Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50068812 (CHEMBL146917 | N-(4-Carboxy-4-{4-[(2,4-diamino-5-c...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50068813 (CHEMBL149962 | N-(4-Carboxy-4-{4-[(2,4-diamino-pyr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50011320 (CHEMBL18155 | N-(4-Carboxy-4-{4-[(2,4-diamino-pter...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50068810 (CHEMBL149164 | N-(4-Carboxy-4-{4-[(2,4-diamino-pyr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50068809 (CHEMBL150607 | N-(4-Carboxy-4-{4-[(2,4-diamino-5-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50068808 (CHEMBL297088 | N-(4-Carboxy-4-{4-[(2,4-diamino-qui...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50068811 (CHEMBL149218 | N-(4-Carboxy-4-{4-[(2,4-diamino-5-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50367055 (4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 0.00500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM | J Med Chem 41: 5310-9 (1999) Article DOI: 10.1021/jm980477+ BindingDB Entry DOI: 10.7270/Q2542P85 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50158569 (2-S-[5-[2,4-diaminopteridin-6-yl)methyamino]-2,3-d...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of human DHFR | J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50158570 (2-R,S-[5-[(2,4-diaminopteridin-6-yl)methylamino]-2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0770 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of human DHFR | J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50158571 (2-S-[5-[N-(2,4--diaminopteridin-6-yl)methyl)-N-met...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of human DHFR | J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50002471 (5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,4a,5,6,7,8-octa...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse liver Folyl-polyglutamate synthase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50005868 (2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50024475 (2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-quinazo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse GAR transformylase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50006906 (2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-am...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity of the compound towards Folyl polyglutamate synthetase (FPGS) | J Med Chem 35: 2626-30 (1992) BindingDB Entry DOI: 10.7270/Q2DV1HVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Lactobacillus casei) | BDBM50016343 (2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-m...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus casei | J Med Chem 29: 1872-6 (1986) BindingDB Entry DOI: 10.7270/Q2JH3K4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Lactobacillus casei) | BDBM50016340 (2-[4-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 172 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus casei | J Med Chem 29: 1872-6 (1986) BindingDB Entry DOI: 10.7270/Q2JH3K4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Lactobacillus casei) | BDBM50016339 (2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 189 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus casei | J Med Chem 29: 1872-6 (1986) BindingDB Entry DOI: 10.7270/Q2JH3K4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50005865 (2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50080450 ((S)-5-Amino-2-{5-[(2-amino-4-oxo-3,4,5,6,7,8-hexah...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity of the compound as Competitive substrate in the presence of 50 gmM aminopterin towards recombinant Human Folyl-polyglutamate synthas... | J Med Chem 42: 3510-9 (1999) Article DOI: 10.1021/jm9807205 BindingDB Entry DOI: 10.7270/Q2X929GV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Lactobacillus casei) | BDBM50016342 (2-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-meth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 205 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus casei | J Med Chem 29: 1872-6 (1986) BindingDB Entry DOI: 10.7270/Q2JH3K4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reduced folate transporter (Homo sapiens (Human)) | BDBM50158569 (2-S-[5-[2,4-diaminopteridin-6-yl)methyamino]-2,3-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cells | J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Lactobacillus casei) | BDBM50016341 (2-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 336 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus casei | J Med Chem 29: 1872-6 (1986) BindingDB Entry DOI: 10.7270/Q2JH3K4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reduced folate transporter (Homo sapiens (Human)) | BDBM50158570 (2-R,S-[5-[(2,4-diaminopteridin-6-yl)methylamino]-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cells | J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reduced folate transporter (Homo sapiens (Human)) | BDBM50158571 (2-S-[5-[N-(2,4--diaminopteridin-6-yl)methyl)-N-met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cells | J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50006907 (2-{4-[(4-Oxo-3,4-dihydro-quinazolin-6-ylmethyl)-am...