190757
(CHEMBL439508 | cis-2-((1-((4-carbamoylcyclohexyl)c...)Show SMILES CCCC(CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(N)=O)C(O)=O |wU:13.13,16.20,(-5.69,-23.39,;-5.69,-24.93,;-4.36,-25.7,;-4.36,-27.24,;-3.03,-28.01,;-1.69,-27.24,;-2.94,-26.34,;-2.46,-24.87,;-.92,-24.87,;-.45,-26.34,;-.36,-28.01,;-.36,-29.55,;.97,-27.24,;2.31,-28.01,;3.63,-27.24,;4.97,-28.02,;4.96,-29.56,;3.62,-30.32,;2.3,-29.55,;6.29,-30.33,;7.63,-29.57,;6.29,-31.87,;-5.69,-28.01,;-7.03,-27.24,;-5.69,-29.55,)| Show InChI InChI=1S/C19H32N2O4/c1-2-5-14(17(23)24)12-19(10-3-4-11-19)18(25)21-15-8-6-13(7-9-15)16(20)22/h13-15H,2-12H2,1H3,(H2,20,22)(H,21,25)(H,23,24)/t13-,14?,15+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190761
(CHEMBL209493 | rac-2-((1-((5-methyl-1,3,4-thiadiaz...)Show InChI InChI=1S/C15H23N3O3S/c1-3-6-11(12(19)20)9-15(7-4-5-8-15)13(21)16-14-18-17-10(2)22-14/h11H,3-9H2,1-2H3,(H,19,20)(H,16,18,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 176 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190780
(2-((1-((4-butylpyridin-2-yl)carbamoyl)cyclopentyl)...)Show InChI InChI=1S/C21H32N2O3/c1-3-5-9-16-10-13-22-18(14-16)23-20(26)21(11-6-7-12-21)15-17(8-4-2)19(24)25/h10,13-14,17H,3-9,11-12,15H2,1-2H3,(H,24,25)(H,22,23,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 184 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190777
(2-((1-(((1R,2R)-2-benzylcyclohexyl)carbamoyl)cyclo...)Show SMILES CCCC(CC1(CCCC1)C(=O)N[C@@H]1CCCC[C@@H]1Cc1ccccc1)C(O)=O Show InChI InChI=1S/C25H37NO3/c1-2-10-21(23(27)28)18-25(15-8-9-16-25)24(29)26-22-14-7-6-13-20(22)17-19-11-4-3-5-12-19/h3-5,11-12,20-22H,2,6-10,13-18H2,1H3,(H,26,29)(H,27,28)/t20-,21?,22-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190743
((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)Show SMILES CCC[C@@H](CC1(CCCC1)C(=O)NC1(CO)Cc2ccccc2C1)C(O)=O Show InChI InChI=1S/C22H31NO4/c1-2-7-18(19(25)26)12-21(10-5-6-11-21)20(27)23-22(15-24)13-16-8-3-4-9-17(16)14-22/h3-4,8-9,18,24H,2,5-7,10-15H2,1H3,(H,23,27)(H,25,26)/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 205 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190782
(2-((1-(((1R,3S)-3-carbamoylcyclopentyl)carbamoyl)c...)Show SMILES CCCC(CC1(CCCC1)C(=O)N[C@@H]1CC[C@@H](C1)C(N)=O)C(O)=O Show InChI InChI=1S/C18H30N2O4/c1-2-5-13(16(22)23)11-18(8-3-4-9-18)17(24)20-14-7-6-12(10-14)15(19)21/h12-14H,2-11H2,1H3,(H2,19,21)(H,20,24)(H,22,23)/t12-,13?,14+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 213 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190763
(3-(1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cyc...)Show InChI InChI=1S/C13H19N3O3S/c1-2-9-15-16-12(20-9)14-11(19)13(6-3-4-7-13)8-5-10(17)18/h2-8H2,1H3,(H,17,18)(H,14,16,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 237 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190775
(2-((1-((5-phenyl-1,3,4-thiadiazol-2-yl)carbamoyl)c...)Show SMILES CCCC(CC1(CCCC1)C(=O)Nc1nnc(s1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C20H25N3O3S/c1-2-8-15(17(24)25)13-20(11-6-7-12-20)18(26)21-19-23-22-16(27-19)14-9-4-3-5-10-14/h3-5,9-10,15H,2,6-8,11-13H2,1H3,(H,24,25)(H,21,23,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 283 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190742
((S)-2-((1-((5-methyl-1,3,4-thiadiazol-2-yl)carbamo...)Show SMILES CCC[C@@H](CC1(CCCC1)C(=O)Nc1nnc(C)s1)C(O)=O Show InChI InChI=1S/C15H23N3O3S/c1-3-6-11(12(19)20)9-15(7-4-5-8-15)13(21)16-14-18-17-10(2)22-14/h11H,3-9H2,1-2H3,(H,19,20)(H,16,18,21)/t11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 286 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190736
((S)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 292 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190767
(2-((1-((3-(dimethylcarbamoyl)cyclohexyl)carbamoyl)...)Show SMILES CCCC(CC1(CCCC1)C(=O)NC1CCCC(C1)C(=O)N(C)C)C(O)=O Show InChI InChI=1S/C21H36N2O4/c1-4-8-16(19(25)26)14-21(11-5-6-12-21)20(27)22-17-10-7-9-15(13-17)18(24)23(2)3/h15-17H,4-14H2,1-3H3,(H,22,27)(H,25,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 297 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190755
(2-((1-((2,3-dihydro-1H-inden-2-yl)carbamoyl)cyclop...)Show InChI InChI=1S/C21H29NO3/c1-2-7-17(19(23)24)14-21(10-5-6-11-21)20(25)22-18-12-15-8-3-4-9-16(15)13-18/h3-4,8-9,17-18H,2,5-7,10-14H2,1H3,(H,22,25)(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 313 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190760
(2-((1-((1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)car...)Show SMILES CCCC(CC1(CCCC1)C(=O)Nc1ccc(=O)n(Cc2ccccc2)c1)C(O)=O Show InChI InChI=1S/C24H30N2O4/c1-2-8-19(22(28)29)15-24(13-6-7-14-24)23(30)25-20-11-12-21(27)26(17-20)16-18-9-4-3-5-10-18/h3-5,9-12,17,19H,2,6-8,13-16H2,1H3,(H,25,30)(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 313 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190772
(CHEMBL213240 | cis-2-((1-((4-(dimethylcarbamoyl)cy...)Show SMILES CCCC(CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(=O)N(C)C)C(O)=O |wU:13.13,16.20,(-6.79,-6.07,;-6.79,-7.61,;-5.46,-8.38,;-5.46,-9.92,;-4.12,-10.69,;-2.79,-9.92,;-4.04,-9.02,;-3.56,-7.55,;-2.02,-7.55,;-1.54,-9.02,;-1.46,-10.69,;-1.46,-12.23,;-.12,-9.92,;1.21,-10.69,;2.53,-9.92,;3.87,-10.7,;3.87,-12.24,;2.53,-13,;1.2,-12.23,;5.2,-13.02,;5.19,-14.56,;6.53,-12.25,;7.86,-13.03,;6.54,-10.71,;-6.79,-10.69,;-8.12,-9.92,;-6.79,-12.23,)| Show InChI InChI=1S/C21H36N2O4/c1-4-7-16(19(25)26)14-21(12-5-6-13-21)20(27)22-17-10-8-15(9-11-17)18(24)23(2)3/h15-17H,4-14H2,1-3H3,(H,22,27)(H,25,26)/t15-,16?,17+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190766
(2-((1-((6-methoxypyridazin-3-yl)carbamoyl)cyclopen...)Show InChI InChI=1S/C17H25N3O4/c1-3-6-12(15(21)22)11-17(9-4-5-10-17)16(23)18-13-7-8-14(24-2)20-19-13/h7-8,12H,3-6,9-11H2,1-2H3,(H,21,22)(H,18,19,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 374 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190774