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity of the compound towards Folyl polyglutamate synthetase (FPGS) | J Med Chem 35: 2626-30 (1992) BindingDB Entry DOI: 10.7270/Q2DV1HVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50006905 (2-{4-[(4-Oxo-3,4-dihydro-benzo[d][1,2,3]triazin-6-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity of the compound towards Folyl polyglutamate synthetase (FPGS) | J Med Chem 35: 2626-30 (1992) BindingDB Entry DOI: 10.7270/Q2DV1HVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50005868 (2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse liver Folyl-polyglutamate synthase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50002471 (5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,4a,5,6,7,8-octa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50005859 (5-Amino-2-{4-[(2,4-diamino-pyrido[3,2-d]pyrimidin-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse liver Folyl-polyglutamate synthase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50005867 (2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyri...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse liver Folyl-polyglutamate synthase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50005865 (2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse liver Folyl-polyglutamate synthase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Mus musculus) | BDBM50006905 (2-{4-[(4-Oxo-3,4-dihydro-benzo[d][1,2,3]triazin-6-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Compound was tested for the inhibition of recombinant mouse thymidylate synthase, competitive with 5,10-methylenetetrahydrofolate as variable substra... | J Med Chem 35: 2626-30 (1992) BindingDB Entry DOI: 10.7270/Q2DV1HVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50028119 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase. | J Med Chem 27: 600-4 (1984) BindingDB Entry DOI: 10.7270/Q2PR7V0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50023710 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of Folyl-polyglutamate synthase from mouse liver | J Med Chem 31: 1326-31 (1988) BindingDB Entry DOI: 10.7270/Q21N8049 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50023710 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 5.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase. | J Med Chem 27: 600-4 (1984) BindingDB Entry DOI: 10.7270/Q2PR7V0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50080449 ((S)-5-Amino-2-{5-[(2-amino-4-oxo-3,4-dihydro-pyrid...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity of the compound as Competitive substrate in the presence of 50 gmM aminopterin towards recombinant Human Folyl-polyglutamate synthas... | J Med Chem 42: 3510-9 (1999) Article DOI: 10.1021/jm9807205 BindingDB Entry DOI: 10.7270/Q2X929GV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50005860 (2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse liver Folyl-polyglutamate synthase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50028118 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 1.36E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase. | J Med Chem 27: 600-4 (1984) BindingDB Entry DOI: 10.7270/Q2PR7V0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50023709 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of Folyl-polyglutamate synthase from mouse liver | J Med Chem 31: 1326-31 (1988) BindingDB Entry DOI: 10.7270/Q21N8049 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50023711 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 1.88E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of Folyl-polyglutamate synthase from mouse liver | J Med Chem 31: 1326-31 (1988) BindingDB Entry DOI: 10.7270/Q21N8049 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50023711 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 1.98E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase. | J Med Chem 27: 600-4 (1984) BindingDB Entry DOI: 10.7270/Q2PR7V0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50005863 (2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyri...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 5.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse liver Folyl-polyglutamate synthase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Mus musculus) | BDBM50005866 (2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyri...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of mouse liver Folyl-polyglutamate synthase | J Med Chem 35: 1578-88 (1992) BindingDB Entry DOI: 10.7270/Q2028S6J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Mycobacterium avium) | BDBM18229 (5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0570 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to... | J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Pneumocystis carinii) | BDBM18229 (5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0970 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Harvard Medical School | Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to... | J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Pneumocystis carinii) | BDBM18228 (4-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Harvard Medical School | Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to... | J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50141010 (6-(5-Chloro-2-methyl-benzyl)-5-methyl-pyrido[2,3-d...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | J Med Chem 47: 1475-86 (2004) Article DOI: 10.1021/jm030438k BindingDB Entry DOI: 10.7270/Q2SJ1K14 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Mycobacterium avium) | BDBM18225 (2,4-diamino-5-deazapteridine, 4 | 4-[3-({2,4-diami...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to... | J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F | |||||||||||
More data for this Ligand-Target Pair |
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