(2-((1-((1,3,4-thiadiazol-2-yl)carbamoyl)cyclopenty...)Show InChI InChI=1S/C14H21N3O3S/c1-2-5-10(11(18)19)8-14(6-3-4-7-14)12(20)16-13-17-15-9-21-13/h9-10H,2-8H2,1H3,(H,18,19)(H,16,17,20) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 377 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190748
(2-((1-(((S)-1-hydroxy-3-phenylpropan-2-yl)carbamoy...)Show SMILES CCCC(CC1(CCCC1)C(=O)N[C@H](CO)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C21H31NO4/c1-2-8-17(19(24)25)14-21(11-6-7-12-21)20(26)22-18(15-23)13-16-9-4-3-5-10-16/h3-5,9-10,17-18,23H,2,6-8,11-15H2,1H3,(H,22,26)(H,24,25)/t17?,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 384 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190770
(2-((1-(((R)-1-phenylethyl)carbamoyl)cyclopentyl)me...)Show SMILES CCCC(CC1(CCCC1)C(=O)N[C@H](C)c1ccccc1)C(O)=O Show InChI InChI=1S/C20H29NO3/c1-3-9-17(18(22)23)14-20(12-7-8-13-20)19(24)21-15(2)16-10-5-4-6-11-16/h4-6,10-11,15,17H,3,7-9,12-14H2,1-2H3,(H,21,24)(H,22,23)/t15-,17?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190740
(2-((1-(((5-methyl-1,3,4-thiadiazol-2-yl)methyl)car...)Show InChI InChI=1S/C16H25N3O3S/c1-3-6-12(14(20)21)9-16(7-4-5-8-16)15(22)17-10-13-19-18-11(2)23-13/h12H,3-10H2,1-2H3,(H,17,22)(H,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190781
(2-((1-(((1R,2S)-2-propylcyclohexyl)carbamoyl)cyclo...)Show SMILES CCCC(CC1(CCCC1)C(=O)N[C@@H]1CCCC[C@@H]1CCC)C(O)=O Show InChI InChI=1S/C21H37NO3/c1-3-9-16-11-5-6-12-18(16)22-20(25)21(13-7-8-14-21)15-17(10-4-2)19(23)24/h16-18H,3-15H2,1-2H3,(H,22,25)(H,23,24)/t16-,17?,18+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190759
(2-((1-(((R)-1-benzylpyrrolidin-3-yl)carbamoyl)cycl...)Show SMILES CCCC(CC1(CCCC1)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1)C(O)=O Show InChI InChI=1S/C23H34N2O3/c1-2-8-19(21(26)27)15-23(12-6-7-13-23)22(28)24-20-11-14-25(17-20)16-18-9-4-3-5-10-18/h3-5,9-10,19-20H,2,6-8,11-17H2,1H3,(H,24,28)(H,26,27)/t19?,20-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190779
(2-((1-(5-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)-...)Show SMILES CCCC(CC1(CCCC1)c1nnc(o1)-c1ccc(=O)n(Cc2ccccc2)c1)C(O)=O Show InChI InChI=1S/C25H29N3O4/c1-2-8-19(23(30)31)15-25(13-6-7-14-25)24-27-26-22(32-24)20-11-12-21(29)28(17-20)16-18-9-4-3-5-10-18/h3-5,9-12,17,19H,2,6-8,13-16H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190741
(2-((1-(pyridin-2-ylcarbamoyl)cyclopentyl)methyl)pe...)Show InChI InChI=1S/C17H24N2O3/c1-2-7-13(15(20)21)12-17(9-4-5-10-17)16(22)19-14-8-3-6-11-18-14/h3,6,8,11,13H,2,4-5,7,9-10,12H2,1H3,(H,20,21)(H,18,19,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190765
(2-((1-((benzo[d][1,3]dioxol-5-ylmethyl)carbamoyl)c...)Show InChI InChI=1S/C20H27NO5/c1-2-5-15(18(22)23)11-20(8-3-4-9-20)19(24)21-12-14-6-7-16-17(10-14)26-13-25-16/h6-7,10,15H,2-5,8-9,11-13H2,1H3,(H,21,24)(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |